LOCUS       NM_001256509            3251 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus FosB proto-oncogene, AP-1 transcription factor
            subunit (Fosb), mRNA.
ACCESSION   NM_001256509 XM_002725539 XM_002725540 XM_002728698
VERSION     NM_001256509.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Ambrozio-Marques,D., Gagnon,M., Radcliff,A.B., Meza,A.L.,
            Baker,T.L., Watters,J.J. and Kinkead,R.
  TITLE     Gestational intermittent hypoxia increases FosB-immunoreactive
            perikaryas in the paraventricular nucleus of the hypothalamus of
            adult male (but not female) rats
  JOURNAL   Exp Physiol 108 (11), 1376-1385 (2023)
   PUBMED   37642495
  REMARK    GeneRIF: Gestational intermittent hypoxia increases
            FosB-immunoreactive perikaryas in the paraventricular nucleus of
            the hypothalamus of adult male (but not female) rats.
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Qian,X., Lin,G., Wang,J., Zhang,S., Ma,J., Yu,B., Wu,R. and Liu,M.
  TITLE     CircRNA_01477 influences axonal growth via regulating
            miR-3075/FosB/Stat3 axis
  JOURNAL   Exp Neurol 347, 113905 (2022)
   PUBMED   34699790
  REMARK    GeneRIF: CircRNA_01477 influences axonal growth via regulating
            miR-3075/FosB/Stat3 axis.
REFERENCE   3  (bases 1 to 3251)
  AUTHORS   Garcia-Garcia,F., Priego-Fernandez,S., Lopez-Mucino,L.A.,
            Acosta-Hernandez,M.E. and Pena-Escudero,C.
  TITLE     Increased alcohol consumption in sleep-restricted rats is mediated
            by delta FosB induction
  JOURNAL   Alcohol 93, 63-70 (2021)
   PUBMED   33662520
REFERENCE   4  (bases 1 to 3251)
  AUTHORS   Yazdanfar,N., Farnam,A., Sadigh-Eteghad,S., Mahmoudi,J. and
            Sarkaki,A.
  TITLE     Enriched environment and social isolation differentially modulate
            addiction-related behaviors in male offspring of morphine-addicted
            dams: The possible role of mu-opioid receptors and DeltaFosB in the
            brain reward pathway
  JOURNAL   Brain Res Bull 170, 98-105 (2021)
   PUBMED   33592274
REFERENCE   5  (bases 1 to 3251)
  AUTHORS   Wang,H., Zhang,W., Liu,J., Gao,J., Fang,L.E., Liu,Z., Xia,B.,
            Fan,X., Li,C., Lu,Q. and Qian,A.
  TITLE     NF-kappaB and FosB mediate inflammation and oxidative stress in the
            blast lung injury of rats exposed to shock waves
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (3), 283-293 (2021)
   PUBMED   33677486
  REMARK    GeneRIF: NF-kappaB and FosB mediate inflammation and oxidative
            stress in the blast lung injury of rats exposed to shock waves.
REFERENCE   6  (bases 1 to 3251)
  AUTHORS   Sharma,S.C. and Richards,J.S.
  TITLE     Regulation of AP1 (Jun/Fos) factor expression and activation in
            ovarian granulosa cells. Relation of JunD and Fra2 to terminal
            differentiation
  JOURNAL   J Biol Chem 275 (43), 33718-33728 (2000)
   PUBMED   10934195
REFERENCE   7  (bases 1 to 3251)
  AUTHORS   Varghese,S., Rydziel,S. and Canalis,E.
  TITLE     Basic fibroblast growth factor stimulates collagenase-3 promoter
            activity in osteoblasts through an activator protein-1-binding site
  JOURNAL   Endocrinology 141 (6), 2185-2191 (2000)
   PUBMED   10830307
REFERENCE   8  (bases 1 to 3251)
  AUTHORS   Ryabinin,A.E. and Wang,Y.M.
  TITLE     Repeated alcohol administration differentially affects c-Fos and
            FosB protein immunoreactivity in DBA/2J mice
  JOURNAL   Alcohol Clin Exp Res 22 (8), 1646-1654 (1998)
   PUBMED   9835277
REFERENCE   9  (bases 1 to 3251)
  AUTHORS   Hiroi,N., Brown,J.R., Haile,C.N., Ye,H., Greenberg,M.E. and
            Nestler,E.J.
  TITLE     FosB mutant mice: loss of chronic cocaine induction of Fos-related
            proteins and heightened sensitivity to cocaine's psychomotor and
            rewarding effects
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10397-10402 (1997)
   PUBMED   9294222
REFERENCE   10 (bases 1 to 3251)
  AUTHORS   Kasof,G.M., Mandelzys,A., Maika,S.D., Hammer,R.E., Curran,T. and
            Morgan,J.I.
  TITLE     Kainic acid-induced neuronal death is associated with DNA damage
            and a unique immediate-early gene response in c-fos-lacZ transgenic
            rats
  JOURNAL   J Neurosci 15 (6), 4238-4249 (1995)
   PUBMED   7790908
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Feb 5, 2012 this sequence version replaced
            XM_002725539.1, XM_002725540.1, XM_002728698.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840115,
                              SAMN16418988 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3251
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /note="FosB proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:100360880"
                     /db_xref="RGD:1308198"
     exon            1..450
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1341
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /note="FBJ osteosarcoma oncogene B; transcription factor
                     AP-1 subunit FosB"
                     /codon_start=1
                     /product="protein FosB"
                     /protein_id="NP_001243438.1"
                     /db_xref="GeneID:100360880"
                     /db_xref="RGD:1308198"
                     /translation="MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQEC
                     AGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGT
                     SYSTPGLSAYSTGGASGSGGPSTSTSTSGPVSARPARARPRRPREETLTPEEEEKRRV
                     RRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAH
                     KPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNL
                     TASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGSQRTSGSEQPSDPLNSPS
                     LLAL"
     exon            451..771
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..879
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..3251
                     /gene="Fosb"
                     /gene_synonym="fra-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtatctgaa tcgcacgctg caccgcggca ctgcccggcg ggtttctggg cggggagcga
       61 tccccgcgtc gccccccgtg aaaccgacag agcctggact ttcaggaggt acagcggagg
      121 tctgaagggg acctgggagc gcaacagagg gaacttgcat cgaaacttgg gcagttctcc
      181 gaaccggaga ctaagcttcc ccgagcagcg cactttggag acgtgtccgg tctactccgg
      241 actcgcatct catcccactc ggccatagcc ttggcttcca gaagacctca gcgtggtcac
      301 aggggccccc ctgtgcccag ggaaatgttt caagctttcc ccggagacta cgactccggc
      361 tcccggtgta gctcatcacc ctccgccgag tctcagtacc tgtcttcggt ggactccttc
      421 ggcagtccac ccaccgccgc cgcctcccag gagtgcgccg gtctcgggga aatgcccggc
      481 tccttcgtgc caacggtcac cgcaatcaca accagccagg accttcagtg gctcgtgcag
      541 cccaccctca tctcttccat ggcccagtcc caggggcagc cactggcctc ccagcctcca
      601 gctgttgacc cttatgacat gcctggaacc agctactcaa ccccgggcct gagtgcctac
      661 agcactggtg gggcaagcgg aagtggtggg ccttcaacta gcacaagcac cagtggaccc
      721 gtgtctgccc gcccagccag agccaggcct agaagacccc gagaagaaac acttacccca
      781 gaagaagaag aaaaacgaag ggttcgcaga gagcggaaca agctggctgc agctaaatgc
      841 agaaaccgtc ggagggagct gacagaccga ctccaggcgg aaacggatca gctcgaagag
      901 gaaaaggcag agctggagtc ggagatcgcc gagctgcaaa aagagaagga acgcctggag
      961 tttgtcctgg tggcccacaa accgggctgc aagatccctt acgaagaggg gccggggcca
     1021 ggcccgctgg ccgaggtgag agatttgcca gggtcaacat ccgctaagga agacggcttc
     1081 ggctggctgc tgccgccccc tccaccaccg cccctgccct tccagagcag ccgagacgca
     1141 ccccccaacc tgacggcttc tctctttaca cacagtgaag ttcaagtcct cggcgacccc
     1201 ttccccgttg ttagcccttc gtacacttcc tcgtttgtcc tcacctgccc ggaggtctcc
     1261 gcgttcgccg gctcccaacg caccagcggc agcgagcagc cgtccgaccc cctgaactcg
     1321 ccctcccttc ttgctctgta aactctttaa acaaacaaaa caaacaaaac cgcaaggaac
     1381 gaggaggagg aagaggagga gaggggagga agcggtccgg ggtgtgtgtg aggacccctt
     1441 gactcttctg tctgaccgcc tgtcgcctct gccatcggac ttgacggaag gacctccttt
     1501 gtgttttgtg ctccgcctct ggttttctgc gccccggcga ggccggagag ctggtgactt
     1561 tggggacggg gtggggcggg tgcacccttc ctgcagataa ctttgtcctg ttacttcaac
     1621 ccaccttctg gggatagatg ctggctggct gggtgggtgg ggtgggatgc gacgcccacc
     1681 tttggcgtcc tgcgtgaggc tggaggggaa agggtgctgg gtgtggggta cagggtgggt
     1741 tgaggtcgag ctggcatgca cccccagaga gacccaacga ggaaatgaca gcactgtcct
     1801 tctcttccct acccacccat ccaccctcca gggtgcaggg tgaccaagat agctctgttt
     1861 tgctccctcg ggccttagct gattaaccta acatttccag gaggttacaa cctcctccgg
     1921 gacgaattga acccccgact gagggaagtc gatggccgct ttgggagtct gctaacccta
     1981 attccccgct gattccaaaa tgtgaacccc tatctgactg ttcagtcttt ccctcctggg
     2041 aaaactgact caggttggat ttttttctca tctgctacgg agcccccttc caactcaggc
     2101 ccgctcccac ccctgtgcag tattatgcca tgtccctctc acccccacgg gcaacccagg
     2161 cgcccttggc cgtcctcgtt gggcctttct ggttttgggc agcagggggc gctgcgacgc
     2221 ccgtcttgct ggagcgcttt atactgtgaa tgaatggcca gattgctggg tgcgccggat
     2281 gggattgacc cccaaccctc caaagccttc cctgggcctc tccttcttcc acttgccccc
     2341 ttccaaccct tgacagggag ttagacccga aaggagtgac tgcgatgcat cccggtggcc
     2401 ttcttgctca ggccccagac attttctcta agtccttcgc cttccccagc ctaggacgcc
     2461 aacttctccc catcctggga gccccgcatc ctctcacaga ggtcgtcgag gcaatttcca
     2521 gagaagtttt cagggctgag gctttggctc ccctaccctc gatatttgaa cccccaaata
     2581 tttttggact ggcatacttc agagggggct gagttcccac tatcctaatc catccaattc
     2641 ctccagcccc gaatatgggt tctggctttt ccctccagct ttcacctcgt gagaattcca
     2701 cgagtcagat ttctattttt taatattggg gagatgggcc ctaccgcccc cccccgtgct
     2761 gcatggaaca ttccatactc tgtcctgggt cctcggttcc aagcctaatc ccaaccccca
     2821 accctcagct atttatccct ttcctggttc ccaaaaagca cttatatcta ttatgtataa
     2881 ataaatatat tatatatggg tgtgcgtgtg tgtgcgtgcg tgcgtgcgag cttcctcgtt
     2941 tgcaagtgtg ctgtggaatt caaaatcgct tttggggatt tgagtcagac tttctggctg
     3001 tccctttcct aacttgtcac tttttttgtt gttgtctcag cccctctggc tgttggaaac
     3061 agcctcttcc tttcctttta tcttttttca actctgtctc gctcagacca cttccaacat
     3121 gtctcctctc tcaatggccc tgacctcccg tctgtctgtt aattccggat ttgtcgggga
     3181 catgcaattt tacttttgta agtaagtgtg actgggtggt agatttttac aatctatatc
     3241 gttgagaatt c
//
