LOCUS       NM_012743               2222 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus forkhead box A2 (Foxa2), transcript variant 2,
            mRNA.
ACCESSION   NM_012743 XM_346676
VERSION     NM_012743.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Yan,D., Lv,M., Kong,X., Feng,L., Ying,Y., Liu,W., Wang,X. and Ma,X.
  TITLE     FXR controls insulin content by regulating Foxa2-mediated insulin
            transcription
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119655 (2024)
   PUBMED   38135007
  REMARK    GeneRIF: FXR controls insulin content by regulating Foxa2-mediated
            insulin transcription.
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Wang,P., Cong,M., Liu,T., Li,Y., Liu,L., Sun,S., Sun,L., Zhu,Z.,
            Ma,H., You,H., Zhang,H. and Jia,J.
  TITLE     FoxA2 inhibits the proliferation of hepatic progenitor cells by
            reducing PI3K/Akt/HK2-mediated glycolysis
  JOURNAL   J Cell Physiol 235 (12), 9524-9537 (2020)
   PUBMED   32495363
  REMARK    GeneRIF: FoxA2 inhibits the proliferation of hepatic progenitor
            cells by reducing PI3K/Akt/HK2-mediated glycolysis.
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Li,X., Liu,H., Lv,Y., Yu,W., Liu,X. and Liu,C.
  TITLE     MiR-130a-5p/Foxa2 axis modulates fetal lung development in
            congenital diaphragmatic hernia by activating the Shh/Gli1
            signaling pathway
  JOURNAL   Life Sci 241, 117166 (2020)
   PUBMED   31843527
  REMARK    GeneRIF: Low FOXA2 expression is associated with congenital
            diaphragmatic hernia.
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Zhang,Q.M., Ouyang,W.X., Chai,X.Q. and Deng,F.T.
  TITLE     Expression of Lung Surfactant Proteins SP-B and SP-C and Their
            Regulatory Factors in Fetal Lung of GDM Rats
  JOURNAL   Curr Med Sci 38 (5), 847-852 (2018)
   PUBMED   30341519
  REMARK    GeneRIF: The expression of SP-B and SP-C in GDM group was
            significantly reduced as compared with control group (P<0.05)...It
            was concluded that gestational diabetes mellitus can cause fetal
            lung development and maturation disorders, and FOXA2 in fetal lung
            tissue decreases while nitrocellulose FOXA2 increases
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Ye,C., Chen,M., Chen,E., Li,W., Wang,S., Ding,Q., Wang,C., Zhou,C.,
            Tang,L., Hou,W., Hang,K., He,R., Pan,Z. and Zhang,W.
  TITLE     Knockdown of FOXA2 enhances the osteogenic differentiation of bone
            marrow-derived mesenchymal stem cells partly via activation of the
            ERK signalling pathway
  JOURNAL   Cell Death Dis 9 (8), 836 (2018)
   PUBMED   30082727
  REMARK    GeneRIF: FOXA2 knockdown significantly increased
            osteoblast-specific gene expression, the number of mineral deposits
            and alkaline phosphatase activity, whereas FOXA2 overexpression
            inhibited osteogenesis-specific activities. Moreover, extracellular
            signal-regulated protein kinase (ERK) signalling was upregulated
            following knockdown of FOXA2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Filosa,S., Rivera-Perez,J.A., Gomez,A.P., Gansmuller,A., Sasaki,H.,
            Behringer,R.R. and Ang,S.L.
  TITLE     Goosecoid and HNF-3beta genetically interact to regulate neural
            tube patterning during mouse embryogenesis
  JOURNAL   Development 124 (14), 2843-2854 (1997)
   PUBMED   9226455
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Farrington,S.M., Belaoussoff,M. and Baron,M.H.
  TITLE     Winged-helix, Hedgehog and Bmp genes are differentially expressed
            in distinct cell layers of the murine yolk sac
  JOURNAL   Mech Dev 62 (2), 197-211 (1997)
   PUBMED   9152011
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   Zhou,L., Lim,L., Costa,R.H. and Whitsett,J.A.
  TITLE     Thyroid transcription factor-1, hepatocyte nuclear factor-3beta,
            surfactant protein B, C, and Clara cell secretory protein in
            developing mouse lung
  JOURNAL   J Histochem Cytochem 44 (10), 1183-1193 (1996)
   PUBMED   8813084
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Venge,P., Zetterstrom,O., Dahl,R., Roxin,L.E. and Olsson,I.
  TITLE     Low levels of eosinophil cationic proteins in patients with asthma
  JOURNAL   Lancet 2 (8034), 373-375 (1977)
   PUBMED   70587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_012743.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09647.1, SRR26643286.11687.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676808
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000003.1  155927321-155927508 c
            189-258             JAXUCZ010000003.1  155926280-155926349 c
            259-2222            JAXUCZ010000003.1  155923307-155925270 c
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2222
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /note="forkhead box A2"
                     /db_xref="GeneID:25099"
                     /db_xref="RGD:2808"
     exon            1..188
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /inference="alignment:Splign:2.1.0"
     exon            189..258
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1569
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hepatocyte nuclear factor 3-beta; HNF-3B; HNF-3-beta;
                     forkhead box protein A2"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-beta isoform 2"
                     /protein_id="NP_036875.2"
                     /db_xref="GeneID:25099"
                     /db_xref="RGD:2808"
                     /translation="MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNASLGMNGMNTYM
                     SMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGM
                     GPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKP
                     PYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFL
                     KVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAGSGGGKK
                     TAPGTQASQVQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGTPASALSPP
                     EPAPSPGQQQQAAAHLLVPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHS
                     HHHHQPHKMDLKTYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGV
                     YSRPIMNSS"
     exon            259..2222
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcccgggt attggctgca gctaagcggg gcttcctggg ccgactgagg tgggtagcca
       61 gaaaaaggcc tgaggtggct gacaaccagg gcggccagac aacgcgagtc ctgcgcgcct
      121 tctgaggcct ccctgggact taactgtaac ggggaggggc ctctggagca gcggccagcg
      181 agttaaagta tgctgggagc cgtgaagatg gaagggcacg agccatccga ctggagcagc
      241 tactacgcgg agcctgaggg ctactcttcc gtgagcaaca tgaacgccag cctggggatg
      301 aatggcatga acacttacat gagcatgtcc gcggctgcaa tgggcagtgg ttccggcaac
      361 atgagcgcag gctccatgaa catgtcatcc tatgtgggcg ctggaatgag cccgtcgctg
      421 gctggcatgt ccccgggcgc gggcgccatg gcgggcatga gcggctcagc tggggcggcc
      481 ggcgtggcgg gcatgggacc gcacctgagt ccgagtctga gcccactcgg gggacaggcg
      541 gccggggcta tgggtggcct tgctccctac gccaatatga actccatgag tcctatgtac
      601 gggcaggcgg gcctgagccg cgctcgggac cccaagacgt accggcgcag ctacactcac
      661 gccaagcctc cctactcgta catctcgctc atcaccatgg ccatccagca gagccccaac
      721 aagatgctga cgctgagcga gatctatcag tggatcatgg acctcttccc tttctaccgg
      781 cagaaccagc agcgctggca gaactccatc cgtcattctc tctccttcaa cgactgcttt
      841 ctcaaggtgc cccgctcgcc agacaagcct ggcaagggct ccttctggac cctgcaccct
      901 gactctggca acatgttcga gaacggttgc tacctgcgcc gccagaagcg cttcaagtgt
      961 gagaagcaac tggcgttgaa ggaagcagcg ggtgcgggca gtggcggagg caagaagacc
     1021 gctcctggga cacaggcttc tcaggttcag ctcggggagg ccgcaggctc ggcctctgag
     1081 actccggcgg gcaccgagtc cccccattcc agcgcttctc cgtgtcagga gcacaagcga
     1141 ggtggcctga gcgagctgaa gggaacacct gcctctgcgc tgagtcctcc ggagccggcg
     1201 ccctcgcctg ggcagcagca gcaggctgca gcccacctgc tggtcccacc tcaccatcct
     1261 ggcctgccac cagaggccca cctgaagccc gagcaccatt acgccttcaa ccaccccttc
     1321 tctatcaaca acctcatgtc ctccgagcag caacatcatc acagccacca ccaccatcag
     1381 ccccacaaaa tggacctcaa gacctacgaa caggtcatgc actaccctgg gggctacggt
     1441 tcccccatgc caggcagctt ggccatgggc ccagtcacga acaaagccgg cctggatgcc
     1501 tcgcccctgg ctgcagacac ttcctactac cagggagtgt actccaggcc tattatgaac
     1561 tcgtcctaag aagatggctt tcaggccctg cctagctctg gccactgggg agaaggacaa
     1621 gggaaatgac aggctgagtg gaaacattgg gggaactttg aggaaaaagt agccaccaca
     1681 cttaaggccc caaaggagca gtttcacctg tctgtgtccc taaatagctg ggccacactg
     1741 atctgtcatt ctaaataggg aagggaatgg aaatatatat gtatacacat aaacttgttt
     1801 taatggagcc tttggttccc actatgtaga ctactgcttc tcaaggcacc tgcagatttt
     1861 gatttttgtt cttgttctct ctctattgct gtcgttgcag agaagtctga cttaaaaaaa
     1921 aaacaaacta aacaaaaaaa aaacttttgt gagtgacttg gtgtaaaacc atgtagtttt
     1981 aacagaaaac cagagggttg tattgatgtt taaaagagaa aaaaaaataa tgatgtaaga
     2041 gtctggtata aatgaccagg agaaaggaca aaaatgcatc ccattctgga catggtgaaa
     2101 tccaggtctc gggtctgatt taatttatgg tttctgcgtg ctttatttat ggcttataaa
     2161 tgtgtgttct ggctagaatg ccagagttcc acaaatctat attaaagtgt tattgccaat
     2221 tt
//
