LOCUS       NM_134338               3983 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus forkhead box C1 (Foxc1), mRNA.
ACCESSION   NM_134338 XM_002725235 XM_002728469 XM_003751676
VERSION     NM_134338.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Ji Z, Chen S, Cui J, Huang W, Zhang R, Wei J and Zhang S.
  TITLE     Oct4-dependent FoxC1 activation improves the survival and
            neovascularization of mesenchymal stem cells under myocardial
            ischemia
  JOURNAL   Stem Cell Res Ther 12 (1), 483 (2021)
   PUBMED   34454602
  REMARK    GeneRIF: Oct4-dependent FoxC1 activation improves the survival and
            neovascularization of mesenchymal stem cells under myocardial
            ischemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Xia W, Zhu J, Wang X, Tang Y, Zhou P, Wei X, Chang B, Zheng X, Zhu
            W, Hou M and Li S.
  TITLE     Overexpression of Foxc1 regenerates crushed rat facial nerves by
            promoting Schwann cells migration via the Wnt/beta-catenin
            signaling pathway
  JOURNAL   J Cell Physiol 235 (12), 9609-9622 (2020)
   PUBMED   32391604
  REMARK    GeneRIF: Overexpression of Foxc1 regenerates crushed rat facial
            nerves by promoting Schwann cells migration via the
            Wnt/beta-catenin signaling pathway.
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Xia S, Qu J, Jia H, He W, Li J, Zhao L, Mao M and Zhao Y.
  TITLE     Overexpression of Forkhead box C1 attenuates oxidative stress,
            inflammation and apoptosis in chronic obstructive pulmonary disease
  JOURNAL   Life Sci 216, 75-84 (2019)
   PUBMED   30428305
  REMARK    GeneRIF: Overexpression of Foxc1 could prevent oxidative stress,
            inflammation responses and cell apoptosis and knockdown of Foxc1
            has the opposite effect, suggesting that Foxc1 may be available for
            lung protection during chronic obstructive pulmonary disease
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Motojima M, Kume T and Matsusaka T.
  TITLE     Foxc1 and Foxc2 are necessary to maintain glomerular podocytes
  JOURNAL   Exp Cell Res 352 (2), 265-272 (2017)
   PUBMED   28223138
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Bin L, Deng L, Yang H, Zhu L, Wang X, Edwards MG, Richers B and
            Leung DY.
  TITLE     Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal
            Differentiation
  JOURNAL   PLoS One 11 (12), e0167392 (2016)
   PUBMED   27907090
  REMARK    Erratum:[PLoS One. 2018 Jan 5;13(1):e0191127. PMID: 29304137]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Clevidence DE, Overdier DG, Tao W, Qian X, Pani L, Lai E and Costa
            RH.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   7  (bases 1 to 3983)
  AUTHORS   Gruneberg,H. and Wickramaratne,G.A.
  TITLE     A re-examination of two skeletal mutants of the mouse,
            vestigial-tail (vt) and congenital hydrocephalus (ch)
  JOURNAL   J Embryol Exp Morphol 31 (1), 207-222 (1974)
   PUBMED   4819561
REFERENCE   8  (bases 1 to 3983)
  AUTHORS   Breen,M., Richardson,R., Bondareff,W. and Weinstein,H.G.
  TITLE     Acidic glycosaminoglycans in developing sterno-costal cartilage of
            the hydrocephalic (ch+-ch+) mouse
  JOURNAL   Biochim Biophys Acta 304 (3), 828-836 (1973)
   PUBMED   4269479
REFERENCE   9  (bases 1 to 3983)
  AUTHORS   Raimondi,A.J., Bailey,O.T., McLone,D.G., Lawson,R.F. and
            Echeverry,A.
  TITLE     The pathophysiology and morphology of murine hydrocephalus in Hy-3
            and Ch mutants
  JOURNAL   Surg Neurol 1 (1), 50-55 (1973)
   PUBMED   4784576
REFERENCE   10 (bases 1 to 3983)
  AUTHORS   Green,M.C.
  TITLE     The developmental effects of congenital hydrocephalus (ch) in the
            mouse
  JOURNAL   Dev Biol 23 (4), 585-608 (1970)
   PUBMED   5500588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000289.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_134338.3.
            
            On Feb 11, 2021 this sequence version replaced NM_134338.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3983              JACYVU010000289.1  1534491-1538473     c
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3983
                     /gene="Foxc1"
                     /note="forkhead box C1"
                     /db_xref="GeneID:364706"
                     /db_xref="RGD:1589718"
     exon            1..3983
                     /gene="Foxc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             559..2220
                     /gene="Foxc1"
                     /codon_start=1
                     /product="forkhead box protein C1"
                     /protein_id="NP_599165.1"
                     /db_xref="GeneID:364706"
                     /db_xref="RGD:1589718"
                     /translation="MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPM
                     SVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLN
                     GIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYN
                     MFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPAPPEQAEGSAPGP
                     QQPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPP
                     GSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTSLRGSPQGSAAELGSGLLA
                     SAAASSRAGIAPPLALGAYSPGHSSLYSSPCSQSSSAGSSGGGGGGGGGGGGSSSAAG
                     TGGAATYHCNLQAMSLYAAGERGGHLQGPAGGGGSAAVDDPLPDYSLPPATSSSSSSL
                     SHGGGGQETSHHPASHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVR
                     EMFESQRIGLNNSPVNGNSSCQMAFPASQSLYRTSGAFVYDCSKF"
ORIGIN      
        1 gaagttttcc caatgcttcc ttaagcggcc ggcgcaagag actgagaaaa ggtgacgcgg
       61 gggcccggga aggcggccgg cgcgctgccc ccgcccctgg ttatttggcc gccttagcta
      121 gcagccccga gcagtgtctc ctggaaggcg caggcagtgg cgagcagggc gccttcttat
      181 ttttattttt ttaatttttt ttgaactttt gtcttttttt tttttttttt tttttgcccc
      241 gactgcgcct ggaagttgct ctgaacgttc ctccgaggcg gcttgcggaa tcctcgtccg
      301 gccctctccc ggttgcagcg accctccctc gccgcccgcg cgggaactga gtgggcagcg
      361 aggcgccagg cgagcgcagg gagaggccga gcagccccgg gcgcaaggag gcggccgcgg
      421 cccggacaga cgcagcgcgg cggggcccgc agcagctcgg cgcggccggg actcggactc
      481 gggggccggt gcggcgcggc ccggcccgag cgagggtggg gggcggcgga ctgcgcctgg
      541 cggcggcgag ccggggccat gcaggcgcgc tactcggtgt ccagccccaa ctccctggga
      601 gtggtgccct acctcggcgg cgagcagagc tactatcgcg ctgccgcggc ggcggccggg
      661 ggcggctaca ccgccatgcc ggcccctatg agcgtgtact cgcaccctgc tcacgccgag
      721 cagtacccgg gcggcatggc gcgcgcctac gggccttata cgccgcagcc gcagcccaag
      781 gacatggtga agcctcccta cagctacatc gctcttatca ccatggctat ccagaatgcc
      841 ccggacaaga agatcaccct gaatggcatc taccagttca tcatggaccg ctttcccttc
      901 tatcgggaca ataagcaggg ctggcagaac agcatacggc acaacctctc gcttaatgag
      961 tgcttcgtca aggtgccccg cgacgacaag aagccaggca agggcagcta ctggacgctg
     1021 gacccggact cctacaacat gttcgagaac ggcagcttcc tgcggcggcg gcggcgcttc
     1081 aagaagaagg acgcggtgaa ggacaaggag gagaagggcc gactgcacct ccaggaaccg
     1141 ccgccgccgc aggccggccg ccagcccgcg cccgcgcccc cggaacaggc cgagggctcc
     1201 gctcccgggc cacagcagcc acccgtgcgc atccaggaca tcaagacgga gaacggtacg
     1261 tgtccctcgc cgccccagcc cctgtccccg gctgccgccc taggcagcgg cagtgcggcc
     1321 acagtgccta aaatcgagag tcccgacagc agcagcagca gcctgtcgag cgggagcagc
     1381 cccccgggca gcctgccctc ggcgcggccg ctcagcctgg acgctgcaga acccgcgccg
     1441 ccgccacagc ccgcgccgcc gccgcatcac agccagggct tcagcgtgga caacatcatg
     1501 acgtcgctgc gggggtcgcc gcagggttcg gctgcggagc tcggctccgg cctcctggcc
     1561 tcagccgctg cgtcctcgcg cgcgggcatc gcgcccccgc tggcgctggg cgcctactcg
     1621 cctggccaca gctccctcta cagctccccc tgcagccaga gctccagtgc gggcagctcg
     1681 ggcggcggcg gcggcggcgg cggcggaggt ggcggcagca gcagcgcagc gggtacgggg
     1741 ggcgccgcca cttaccactg caacctgcag gccatgagcc tgtacgcggc gggcgagcgt
     1801 ggcggccact tgcagggtcc ggccggaggc gggggcagcg cggcggtgga cgaccccctg
     1861 cccgattact cgctgccccc agcgaccagc agcagctctt cgtccctgag tcacggcggg
     1921 ggcggccagg agaccagcca ccaccctgcg tcccaccaag gccgactcac ctcgtggtac
     1981 ctgaaccagg caggtggaga cctgggtcac ttggcgagcg cagcggcggc tgctgcggcc
     2041 gcgggctatc ctggccagca gcagaacttc cactcggtgc gggaaatgtt cgagtctcag
     2101 cggatcggct taaacaactc tccggtgaat gggaatagta gctgtcagat ggcttttcct
     2161 gccagccagt ctctgtaccg cacgtcgggg gctttcgtct atgactgtag caaattctga
     2221 ccctattccc ggcaccctta gagccaaacg gaatggaacc ccagagcagg aacagtaaaa
     2281 gaacccagca atgcaaaatc gaaactaaaa acttacaaaa tttaaaactt gagaagattc
     2341 atcacaccag cgaacagaat ctctcctgaa attcaactca ccagcatcaa ttaaaagaaa
     2401 acctattttt ctaaaagatt aatgcagaac ctcctccatt tttgccttat ctaagtaagc
     2461 aaaaccgtaa actattttgt acagacagca aaatcatggt ttattaaaag gacagtttac
     2521 tccagatacc acgtaagttt cttgcgttca gagactcgct ttcctgctca ttttgtcttg
     2581 cccctctgcc tctgccttgc ctctcacctg taagataata ttttatccta tgtcgaaaga
     2641 agggggaaag tccctgttta tgaaaatcgc tttcttttta ttcatggact tgtttttaaa
     2701 tgtaaattgc aacatagtaa tttattttta atttgtagtt ggatgttacg gaccaaacac
     2761 cagaaagtgt tccaaaaact tttcaagtta aattgcctga aacttttaaa atgtgccttt
     2821 tctctcatta taaaaaggga aactgtatta atctcattct atcatccttt tctttttgtt
     2881 gatcatatcc attgtttgtt tattaataaa ttgccgttca gtttgaataa gacctatatg
     2941 tctggatact ttaatatagc tttaatataa ggaaaagatt tcagagcgga agttgtagaa
     3001 gttccctatt ctctgtgaga tcttttaaat gtggagaaaa cctctagttc acgtcaaatt
     3061 tcgctaaaag cagattttaa gattgttaag tagatatttt tcttacagcg ttttctgcaa
     3121 aacatactat ctactcgact tgctttgtgg ctattaaaaa ggtaatttcc taagtagatc
     3181 tgagttggca tatgaacaaa tacttttctt cagtaactac agaacatgat ttggcaattt
     3241 ttaagtccgt gaatcagcac agcgttacta cagtggtacc tgtgcgcaga gatgcaaatg
     3301 ttcttgagat actaacagat ggatattagt cttcatgtcc cacatagatt tcagtaagtg
     3361 ttacacatac ctgtgagcca gatgccgaat agattttttt ctattaattt cattcctttg
     3421 ttagaggaga aataaactag ttttaaaatg tttgtatata actcactcac agttacaatt
     3481 cttcatgtat tgcacagaag gattaatttt ttaaaaatat atactgtggg ttggaaatag
     3541 atatttaatc ttggggaaac ctttagaaga tgtttgtaga acaatttttg ttttgaagat
     3601 ttacagcaat aaccagaagg aagagtaaga aggcagaaaa aaaaatagtc tggggtgatt
     3661 tcttttcaaa ccaatttttc ttgttaattt acagttaaac ctagggggca atccggattg
     3721 gccctccccc ttttgtaaat aacccaggaa atgtaataaa ttcattatct tagggtgatc
     3781 tgccctgtca atcagacttg gggagatggc ggtttgatta cagatattca ggccttcggt
     3841 ttgttttcga gataaagcag gttcctatct gccgctccta tctagaggca acacttaagc
     3901 agtaattgct gttgcttgtt gtcaaaattt gatcattgtt aaaggattgc tgcaaataaa
     3961 tacactctaa tttcagtcaa aaa
//
