LOCUS       NP_001388790             650 aa            linear   ROD 30-MAR-2024
DEFINITION  forkhead box protein K2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001388790 XP_006247952
VERSION     NP_001388790.1
DBSOURCE    REFSEQ: accession NM_001401861.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 650)
  AUTHORS   Sukonina,V., Ma,H., Zhang,W., Bartesaghi,S., Subhash,S.,
            Heglind,M., Foyn,H., Betz,M.J., Nilsson,D., Lidell,M.E.,
            Naumann,J., Haufs-Brusberg,S., Palmgren,H., Mondal,T., Beg,M.,
            Jedrychowski,M.P., Tasken,K., Pfeifer,A., Peng,X.R., Kanduri,C. and
            Enerback,S.
  TITLE     FOXK1 and FOXK2 regulate aerobic glycolysis
  JOURNAL   Nature 566 (7743), 279-283 (2019)
   PUBMED   30700909
REFERENCE   2  (residues 1 to 650)
  AUTHORS   He,L., Gomes,A.P., Wang,X., Yoon,S.O., Lee,G., Nagiec,M.J., Cho,S.,
            Chavez,A., Islam,T., Yu,Y., Asara,J.M., Kim,B.Y. and Blenis,J.
  TITLE     mTORC1 Promotes Metabolic Reprogramming by the Suppression of
            GSK3-Dependent Foxk1 Phosphorylation
  JOURNAL   Mol Cell 70 (5), 949-960 (2018)
   PUBMED   29861159
REFERENCE   3  (residues 1 to 650)
  AUTHORS   Okino,Y., Machida,Y., Frankland-Searby,S. and Machida,Y.J.
  TITLE     BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the
            ubiquitin-mediated activation of FoxK2 target genes
  JOURNAL   J Biol Chem 290 (3), 1580-1591 (2015)
   PUBMED   25451922
REFERENCE   4  (residues 1 to 650)
  AUTHORS   Bowman,C.J., Ayer,D.E. and Dynlacht,B.D.
  TITLE     Foxk proteins repress the initiation of starvation-induced atrophy
            and autophagy programs
  JOURNAL   Nat Cell Biol 16 (12), 1202-1214 (2014)
   PUBMED   25402684
REFERENCE   5  (residues 1 to 650)
  AUTHORS   Ji,Z., Donaldson,I.J., Liu,J., Hayes,A., Zeef,L.A. and
            Sharrocks,A.D.
  TITLE     The forkhead transcription factor FOXK2 promotes AP-1-mediated
            transcriptional regulation
  JOURNAL   Mol Cell Biol 32 (2), 385-398 (2012)
   PUBMED   22083952
  REMARK    Erratum:[Mol Cell Biol. 2014 May;34(10):1892]
REFERENCE   6  (residues 1 to 650)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Identification of forkhead transcription factors in cortical and
            dopaminergic areas of the adult murine brain
  JOURNAL   Brain Res 1068 (1), 23-33 (2006)
   PUBMED   16376864
REFERENCE   7  (residues 1 to 650)
  AUTHORS   Liu,P.P., Chen,Y.C., Li,C., Hsieh,Y.H., Chen,S.W., Chen,S.H.,
            Jeng,W.Y. and Chuang,W.J.
  TITLE     Solution structure of the DNA-binding domain of interleukin
            enhancer binding factor 1 (FOXK1a)
  JOURNAL   Proteins 49 (4), 543-553 (2002)
   PUBMED   12402362
REFERENCE   8  (residues 1 to 650)
  AUTHORS   Nirula,A., Moore,D.J. and Gaynor,R.B.
  TITLE     Constitutive binding of the transcription factor interleukin-2
            (IL-2) enhancer binding factor to the IL-2 promoter
  JOURNAL   J Biol Chem 272 (12), 7736-7745 (1997)
   PUBMED   9065434
REFERENCE   9  (residues 1 to 650)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Nirula,A. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein ILF
  JOURNAL   Genomics 13 (3), 665-671 (1992)
   PUBMED   1339390
REFERENCE   10 (residues 1 to 650)
  AUTHORS   Li,C., Lai,C.F., Sigman,D.S. and Gaynor,R.B.
  TITLE     Cloning of a cellular factor, interleukin binding factor, that
            binds to NFAT-like motifs in the human immunodeficiency virus long
            terminal repeat
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7739-7743 (1991)
   PUBMED   1909027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 28, 2022 this sequence version replaced XP_006247952.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.68030.1,
                                           SRR26360181.1717298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     Protein         1..650
                     /product="forkhead box protein K2 isoform 1"
                     /note="forkhead box protein K2"
                     /calculated_mol_wt=68320
     Region          29..148
                     /region_name="FHA_FOXK2"
                     /note="forkhead associated (FHA) domain found in forkhead
                     box protein K2 (FOXK2) and similar proteins; cd22723"
                     /db_xref="CDD:438775"
     Site            order(51..52,70..71,73,108,110..111)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438775"
     Region          247..344
                     /region_name="FH_FOXK2"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     K2 (FOXK2) and similar proteins; cd20055"
                     /db_xref="CDD:410829"
     Site            order(249,252..254,272..273,276,291,295..296,298..299,
                     302..303,309,317,319..321,323,341,344)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410829"
     CDS             1..650
                     /gene="Foxk2"
                     /coded_by="NM_001401861.1:134..2086"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:303753"
                     /db_xref="RGD:1305408"
ORIGIN      
        1 maaaaalsga gappagggag gggsppggwa varlegrefe ylmkkrsvti grnssqgsvd
       61 vsmghssfis rrhleiftpp ggghsaaape paqprpdagg dfylrclgkn gvfvdgvfqr
      121 rgapplqlpr vctfrfpstn ikitftalss ekrekqeape spvkpvqphi spltinipdt
      181 mahlisplps ptgtisaans cpssprgags sgykmgrvip sdlnlmadns qpenekeasg
      241 gdspkddskp pysyaqlivq aitmapdkql tlngiythit knypyyrtad kgwqnsirhn
      301 lslnryfikv prsqeepgkg sfwridpase sklveqafrk rrprgvpcfr tplgplssrs
      361 apaspnhagv lsahssgaqt peslsregsp aplepepgas qpklaviqea rfaqsapgsp
      421 lssqpvlitv qrqlppaikp vtytvatpvt tptsqppvvq tvhvvhqipa vavtsvagla
      481 pantytvagq avvtqaavla pktepqengd hrevrvkvep vpaispatlg aasriiqtsq
      541 gtpvqtvtiv qqaplgqhql piktvtqngt hvvpmptavh sqvnnavasp lhmlathasa
      601 saslptkrqn gdqaeqpelk rvkaedgesi vialsvdapp aavrekaiqn
//
