LOCUS       NM_134339               1583 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus forkhead box E3 (Foxe3), mRNA.
ACCESSION   NM_134339 XM_001069443 XM_233428
VERSION     NM_134339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Khan,S.Y., Vasanth,S., Kabir,F., Gottsch,J.D., Khan,A.O.,
            Chaerkady,R., Lee,M.C., Leitch,C.C., Ma,Z., Laux,J., Villasmil,R.,
            Khan,S.N., Riazuddin,S., Akram,J., Cole,R.N., Talbot,C.C.,
            Pourmand,N., Zaghloul,N.A., Hejtmancik,J.F. and Riazuddin,S.A.
  TITLE     FOXE3 contributes to Peters anomaly through transcriptional
            regulation of an autophagy-associated protein termed DNAJB1
  JOURNAL   Nat Commun 7, 10953 (2016)
   PUBMED   27218149
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Islam,L., Kelberman,D., Williamson,L., Lewis,N., Glindzicz,M.B.,
            Nischal,K.K. and Sowden,J.C.
  TITLE     Functional analysis of FOXE3 mutations causing dominant and
            recessive ocular anterior segment disease
  JOURNAL   Hum Mutat 36 (3), 296-300 (2015)
   PUBMED   25504734
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Wang,Y., Li,W., Wang,Y. and Huang,Y.
  TITLE     Growth inhibition of human lens epithelial cells by short hairpin
            RNA in transcription factor forkhead box E3 (FOXE3)
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 250 (7), 999-1007 (2012)
   PUBMED   22527307
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Blixt,A., Landgren,H., Johansson,B.R. and Carlsson,P.
  TITLE     Foxe3 is required for morphogenesis and differentiation of the
            anterior segment of the eye and is sensitive to Pax6 gene dosage
  JOURNAL   Dev Biol 302 (1), 218-229 (2007)
   PUBMED   17064680
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Valleix,S., Niel,F., Nedelec,B., Algros,M.P., Schwartz,C.,
            Delbosc,B., Delpech,M. and Kantelip,B.
  TITLE     Homozygous nonsense mutation in the FOXE3 gene as a cause of
            congenital primary aphakia in humans
  JOURNAL   Am J Hum Genet 79 (2), 358-364 (2006)
   PUBMED   16826526
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Maeda,Y.Y., Funata,N., Takahama,S., Sugata,Y. and Yonekawa,H.
  TITLE     Two interactive genes responsible for a new inherited cataract
            (RCT) in the mouse
  JOURNAL   Mamm Genome 12 (4), 278-283 (2001)
   PUBMED   11309658
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Semina,E.V., Brownell,I., Mintz-Hittner,H.A., Murray,J.C. and
            Jamrich,M.
  TITLE     Mutations in the human forkhead transcription factor FOXE3
            associated with anterior segment ocular dysgenesis and cataracts
  JOURNAL   Hum Mol Genet 10 (3), 231-236 (2001)
   PUBMED   11159941
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Brownell,I., Dirksen,M. and Jamrich,M.
  TITLE     Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in
            lens development and differentiation
  JOURNAL   Genesis 27 (2), 81-93 (2000)
   PUBMED   10890982
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Blixt,A., Mahlapuu,M., Aitola,M., Pelto-Huikko,M., Enerback,S. and
            Carlsson,P.
  TITLE     A forkhead gene, FoxE3, is essential for lens epithelial
            proliferation and closure of the lens vesicle
  JOURNAL   Genes Dev 14 (2), 245-254 (2000)
   PUBMED   10652278
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 5, 2022 this sequence version replaced NM_134339.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1583              JAXUCZ010000005.1  133681684-133683266 c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1583
                     /gene="Foxe3"
                     /gene_synonym="FREAC-8; HFH7; HNF3"
                     /note="forkhead box E3"
                     /db_xref="GeneID:171302"
                     /db_xref="RGD:621727"
     exon            1..1583
                     /gene="Foxe3"
                     /gene_synonym="FREAC-8; HFH7; HNF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..901
                     /gene="Foxe3"
                     /gene_synonym="FREAC-8; HFH7; HNF3"
                     /note="forkhead-related protein FKHL12; forkhead-related
                     transcription factor 8; hepatocyte nuclear factor 3
                     forkhead homolog 7"
                     /codon_start=1
                     /product="forkhead box protein E3"
                     /protein_id="NP_599166.1"
                     /db_xref="GeneID:171302"
                     /db_xref="RGD:621727"
                     /translation="MDAHVAFSGFPTLPSVSPSGPQPPSLAGDEPGREPEEVVGGGDS
                     EPPAAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYR
                     DSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRF
                     KRTELPAPPPPPFPYAPFPPAPAPAPAPPARLFRLDSLLGLQTEPPGPLAPEPPCCAA
                     PDASFPPCAAAASPPLYSPAPERLGLPAPLPAEPLLALAGSAGALGPLGAGEAYLRQP
                     GFPPGLERYL"
ORIGIN      
        1 ggggcgcggg caggggctcc gcatccctag atcctagcac atggatgcgc acgtcgcttt
       61 ctccggcttt ccgaccctgc cctcggtctc gccgtcgggg ccgcagcctc catcgctggc
      121 cggagacgag cccgggcgcg aaccagagga ggtggtgggc ggtggggact ccgagccccc
      181 ggccgcgccg ggccctggga ggcgacgtcg gcggccgcta cagcgtggga agccgcctta
      241 ctcgtacatc gctcttatcg ctatggccct ggcgcacgct ccgggccgtc gtctcacgct
      301 ggcagccatc taccgcttca tcaccgagcg cttcgccttc taccgcgaca gcccgcgcaa
      361 gtggcagaac agcatccgcc acaacctcac cctcaacgac tgcttcgtca aggtgccgcg
      421 cgagccgggc aatccgggca agggcaacta ctggacgctc gatcccgcgg ccgccgacat
      481 gttcgacaac ggcagcttcc tgcggcgccg caagcgcttt aagcgcaccg agctgcccgc
      541 gccgccgcca ccgccctttc cctacgcgcc cttcccgccc gcacctgcac ctgcgcccgc
      601 accgcccgcg cgcctcttcc gcctggacag cctgctgggc ttgcaaaccg agccgccagg
      661 acccttggcg cccgagccgc cttgctgcgc cgcgcccgac gcctccttcc cgccctgcgc
      721 cgccgcagcc tcgccgccgc tctactcgcc cgcgcccgag cgcctggggc tgcccgcgcc
      781 gttgccggcg gagcctctcc tggccttggc aggatcggct ggcgcgctgg ggccactcgg
      841 cgccggagaa gcctacctga gacagccggg cttcccgccc gggctggagc gctacctgtg
      901 agcctctctt ctgagggaga ccctggcgga gcttgtctgt ggtgctgccc gcccgcagcg
      961 tggtgtgatc cgctgggtcc ctgagcctta caggaggcta aaccttccct acccttctcc
     1021 atgcctggag agactctgac cgtctcacca ctagtctgaa gcgccctctc taatttgagg
     1081 ccttcattcc tccctctact tgtgtaccca cctatgcagt ctcgcactgc catgtcccgt
     1141 gctctggaac tggacgatca aaatggggac ttcagcccca aatgtgtccc ggtgagttcc
     1201 agtcagtgga agctttccac ccagggcacc tcctccatct ctgatgtttg ccagtatgtc
     1261 agaggtcaga cttctgggtt cactacttct tacacctctt tctccatttt ctgataatta
     1321 tgacaaattt gtctcctgcc ccagctttac ctgtctgcac ttgttttctt tccgagcccc
     1381 gcccctccac agactcattt gaggctctgc tcctggttct gaggacagtt cttcagacta
     1441 ggttacacag taccaggatc ttctgactga aggggaaatt aacgggcgtc tgtggctgtc
     1501 ccatcccatg gaaagcacag aacttatctg gttattgtta tttttcaatc aaagctagtt
     1561 taattaaaaa gaaaaacgaa gaa
//
