LOCUS       NM_001399085            2175 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus forkhead box A2 (Foxa2), transcript variant 1,
            mRNA.
ACCESSION   NM_001399085 XM_006235139
VERSION     NM_001399085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Yan,D., Lv,M., Kong,X., Feng,L., Ying,Y., Liu,W., Wang,X. and Ma,X.
  TITLE     FXR controls insulin content by regulating Foxa2-mediated insulin
            transcription
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119655 (2024)
   PUBMED   38135007
  REMARK    GeneRIF: FXR controls insulin content by regulating Foxa2-mediated
            insulin transcription.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Wang,P., Cong,M., Liu,T., Li,Y., Liu,L., Sun,S., Sun,L., Zhu,Z.,
            Ma,H., You,H., Zhang,H. and Jia,J.
  TITLE     FoxA2 inhibits the proliferation of hepatic progenitor cells by
            reducing PI3K/Akt/HK2-mediated glycolysis
  JOURNAL   J Cell Physiol 235 (12), 9524-9537 (2020)
   PUBMED   32495363
  REMARK    GeneRIF: FoxA2 inhibits the proliferation of hepatic progenitor
            cells by reducing PI3K/Akt/HK2-mediated glycolysis.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Li,X., Liu,H., Lv,Y., Yu,W., Liu,X. and Liu,C.
  TITLE     MiR-130a-5p/Foxa2 axis modulates fetal lung development in
            congenital diaphragmatic hernia by activating the Shh/Gli1
            signaling pathway
  JOURNAL   Life Sci 241, 117166 (2020)
   PUBMED   31843527
  REMARK    GeneRIF: Low FOXA2 expression is associated with congenital
            diaphragmatic hernia.
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Zhang,Q.M., Ouyang,W.X., Chai,X.Q. and Deng,F.T.
  TITLE     Expression of Lung Surfactant Proteins SP-B and SP-C and Their
            Regulatory Factors in Fetal Lung of GDM Rats
  JOURNAL   Curr Med Sci 38 (5), 847-852 (2018)
   PUBMED   30341519
  REMARK    GeneRIF: The expression of SP-B and SP-C in GDM group was
            significantly reduced as compared with control group (P<0.05)...It
            was concluded that gestational diabetes mellitus can cause fetal
            lung development and maturation disorders, and FOXA2 in fetal lung
            tissue decreases while nitrocellulose FOXA2 increases
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Ye,C., Chen,M., Chen,E., Li,W., Wang,S., Ding,Q., Wang,C., Zhou,C.,
            Tang,L., Hou,W., Hang,K., He,R., Pan,Z. and Zhang,W.
  TITLE     Knockdown of FOXA2 enhances the osteogenic differentiation of bone
            marrow-derived mesenchymal stem cells partly via activation of the
            ERK signalling pathway
  JOURNAL   Cell Death Dis 9 (8), 836 (2018)
   PUBMED   30082727
  REMARK    GeneRIF: FOXA2 knockdown significantly increased
            osteoblast-specific gene expression, the number of mineral deposits
            and alkaline phosphatase activity, whereas FOXA2 overexpression
            inhibited osteogenesis-specific activities. Moreover, extracellular
            signal-regulated protein kinase (ERK) signalling was upregulated
            following knockdown of FOXA2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Filosa,S., Rivera-Perez,J.A., Gomez,A.P., Gansmuller,A., Sasaki,H.,
            Behringer,R.R. and Ang,S.L.
  TITLE     Goosecoid and HNF-3beta genetically interact to regulate neural
            tube patterning during mouse embryogenesis
  JOURNAL   Development 124 (14), 2843-2854 (1997)
   PUBMED   9226455
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Farrington,S.M., Belaoussoff,M. and Baron,M.H.
  TITLE     Winged-helix, Hedgehog and Bmp genes are differentially expressed
            in distinct cell layers of the murine yolk sac
  JOURNAL   Mech Dev 62 (2), 197-211 (1997)
   PUBMED   9152011
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Zhou,L., Lim,L., Costa,R.H. and Whitsett,J.A.
  TITLE     Thyroid transcription factor-1, hepatocyte nuclear factor-3beta,
            surfactant protein B, C, and Clara cell secretory protein in
            developing mouse lung
  JOURNAL   J Histochem Cytochem 44 (10), 1183-1193 (1996)
   PUBMED   8813084
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Venge,P., Zetterstrom,O., Dahl,R., Roxin,L.E. and Olsson,I.
  TITLE     Low levels of eosinophil cationic proteins in patients with asthma
  JOURNAL   Lancet 2 (8034), 373-375 (1977)
   PUBMED   70587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006235139.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.10501.1,
                                           SRR21887621.418698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000003.1  155926280-155926488 c
            210-2175            JAXUCZ010000003.1  155923305-155925270 c
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2175
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /note="forkhead box A2"
                     /db_xref="GeneID:25099"
                     /db_xref="RGD:2808"
     exon            1..209
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1520
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatocyte nuclear factor 3-beta; HNF-3B; HNF-3-beta;
                     forkhead box protein A2"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-beta isoform 1"
                     /protein_id="NP_001386014.1"
                     /db_xref="GeneID:25099"
                     /db_xref="RGD:2808"
                     /translation="MHSASSMLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNASLGMN
                     GMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGA
                     AGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRS
                     YTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLS
                     FNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAG
                     SGGGKKTAPGTQASQVQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGTPA
                     SALSPPEPAPSPGQQQQAAAHLLVPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSE
                     QQHHHSHHHHQPHKMDLKTYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADT
                     SYYQGVYSRPIMNSS"
     exon            210..2175
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgcgag agagggcggg agggagggga cggtgccata gctgactttt ttttttttta
       61 agagggtggg ggtgggggct gattgctggt cgtttgttgt ggctgttaaa ttttaaaccg
      121 ccatgcactc ggcttccagt atgctgggag ccgtgaagat ggaagggcac gagccatccg
      181 actggagcag ctactacgcg gagcctgagg gctactcttc cgtgagcaac atgaacgcca
      241 gcctggggat gaatggcatg aacacttaca tgagcatgtc cgcggctgca atgggcagtg
      301 gttccggcaa catgagcgca ggctccatga acatgtcatc ctatgtgggc gctggaatga
      361 gcccgtcgct ggctggcatg tccccgggcg cgggcgccat ggcgggcatg agcggctcag
      421 ctggggcggc cggcgtggcg ggcatgggac cgcacctgag tccgagtctg agcccactcg
      481 ggggacaggc ggccggggct atgggtggcc ttgctcccta cgccaatatg aactccatga
      541 gtcctatgta cgggcaggcg ggcctgagcc gcgctcggga ccccaagacg taccggcgca
      601 gctacactca cgccaagcct ccctactcgt acatctcgct catcaccatg gccatccagc
      661 agagccccaa caagatgctg acgctgagcg agatctatca gtggatcatg gacctcttcc
      721 ctttctaccg gcagaaccag cagcgctggc agaactccat ccgtcattct ctctccttca
      781 acgactgctt tctcaaggtg ccccgctcgc cagacaagcc tggcaagggc tccttctgga
      841 ccctgcaccc tgactctggc aacatgttcg agaacggttg ctacctgcgc cgccagaagc
      901 gcttcaagtg tgagaagcaa ctggcgttga aggaagcagc gggtgcgggc agtggcggag
      961 gcaagaagac cgctcctggg acacaggctt ctcaggttca gctcggggag gccgcaggct
     1021 cggcctctga gactccggcg ggcaccgagt ccccccattc cagcgcttct ccgtgtcagg
     1081 agcacaagcg aggtggcctg agcgagctga agggaacacc tgcctctgcg ctgagtcctc
     1141 cggagccggc gccctcgcct gggcagcagc agcaggctgc agcccacctg ctggtcccac
     1201 ctcaccatcc tggcctgcca ccagaggccc acctgaagcc cgagcaccat tacgccttca
     1261 accacccctt ctctatcaac aacctcatgt cctccgagca gcaacatcat cacagccacc
     1321 accaccatca gccccacaaa atggacctca agacctacga acaggtcatg cactaccctg
     1381 ggggctacgg ttcccccatg ccaggcagct tggccatggg cccagtcacg aacaaagccg
     1441 gcctggatgc ctcgcccctg gctgcagaca cttcctacta ccagggagtg tactccaggc
     1501 ctattatgaa ctcgtcctaa gaagatggct ttcaggccct gcctagctct ggccactggg
     1561 gagaaggaca agggaaatga caggctgagt ggaaacattg ggggaacttt gaggaaaaag
     1621 tagccaccac acttaaggcc ccaaaggagc agtttcacct gtctgtgtcc ctaaatagct
     1681 gggccacact gatctgtcat tctaaatagg gaagggaatg gaaatatata tgtatacaca
     1741 taaacttgtt ttaatggagc ctttggttcc cactatgtag actactgctt ctcaaggcac
     1801 ctgcagattt tgatttttgt tcttgttctc tctctattgc tgtcgttgca gagaagtctg
     1861 acttaaaaaa aaaacaaact aaacaaaaaa aaaacttttg tgagtgactt ggtgtaaaac
     1921 catgtagttt taacagaaaa ccagagggtt gtattgatgt ttaaaagaga aaaaaaaata
     1981 atgatgtaag agtctggtat aaatgaccag gagaaaggac aaaaatgcat cccattctgg
     2041 acatggtgaa atccaggtct cgggtctgat ttaatttatg gtttctgcgt gctttattta
     2101 tggcttataa atgtgtgttc tggctagaat gccagagttc cacaaatcta tattaaagtg
     2161 ttattgccaa tttta
//
