LOCUS       NM_080774               2367 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus forkhead box D3 (Foxd3), mRNA.
ACCESSION   NM_080774 XM_008763960
VERSION     NM_080774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Huang,Z., Zhang,Y., Wang,S., Qi,R., Tao,Y., Sun,Y., Jiang,D.,
            Jiang,X. and Tao,J.
  TITLE     FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain
            via m6A-dependent stabilization of 5-HT3A mRNA in sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2312861121 (2024)
   PUBMED   38285939
  REMARK    GeneRIF: FOXD3-mediated transactivation of ALKBH5 promotes
            neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA
            in sensory neurons.
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Li,R., Zhao,K., Ruan,Q., Meng,C. and Yin,F.
  TITLE     The transcription factor Foxd3 induces spinal cord
            ischemia-reperfusion injury by potentiating microRNA-214-dependent
            inhibition of Kcnk2
  JOURNAL   Exp Mol Med 52 (1), 118-129 (2020)
   PUBMED   31959866
  REMARK    GeneRIF: The transcription factor Foxd3 induces spinal cord
            ischemia-reperfusion injury by potentiating microRNA-214-dependent
            inhibition of Kcnk2.
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Xiang,J., Wen,F., Zhang,L. and Zhou,Y.
  TITLE     FOXD3 inhibits SCN2A gene transcription in intractable epilepsy
            cell models
  JOURNAL   Exp Neurol 302, 14-21 (2018)
   PUBMED   29288635
  REMARK    GeneRIF: This study demonstrated that FOXD3 is a trans-acting
            factor of SCN2A, and this mechanism may play a role in cell injury.
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Wang,L.J., Wang,W.L., Gao,H., Bai,Y.Z. and Zhang,S.C.
  TITLE     FOXD3/FOXD4 is required for the development of hindgut in the rat
            model of anorectal malformation
  JOURNAL   Exp Biol Med (Maywood) 243 (4), 327-333 (2018)
   PUBMED   29307282
  REMARK    GeneRIF: Tentative conclusions were drawn that FOXD3/FOXD4 is
            expressed in the hindgut in rat embryos and is upregulated in
            anorectal malformation.
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Wang,J., Qu,D., An,J., Yuan,G. and Liu,Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Guo,Y., Costa,R., Ramsey,H., Starnes,T., Vance,G., Robertson,K.,
            Kelley,M., Reinbold,R., Scholer,H. and Hromas,R.
  TITLE     The embryonic stem cell transcription factors Oct-4 and FoxD3
            interact to regulate endodermal-specific promoter expression
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3663-3667 (2002)
   PUBMED   11891324
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Marsden,I., Jin,C. and Liao,X.
  TITLE     Structural changes in the region directly adjacent to the
            DNA-binding helix highlight a possible mechanism to explain the
            observed changes in the sequence-specific binding of winged helix
            proteins
  JOURNAL   J Mol Biol 278 (2), 293-299 (1998)
   PUBMED   9571051
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Sutton,J., Costa,R., Klug,M., Field,L., Xu,D., Largaespada,D.A.,
            Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Klemsz,M. and Hromas,R.
  TITLE     Genesis, a winged helix transcriptional repressor with expression
            restricted to embryonic stem cells
  JOURNAL   J Biol Chem 271 (38), 23126-23133 (1996)
   PUBMED   8798505
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Peterson,R.S., Porcella,A., Ye,H.,
            Paulson,K.E. and Costa,R.H.
  TITLE     Members of the HNF-3/forkhead family of transcription factors
            exhibit distinct cellular expression patterns in lung and regulate
            the surfactant protein B promoter
  JOURNAL   Dev Biol 166 (1), 195-209 (1994)
   PUBMED   7958446
REFERENCE   10 (bases 1 to 2367)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2022 this sequence version replaced XM_008763960.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2367              JAXUCZ010000005.1  119450532-119452898
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2367
                     /gene="Foxd3"
                     /gene_synonym="CWH3; Genesis; Hfh2"
                     /note="forkhead box D3"
                     /db_xref="GeneID:29203"
                     /db_xref="RGD:621715"
     exon            1..2367
                     /gene="Foxd3"
                     /gene_synonym="CWH3; Genesis; Hfh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1734
                     /gene="Foxd3"
                     /gene_synonym="CWH3; Genesis; Hfh2"
                     /note="HFH-2; HNF3/FH transcription factor genesis;
                     hepatocyte nuclear factor 3 forkhead homolog 2"
                     /codon_start=1
                     /product="forkhead box protein D3"
                     /protein_id="NP_542952.1"
                     /db_xref="GeneID:29203"
                     /db_xref="RGD:621715"
                     /translation="MTLSGSGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGC
                     DSPAGPPDLRLDEADEGLPASAHHGQSQPQALALPSEATGPGNDTGAPEADGCKGGED
                     AVTGGGGPGAGGGATGGLTPNKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEF
                     ISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNG
                     SFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAASAGPYGRPYGLHPAAAAGAYS
                     HPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPSLQLQL
                     NTLGAAAAAAGTAGAAGTTSLIKSEPSARPSFSIENIIGAGPAAPGSSAGGGGSAGGA
                     GGGGGSGGGGSAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQP
                     AASAAAAAAAAVQAKWPAQ"
ORIGIN      
        1 aggctgatga agtgaggggg tgaggcgtgg agaaacctcc ggggtcctga gcagtagctg
       61 ccgcctcgta aggaagcgtc gacgaccgca agagttcgcg gagcgcggct gcgggcggcg
      121 aagcgcagcg cccgcaccgc gcgatgccag tcctctgggt gtgagctgac ccgagagggc
      181 cccgagctac ctgtgccctc tcctcccgct cagctttttt tcagggagcg cccgcacccc
      241 ctttccctga gctccgccgc cgccccttac ggccctcctc gctctctgct agctcccggc
      301 cgccgccacc aaccccgcgg agggatgacc ctctccggca gcggcagcgc cagcgatatg
      361 tccggccaga cggtgctgac ggccgaggac gtggacatcg atgtggtggg cgagggcgac
      421 gacgggctgg aggagaaaga cagcgacgcg ggttgcgaca gccccgcggg gcctccggac
      481 ctgcgcctgg acgaggcgga cgaagggcta ccggcgagcg ctcatcacgg ccagtctcaa
      541 cctcaagccc tggcactgcc ctccgaggcg accgggccgg ggaacgacac gggagcgccg
      601 gaggccgacg gttgcaaggg cggcgaggac gcggtgacag gcggtggtgg gcccggcgct
      661 ggcggcgggg cgacgggagg tctgaccccg aacaagccca agaacagcct ggtgaagcca
      721 ccctactctt acatcgcgct catcaccatg gccatcctgc agagcccgca gaagaagctg
      781 accctgagtg gcatctgcga gttcatcagc aaccgcttcc cgtactaccg ggagaagttc
      841 cccgcctggc agaacagcat ccgccacaac ctgtcgctca acgactgctt cgtcaagatc
      901 ccccgcgagc cgggcaaccc gggcaagggt aactactgga ccctggaccc ccagtccgag
      961 gacatgttcg acaacggcag cttcctgcgg cgccggaagc gcttcaagcg ccaccagcag
     1021 gagcacctgc gcgagcagac ggcgctgatg atgcagagct tcggagccta cagcctggct
     1081 gcggcggcga gcgcaggacc ctacggccgc ccctacggcc tgcaccccgc ggcggcggcg
     1141 ggcgcctact cgcatcccgc ggcagcggcg gcggcggcgg ctgccgcggc gctccagtac
     1201 ccgtacgcgc tgcctcccgt ggcgccggtg ctgccgccag ccgtgcccct gctgccctcg
     1261 ggcgagctgg gccgcaaagc ggccgccttc ggctcgcagc tcggtccgag ccttcagctc
     1321 cagctcaaca ccctgggcgc cgccgcggca gccgcgggca cggcgggcgc cgcgggcacc
     1381 acgtcgctca tcaagtccga gcccagtgcg cggccgtcgt tcagcattga gaacatcata
     1441 ggcgcgggac ccgcggcgcc cgggagctcg gctgggggtg gcgggagcgc gggcggggcc
     1501 gggggcggcg ggggcagtgg gggcggcggc agcgcccagt ccttcctgcg gccgcccggg
     1561 actgtgcagt cggctgcgct catggccacg caccagcccc tgtcgctgag ccggacgact
     1621 gccaccatcg cgcccattct gagcgtgccg ctgtccggac agttcctgca acccgcagcc
     1681 tcagccgcag ccgctgcggc agccgcagtg caagccaagt ggcccgcgca atagtgatga
     1741 gctggtggcc gggccgggcg gcggcctctg gcagcagcct gagcttccag gttgtccgcc
     1801 ctttctgatc ctggtccatc agccctgttc ctggtccctc tacccaatcc tggactctac
     1861 aacccgcccc cgactcccca accacgacca acagcggcct ccatccccct cgctcaccta
     1921 aactggcgga gcaaactcaa ctcgcttccg ctgggaataa ctttccgtac aggtaaaact
     1981 gataaccgaa tttccaaaaa tgcaccccga cggcgcctgt gctctcagta ctgtgggggt
     2041 tggagggaaa ttctttgtac atatttgtat aaaaatcatt gactttcctt ttggggtttt
     2101 tattttttta agaaaagaaa aagcaattca gtagatttag agctttgaac tttcattttt
     2161 tttgaaggtt cactctccgc agttttatct gagaaaaaga atgtatgaag acgttgggag
     2221 attttaaata caagaaaatt tttcaaaaag gcgaagtgtc attgtattat aaaagtctgt
     2281 ttatatatga atgaatatat atggtattct aaatgttact ccatcgtgtt gtacacaatt
     2341 ttgtaaataa atttttaaaa atgctca
//
