LOCUS       NM_001101680            2703 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus forkhead box C2 (Foxc2), mRNA.
ACCESSION   NM_001101680 XM_001079064
VERSION     NM_001101680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Peng,Y.H., Wang,P., He,X.Q., Hong,M.Z. and Liu,F.
  TITLE     Micro ribonucleic acid-363 regulates the phosphatidylinositol
            3-kinase/threonine protein kinase axis by targeting NOTCH1 and
            forkhead box C2, leading to hepatic glucose and lipids metabolism
            disorder in type 2 diabetes mellitus
  JOURNAL   J Diabetes Investig 13 (2), 236-248 (2022)
   PUBMED   34739190
  REMARK    GeneRIF: Micro ribonucleic acid-363 regulates the
            phosphatidylinositol 3-kinase/threonine protein kinase axis by
            targeting NOTCH1 and forkhead box C2, leading to hepatic glucose
            and lipids metabolism disorder in type 2 diabetes mellitus.
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Zhang,X.X., Wang,Y.M., Su,Y.D., Zuo,F., Wu,B. and Nian,X.
  TITLE     MiR-26a regulated adipogenic differentiation of ADSCs induced by
            insulin through CDK5/FOXC2 pathway
  JOURNAL   Mol Cell Biochem 476 (4), 1705-1716 (2021)
   PUBMED   33423166
  REMARK    GeneRIF: MiR-26a regulated adipogenic differentiation of ADSCs
            induced by insulin through CDK5/FOXC2 pathway.
            Erratum:[Mol Cell Biochem. 2021 Aug;476(8):3217. doi:
            10.1007/s11010-021-04212-3.. PMID: 34156588]
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Wang,Z., Fu,C., Chen,Y., Xu,F., Wang,Z., Qu,Z. and Liu,Y.
  TITLE     FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of
            the Intervertebral Disc
  JOURNAL   PLoS One 11 (1), e0147764 (2016)
   PUBMED   26824865
  REMARK    GeneRIF: Adenovirus-mediated FoxC2 expression enhances
            BMP7-facilitated anabolism in nucleus pulposus cells of the
            intervertebral discs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Li,X., Wang,W., Wang,J., Malovannaya,A., Xi,Y., Li,W., Guerra,R.,
            Hawke,D.H., Qin,J. and Chen,J.
  TITLE     Proteomic analyses reveal distinct chromatin-associated and soluble
            transcription factor complexes
  JOURNAL   Mol Syst Biol 11 (1), 775 (2015)
   PUBMED   25609649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2703)
  AUTHORS   Iascone,M., Ciccone,R., Galletti,L., Marchetti,D., Seddio,F.,
            Lincesso,A.R., Pezzoli,L., Vetro,A., Barachetti,D., Boni,L.,
            Federici,D., Soto,A.M., Comas,J.V., Ferrazzi,P. and Zuffardi,O.
  TITLE     Identification of de novo mutations and rare variants in
            hypoplastic left heart syndrome
  JOURNAL   Clin Genet 81 (6), 542-554 (2012)
   PUBMED   21457232
REFERENCE   6  (bases 1 to 2703)
  AUTHORS   Iida,K., Koseki,H., Kakinuma,H., Kato,N., Mizutani-Koseki,Y.,
            Ohuchi,H., Yoshioka,H., Noji,S., Kawamura,K., Kataoka,Y., Ueno,F.,
            Taniguchi,M., Yoshida,N., Sugiyama,T. and Miura,N.
  TITLE     Essential roles of the winged helix transcription factor MFH-1 in
            aortic arch patterning and skeletogenesis
  JOURNAL   Development 124 (22), 4627-4638 (1997)
   PUBMED   9409679
REFERENCE   7  (bases 1 to 2703)
  AUTHORS   Miura,N., Iida,K., Kakinuma,H., Yang,X.L. and Sugiyama,T.
  TITLE     Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork
            head-1 genes reveals conservation of their gene and protein
            structures
  JOURNAL   Genomics 41 (3), 489-492 (1997)
   PUBMED   9169153
REFERENCE   8  (bases 1 to 2703)
  AUTHORS   Winnier,G.E., Hargett,L. and Hogan,B.L.
  TITLE     The winged helix transcription factor MFH1 is required for
            proliferation and patterning of paraxial mesoderm in the mouse
            embryo
  JOURNAL   Genes Dev 11 (7), 926-940 (1997)
   PUBMED   9106663
REFERENCE   9  (bases 1 to 2703)
  AUTHORS   Miura,N., Wanaka,A., Tohyama,M. and Tanaka,K.
  TITLE     MFH-1, a new member of the fork head domain family, is expressed in
            developing mesenchyme
  JOURNAL   FEBS Lett 326 (1-3), 171-176 (1993)
   PUBMED   8325367
REFERENCE   10 (bases 1 to 2703)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On Aug 19, 2007 this sequence version replaced XM_001079064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2703
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Fkhl14; Hfhbf3"
                     /note="forkhead box C2"
                     /db_xref="GeneID:171356"
                     /db_xref="RGD:621703"
     exon            1..2703
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Fkhl14; Hfhbf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1900
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Fkhl14; Hfhbf3"
                     /note="BF-3; HFH-BF-3; brain factor 3; forkhead box C2
                     (MFH-1, mesenchyme forkhead 1)"
                     /codon_start=1
                     /product="forkhead box protein C2"
                     /protein_id="NP_001095150.1"
                     /db_xref="GeneID:171356"
                     /db_xref="RGD:621703"
                     /translation="MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGH
                     PEQYGAGMGRSYAPYHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIM
                     DRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSF
                     LRRRRRFKKKDVPKDKEERAHLKEPPPASAKGAPTGTPVADGPKEAEKKVVVKSEAAS
                     PALPVITKVETLSPEGALQASPRSSASTPAGSPDGSLPEHHAAAPNGLPGFSVETIMT
                     LRTSPPGGDLSPAAARAGLVVPPLALPYAAAPPAAYAQPCAQGLEAAGSAGYQCSMRA
                     MSLYTGAERPAHVCVPPALDEALSDHPSGPGSPLGALNLAAGQEGALGASGHHHQHHS
                     HLHPQAPPPAPQPPPAPQPATQATSWYLNHGGDLSHLPGHTFATQQQTFPNVREMFNS
                     HRLGLDNSTLGESQVSNASCQLPYRATPSLYRHAAPYSYDCTKY"
ORIGIN      
        1 agggacttcg cttctttttc cgggctcggc cgcgcagcct ctccggatcc cagctcgcgg
       61 acactgtggg ctgccgttct cctggcggag ccccgagagc cgctgtctcc ttttctagca
      121 ctccgaaggg ctggtctagc tccacggtcg cgcgtggcgt ctgtgccgcc agctcagggc
      181 ttccatccgc cggtccgaga gcgcgcggcc agccgggccg cccggggtgc gccctccagg
      241 atgctgatcc gcccggtcgg ctgaacccga gcgccagcgc gcgtggcccg cgaggctgcc
      301 ccgagccagg gctgcccgca tcgctccgtc ccttcctgct ctcttgctcc gggcctcgct
      361 ccccgcgggc cgcagtcggt gcgcgcaggc ggcggccggg cgtctgggac gcagcatgca
      421 ggcgcgctac tcggtgtcgg accccaacgc cctgggagtg gtaccctact tgagcgagca
      481 aaactactac cgggcggcgg gcagctacgg cggcatggcc agccccatgg gcgtctactc
      541 cggccacccg gagcagtacg gcgccggcat gggccgctct tacgcgccct accaccacca
      601 gcccgcggcg cccaaggacc tggtgaagcc gccctacagc tacatagcgc tcatcaccat
      661 ggcgatccag aacgcgccgg agaagaagat caccctgaac ggcatctacc agttcatcat
      721 ggaccgtttt cccttctacc gcgagaacaa gcagggctgg cagaacagca tccgccacaa
      781 cctgtcgctc aacgagtgct tcgtgaaggt gccgcgcgat gacaagaagc caggcaaagg
      841 tagctactgg acgctcgacc cggactccta caatatgttc gagaacggca gcttcctgcg
      901 gcggcggcgg cgcttcaaga agaaggacgt gcccaaggat aaggaggagc gggcccacct
      961 caaggagccg ccccctgcct cggccaaagg cgccccgaca gggaccccgg tagctgacgg
     1021 gcccaaggag gccgagaaga aagtggtggt caagagcgag gcggcgtcac ccgcgctgcc
     1081 ggtcatcacc aaggtggaga cgctgagtcc cgagggcgcg ctgcaagcca gtccccgcag
     1141 ctcagcctcc acgcctgccg gctccccaga cggctcgctg ccggagcacc acgccgccgc
     1201 gcccaacggg ctgcccggct tcagcgtgga gaccatcatg acgctgcgca cgtcgcctcc
     1261 gggcggcgat ctgagcccag cggccgcgcg cgccggcctg gtggtgccac cgctggcgct
     1321 gccatacgcc gcagctccac cagccgctta cgcacagccg tgcgcgcagg gcctggaggc
     1381 tgcgggctcc gcgggctacc agtgcagcat gcgggctatg agtctgtaca ccggggccga
     1441 gcggcctgcg cacgtgtgcg ttccgcccgc gctggacgag gctctgtcgg accacccgag
     1501 cggccccggc tccccgctcg gcgccctcaa cctcgcagcg ggtcaggagg gtgcgttggg
     1561 ggcctcgggc caccaccacc agcatcacag tcacctccac ccgcaggcgc cgccgcccgc
     1621 cccgcagccc cctcccgcgc cgcagcccgc cacccaggcc acctcctggt atctgaacca
     1681 cggcggggac ctgagccacc tccccggcca cacgttcgcg acccaacagc aaactttccc
     1741 caatgtccgg gagatgttca actcgcaccg gctaggactg gacaactcga ccctcgggga
     1801 gtcccaggtg agcaatgcga gctgtcagct gccctaccga gctacgccgt ccctctaccg
     1861 ccatgcagcc ccctactcct acgactgcac caaatattaa ggcgtccagt ccgctccagc
     1921 cccaggcccg caccggcttc acctccccat gggaccttct tcgacagagc cgcaaaaagc
     1981 gaccgaacgc gcccctctct cagacccggg agcagagagc tccgtgcatc tcgcaggtaa
     2041 cttctccgca gctcagtttg agatcccaga gagtccctct aaccgggatg cagcacagca
     2101 aaacgaaata ccgatttatt ttttttttta attcccgttc cctgcccgga tgctgcgcct
     2161 gctccccttg gggttttaat agattggttt atggaccaaa ccccacaggg accccctaat
     2221 gacttctgtg gagactctcc ccgggctcaa gaggtctctc cggataaggt gccttctgta
     2281 aacgagtgcg gatttgtaac caggcgagtt cgttgttacc cagagccttt aatataatat
     2341 ttaaagttgt gtccactgga taaggtttca tcttgcccaa ctgttactgc caaattgaat
     2401 tcaagaaacc tgtgtgggtc ttttctcccc acagtaccat aataaaatag gtttttcccc
     2461 cacaaatgaa ggtcttttac aaaacaagaa aataatttat ttattttttt gttgttgttg
     2521 gataacgaaa ttaagtattg gatacttttt atttaggaag cgcatggctt tgtacagtag
     2581 acgccatctg gagtattcct aaaacacaca aagagacttt aaaatttcaa cttcatctgt
     2641 gtttgtcttc tgtgatctca gtgttgtatt taccttaaaa taaacccacg ttgttcttct
     2701 gcc
//
