LOCUS       NM_012954               1526 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus FOS like 2, AP-1 transcription factor subunit
            (Fosl2), transcript variant 1, mRNA.
ACCESSION   NM_012954 XM_001052980
VERSION     NM_012954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Ma,W., Niu,Z., Han,D., Wang,B. and Wang,X.
  TITLE     Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to
            Facilitate Colorectal Cancer Progression
  JOURNAL   Biochem Genet 60 (4), 1362-1379 (2022)
   PUBMED   35034245
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Alam,M. and Mishra,R.
  TITLE     Bcl-xL expression and regulation in the progression, recurrence,
            and cisplatin resistance of oral cancer
  JOURNAL   Life Sci 280, 119705 (2021)
   PUBMED   34111459
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Li,S., Fang,X.D., Wang,X.Y. and Fei,B.Y.
  TITLE     Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer
  JOURNAL   Exp Cell Res 373 (1-2), 57-61 (2018)
   PUBMED   30114390
REFERENCE   4  (bases 1 to 1526)
  AUTHORS   Sun,L., Guo,Z., Sun,J., Li,J., Dong,Z., Zhang,Y., Chen,J., Kan,Q.
            and Yu,Z.
  TITLE     MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by
            inhibiting FOSL2 through TGF-beta/Smad3 signaling pathway
  JOURNAL   Biomed Pharmacother 107, 168-176 (2018)
   PUBMED   30086463
REFERENCE   5  (bases 1 to 1526)
  AUTHORS   Lian,Y., Xiong,F., Yang,L., Bo,H., Gong,Z., Wang,Y., Wei,F.,
            Tang,Y., Li,X., Liao,Q., Wang,H., Zhou,M., Xiang,B., Wu,X., Li,Y.,
            Li,X., Chen,X., Li,G., Guo,C., Zeng,Z. and Xiong,W.
  TITLE     Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of
            miR-423-5p to facilitate nasopharyngeal carcinoma metastasis
            through regulating the Rho/Rac pathway
  JOURNAL   J Exp Clin Cancer Res 37 (1), 253 (2018)
   PUBMED   30326930
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1526)
  AUTHORS   Varghese,S., Rydziel,S. and Canalis,E.
  TITLE     Basic fibroblast growth factor stimulates collagenase-3 promoter
            activity in osteoblasts through an activator protein-1-binding site
  JOURNAL   Endocrinology 141 (6), 2185-2191 (2000)
   PUBMED   10830307
REFERENCE   7  (bases 1 to 1526)
  AUTHORS   Urakami,S., Tsuchiya,H., Orimoto,K., Kobayashi,T., Igawa,M. and
            Hino,O.
  TITLE     Overexpression of members of the AP-1 transcriptional factor family
            from an early stage of renal carcinogenesis and inhibition of cell
            growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene
            mutant (Eker) rat model
  JOURNAL   Biochem Biophys Res Commun 241 (1), 24-30 (1997)
   PUBMED   9405228
REFERENCE   8  (bases 1 to 1526)
  AUTHORS   Baler,R. and Klein,D.C.
  TITLE     Circadian expression of transcription factor Fra-2 in the rat
            pineal gland
  JOURNAL   J Biol Chem 270 (45), 27319-27325 (1995)
   PUBMED   7592994
REFERENCE   9  (bases 1 to 1526)
  AUTHORS   Kasof,G.M., Mandelzys,A., Maika,S.D., Hammer,R.E., Curran,T. and
            Morgan,J.I.
  TITLE     Kainic acid-induced neuronal death is associated with DNA damage
            and a unique immediate-early gene response in c-fos-lacZ transgenic
            rats
  JOURNAL   J Neurosci 15 (6), 4238-4249 (1995)
   PUBMED   7790908
REFERENCE   10 (bases 1 to 1526)
  AUTHORS   Foletta,V.C., Sonobe,M.H., Suzuki,T., Endo,T., Iba,H. and
            Cohen,D.R.
  TITLE     Cloning and characterisation of the mouse fra-2 gene
  JOURNAL   Oncogene 9 (11), 3305-3311 (1994)
   PUBMED   7936655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 9, 2021 this sequence version replaced NM_012954.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY622611.1, U18913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000006.1  30039106-30039269   c
            165-416             JAXUCZ010000006.1  30028359-30028610   c
            417-524             JAXUCZ010000006.1  30025169-30025276   c
            525-1526            JAXUCZ010000006.1  30021916-30022917   c
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1526
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /note="FOS like 2, AP-1 transcription factor subunit"
                     /db_xref="GeneID:25446"
                     /db_xref="RGD:2628"
     exon            1..164
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1043
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fos-related antigen 2; FRA-2; fos-like antigen 2; FOS like
                     2, AP-1 trancription factor subunit"
                     /codon_start=1
                     /product="fos-related antigen 2 isoform 1"
                     /protein_id="NP_037086.2"
                     /db_xref="GeneID:25446"
                     /db_xref="RGD:2628"
                     /translation="MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSG
                     SAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGV
                     IKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELE
                     EEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPTSGLQSLRGTGSAVGP
                     VVVKQEPPEEDSPSSSAGMDKTQRSVIKPISIAGGGFYGEEPLHTPIVVTSTPAITPG
                     TSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL"
     exon            165..416
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..524
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..1526
                     /gene="Fosl2"
                     /gene_synonym="Fra2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc gagggcgggg aagaaaacca ccctgtttcc tctccggccc ccaccgcgga
       61 tcatgtacca ggattatccc gggaactttg acacctcgtc ccggggcagc agtggctctc
      121 ctgcgcacgc cgagtcctac tccagcggtg gcggcggcca gcagaagttc cgggtagata
      181 tgcctggctc aggcagtgcc ttcatcccca caatcaacgc catcaccacc agccaggacc
      241 tgcagtggat ggtacagccc acagtgatta cctccatgtc caacccctat ccgcgctcgc
      301 acccctacag ccccctgcca ggcttggcat cagtccctgg gcacatggct ctccccagac
      361 caggagtgat caagaccatt ggtaccaccg tgggccgcag aaggagagat gagcagctgt
      421 ctcccgaaga ggaggagaag cgtcgaatcc ggagggagag aaacaagctg gccgctgcca
      481 agtgtcggaa ccgtcgacgt gagctgacgg agaagctgca ggcggagaca gaggagctgg
      541 aggaggagaa gtccggtctg cagaaagaaa tcgctgagct gcagaaggag aaggagaagc
      601 tggagttcat gctggtggct cacggccctg tgtgcaaaat cagtcctgag gaacgccgat
      661 ctccccccac ctccgggcta cagtccttac gcggtacggg cagtgctgtc ggccctgtgg
      721 tggtgaaaca ggagcctcct gaagaggaca gcccctcttc ctcagcaggg atggacaaga
      781 cccagcgctc tgtcatcaag cccattagca ttgctggggg tggtttctac ggggaagagc
      841 ctctgcacac ccccatcgtg gtgacctcca cacctgccat cactccgggc acttcaaacc
      901 ttgtcttcac ctaccccagt gtcctggagc aggagtcgcc tgcgtcgccc tccgagtcct
      961 gttccaaggc tcaccgcaga agcagtagca gtggggacca gtcatcagac tccttgaact
     1021 cccccacact gctggccctg taaccccatg ctcctctggc cagctctgga ggagtccaca
     1081 ttcatcactg cccttcccag ggaccagcac ctttaagcac tccggggcaa cgagggcaaa
     1141 aggggtccct ggctctgggg acccacccga tgggacttag tggtgagaca ctggttgttc
     1201 tcttagaagc cctgggacac ccctctccct catgcatctt gcaagcaaat cctctttctt
     1261 gaaaagccgc agagaacttg gtttgtggac tcagacttgt ctcccgcttc tgaagccccc
     1321 cgagctggcc cggatggctc ctgtcccttt gttattcgtt gtctctggag tgacagtgtc
     1381 ctttcctgcc ccgccaagca tgctcagtgc cttttggttt cccttccttc ccctagtatc
     1441 agtttctgct ccctctgggt ttttatgaga tttgccatga catttcatct gggtggtcca
     1501 gatattaaag cgcttttatt tctgga
//
