LOCUS       NM_138909               2809 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus forkhead box E1 (Foxe1), mRNA.
ACCESSION   NM_138909
VERSION     NM_138909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Pires,C., Saramago,A., Moura,M.M., Li,J., Donato,S., Marques,I.J.,
            Belo,H., Machado,A.C., Cabrera,R., Grunewald,T.G.P., Leite,V. and
            Cavaco,B.M.
  TITLE     Identification of Germline FOXE1 and Somatic MAPK Pathway Gene
            Alterations in Patients with Malignant Struma Ovarii, Cleft Palate
            and Thyroid Cancer
  JOURNAL   Int J Mol Sci 25 (4), 1966 (2024)
   PUBMED   38396644
  REMARK    GeneRIF: Identification of Germline FOXE1 and Somatic MAPK Pathway
            Gene Alterations in Patients with Malignant Struma Ovarii, Cleft
            Palate and Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Montesinos Mdel,M., Nicola,J.P., Nazar,M., Peyret,V., Lucero,A.M.,
            Pellizas,C.G. and Masini-Repiso,A.M.
  TITLE     Nitric oxide-repressed Forkhead factor FoxE1 expression is involved
            in the inhibition of TSH-induced thyroid peroxidase levels
  JOURNAL   Mol Cell Endocrinol 420, 105-115 (2016)
   PUBMED   26610751
  REMARK    GeneRIF: Nitric oxide decreases TSH-induced FoxE1 expression, thus
            repressing the transcripcional activation of TPO gene.
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Carre,A., Hamza,R.T., Kariyawasam,D., Guillot,L., Teissier,R.,
            Tron,E., Castanet,M., Dupuy,C., El Kholy,M. and Polak,M.
  TITLE     A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing
            increased thyroidal gene expression
  JOURNAL   Thyroid 24 (4), 649-654 (2014)
   PUBMED   24219130
REFERENCE   4  (bases 1 to 2809)
  AUTHORS   Fernandez,L.P., Lopez-Marquez,A., Martinez,A.M., Gomez-Lopez,G. and
            Santisteban,P.
  TITLE     New insights into FoxE1 functions: identification of direct FoxE1
            targets in thyroid cells
  JOURNAL   PLoS One 8 (5), e62849 (2013)
   PUBMED   23675434
  REMARK    GeneRIF: Nis and Duox2 are two novel direct transcriptional
            regulation FoxE1 targets in thyroid follicular cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2809)
  AUTHORS   Venza,I., Visalli,M., Parrillo,L., De Felice,M., Teti,D. and
            Venza,M.
  TITLE     MSX1 and TGF-beta3 are novel target genes functionally regulated by
            FOXE1
  JOURNAL   Hum Mol Genet 20 (5), 1016-1025 (2011)
   PUBMED   21177256
REFERENCE   6  (bases 1 to 2809)
  AUTHORS   Castanet,M., Park,S.M., Smith,A., Bost,M., Leger,J., Lyonnet,S.,
            Pelet,A., Czernichow,P., Chatterjee,K. and Polak,M.
  TITLE     A novel loss-of-function mutation in TTF-2 is associated with
            congenital hypothyroidism, thyroid agenesis and cleft palate
  JOURNAL   Hum Mol Genet 11 (17), 2051-2059 (2002)
   PUBMED   12165566
REFERENCE   7  (bases 1 to 2809)
  AUTHORS   Miyazaki,A., Shimura,H., Endo,T., Haraguchi,K. and Onaya,T.
  TITLE     Tumor necrosis factor-alpha and interferon-gamma suppress both gene
            expression and deoxyribonucleic acid-binding of TTF-2 in FRTL-5
            cells
  JOURNAL   Endocrinology 140 (9), 4214-4220 (1999)
   PUBMED   10465294
REFERENCE   8  (bases 1 to 2809)
  AUTHORS   Clifton-Bligh,R.J., Wentworth,J.M., Heinz,P., Crisp,M.S., John,R.,
            Lazarus,J.H., Ludgate,M. and Chatterjee,V.K.
  TITLE     Mutation of the gene encoding human TTF-2 associated with thyroid
            agenesis, cleft palate and choanal atresia
  JOURNAL   Nat Genet 19 (4), 399-401 (1998)
   PUBMED   9697705
REFERENCE   9  (bases 1 to 2809)
  AUTHORS   De Felice,M., Ovitt,C., Biffali,E., Rodriguez-Mallon,A., Arra,C.,
            Anastassiadis,K., Macchia,P.E., Mattei,M.G., Mariano,A.,
            Scholer,H., Macchia,V. and Di Lauro,R.
  TITLE     A mouse model for hereditary thyroid dysgenesis and cleft palate
  JOURNAL   Nat Genet 19 (4), 395-398 (1998)
   PUBMED   9697704
REFERENCE   10 (bases 1 to 2809)
  AUTHORS   Zannini,M., Avantaggiato,V., Biffali,E., Arnone,M.I., Sato,K.,
            Pischetola,M., Taylor,B.A., Phillips,S.J., Simeone,A. and Di
            Lauro,R.
  TITLE     TTF-2, a new forkhead protein, shows a temporal expression in the
            developing thyroid which is consistent with a role in controlling
            the onset of differentiation
  JOURNAL   EMBO J 16 (11), 3185-3197 (1997)
   PUBMED   9214635
  REMARK    Erratum:[EMBO J 2001 Apr 17;20(8):2108]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138909.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: Y11321.1, SRR22582424.464105.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2809              JAXUCZ010000005.1  65425630-65428438
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2809
                     /gene="Foxe1"
                     /gene_synonym="Ttf-2"
                     /note="forkhead box E1"
                     /db_xref="GeneID:192274"
                     /db_xref="RGD:621723"
     exon            1..2809
                     /gene="Foxe1"
                     /gene_synonym="Ttf-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..1706
                     /gene="Foxe1"
                     /gene_synonym="Ttf-2"
                     /note="forkhead box E1 (thyroid transcription factor 2)"
                     /codon_start=1
                     /product="forkhead box protein E1"
                     /protein_id="NP_620264.1"
                     /db_xref="GeneID:192274"
                     /db_xref="RGD:621723"
                     /translation="MTAESAPPPPPQPEALAAVKEERGEAAAGAGVPAEVAGRGAGGR
                     RRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSI
                     RHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPA
                     YMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCRV
                     FGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAPGTGSFQPAVCTGARPVNPAAYAAAY
                     AGPDGAYPQGASSALFAAAAGRLAGPTSPTAGGGSGGVEATVDFYGRTSPGQFGAALG
                     PCYNPSGQLGAGGGGAYHSRHATAYPGAVDRFVSAM"
ORIGIN      
        1 ctggcgcctt taaggaggcg aagccagcgg agggaggagc tggcccaggt gtgtgcagga
       61 gagcgcctcg ccggcggtac tcggggctgg agtccagggc ggcagagcgg agcagttgct
      121 cgccacccgg cccggcccac tcgcccgcct cgccactggc ttcgcctctc tgccctccgc
      181 ttgggctgta tcttcaccgc agaggtgcgg catgggcggc caccgcaggg gtgtacgttt
      241 cccccactga ctgctcctgc acgagacccc agcccgcagc ctcctctacg cgcaccgcct
      301 cgacagtcat cctcggaccc gcaggaactc ccaaacagtt gccaccaccc gagcctccga
      361 gccacctctg gaccccctga tctcttggca ccagaacttc aaggaccctc tggcccgtgc
      421 cccgcaggag ccgtcggtgg acgccgcgct ccagaccccg aagtcccctg ctctcagtgc
      481 tctccgtgcc agccgcgaag ccccggcaga gtcggctctc ggggttcggg atctggggcc
      541 ggcgcggccg tccgcagctg cagacgacgg ggggtacggg ggaccgcggc gccatgacag
      601 ccgagagcgc gccgccgccc ccgccgcagc ccgaggcgct ggcggccgtg aaggaagagc
      661 gcggtgaggc ggcggcgggc gcgggggtcc cggcggaggt ggcgggtcgc ggcgccggag
      721 gacggcgacg caagcgcccc ctgcagcggg ggaagccgcc gtacagctac atcgcactca
      781 tcgcgatggc tatcgcgcac gcgcccgagc gccgcctgac tctgggcggc atctacaagt
      841 tcatcaccga gcgcttcccg ttctaccgcg acaaccccaa gaagtggcag aacagcatcc
      901 gccacaacct caccctcaac gactgcttcc tcaagatccc gcgcgaggcg ggccgcccgg
      961 gcaaaggcaa ctactgggcg ctcgacccca acgccgagga catgttcgag agcggcagct
     1021 tcctgcgccg gcgcaagcgc ttcaagcgct cggacctgtc cacctacccg gcgtacatgc
     1081 atgatgcagc cgctgctgcc gccgccgccg ccgccgccat cttcccgggt gccgtgcctg
     1141 ccgcgaggcc ggcctacccg ggagccgtct atgcgggcta cgcgccgccg ctcgccgcac
     1201 ccccgccggt ctactacccc gcagcgtcgc ccgggccctg ccgggtcttc ggcttggttc
     1261 ccgagcggcc gctcagcccg gatctgggcc ccgcaccatc agcagccgga ggttcgtgcg
     1321 ccttcgcggc tgcggcgggc gcgccgggca cagggagctt ccagcccgcg gtatgcacgg
     1381 gcgcgcggcc ggtcaacccg gctgcctatg ccgctgccta cgcgggcccc gacggcgcgt
     1441 acccgcaagg ggcgagcagc gcgctcttcg ccgctgctgc gggccgtctg gccggaccca
     1501 cttcgcccac cgcgggagga ggcagcggcg gcgtggaggc cacggtggac ttctacgggc
     1561 gcacgtctcc tggccagttc ggagcggcgc tggggccctg ctataatccc agtgggcaac
     1621 tcggagccgg tggtggaggt gcctatcact cccgccacgc caccgcctac cccggcgcgg
     1681 tggatcggtt cgtgtctgcc atgtgagccg ggggtaggca caaaacctca ctgactccgg
     1741 cacgttctga aagatgtaaa tcccccggga ccggtggaca ggactaaaag tgtatcggac
     1801 tgagactcac gagtgtgcga gggctccgag ggtcgcggag gctcggtgtc ttgccctgtt
     1861 cacagaccgg atttgctttg gacgtgggcg gacgtaggga ggccatagcc acgtttgggc
     1921 tgacacaggg gaccctcgat gatgcgaagc tccaaagagc atgcctttcc gccattctac
     1981 tagggagagc cctaggctgt aaagggtgga gtgttgcgtc gttgcccaca ccagaatcta
     2041 gaatcctgaa ctgtggtgga gtcgtatggc ttcagcgtgt gctatgctgg gctaaactcg
     2101 ggctttttac acgttcgcct cttaactttt gactaccgta ccccaaataa aaggctcgga
     2161 cagtgccttt ataattaaag tgagagcaag tttgcaaaaa gagttgcttt ttaaaaatta
     2221 gttcggttca gctggattag ttttccctgc ctctgagagt cacaagcctg ggtcgcaatc
     2281 gtaactgaga attcctcggt gtgatccagc cctaacacct gaattttgag tctgtctgtt
     2341 atacagaact gtgcgattcc gccgtctcat ttttaaaccc cctcccatta tcttgggtgc
     2401 caaccttcca tatttggcag cattggtcaa ccacctaggg cttcccagta gccatgacag
     2461 aaggccatcc aggaatggga acagaacatt ggcaagtatt taacccaaag tcccaggact
     2521 ggctccaagt agagattgtg ccttaattat tgattttttt gttgttgttg ttgttttgag
     2581 agagagagag agattggtca ttccgcagca gtgactaccc agtcaaaaat ctgattttct
     2641 gataagaatg taggtgggga gactttcctt aactgggtct gtctgttctg tttcctgtgc
     2701 gctccttctt cggcgccctc ctcgaacaaa aaggaaaagt aataaattag atggttaaca
     2761 aagagatctt tttttaattt tttatttcat tctgtatctt gtttgtttt
//
