LOCUS       NM_012742               2881 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus forkhead box A1 (Foxa1), mRNA.
ACCESSION   NM_012742
VERSION     NM_012742.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Zhou,Y., Wang,Y., Wang,Y., Chen,L., Wang,N., Su,Y., Diwu,Y. and
            Zhang,Q.
  TITLE     LncRNA NKILA Exacerbates Alzheimer's Disease Progression by
            Regulating the FOXA1-Mediated Transcription of TNFAIP1
  JOURNAL   Neurochem Res 48 (9), 2895-2910 (2023)
   PUBMED   37217807
  REMARK    GeneRIF: LncRNA NKILA Exacerbates Alzheimer's Disease Progression
            by Regulating the FOXA1-Mediated Transcription of TNFAIP1.
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Zhao,J., Zhang,L., Du,L., Chen,Z., Tang,Y., Chen,L., Liu,X.,
            You,L., Zhang,Y., Fu,X. and Li,H.
  TITLE     Foxa1 mediates eccrine sweat gland development through
            transcriptional regulation of Na-K-ATPase expression
  JOURNAL   Braz J Med Biol Res 55, e12149 (2022)
   PUBMED   35976271
  REMARK    GeneRIF: Foxa1 mediates eccrine sweat gland development through
            transcriptional regulation of Na-K-ATPase expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Mu,X., Wang,H. and Li,H.
  TITLE     Silencing of long noncoding RNA H19 alleviates pulmonary injury,
            inflammation, and fibrosis of acute respiratory distress syndrome
            through regulating the microRNA-423-5p/FOXA1 axis
  JOURNAL   Exp Lung Res 47 (4), 183-197 (2021)
   PUBMED   33629893
  REMARK    GeneRIF: Silencing of long noncoding RNA H19 alleviates pulmonary
            injury, inflammation, and fibrosis of acute respiratory distress
            syndrome through regulating the microRNA-423-5p/FOXA1 axis.
REFERENCE   4  (bases 1 to 2881)
  AUTHORS   Pan,J., Xu,Z., Xu,M., Lin,X., Lin,B. and Lin,M.
  TITLE     Knockdown of Forkhead box A1 suppresses the tumorigenesis and
            progression of human colon cancer cells through regulating the
            phosphatase and tensin homolog/Akt pathway
  JOURNAL   J Int Med Res 48 (12), 300060520971453 (2020)
   PUBMED   33296605
REFERENCE   5  (bases 1 to 2881)
  AUTHORS   Lazar,S.B., Pongor,L., Li,X.L., Grammatikakis,I., Muys,B.R.,
            Dangelmaier,E.A., Redon,C.E., Jang,S.M., Walker,R.L., Tang,W.,
            Ambs,S., Harris,C.C., Meltzer,P.S., Aladjem,M.I. and Lal,A.
  TITLE     Genome-Wide Analysis of the FOXA1 Transcriptional Network
            Identifies Novel Protein-Coding and Long Noncoding RNA Targets in
            Colorectal Cancer Cells
  JOURNAL   Mol Cell Biol 40 (21), e00224-20 (2020)
   PUBMED   32839292
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2881)
  AUTHORS   Hsiang,C.H., Marten,N.W. and Straus,D.S.
  TITLE     Upstream region of rat serum albumin gene promoter contributes to
            promoter activity: presence of functional binding site for
            hepatocyte nuclear factor-3
  JOURNAL   Biochem J 338 (Pt 2) (Pt 2), 241-249 (1999)
   PUBMED   10024498
REFERENCE   7  (bases 1 to 2881)
  AUTHORS   Kaestner,K.H., Katz,J., Liu,Y., Drucker,D.J. and Schutz,G.
  TITLE     Inactivation of the winged helix transcription factor HNF3alpha
            affects glucose homeostasis and islet glucagon gene expression in
            vivo
  JOURNAL   Genes Dev 13 (4), 495-504 (1999)
   PUBMED   10049364
REFERENCE   8  (bases 1 to 2881)
  AUTHORS   Cui,Y., Narayanan,C.S., Zhou,J. and Kumar,A.
  TITLE     Exon-I is involved in positive as well as negative regulation of
            human angiotensinogen gene expression
  JOURNAL   Gene 224 (1-2), 97-107 (1998)
   PUBMED   9931457
REFERENCE   9  (bases 1 to 2881)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   10 (bases 1 to 2881)
  AUTHORS   Lai,E., Prezioso,V.R., Smith,E., Litvin,O., Costa,R.H. and
            Darnell,J.E. Jr.
  TITLE     HNF-3A, a hepatocyte-enriched transcription factor of novel
            structure is regulated transcriptionally
  JOURNAL   Genes Dev 4 (8), 1427-1436 (1990)
   PUBMED   2227418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012742.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.27469.1,
                                           SRR26643297.22639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000006.1  80871063-80871191   c
            130-2881            JAXUCZ010000006.1  80866062-80868813   c
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2881
                     /gene="Foxa1"
                     /gene_synonym="Hnf3a"
                     /note="forkhead box A1"
                     /db_xref="GeneID:25098"
                     /db_xref="RGD:2807"
     exon            1..129
                     /gene="Foxa1"
                     /gene_synonym="Hnf3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1464
                     /gene="Foxa1"
                     /gene_synonym="Hnf3a"
                     /note="HNF-3A; HNF-3-alpha; forkhead box protein A1"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-alpha"
                     /protein_id="NP_036874.2"
                     /db_xref="GeneID:25098"
                     /db_xref="RGD:2807"
                     /translation="MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSM
                     NTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVT
                     AMGAALSPGGMGSMGAQPAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAK
                     TFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSI
                     RHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGG
                     GSGGGGSKGVPENRKDPSGPVNPSAESPIHRGVHGKASQLEGAPAPGPAASPQTLDHS
                     GATATGGASELKSPASSSAPPISSGPGALASVPPSHPAHGLAPHESQLHLKGDPHYSF
                     NHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGATLPASLPLGSASVATRSPIEPSA
                     LEPAYYQGVYSRPVLNTS"
     exon            130..2881
                     /gene="Foxa1"
                     /gene_synonym="Hnf3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccgcccgt cgttccgcac agggttggat agttgtgtcg gccagggtgg ctccaggatg
       61 ttagggactg tgaagatgga agggcatgag agcaacgact ggaacagcta ctacgcggac
      121 acgcaggagg cctactcctc tgtcccggtc agcaacatga actccggcct gggctccatg
      181 aactccatga acacctacat gaccatgaac accatgacca cgagcggcaa catgaccccg
      241 gcttccttca acatgtccta cgccaacccg ggcttagggg ccggcctgag tccgggtgct
      301 gtggccggca tgcccggggg ctctgcaggc gccatgaaca gcatgacggc ggcgggcgtc
      361 acagccatgg gtgcggcgct gagcccggga ggcatgggct ccatgggcgc gcagcccgcg
      421 gcctctatga acggcctggg tccctacgct gccgccatga acccgtgcat gagtcccatg
      481 gcgtacgctc cgtccaatct gggccgcagc cgcgcggggg gcggcggcga cgccaagacg
      541 ttcaagcgca gttaccctca cgccaagccg ccctactcct acatctcgct catcaccatg
      601 gccatccagc aggcgcccag caagatgctc acgctgagcg aaatctacca gtggatcatg
      661 gacctcttcc cctattaccg tcagaaccag cagcgctggc agaactccat tcgccactca
      721 ctgtctttca acgattgttt cgtcaaggtg gcgcgatccc cggacaagcc gggcaagggc
      781 tcctactgga cgctgcaccc ggactccggc aacatgttcg agaacggctg ctacttgcgc
      841 cgtcaaaagc gcttcaagtg tgagaagcag ccgggggccg gaggtgggag tgggggcggc
      901 ggctccaagg gggtcccaga aaaccgcaaa gacccctcag gcccggttaa ccccagtgcc
      961 gaatcaccca ttcatcgggg tgtgcacgga aaggctagcc agctagaggg cgcgccggcc
     1021 cccgggcccg ccgccagccc ccagactctg gaccacagtg gggccacggc gacagggggc
     1081 gcttcggagt tgaagtctcc agcttcttca tctgcgcccc ccataagctc cgggccaggg
     1141 gcgctggcat ctgtaccccc ctctcacccg gcacatggcc ttgcacccca cgaatctcag
     1201 ctgcacctga aaggggaccc ccactactcc tttaaccacc ccttctccat caacaacctc
     1261 atgtcctcct cggagcagca gcacaagctg gacttcaagg catatgagca ggcactgcag
     1321 tactctcctt acggcgccac cttgcccgcc agtctgcccc ttggcagcgc ctcagtggcc
     1381 acgaggagcc ccatcgagcc ctcagccctg gagccggcct actaccaagg tgtgtattcc
     1441 agacccgtgc taaatacttc ctagctccca gaactgaggg tttgtctgca tggccaacct
     1501 ggtatggtag caggagagaa aaaccaacag caaacacaca cacacacaca cacacacaca
     1561 cacacacaca cacacacaca cacgccaaac gaaccacata atacaattcc aaatagtttt
     1621 atttttcatg cacaattttc cccggttcaa aggactgtta ctttattatt gtattcaaca
     1681 ctcatcgtgt gtattcctac agatactacc gactccatac caacagtttt tttttttctg
     1741 gcaacattca atgatccata aatgtatata tagaaaatct tcctcctgtg ccccttcccc
     1801 ctctttcact ccttcccctg tggacacatt ctagtcccgt ggcagggctt tatttaaaaa
     1861 gatggtcaag tttgtaaaat atttgtttgt gctttttttg ttgttgttgc tcctcctccg
     1921 tacttaggcc caccacacga gtttacaggt ctgtgacgat atccttaact cagtaaagat
     1981 gggaaaggta aagaaaacaa gtagacagta ggggctcttg agagcattga aaggtaggac
     2041 agccattatg caggaaggtt aaaaacaggt tccatccatc gcggccattt gtttttagcc
     2101 tacgtttcag atgcattcag ttagcggacg tctttaaatg aaatgcatat atatgttatg
     2161 gacttaatat cgtgcccagg tatgaagacc tcgttcactt ttgcataaca cgtagaggaa
     2221 atagctaggt gatagatgtg ctacgttttc aaaaattgcc tgaccaagtt acaaggaaac
     2281 ccctacacgc ttgtcctctc cacccaccta ccaccctgga aatccaattc ttcaggaacc
     2341 accttccttc ctaattctgc tccttgcttt gcagagagcc atcatggtca tgtcattctg
     2401 aggtcacatg tataaaatta gcctttgtgt atgtatgcca tttaaaggtt cccccaaccc
     2461 caggggaaaa aggaagtatc atactatcga ggagacagaa gttataagaa atgcatttca
     2521 aaatttggtc cggagttcca aaatcccaat tgtggccatt ttagttatta ccatcctatt
     2581 ggttcatcca gtgttaatgc actttccaca gttagacgtg atgttagtgt tagacaaacg
     2641 ggtttcatta ttgccttctc aatgttaatt tattgcatgg tttattcctt ttctttacag
     2701 ccgaaattgc tttaagtgat ggttaaaatg acaaattaaa atgttaattt ttatcgatgt
     2761 gatttgtaat taagatattt tgatttcaat aacaaaaaat aatacacgat tttaatctgt
     2821 ggaatgtgtt tctgatcatt tgcagttaag gaatttaaat aaatcacatg ttaacgacaa
     2881 a
//
