LOCUS       NM_001400749            3514 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus forkhead box F2 (Foxf2), mRNA.
ACCESSION   NM_001400749 XM_008771604
VERSION     NM_001400749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3514)
  AUTHORS   Higashimori A, Dong Y, Zhang Y, Kang W, Nakatsu G, Ng SSM, Arakawa
            T, Sung JJY, Chan FKL and Yu J.
  TITLE     Forkhead Box F2 Suppresses Gastric Cancer through a Novel
            FOXF2-IRF2BPL-beta-Catenin Signaling Axis
  JOURNAL   Cancer Res 78 (7), 1643-1656 (2018)
   PUBMED   29374064
REFERENCE   2  (bases 1 to 3514)
  AUTHORS   McKeone R, Vieira H, Gregory-Evans K, Gregory-Evans CY and Denny P.
  TITLE     Foxf2: a novel locus for anterior segment dysgenesis adjacent to
            the Foxc1 gene
  JOURNAL   PLoS One 6 (10), e25489 (2011)
   PUBMED   22022403
REFERENCE   3  (bases 1 to 3514)
  AUTHORS   Philip-Couderc P, Tavares NI, Roatti A, Lerch R, Montessuit C and
            Baertschi AJ.
  TITLE     Forkhead transcription factors coordinate expression of myocardial
            KATP channel subunits and energy metabolism
  JOURNAL   Circ Res 102 (2), e20-e35 (2008)
   PUBMED   18202312
  REMARK    GeneRIF: FoxF2 and -O are key transcription factors coordinating
            expression of KATP channels and energy metabolism.
REFERENCE   4  (bases 1 to 3514)
  AUTHORS   Jochumsen U, Werner R, Miura N, Richter-Unruh A, Hiort O and
            Holterhus PM.
  TITLE     Mutation analysis of FOXF2 in patients with disorders of sex
            development (DSD) in combination with cleft palate
  JOURNAL   Sex Dev 2 (6), 302-308 (2008)
   PUBMED   19276632
REFERENCE   5  (bases 1 to 3514)
  AUTHORS   Malin D, Kim IM, Boetticher E, Kalin TV, Ramakrishna S, Meliton L,
            Ustiyan V, Zhu X and Kalinichenko VV.
  TITLE     Forkhead box F1 is essential for migration of mesenchymal cells and
            directly induces integrin-beta3 expression
  JOURNAL   Mol Cell Biol 27 (7), 2486-2498 (2007)
   PUBMED   17261592
REFERENCE   6  (bases 1 to 3514)
  AUTHORS   Blixt A, Mahlapuu M, Bjursell C, Darnfors C, Johannesson T,
            Enerback S and Carlsson P.
  TITLE     The two-exon gene of the human forkhead transcription factor
            FREAC-2 (FKHL6) is located at 6p25.3
  JOURNAL   Genomics 53 (3), 387-390 (1998)
   PUBMED   9799607
REFERENCE   7  (bases 1 to 3514)
  AUTHORS   Hellqvist M, Mahlapuu M, Blixt A, Enerback S and Carlsson P.
  TITLE     The human forkhead protein FREAC-2 contains two functionally
            redundant activation domains and interacts with TBP and TFIIB
  JOURNAL   J Biol Chem 273 (36), 23335-23343 (1998)
   PUBMED   9722567
REFERENCE   8  (bases 1 to 3514)
  AUTHORS   Miura N, Kakinuma H, Sato M, Aiba N, Terada K and Sugiyama T.
  TITLE     Mouse forkhead (winged helix) gene LUN encodes a transactivator
            that acts in the lung
  JOURNAL   Genomics 50 (3), 346-356 (1998)
   PUBMED   9676429
REFERENCE   9  (bases 1 to 3514)
  AUTHORS   Hellqvist M, Mahlapuu M, Samuelsson L, Enerback S and Carlsson P.
  TITLE     Differential activation of lung-specific genes by two forkhead
            proteins, FREAC-1 and FREAC-2
  JOURNAL   J Biol Chem 271 (8), 4482-4490 (1996)
   PUBMED   8626802
REFERENCE   10 (bases 1 to 3514)
  AUTHORS   Pierrou S, Hellqvist M, Samuelsson L, Enerback S and Carlsson P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000289.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001400749.2.
            
            On Jan 26, 2022 this sequence version replaced XM_008771604.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.39474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093047, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1548              JACYVU010000289.1  1744112-1745659     c
            1549-3514           JACYVU010000289.1  1738842-1740807     c
FEATURES             Location/Qualifiers
     source          1..3514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3514
                     /gene="Foxf2"
                     /note="forkhead box F2"
                     /db_xref="GeneID:364707"
                     /db_xref="RGD:1589717"
     exon            1..1548
                     /gene="Foxf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..1712
                     /gene="Foxf2"
                     /codon_start=1
                     /product="forkhead box protein F2"
                     /protein_id="NP_001387678.1"
                     /db_xref="GeneID:364707"
                     /db_xref="RGD:1589717"
                     /translation="MSTEGGPPPPPPRPPPAPLRRACSPAPGALQAALMSPPPAATLE
                     STSSSSSSSSASCASSSSNSVSASAGACKSAASSGGTGAGSGGTKKATSGLRRPEKPP
                     YSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIK
                     LPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGA
                     SLLPQGFDFQAPPSAPLGCHGQGGYGGLDMMPAGYDTGAGAPGHAHPHHLHHHHVPHM
                     SPNPGSTYMASCPVPAGPAGVGAAAGGGGGGGDYGPDSSSSPVPSSPAMASAIECHSP
                     YTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHPSMSSYSLEQSYLHQNAREDLS
                     VGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM"
     exon            1549..3514
                     /gene="Foxf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagagga gcactcctga aagaagacga cgggctagtc cccggggtcc gggctgagat
       61 cttggctcga gggcgcaact gtccggcccc aggcagcgtc gcctcggtgg cttaggagac
      121 ggttgcgcaa ggcgcgggcc ggaggctcgg aagagggatg cgcggggcgt tgccttcgac
      181 ccgccgccgc cgcccgaagc cccagaagag ctgagggagg cgacgccgaa gcgctggccc
      241 gcagtggccc cggctgcagc gcggccggcg cagtagggca ctcactcggt ttgtggaccg
      301 acccggctcc ggcgccgcca atctccgtcc ggggtccacc ccccaggccg ggccttgctc
      361 ccggctccca gatgagcacc gagggcgggc ctccgccacc cccgccgcgc ccgccgcctg
      421 ccccactccg ccgcgcgtgc agcccggcgc ccggcgcgct ccaggccgcc ttgatgagcc
      481 cgccacccgc cgccaccctg gagtccacct cgtcgtcgtc ctcttcatcc tctgcttcct
      541 gtgcctcgtc ttcttccaac tcggtcagcg cctcggcggg tgcttgcaag agtgcggcga
      601 gcagcggcgg cacaggcgct gggagtgggg gcactaagaa ggcgacctcc gggctgcgac
      661 ggccagagaa gcctccttac tcgtacatcg cgctcatcgt catggccata cagagctcgc
      721 ccagcaaacg cctgacgctc agcgagatct accagttcct gcaggcgcgc ttcccttttt
      781 tccgtggcgc ctaccagggc tggaagaact ctgtgcgcca caacctctcg cttaacgaat
      841 gcttcatcaa gctgcccaag ggcctcgggc gaccgggcaa gggccactac tggaccatcg
      901 acccggccag cgagttcatg ttcgaggagg gttcgttccg ccggcgtccg cgcggcttca
      961 ggcggaagtg ccaggctctc aaacccatgt accatcgcgt ggtgagcggc ttgggcttcg
     1021 gggcctcgct actgccccag ggcttcgact tccaagcgcc cccgtcagcg cccctgggtt
     1081 gccacggcca gggcggctat ggtggcctcg acatgatgcc cgcagggtat gatacagggg
     1141 cgggtgctcc gggccacgcg cacccacacc acctccacca ccatcacgtc ccccacatgt
     1201 cgcccaaccc gggctccacc tatatggcca gctgcccggt acccgcaggt cctgcgggcg
     1261 tcggtgcggc agcgggtggc ggcggtggcg gcggtgacta tgggccggac agcagcagca
     1321 gccctgtgcc ctcatccccg gccatggcaa gcgccatcga gtgccattcg ccctatacta
     1381 gccctgcggc acattggagc tcgcctggcg cttcacctta cctcaagcag ccgcctgccc
     1441 tgacgccaag cagtaatccc gcggcctctg ctggtctgca tcccagcatg tcttcctact
     1501 ctttggaaca gagctacttg caccagaacg cccgggagga tctctcagtg ggactgcccc
     1561 gttaccagca tcactccact ccagtgtgtg acagaaaaga tttcgtcctc aatttcaatg
     1621 gcatttcttc tttccacccc tccgctagtg gctcttatta tcaccatcac caccagagcg
     1681 tgtgccaaga tattaagccc tgtgttatgt gaatgaacag aggccttgaa ggccgttctc
     1741 cctcttctgc cctttcctcc tctcccctcc gagaggggca gctacagact cacacactgt
     1801 gcacgaggat agcagtaagt agcacaccca tcacttagac aaatacccag aggagtcctg
     1861 ctcaccgatg tttgccaccc gtggaagagg aaacctttca aagggcaata ccccagaaga
     1921 gggacagaca gaggaggtta ctccatgtaa gacatatgtt actatatgga agacataaaa
     1981 cttttcagtt ctggggtggc cactgcattc actgatcagg gtctgaaaag ggaggtgtgt
     2041 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg ggtgtgcatt
     2101 tcaaacttgt agtgctaaaa gcacagcatt tcaagaaagc ctctagttcc ctggcccggt
     2161 aggaggtctc tcccaccccc agccccccaa cactcccttc ggatacaggt gccaaagaac
     2221 tttgtgaaga aatgaagaac caatcgtctg ggttaagaaa gtggctctca gtattgcgac
     2281 agtacaacat tttttacaag gttgtttttc taccaccgta tttttaaagt atttttatga
     2341 tcttcgtata ctcacttcgc ttgtattgta aaaggagggt atatttgcac ttatatatac
     2401 ttttacagtt tgccaagata ttttgatgta agtttctttt ttttttcaat aaaacgtgta
     2461 taatgagtag ttgttctagg gaccctttcc tctgcagact ccctttcatg gccacaccct
     2521 ccaggcaaca ttgcaactct aggctgcccc ccccaagttt tataactgac atgatgtgag
     2581 gtttctgttt tgaataagcc aggtcagtcc tgatggtggg ctttctcagc ggagagggca
     2641 catctattat ttttctctct ctagttcact ctcacttttt ctagtcaaac aaaaaccaga
     2701 aggtgaaagg aacttcaaga caaaacagca aaaaataaaa ataaaattaa attaaaagta
     2761 aaaccaacaa aagcaggcaa aatactgaaa gccgagggtt tgatctgaag aagcttgaat
     2821 ttggtgttct ctgttgcctt tcatgatgcc caagacttct gcccttttgc tccttcctct
     2881 ctcccactag taccaggcgc taggccagag taaagaatgg ccaccggagc atcccctgca
     2941 ggctgcaggc tgcaggctgc aggctgcttt gggtggtggt cagatcaaag aggatttaaa
     3001 ttgcccccaa cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     3061 cacacacaca cacgggctcc cacagatcgc acagcttctg ctctctttct tgccatgttt
     3121 cccagccctg aatgttaccc acagaactgg caggacacaa gattacaatg gggaaacagt
     3181 ccagtgaggt ggaggattca tttcccaccc agaacacaca tctgttggga gcagagcaat
     3241 gttcactttt aatcatgtcg aagtaatttt cttaactcag ggatggattt ttggttttgg
     3301 tttttttaaa ctctctttcc ttccaatcca ccaccaggca cttattggta actcaggaga
     3361 tgggtatttt tctcccaatt tcaatgaatc ctaactgagg tgttctcctg aataaaacat
     3421 ctagtttcaa aactcctagc tatattccta atccttaggc ctctcctctg taattttttt
     3481 aaagtatgga attaaacact tttgtttctg tatt
//
