LOCUS       NP_599164                455 aa            linear   ROD 31-MAR-2024
DEFINITION  forkhead box protein D1 [Rattus norvegicus].
ACCESSION   NP_599164 XP_001057782
VERSION     NP_599164.2
DBSOURCE    REFSEQ: accession NM_134337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 455)
  AUTHORS   Meng,F., Liu,Y., Chen,Q., Ma,Q., Gu,S., Cui,R., Cao,R. and Zhao,M.
  TITLE     METTL3 contributes to renal ischemia-reperfusion injury by
            regulating Foxd1 methylation
  JOURNAL   Am J Physiol Renal Physiol 319 (5), F839-F847 (2020)
   PUBMED   32954854
  REMARK    GeneRIF: METTL3 contributes to renal ischemia-reperfusion injury by
            regulating Foxd1 methylation.
REFERENCE   2  (residues 1 to 455)
  AUTHORS   Gumbel,J.H., Patterson,E.M., Owusu,S.A., Kabat,B.E., Jung,D.O.,
            Simmons,J., Hopkins,T. and Ellsworth,B.S.
  TITLE     The forkhead transcription factor, Foxd1, is necessary for
            pituitary luteinizing hormone expression in mice
  JOURNAL   PLoS One 7 (12), e52156 (2012)
   PUBMED   23284914
REFERENCE   3  (residues 1 to 455)
  AUTHORS   Levinson,R.S., Batourina,E., Choi,C., Vorontchikhina,M.,
            Kitajewski,J. and Mendelsohn,C.L.
  TITLE     Foxd1-dependent signals control cellularity in the renal capsule, a
            structure required for normal renal development
  JOURNAL   Development 132 (3), 529-539 (2005)
   PUBMED   15634693
REFERENCE   4  (residues 1 to 455)
  AUTHORS   Herrera,E., Marcus,R., Li,S., Williams,S.E., Erskine,L., Lai,E. and
            Mason,C.
  TITLE     Foxd1 is required for proper formation of the optic chiasm
  JOURNAL   Development 131 (22), 5727-5739 (2004)
   PUBMED   15509772
REFERENCE   5  (residues 1 to 455)
  AUTHORS   Zhang,H., Palmer,R., Gao,X., Kreidberg,J., Gerald,W., Hsiao,L.,
            Jensen,R.V., Gullans,S.R. and Haber,D.A.
  TITLE     Transcriptional activation of placental growth factor by the
            forkhead/winged helix transcription factor FoxD1
  JOURNAL   Curr Biol 13 (18), 1625-1629 (2003)
   PUBMED   13678594
REFERENCE   6  (residues 1 to 455)
  AUTHORS   Dahle,M.K., Gronning,L.M., Cederberg,A., Blomhoff,H.K., Miura,N.,
            Enerback,S., Tasken,K.A. and Tasken,K.
  TITLE     Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha
            subunit of cAMP-dependent protein kinase include release of
            transcriptional repression and activation by protein kinase B alpha
            and cAMP
  JOURNAL   J Biol Chem 277 (25), 22902-22908 (2002)
   PUBMED   11943768
  REMARK    GeneRIF: Mechanisms of FOXC2- and FOXD1-mediated regulation of the
            RI alpha subunit of cAMP-dependent protein kinase include release
            of transcriptional repression and activation by protein kinase B
            alpha and cAMP.
REFERENCE   7  (residues 1 to 455)
  AUTHORS   Hatini,V., Huh,S.O., Herzlinger,D., Soares,V.C. and Lai,E.
  TITLE     Essential role of stromal mesenchyme in kidney morphogenesis
            revealed by targeted disruption of Winged Helix transcription
            factor BF-2
  JOURNAL   Genes Dev 10 (12), 1467-1478 (1996)
   PUBMED   8666231
REFERENCE   8  (residues 1 to 455)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   9  (residues 1 to 455)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 11, 2021 this sequence version replaced NP_599164.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments and orthologous data.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     Protein         1..455
                     /product="forkhead box protein D1"
                     /note="brain factor 2"
                     /calculated_mol_wt=45226
     Region          130..228
                     /region_name="FH_FOXD1_D2-like"
                     /note="Forkhead (FH) domain found in Forkhead box proteins
                     FOXD1, FOXD2 and similar proteins; cd20046"
                     /db_xref="CDD:410820"
     Site            order(131..136,153..154,172..173,175..177,179..181,184,
                     190..195,197,199..204,221..225)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410820"
     CDS             1..455
                     /gene="Foxd1"
                     /gene_synonym="BF-2; Hfhbf2"
                     /coded_by="NM_134337.2:363..1730"
                     /db_xref="GeneID:171299"
                     /db_xref="RGD:621712"
ORIGIN      
        1 mtlstemsda sglaeetdid vvgegedeee eeddddeggg gsqlpssaqr rrrsyagede
       61 ledleeeddd edlllasrpa aspappgpap apgagsggcs gagagggagg gvgagagtgg
      121 ggssknplvk ppysyialit mailqspkkr ltlseicefi sgrfpyyrek fpawqnsirh
      181 nlslndcfvk iprepgnpgk gnywtldpes admfdngsfl rrrkrfkrqp llaphaaaea
      241 lllrgagpaa sagdpgaalf pppppppacg ygaygcaygl qlppcappsa lfaaaaaaaa
      301 aafhphsppp ppppppppga aaelartafg yrphalaaal pgplqaaavk aggpgtaala
      361 rspfsiesli grtrgpatag ahaspgatsg tapgpggggc avqaaagpav altrslvvaa
      421 aaaassvsss aalgtlhqgt alssvenfta risnc
//
