LOCUS       NM_134337               2421 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus forkhead box D1 (Foxd1), mRNA.
ACCESSION   NM_134337 XM_001057782
VERSION     NM_134337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Meng,F., Liu,Y., Chen,Q., Ma,Q., Gu,S., Cui,R., Cao,R. and Zhao,M.
  TITLE     METTL3 contributes to renal ischemia-reperfusion injury by
            regulating Foxd1 methylation
  JOURNAL   Am J Physiol Renal Physiol 319 (5), F839-F847 (2020)
   PUBMED   32954854
  REMARK    GeneRIF: METTL3 contributes to renal ischemia-reperfusion injury by
            regulating Foxd1 methylation.
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Gumbel,J.H., Patterson,E.M., Owusu,S.A., Kabat,B.E., Jung,D.O.,
            Simmons,J., Hopkins,T. and Ellsworth,B.S.
  TITLE     The forkhead transcription factor, Foxd1, is necessary for
            pituitary luteinizing hormone expression in mice
  JOURNAL   PLoS One 7 (12), e52156 (2012)
   PUBMED   23284914
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Levinson,R.S., Batourina,E., Choi,C., Vorontchikhina,M.,
            Kitajewski,J. and Mendelsohn,C.L.
  TITLE     Foxd1-dependent signals control cellularity in the renal capsule, a
            structure required for normal renal development
  JOURNAL   Development 132 (3), 529-539 (2005)
   PUBMED   15634693
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Herrera,E., Marcus,R., Li,S., Williams,S.E., Erskine,L., Lai,E. and
            Mason,C.
  TITLE     Foxd1 is required for proper formation of the optic chiasm
  JOURNAL   Development 131 (22), 5727-5739 (2004)
   PUBMED   15509772
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Zhang,H., Palmer,R., Gao,X., Kreidberg,J., Gerald,W., Hsiao,L.,
            Jensen,R.V., Gullans,S.R. and Haber,D.A.
  TITLE     Transcriptional activation of placental growth factor by the
            forkhead/winged helix transcription factor FoxD1
  JOURNAL   Curr Biol 13 (18), 1625-1629 (2003)
   PUBMED   13678594
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Dahle,M.K., Gronning,L.M., Cederberg,A., Blomhoff,H.K., Miura,N.,
            Enerback,S., Tasken,K.A. and Tasken,K.
  TITLE     Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha
            subunit of cAMP-dependent protein kinase include release of
            transcriptional repression and activation by protein kinase B alpha
            and cAMP
  JOURNAL   J Biol Chem 277 (25), 22902-22908 (2002)
   PUBMED   11943768
  REMARK    GeneRIF: Mechanisms of FOXC2- and FOXD1-mediated regulation of the
            RI alpha subunit of cAMP-dependent protein kinase include release
            of transcriptional repression and activation by protein kinase B
            alpha and cAMP.
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Hatini,V., Huh,S.O., Herzlinger,D., Soares,V.C. and Lai,E.
  TITLE     Essential role of stromal mesenchyme in kidney morphogenesis
            revealed by targeted disruption of Winged Helix transcription
            factor BF-2
  JOURNAL   Genes Dev 10 (12), 1467-1478 (1996)
   PUBMED   8666231
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 11, 2021 this sequence version replaced NM_134337.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments and orthologous data.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2421              JAXUCZ010000002.1  31436802-31439222
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2421
                     /gene="Foxd1"
                     /gene_synonym="BF-2; Hfhbf2"
                     /note="forkhead box D1"
                     /db_xref="GeneID:171299"
                     /db_xref="RGD:621712"
     exon            1..2421
                     /gene="Foxd1"
                     /gene_synonym="BF-2; Hfhbf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1730
                     /gene="Foxd1"
                     /gene_synonym="BF-2; Hfhbf2"
                     /note="brain factor 2"
                     /codon_start=1
                     /product="forkhead box protein D1"
                     /protein_id="NP_599164.2"
                     /db_xref="GeneID:171299"
                     /db_xref="RGD:621712"
                     /translation="MTLSTEMSDASGLAEETDIDVVGEGEDEEEEEDDDDEGGGGSQL
                     PSSAQRRRRSYAGEDELEDLEEEDDDEDLLLASRPAASPAPPGPAPAPGAGSGGCSGA
                     GAGGGAGGGVGAGAGTGGGGSSKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFI
                     SGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGS
                     FLRRRKRFKRQPLLAPHAAAEALLLRGAGPAASAGDPGAALFPPPPPPPACGYGAYGC
                     AYGLQLPPCAPPSALFAAAAAAAAAAFHPHSPPPPPPPPPPPGAAAELARTAFGYRPH
                     ALAAALPGPLQAAAVKAGGPGTAALARSPFSIESLIGRTRGPATAGAHASPGATSGTA
                     PGPGGGGCAVQAAAGPAVALTRSLVVAAAAAASSVSSSAALGTLHQGTALSSVENFTA
                     RISNC"
ORIGIN      
        1 actcagccct ggccttgccg agctctgttt ctagattctc actcgtctcg cgcccctctg
       61 ggcgcccgac accgactggc ccgccagggt ccagccaacc cctcctggac tgaccgggct
      121 agagggaccg cagtggaaaa ggtcaagtct agcacgcccg ccaccccgtg cacgccgagc
      181 cggggagcgc aggcaccccg cgcagcccgg ctcgtcaagt agcggcgcgg agcggcccca
      241 gccgcccgtc gcagcgtggc gtcctcgctc cgggtccgcc gctccggggt cggcctgggg
      301 aggccagaga gccgggagcc cggtgcccct atgtgccgcc gcgccaccgc gccgccccag
      361 ctatgaccct gagcacagag atgtccgatg cctccggcct cgccgaggag acagacatcg
      421 acgtggtggg ggagggagag gacgaagagg aggaagagga cgatgacgac gagggcggcg
      481 gcgggtccca gttgcccagc tcggcccagc ggcggcggcg ctcctacgcc ggggaggacg
      541 agctcgagga cctggaggaa gaggacgacg acgaagacct gctgctggcc tcgcggcctg
      601 ccgcgtcccc cgcgcctccg ggtcctgcgc ccgccccagg ggccggatcg ggcggctgca
      661 gcggcgcggg agcgggaggc ggcgcgggag gtggcgtggg cgcgggcgcg ggcacgggtg
      721 ggggcgggag ctccaagaac ccgctggtga agcctcccta ctcgtacatc gcgctcatca
      781 ccatggccat cctgcagagc cccaagaagc gcctgacgct cagcgagatc tgcgagttca
      841 tcagcggtcg cttcccttac taccgggaga agttccccgc ctggcagaac agcatccgtc
      901 acaacctgtc gctcaacgac tgcttcgtca agatcccgcg cgagcccggc aacccgggca
      961 agggcaacta ctggacgctc gacccggagt ccgcagacat gttcgacaac ggcagcttcc
     1021 tgcggcgccg caagcgcttc aagcgccagc cgttgctcgc cccccacgcg gcggccgagg
     1081 cgctgctgct gcgcggtgcg gggcccgcgg cgagcgcagg ggacccgggc gccgcgctct
     1141 tcccgccgcc gcccccgccg cccgcctgcg gctatggagc ctacggctgc gcctacggcc
     1201 tgcagctgcc gccctgcgcg ccgccctccg cgctcttcgc tgccgccgcc gccgcagccg
     1261 ctgccgcctt ccacccgcac tcacccccgc caccgccgcc gccgccgcct cctcccggcg
     1321 cggccgccga gctggcgcgg accgccttcg gctaccggcc gcatgcgctg gccgccgccc
     1381 tgcccggccc gttgcaggcg gccgcagtca aggcgggagg cccgggcacc gcagcgctcg
     1441 cacgctcgcc cttctccatt gagagcctca tcgggcgcac tcggggtccc gcgaccgccg
     1501 gtgcacacgc ctcgcctggg gccaccagcg ggaccgcacc gggccccggg ggcggaggct
     1561 gcgccgtgca agcggctgcg ggtcccgccg tcgcgctcac ccgctcgctg gtggtcgccg
     1621 ccgcggctgc tgcctcctcc gtgtcgtcgt ccgccgcgct gggtactctg caccaaggga
     1681 ctgcgctgtc cagtgtggag aactttactg ctaggatttc caattgttag aaacgccgtt
     1741 agcgcgcggg agagagtgaa ggtaggaccc cggctccttt ctacggatgg ggggttggtt
     1801 ttgttcgccc ctcccggccc tcggcgacct cgcgccccca ttttcgccac ttcggaatct
     1861 tggaccagac cgtgttgggc gacagcgggg gcgccgcgca gtttggctga gagggtcaat
     1921 ctatttatgc aaaatcgccc tatgctgcaa ccctgacttg gggtgggaga gaggggaatc
     1981 gccctgtctt ggcactagga gcttccttga cttttgaaaa attgagaaaa accaagcaaa
     2041 atcatcaaaa ccaagccttt ttgaagtata gagattctca ggttcaggcg ttaaaaaaaa
     2101 aaaatcagta atgtttaaat gcagcttatg caaaaccagt aaaggtctcc aagaaacgcc
     2161 tttatttgtt cacacatgtt tggtatactt tttcatggaa aggaaaaaat gattaacatg
     2221 tttacacaag aaacaagtcg agacttatca tttcctattt ttaacctgtg ttttgtatca
     2281 taatggactt gcggaatttt tattttgtac ttactacgta ttctttgcaa ggagtattgt
     2341 aaattttact ggcaattatt attgtactat tctaatgtaa gatttttacg cggttttcca
     2401 gaaataaaat gcttaatttt c
//
