LOCUS       NP_001386014             465 aa            linear   ROD 31-MAR-2024
DEFINITION  hepatocyte nuclear factor 3-beta isoform 1 [Rattus norvegicus].
ACCESSION   NP_001386014 XP_006235201
VERSION     NP_001386014.1
DBSOURCE    REFSEQ: accession NM_001399085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Yan,D., Lv,M., Kong,X., Feng,L., Ying,Y., Liu,W., Wang,X. and Ma,X.
  TITLE     FXR controls insulin content by regulating Foxa2-mediated insulin
            transcription
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119655 (2024)
   PUBMED   38135007
  REMARK    GeneRIF: FXR controls insulin content by regulating Foxa2-mediated
            insulin transcription.
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Wang,P., Cong,M., Liu,T., Li,Y., Liu,L., Sun,S., Sun,L., Zhu,Z.,
            Ma,H., You,H., Zhang,H. and Jia,J.
  TITLE     FoxA2 inhibits the proliferation of hepatic progenitor cells by
            reducing PI3K/Akt/HK2-mediated glycolysis
  JOURNAL   J Cell Physiol 235 (12), 9524-9537 (2020)
   PUBMED   32495363
  REMARK    GeneRIF: FoxA2 inhibits the proliferation of hepatic progenitor
            cells by reducing PI3K/Akt/HK2-mediated glycolysis.
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Li,X., Liu,H., Lv,Y., Yu,W., Liu,X. and Liu,C.
  TITLE     MiR-130a-5p/Foxa2 axis modulates fetal lung development in
            congenital diaphragmatic hernia by activating the Shh/Gli1
            signaling pathway
  JOURNAL   Life Sci 241, 117166 (2020)
   PUBMED   31843527
  REMARK    GeneRIF: Low FOXA2 expression is associated with congenital
            diaphragmatic hernia.
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Zhang,Q.M., Ouyang,W.X., Chai,X.Q. and Deng,F.T.
  TITLE     Expression of Lung Surfactant Proteins SP-B and SP-C and Their
            Regulatory Factors in Fetal Lung of GDM Rats
  JOURNAL   Curr Med Sci 38 (5), 847-852 (2018)
   PUBMED   30341519
  REMARK    GeneRIF: The expression of SP-B and SP-C in GDM group was
            significantly reduced as compared with control group (P<0.05)...It
            was concluded that gestational diabetes mellitus can cause fetal
            lung development and maturation disorders, and FOXA2 in fetal lung
            tissue decreases while nitrocellulose FOXA2 increases
REFERENCE   5  (residues 1 to 465)
  AUTHORS   Ye,C., Chen,M., Chen,E., Li,W., Wang,S., Ding,Q., Wang,C., Zhou,C.,
            Tang,L., Hou,W., Hang,K., He,R., Pan,Z. and Zhang,W.
  TITLE     Knockdown of FOXA2 enhances the osteogenic differentiation of bone
            marrow-derived mesenchymal stem cells partly via activation of the
            ERK signalling pathway
  JOURNAL   Cell Death Dis 9 (8), 836 (2018)
   PUBMED   30082727
  REMARK    GeneRIF: FOXA2 knockdown significantly increased
            osteoblast-specific gene expression, the number of mineral deposits
            and alkaline phosphatase activity, whereas FOXA2 overexpression
            inhibited osteogenesis-specific activities. Moreover, extracellular
            signal-regulated protein kinase (ERK) signalling was upregulated
            following knockdown of FOXA2.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Filosa,S., Rivera-Perez,J.A., Gomez,A.P., Gansmuller,A., Sasaki,H.,
            Behringer,R.R. and Ang,S.L.
  TITLE     Goosecoid and HNF-3beta genetically interact to regulate neural
            tube patterning during mouse embryogenesis
  JOURNAL   Development 124 (14), 2843-2854 (1997)
   PUBMED   9226455
REFERENCE   7  (residues 1 to 465)
  AUTHORS   Farrington,S.M., Belaoussoff,M. and Baron,M.H.
  TITLE     Winged-helix, Hedgehog and Bmp genes are differentially expressed
            in distinct cell layers of the murine yolk sac
  JOURNAL   Mech Dev 62 (2), 197-211 (1997)
   PUBMED   9152011
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Zhou,L., Lim,L., Costa,R.H. and Whitsett,J.A.
  TITLE     Thyroid transcription factor-1, hepatocyte nuclear factor-3beta,
            surfactant protein B, C, and Clara cell secretory protein in
            developing mouse lung
  JOURNAL   J Histochem Cytochem 44 (10), 1183-1193 (1996)
   PUBMED   8813084
REFERENCE   9  (residues 1 to 465)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Venge,P., Zetterstrom,O., Dahl,R., Roxin,L.E. and Olsson,I.
  TITLE     Low levels of eosinophil cationic proteins in patients with asthma
  JOURNAL   Lancet 2 (8034), 373-375 (1977)
   PUBMED   70587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced XP_006235201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.10501.1,
                                           SRR21887621.418698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..465
                     /product="hepatocyte nuclear factor 3-beta isoform 1"
                     /note="hepatocyte nuclear factor 3-beta; HNF-3B;
                     HNF-3-beta; forkhead box protein A2"
                     /calculated_mol_wt=49128
     Region          23..164
                     /region_name="Forkhead_N"
                     /note="Forkhead N-terminal region; pfam08430"
                     /db_xref="CDD:369872"
     Region          163..264
                     /region_name="FH_FOXA2"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     A2 (FOXA2) and similar proteins; cd20039"
                     /db_xref="CDD:410813"
     Region          <164..380
                     /region_name="COG5025"
                     /note="Transcription factor of the Forkhead/HNF3 family
                     [Transcription]"
                     /db_xref="CDD:227358"
     Site            order(169..171,188..189,192,208,211..212,214..215,218,225,
                     234,236..237,239,255..257,259..260)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410813"
     Region          380..454
                     /region_name="HNF_C"
                     /note="HNF3 C-terminal domain; pfam09354"
                     /db_xref="CDD:430552"
     CDS             1..465
                     /gene="Foxa2"
                     /gene_synonym="Hnf3b"
                     /coded_by="NM_001399085.1:123..1520"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:25099"
                     /db_xref="RGD:2808"
ORIGIN      
        1 mhsassmlga vkmeghepsd wssyyaepeg yssvsnmnas lgmngmntym smsaaamgsg
       61 sgnmsagsmn mssyvgagms pslagmspga gamagmsgsa gaagvagmgp hlspslsplg
      121 gqaagamggl apyanmnsms pmygqaglsr ardpktyrrs ythakppysy islitmaiqq
      181 spnkmltlse iyqwimdlfp fyrqnqqrwq nsirhslsfn dcflkvprsp dkpgkgsfwt
      241 lhpdsgnmfe ngcylrrqkr fkcekqlalk eaagagsggg kktapgtqas qvqlgeaags
      301 asetpagtes phssaspcqe hkrgglselk gtpasalspp epapspgqqq qaaahllvpp
      361 hhpglppeah lkpehhyafn hpfsinnlms seqqhhhshh hhqphkmdlk tyeqvmhypg
      421 gygspmpgsl amgpvtnkag ldasplaadt syyqgvysrp imnss
//
