LOCUS       NM_053832               2427 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus forkhead box J1 (Foxj1), mRNA.
ACCESSION   NM_053832
VERSION     NM_053832.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Wallmeier,J., Frank,D., Shoemark,A., Nothe-Menchen,T., Cindric,S.,
            Olbrich,H., Loges,N.T., Aprea,I., Dougherty,G.W., Pennekamp,P.,
            Kaiser,T., Mitchison,H.M., Hogg,C., Carr,S.B., Zariwala,M.A.,
            Ferkol,T., Leigh,M.W., Davis,S.D., Atkinson,J., Dutcher,S.K.,
            Knowles,M.R., Thiele,H., Altmuller,J., Krenz,H., Woste,M.,
            Brentrup,A., Ahrens,F., Vogelberg,C., Morris-Rosendahl,D.J. and
            Omran,H.
  TITLE     De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with
            Hydrocephalus and Randomization of Left/Right Body Asymmetry
  JOURNAL   Am J Hum Genet 105 (5), 1030-1039 (2019)
   PUBMED   31630787
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Stauber,M., Boldt,K., Wrede,C., Weidemann,M., Kellner,M.,
            Schuster-Gossler,K., Kuhnel,M.P., Hegermann,J., Ueffing,M. and
            Gossler,A.
  TITLE     1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of
            the mouse but not essential for motile ciliogenesis
  JOURNAL   Dev Biol 429 (1), 186-199 (2017)
   PUBMED   28666954
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Nakakura,T., Suzuki,T., Horiguchi,K., Fujiwara,K., Tsukada,T.,
            Asano-Hoshino,A., Tanaka,H., Arisawa,K., Nishijima,Y.,
            Nekooki-Machida,Y., Kiuchi,Y. and Hagiwara,H.
  TITLE     Expression and localization of forkhead box protein FOXJ1 in
            S100beta-positive multiciliated cells of the rat pituitary
  JOURNAL   Med Mol Morphol 50 (2), 59-67 (2017)
   PUBMED   27660208
  REMARK    GeneRIF: Expression and localization of FOXJ1 in S100beta-positive
            multiciliated cells of the rat pituitary has been described.
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Weidemann,M., Schuster-Gossler,K., Stauber,M., Wrede,C.,
            Hegermann,J., Ott,T., Boldt,K., Beyer,T., Serth,K., Kremmer,E.,
            Blum,M., Ueffing,M. and Gossler,A.
  TITLE     CFAP157 is a murine downstream effector of FOXJ1 that is
            specifically required for flagellum morphogenesis and sperm
            motility
  JOURNAL   Development 143 (24), 4736-4748 (2016)
   PUBMED   27965440
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Brody,S.L., Yan,X.H., Wuerffel,M.K., Song,S.K. and Shapiro,S.D.
  TITLE     Ciliogenesis and left-right axis defects in forkhead factor
            HFH-4-null mice
  JOURNAL   Am J Respir Cell Mol Biol 23 (1), 45-51 (2000)
   PUBMED   10873152
REFERENCE   7  (bases 1 to 2427)
  AUTHORS   Chen,J., Knowles,H.J., Hebert,J.L. and Hackett,B.P.
  TITLE     Mutation of the mouse hepatocyte nuclear factor/forkhead homologue
            4 gene results in an absence of cilia and random left-right
            asymmetry
  JOURNAL   J Clin Invest 102 (6), 1077-1082 (1998)
   PUBMED   9739041
REFERENCE   8  (bases 1 to 2427)
  AUTHORS   Pelletier,G.J., Brody,S.L., Liapis,H., White,R.A. and Hackett,B.P.
  TITLE     A human forkhead/winged-helix transcription factor expressed in
            developing pulmonary and renal epithelium
  JOURNAL   Am J Physiol 274 (3), L351-L359 (1998)
   PUBMED   9530170
REFERENCE   9  (bases 1 to 2427)
  AUTHORS   Lim,L., Zhou,H. and Costa,R.H.
  TITLE     The winged helix transcription factor HFH-4 is expressed during
            choroid plexus epithelial development in the mouse embryo
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3094-3099 (1997)
   PUBMED   9096351
REFERENCE   10 (bases 1 to 2427)
  AUTHORS   Hackett,B.P., Brody,S.L., Liang,M., Zeitz,I.D., Bruns,L.A. and
            Gitlin,J.D.
  TITLE     Primary structure of hepatocyte nuclear factor/forkhead homologue 4
            and characterization of gene expression in the developing
            respiratory and reproductive epithelium
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4249-4253 (1995)
   PUBMED   7753791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 26, 2021 this sequence version replaced NM_053832.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L36388.1, SRR26643293.67500.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-667               JAXUCZ010000010.1  102068575-102069241 c
            668-2427            JAXUCZ010000010.1  102065170-102066929 c
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2427
                     /gene="Foxj1"
                     /gene_synonym="Hfh-4; Hfh4"
                     /note="forkhead box J1"
                     /db_xref="GeneID:116557"
                     /db_xref="RGD:621764"
     exon            1..667
                     /gene="Foxj1"
                     /gene_synonym="Hfh-4; Hfh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1435
                     /gene="Foxj1"
                     /gene_synonym="Hfh-4; Hfh4"
                     /note="hepatocyte nuclear factor 3 forkhead homolog 4"
                     /codon_start=1
                     /product="forkhead box protein J1"
                     /protein_id="NP_446284.2"
                     /db_xref="GeneID:116557"
                     /db_xref="RGD:621764"
                     /translation="MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSI
                     LNAKAPTLPPGGTDPHGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPP
                     GLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRH
                     ADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPV
                     HIHPAFARQAAQEPSTAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQ
                     PLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSP
                     PLSPSSHGEVDLTVHGRHINCPATWGPPVEQATDSLDFDETFLATSFLQHPWDESSSG
                     CLPPEPLFEAGDATLAADLQDWASVGAFL"
     exon            668..2427
                     /gene="Foxj1"
                     /gene_synonym="Hfh-4; Hfh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccacact cgagttcgga ggaggcgacc cccggggtcg cagaatggaa gtgagtgttc
       61 tggagactga gtaactggag tctggggcac cagcgggctg gagagcgcgg cgggccactc
      121 cggctcagcc tgtggatgtt gaccgcccct tcgaagagtc cccgcagaca tggcggagag
      181 ctggctgcgc ctctgcggag cggggcccgg ggaggaggcc gggccggaag gtggcatgga
      241 ggagccggac gccctggatg acagcctgac cagcttgcaa tggctgcagg aattctccat
      301 tctcaacgcc aaggccccca ctcttccccc gggaggcacc gacccccatg gctaccacca
      361 agtaccgggt ttggtggcgc ccgggtcacc gctggcggca gaccctgcct gccttgggca
      421 gccacacaca cccggcaagc ccacatcgtc gtgcacatct cgaagcgcgc ccccagggct
      481 gcaggccccg ccccctgacg acgtggacta tgccaccaac ccacatgtga agccgcccta
      541 ctcgtatgcc actctcatct gcatggccat gcaagccagc aaggccacca agatcactct
      601 gtcggccatc tacaagtgga tcacggacaa cttctgctac ttccgccatg ctgaccccac
      661 ctggcagaat tccatccgcc acaacctgtc cttgaacaag tgcttcatca aagtgcctcg
      721 ggagaaggat gagcccggca aggggggctt ctggcgcatc gacccccagt atgcagaacg
      781 cctgctcagt ggggccttca agaagcggag gctgcccccg gtccacatcc accctgcctt
      841 tgcccggcag gccgcccagg aacccagcac tgccccctgg ggtgggcctc tgaccgtgaa
      901 cagggaggcc cagcagctac tgcaggagtt tgaggaggcc acaggggagg gaggctgggg
      961 cacaggagag ggaaggctgg ggcataagcg aaagcagccg ctgcccaaga gggtggccaa
     1021 ggtcctgcgg cctcccagca ccttgctgct gacccaggag gagcagggtg agctggaacc
     1081 cctcaaaggt aactttgact gggaggccat cttcgaggct ggcgcactgg gtgaggagct
     1141 gagctcactg gagggtctgg aactaagccc cccgctgagc cccagctcac acggagaggt
     1201 ggatctcaca gtccatggcc gccacatcaa ctgtcctgct acctggggcc ctccagtgga
     1261 gcaggctact gacagcctgg actttgatga gaccttcctg gccacgtcct tcctccagca
     1321 tccctgggac gagagtagta gtggttgcct gcccccagaa cccctctttg aagcagggga
     1381 tgccaccctg gccgctgacc tgcaggactg ggccagtgtg ggagccttct tataaaaggt
     1441 caggccccac cccatctccg gacagtgctc aagtcagggc ccagaactgc ctcccaagac
     1501 aggccctttg gacatcccag cacccaggca gggactgggc caggtcgctg gagggccaca
     1561 ctgctgccag ctggggatgt cctcatatcc aagcccagaa gaactgggaa ctggggactg
     1621 cctccccctc atcagcaacc cccatacaca cagtgtttca tccacccgtg ttcccccaag
     1681 cccaagaatt ggcaaaagca cccctgcccc tgcctgcccc cctgtactcc gagagccgaa
     1741 gcccggaggg gtcctaccta ccgggcctgg gaggaactga acagggccct caccaaagct
     1801 tcacctcacc cacttctgct gcttctccag gtccctaccc agagaaagtt cccaggtaca
     1861 acaaatggct cgttagagga taacaaatta acccccagga ggcccctccc ggcagagttc
     1921 tctcaggggc cctggcagcc ttggccaggg acagcgaggg caggggactg gggaagggaa
     1981 cagaaagagg aggcagaaac caggtggggg cagcaaggtg gggtgagatg gtctctaagc
     2041 cttctggggc cttctcctgg cccgacgcct gtgaagggag gctgcaagct tttgagtctg
     2101 acttgagggt gagagcaaca ggaagttggg gcttggggtg gttggggcag gggcagccaa
     2161 gctgctaggt ggggggggag agagattaat atagcgactg tagttatagc taagacttaa
     2221 ctggggaagg ggtgcctgac ttactggaaa cactgggacc aggaagggga caaaccctag
     2281 gcccctgtct gcactggggg ggaccaggtc ttgctccacc ttgacccctg gggctggagc
     2341 ctgtatctac cctccacgtg gagcaagtta acctttttca tgtaaagttc tttacaataa
     2401 aatttttttt tcaaaataaa atttaaa
//
