LOCUS       NM_001130493            1721 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus forkhead box H1 (Foxh1), mRNA.
ACCESSION   NM_001130493
VERSION     NM_001130493.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Wei,W., Li,B., Li,F., Sun,K., Jiang,X. and Xu,R.
  TITLE     Identification of FOXH1 mutations in patients with sporadic
            conotruncal heart defect
  JOURNAL   Clin Genet 97 (4), 576-585 (2020)
   PUBMED   32003456
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Ouyang,J., Shao,J., Zou,H., Lou,Y. and Yu,Y.
  TITLE     Hepatic differentiation of rat mesenchymal stem cells by a small
            molecule
  JOURNAL   ChemMedChem 7 (8), 1447-1452 (2012)
   PUBMED   22715131
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Yoon,S.J., Wills,A.E., Chuong,E., Gupta,R. and Baker,J.C.
  TITLE     HEB and E2A function as SMAD/FOXH1 cofactors
  JOURNAL   Genes Dev 25 (15), 1654-1661 (2011)
   PUBMED   21828274
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Silvestri,C., Narimatsu,M., von Both,I., Liu,Y., Tan,N.B., Izzi,L.,
            McCaffery,P., Wrana,J.L. and Attisano,L.
  TITLE     Genome-wide identification of Smad/Foxh1 targets reveals a role for
            Foxh1 in retinoic acid regulation and forebrain development
  JOURNAL   Dev Cell 14 (3), 411-423 (2008)
   PUBMED   18331719
  REMARK    Erratum:[Dev Cell. 2008 Apr;14(4):633]
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Ross,S. and Hill,C.S.
  TITLE     How the Smads regulate transcription
  JOURNAL   Int J Biochem Cell Biol 40 (3), 383-408 (2008)
   PUBMED   18061509
  REMARK    Review article
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Liu,B., Dou,C.L., Prabhu,L. and Lai,E.
  TITLE     FAST-2 is a mammalian winged-helix protein which mediates
            transforming growth factor beta signals
  JOURNAL   Mol Cell Biol 19 (1), 424-430 (1999)
   PUBMED   9858566
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Weisberg,E., Winnier,G.E., Chen,X., Farnsworth,C.L., Hogan,B.L. and
            Whitman,M.
  TITLE     A mouse homologue of FAST-1 transduces TGF beta superfamily signals
            and is expressed during early embryogenesis
  JOURNAL   Mech Dev 79 (1-2), 17-27 (1998)
   PUBMED   10349617
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Zhou,S., Zawel,L., Lengauer,C., Kinzler,K.W. and Vogelstein,B.
  TITLE     Characterization of human FAST-1, a TGF beta and activin signal
            transducer
  JOURNAL   Mol Cell 2 (1), 121-127 (1998)
   PUBMED   9702198
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Labbe,E., Silvestri,C., Hoodless,P.A., Wrana,J.L. and Attisano,L.
  TITLE     Smad2 and Smad3 positively and negatively regulate TGF
            beta-dependent transcription through the forkhead DNA-binding
            protein FAST2
  JOURNAL   Mol Cell 2 (1), 109-120 (1998)
   PUBMED   9702197
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Liu,F., Pouponnot,C. and Massague,J.
  TITLE     Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible
            transcriptional complexes
  JOURNAL   Genes Dev 11 (23), 3157-3167 (1997)
   PUBMED   9389648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.41831.1, EV769860.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               JAXUCZ010000007.1  110270418-110270692 c
            276-380             JAXUCZ010000007.1  110270049-110270153 c
            381-1721            JAXUCZ010000007.1  110268612-110269952 c
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1721
                     /gene="Foxh1"
                     /note="forkhead box H1"
                     /db_xref="GeneID:300054"
                     /db_xref="RGD:1311275"
     exon            1..275
                     /gene="Foxh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1214
                     /gene="Foxh1"
                     /codon_start=1
                     /product="forkhead box protein H1"
                     /protein_id="NP_001123965.1"
                     /db_xref="GeneID:300054"
                     /db_xref="RGD:1311275"
                     /translation="MASGWDLASTYSPTTLSPQLVQALAQGYIPCMGPLDNSQLRPPE
                     AESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFR
                     DDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCR
                     RWQNRGTHRAFAKDLSPYVLHGQPYRPPSPPPPSREDFSIKSLLGDPGKASTWPQHPR
                     LAGQSTPAQASTLSKGEEGIGAGPSNVSDKPLWPLSSLPRPTRIEGETSQGEVIRPSP
                     VSSDQGSWPLHLLQDSSDSMGMSRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPPTS
                     CPRCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAP
                     GWLLSWYSM"
     exon            276..380
                     /gene="Foxh1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1721
                     /gene="Foxh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccagcat ggcctcgggc tgggacctgg cctcaactta cagtccgact accctgagcc
       61 cccagttggt ccaggctctg gcccagggct acatcccttg tatggggcct ctcgacaact
      121 ctcagctgag gcctccagaa gcagagtctc tttcgaagac ccccaagagg aggaagaaga
      181 gatacctacg gcatgacaag cccccctaca cttacttggc catgatcgcc ttggtaattc
      241 aggccgcacc cttccgcaga ctgaaactgg ctcagattat ccgtcaggtc caggcagtgt
      301 tccccttctt cagggacgac tatgagggct ggaaggactc catccgccac aacctttcct
      361 ctaaccggtg cttccgtaag gtgcctaagg accctgcaaa gccccaggcc aagggcaact
      421 tctgggcggt ggacgtgagc ctgattcctg cagaggcgct gcgccttcag aacactgccc
      481 tgtgccgtcg atggcagaac cggggcacac acagagcgtt cgccaaggac ctgagcccct
      541 atgtgctcca cggccagcct tatcggccac ccagtccccc accaccatct agggaggatt
      601 tcagcatcaa gtccctgcta ggggaccctg ggaaagcatc cacatggccc cagcatccta
      661 ggctagctgg acagagcact ccagctcagg caagcacctt gtcaaagggg gaagagggga
      721 taggcgctgg accctctaac gtctctgata agcctctgtg gcccctcagc tcccttccca
      781 ggcccacaag aatagagggg gagacttccc aaggggaagt catcaggcct tctcccgttt
      841 cctcagacca aggctcctgg cccctccact tacttcagga ttcctcagat tccatgggaa
      901 tgtccaggag ggggagcaga gcttccttgt ggggacagct acccacctct tacttgccca
      961 tctacacgcc caatgtagta atgcccttgg ccacgctacc ccctacctct tgtccccggt
     1021 gcccatcttc agccagccca gcctactgga gcgtgggtac tgaatcccaa gggtcccagg
     1081 atctgctctg tgatctggac tccctcttcc agggagtacc acccaacaag agcatctatg
     1141 atgtgtgggt cagccaccct agggacctgg cagctcctgc cccaggctgg ctcctttcct
     1201 ggtatagcat gtaatatttt agggcagaca agggctactt ctctcttcca tccatgaata
     1261 tcattttgat gaaccagagc taggagcacg tccactgcaa cagcttcaaa acaccaggca
     1321 cagccttgct gaaaacccac agctttaatt aggtaactcc agaaagggtt ttgcctctgc
     1381 tagataggaa ggcctggcca accgcgcctt tgacactctc acacacaggg accagatctg
     1441 gagagcaggg ctcaacctag atagtgcctc ctcttgatcc caccttctca ggccctcaag
     1501 ccatccatct atccatcccg ctgtcaccat gccttcctgg ctccaggctg ggggagggag
     1561 agccaaaagt gggtccaatc tgaagtcttg ccctctgtca actgcctggg tggaaggtag
     1621 cacctttcag ggaaagggtt aagaaagact ggaccataca tgattttggt gtaatggaag
     1681 tcggggagtg attaacagta aaggaattta caacgtttta a
//
