LOCUS       NM_012953               1663 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus FOS like 1, AP-1 transcription factor subunit
            (Fosl1), mRNA.
ACCESSION   NM_012953
VERSION     NM_012953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   Chen,Q., Zhang,L., Zhang,F. and Yi,S.
  TITLE     FOSL1 modulates Schwann cell responses in the wound
            microenvironment and regulates peripheral nerve regeneration
  JOURNAL   J Biol Chem 299 (12), 105444 (2023)
   PUBMED   37949219
  REMARK    GeneRIF: FOSL1 modulates Schwann cell responses in the wound
            microenvironment and regulates peripheral nerve regeneration.
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Chen,Y., Dong,Y., Zhang,Z.L., Han,J., Chen,F.S., Tong,X.Y. and
            Ma,H.
  TITLE     Fra-1 induces apoptosis and neuroinflammation by targeting S100A8
            to modulate TLR4 pathways in spinal cord ischemia/reperfusion
            injury
  JOURNAL   Brain Pathol 33 (1), e13113 (2023)
   PUBMED   36634215
  REMARK    GeneRIF: Fra-1 induces apoptosis and neuroinflammation by targeting
            S100A8 to modulate TLR4 pathways in spinal cord
            ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Zhong,L., Fang,S., Wang,A.Q., Zhang,Z.H., Wang,T., Huang,W.,
            Zhou,H.X., Zhang,H. and Yin,Z.S.
  TITLE     Identification of the Fosl1/AMPK/autophagy axis involved in
            apoptotic and inflammatory effects following spinal cord injury
  JOURNAL   Int Immunopharmacol 103, 108492 (2022)
   PUBMED   34973528
  REMARK    GeneRIF: Identification of the Fosl1/AMPK/autophagy axis involved
            in apoptotic and inflammatory effects following spinal cord injury.
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Yang,D., Xiao,C., Long,F., Wu,W., Huang,M., Qu,L., Liu,X. and
            Zhu,Y.
  TITLE     Fra-1 plays a critical role in angiotensin II-induced vascular
            senescence
  JOURNAL   FASEB J 33 (6), 7603-7614 (2019)
   PUBMED   30892941
  REMARK    GeneRIF: results identify that Fra-1 plays a novel and key role in
            promoting vascular aging by directly binding and transcriptionally
            activating p21 and p16 signaling, suggesting intervention of Fra-1
            is a potential strategy for preventing aging-associated
            cardiovascular disorders
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   Liu,W., Tian,T., Liu,L., Du,J., Gu,Y., Qin,N., Yan,C., Wang,Z.,
            Dai,J. and Fan,Z.
  TITLE     A functional SNP rs1892901 in FOSL1 is associated with gastric
            cancer in Chinese population
  JOURNAL   Sci Rep 7, 41737 (2017)
   PUBMED   28169308
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   Matsuo,K., Owens,J.M., Tonko,M., Elliott,C., Chambers,T.J. and
            Wagner,E.F.
  TITLE     Fosl1 is a transcriptional target of c-Fos during osteoclast
            differentiation
  JOURNAL   Nat Genet 24 (2), 184-187 (2000)
   PUBMED   10655067
REFERENCE   7  (bases 1 to 1663)
  AUTHORS   Urakami,S., Tsuchiya,H., Orimoto,K., Kobayashi,T., Igawa,M. and
            Hino,O.
  TITLE     Overexpression of members of the AP-1 transcriptional factor family
            from an early stage of renal carcinogenesis and inhibition of cell
            growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene
            mutant (Eker) rat model
  JOURNAL   Biochem Biophys Res Commun 241 (1), 24-30 (1997)
   PUBMED   9405228
REFERENCE   8  (bases 1 to 1663)
  AUTHORS   Schreiber,M., Poirier,C., Franchi,A., Kurzbauer,R., Guenet,J.L.,
            Carle,G.F. and Wagner,E.F.
  TITLE     Structure and chromosomal assignment of the mouse fra-1 gene, and
            its exclusion as a candidate gene for oc (osteosclerosis)
  JOURNAL   Oncogene 15 (10), 1171-1178 (1997)
   PUBMED   9294610
REFERENCE   9  (bases 1 to 1663)
  AUTHORS   Bergers,G., Graninger,P., Braselmann,S., Wrighton,C. and
            Busslinger,M.
  TITLE     Transcriptional activation of the fra-1 gene by AP-1 is mediated by
            regulatory sequences in the first intron
  JOURNAL   Mol Cell Biol 15 (7), 3748-3758 (1995)
   PUBMED   7791782
REFERENCE   10 (bases 1 to 1663)
  AUTHORS   Cohen,D.R. and Curran,T.
  TITLE     fra-1: a serum-inducible, cellular immediate-early gene that
            encodes a fos-related antigen
  JOURNAL   Mol Cell Biol 8 (5), 2063-2069 (1988)
   PUBMED   3133553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012953.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19651.1, BC097342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               JAXUCZ010000001.1  212183885-212184213
            330-527             JAXUCZ010000001.1  212186572-212186769
            528-635             JAXUCZ010000001.1  212190875-212190982
            636-1663            JAXUCZ010000001.1  212191364-212192391
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1663
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /note="FOS like 1, AP-1 transcription factor subunit"
                     /db_xref="GeneID:25445"
                     /db_xref="RGD:2627"
     exon            1..329
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1052
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /note="fos-like antigen 1; FOS like 1, AP-1 trancription
                     factor subunit"
                     /codon_start=1
                     /product="fos-related antigen 1"
                     /protein_id="NP_037085.1"
                     /db_xref="GeneID:25445"
                     /db_xref="RGD:2627"
                     /translation="MYRDFGEPGPSSGAGSAYGRPAQPQQAQTQTVQQQKFHLVPSIN
                     AVSGSQELQWMVQPHFLGPSGYPRPLTYPQYSPPQPRPGVIRALGPPPGVRRRPCEQI
                     SPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQK
                     ERLELVLEAHRPICKIPEEDKKDTGGTSSTSGAGSPPGPCRPVPCISLSPGPVLEPEA
                     LHTPTLMTTPSLTPFTPSLVFTYPSTPEPCSSAHRKSSSSSGDPSSDPLGSPTLLAL"
     exon            330..527
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..635
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1663
                     /gene="Fosl1"
                     /gene_synonym="fra-1; Fra-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggggtcg tgaagttccg agcggacggg tccacggagg ttcatctgga gaggtgggtc
       61 ccctgcgagg tgaaaggcgc cgctgcgaca cacccccacc ccccgcggtg cagtggttca
      121 gcccaagaac ttttcattca taaaaaagac cagactctgc gaggcgcgag tgagtcagaa
      181 ccgcagccgc cgacgcggac cctaccgaac atccagccca gggcatgtac cgagacttcg
      241 gggaaccggg accgagttcc ggggctggca gcgcgtacgg tcgccccgcg cagccccagc
      301 aagcgcagac acagacagtc cagcagcaga agttccacct tgtgccaagc atcaacgctg
      361 tcagtggcag ccaggaattg cagtggatgg tgcagcctca tttcctggga cccagcggct
      421 atccccgacc tctgacctat ccccagtaca gtccccctca gccccgacca ggagtcatac
      481 gagccctagg gccacctcca ggggtgcgac gcaggccctg tgagcagatc agcccggagg
      541 aggaagagcg ccgcagggtg agacgagagc ggaacaagct agcagctgct aagtgcagaa
      601 accgaagaaa ggaattgaca gacttcctgc aggcggagac cgacaagttg gaggatgaga
      661 aatcggggct gcagcgtgag atcgaagagc tgcagaagca gaaggaacgc cttgagctgg
      721 tgctggaagc ccatcgcccc atctgcaaaa tcccagaaga agacaagaag gacacaggtg
      781 gtaccagcag cacgagtggg gcgggtagcc caccgggccc ctgccgccca gtgccttgta
      841 tctccctttc tccaggaccc gtacttgaac cggaagcact gcataccccc acgctcatga
      901 ccacaccctc tctgactcct tttactccga gtctggtttt cacctatcct agcacaccag
      961 agccttgttc ctcagcccat cgaaagagta gcagcagcag tggtgacccc tcctccgacc
     1021 ccctaggttc tcccacactc ctggctttgt gaggcaccca gccacacccc ttgcaggtgc
     1081 tacccgttgt catctccttt ccctgttcat ccagcaggcc tggaccatac ccatgcccca
     1141 aaccagcagg tcttttatct ctttcaagta gaacaaacat gttatgcttt gatatagagc
     1201 cagcttgggg gtccccaaag ctgctcactg tttctctaga gctggcctat cataatttgc
     1261 atacagagaa aatatgtccc ctctgccaga gtaagcctgg cagctctgac tttgtagatc
     1321 cccagtggtc ctttgatgcc ttgcagacca ctttcccaca ccatgtcact ttcttcatgt
     1381 tatccagcct actctaagcc tagatagaag gtgcccttta actagcctag aacactaact
     1441 cacacagcac caacagccag cagcaccagg acaccctgta ggctcctcct gatcaggagg
     1501 caccaacagc ttctgtgatg agctgagctg tactccctag ctctgagaag cttttagctc
     1561 tggggtatcc aagcctccac agcaagggca gctgctattt attttcctaa agagactatt
     1621 tttatacaaa ccttccaaaa tggaataaaa ggcttgaagc tct
//
