LOCUS       NM_017077               1496 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus forkhead box A3 (Foxa3), mRNA.
ACCESSION   NM_017077
VERSION     NM_017077.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Fan,J.Y., Dama,G., Liu,Y.L., Guo,W.Y. and Lin,J.T.
  TITLE     [Combinational Overexpression of Foxa3 and Hnf4alpha Enhance the
            Proliferation and Prolong the Functional Maintenance of Primary
            Hepatocytes]
  JOURNAL   Mol Biol (Mosk) 57 (4), 668-670 (2023)
   PUBMED   37528786
  REMARK    GeneRIF: [Combinational Overexpression of Foxa3 and Hnf4alpha
            Enhance the Proliferation and Prolong the Functional Maintenance of
            Primary Hepatocytes].
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Dong,R., Yang,Y., Shen,Z., Zheng,C., Jin,Z., Huang,Y., Zhang,Z.,
            Zheng,S. and Chen,G.
  TITLE     Forkhead box A3 attenuated the progression of fibrosis in a rat
            model of biliary atresia
  JOURNAL   Cell Death Dis 8 (3), e2719 (2017)
   PUBMED   28358366
  REMARK    GeneRIF: data suggested a protection role for Foxa3 during the
            progression of liver fibrosis in biliary atresia, and thereby
            supported increasing Foxa3 as a targeted treatment strategy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Dai,K., Chen,R., Ding,Y., Niu,Z., Fan,J. and Xu,C.
  TITLE     Induction of Functional Hepatocyte-Like Cells by Overexpression of
            FOXA3 and HNF4alpha in Rat Bone Marrow Mesenchymal Stem Cells
  JOURNAL   Cells Tissues Organs 200 (2), 132-140 (2014)
   PUBMED   25896100
  REMARK    GeneRIF: FOXA3 and HNF4alpha are powerful transcription factors for
            inducing rat bone marrow mesenchymal stem cells to differentiate
            into functional hepatocyte-like cells.
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Chen,G., Korfhagen,T.R., Xu,Y., Kitzmiller,J., Wert,S.E., Maeda,Y.,
            Gregorieff,A., Clevers,H. and Whitsett,J.A.
  TITLE     SPDEF is required for mouse pulmonary goblet cell differentiation
            and regulates a network of genes associated with mucus production
  JOURNAL   J Clin Invest 119 (10), 2914-2924 (2009)
   PUBMED   19759516
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Zhou,B., Zhong,Q., Minoo,P., Li,C., Ann,D.K., Frenkel,B.,
            Morrisey,E.E., Crandall,E.D. and Borok,Z.
  TITLE     Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via
            interactions with the Nkx2.1 homeodomain
  JOURNAL   Am J Respir Cell Mol Biol 38 (6), 750-758 (2008)
   PUBMED   18239190
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Lin,B., Morris,D.W. and Chou,J.Y.
  TITLE     The role of HNF1alpha, HNF3gamma, and cyclic AMP in
            glucose-6-phosphatase gene activation
  JOURNAL   Biochemistry 36 (46), 14096-14106 (1997)
   PUBMED   9369482
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Clark,K.L., Halay,E.D., Lai,E. and Burley,S.K.
  TITLE     Co-crystal structure of the HNF-3/fork head DNA-recognition motif
            resembles histone H5
  JOURNAL   Nature 364 (6436), 412-420 (1993)
   PUBMED   8332212
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L09648.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_017077.3.
            
            On Aug 30, 2012 this sequence version replaced NM_017077.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1496              L09648.1           2-1497
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1496
                     /gene="Foxa3"
                     /gene_synonym="Hnf3g"
                     /note="forkhead box A3"
                     /db_xref="GeneID:25100"
                     /db_xref="RGD:2809"
     exon            1..145
                     /gene="Foxa3"
                     /gene_synonym="Hnf3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1141
                     /gene="Foxa3"
                     /gene_synonym="Hnf3g"
                     /function="'transcription factor'"
                     /note="HNF-3G; HNF-3-gamma; forkhead box protein A3"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-gamma"
                     /protein_id="NP_058773.1"
                     /db_xref="GeneID:25100"
                     /db_xref="RGD:2809"
                     /translation="MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMSLN
                     PLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPGLGAGSGTGGSASGYGAPGPGLV
                     HGKEMAKGYRRPLTHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQ
                     QRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLE
                     EKAKKGNSATSATRNGTVGSATSATTTAATAVTSPAQPQPTPPSEPEAQSGEDVGGLD
                     CASPPSSAPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAE
                     SGEPGVYYQSLYSRSLLNAS"
     exon            146..1496
                     /gene="Foxa3"
                     /gene_synonym="Hnf3g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgtagag agaccgaagc gctcggttcc cccgggggga ccgcagcctg ggcgtgtggg
       61 ggcacaggcc cgggggatgc tgggctcagt gaagatggag gcccatgacc tggccgagtg
      121 gagctactac ccggaggcgg gcgaggtgta ttctccagtg aatcctgtgc ccaccatggc
      181 ccctctcaac tcctacatgt ccttgaaccc tcttagctct ccctaccctc ccggagggct
      241 tcaggcctcc cctctgccta caggacccct ggcaccccca gcccccaccg ctcccctggg
      301 gcccaccttc ccaggcctgg gcgcaggcag cggcaccgga ggcagtgctt ccgggtatgg
      361 cgccccaggg cccgggcttg tacacggaaa ggaaatggcc aaggggtacc ggcggccact
      421 gactcatgcc aaaccacctt attcctacat ctctctcatc accatggcta tccagcaggc
      481 accaggcaag atgctgaccc tgagtgaaat ctaccaatgg atcatggacc tcttcccgta
      541 ctaccgggag aaccagcaac gttggcagaa ctccatccgg cactcgctgt ccttcaatga
      601 ctgcttcgtc aaggtggcac gctccccaga caaaccgggc aaaggctcct actgggcctt
      661 gcatcccagc tctgggaaca tgtttgagaa cggctgctat ctccgccgtc agaagcgctt
      721 caagctggag gagaaggcaa agaaaggaaa cagtgccaca tccgccacca ggaatggaac
      781 agtggggtca gccacctctg ccaccactac agctgccact gcagtcactt ccccggctca
      841 gccccagcct acgccgccgt ctgagcccga ggcccagagt ggggaagatg tggggggtct
      901 ggactgcgcc tcgcctcctt catccgcacc ctatttcact ggcctggagc tcccagggga
      961 actgaagttg gatgcgccct acaacttcaa ccaccctttc tctatcaaca acctgatgtc
     1021 agaacagaca tcaacacctt ccaaactaga tgtggggttt gggggctacg gtgctgagag
     1081 tggggaacct ggggtctact accagagcct ctattcccgc tctctgctca atgcatccta
     1141 gcggcgcaac tgggagaaat gcggtgatgg gggtttgctg tgacagatga ccggttcttc
     1201 ggccctgatc tttctggtta cactctgctt atccagttaa ttaacatcgt atttggtcta
     1261 ttactgtgat atgacccatt ggctactgtg gtaactgcat ggactcttcg gtgggcctag
     1321 ggttggggta ttgtgaaggc agatgcattt gggagtgtta cgaaggtggc catgtcggac
     1381 ataccgtgaa ggcaattaga ctggtgtact ataaaagctg catgttaagt gagtgatcca
     1441 ctgggtgcct gatggccgcg atgtcggagg acatattgtt tggccctttg gatgct
//
