LOCUS       NM_022197               1589 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus Fos proto-oncogene, AP-1 transcription factor
            subunit (Fos), mRNA.
ACCESSION   NM_022197 XM_234422
VERSION     NM_022197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1589)
  AUTHORS   Glaeser,B., Panariello,V., Banerjee,A. and Olsen,C.M.
  TITLE     Environmental Enrichment during Abstinence Reduces Oxycodone
            Seeking and c-Fos Expression in a Subpopulation of Medial
            Prefrontal Cortex Neurons
  JOURNAL   Drug Alcohol Depend 255, 111077 (2024)
   PUBMED   38228055
  REMARK    GeneRIF: Environmental Enrichment during Abstinence Reduces
            Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial
            Prefrontal Cortex Neurons.
REFERENCE   2  (bases 1 to 1589)
  AUTHORS   Vega-Rivera,N.M., Estrada-Camarena,E., Azpilcueta-Morales,G.,
            Cervantes-Anaya,N., Trevino,S., Becerril-Villanueva,E. and
            Lopez-Rubalcava,C.
  TITLE     Chronic Variable Stress and Cafeteria Diet Combination Exacerbate
            Microglia and c-fos Activation but Not Experimental Anxiety or
            Depression in a Menopause Model
  JOURNAL   Int J Mol Sci 25 (3), 1455 (2024)
   PUBMED   38338735
  REMARK    GeneRIF: Chronic Variable Stress and Cafeteria Diet Combination
            Exacerbate Microglia and c-fos Activation but Not Experimental
            Anxiety or Depression in a Menopause Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1589)
  AUTHORS   Byun,Y. and Noh,J.
  TITLE     Social play exclusion model in adolescent rats: Monitoring
            locomotor and emotional behavior associated with social play and
            examining c-Fos expression in the brain
  JOURNAL   Physiol Behav 273, 114379 (2024)
   PUBMED   37858915
  REMARK    GeneRIF: Social play exclusion model in adolescent rats: Monitoring
            locomotor and emotional behavior associated with social play and
            examining c-Fos expression in the brain.
REFERENCE   4  (bases 1 to 1589)
  AUTHORS   Feng,L., A,L., Bao,T., Mu,X., Ta,N., Duan,Q., Ta,L., Chen,Y.,
            Bai,L. and Fu,M.
  TITLE     An integrated network analysis, RNA-seq and in vivo validation
            approaches to explore the protective mechanism of Mongolian
            medicine formulae Ruda-6 against indomethacin-induced gastric ulcer
            in rats
  JOURNAL   Front Pharmacol 14, 1181133 (2023)
   PUBMED   37637418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1589)
  AUTHORS   Akdag,M.Z., Ogras,E., Doganyigit,Z., Akyuz,E., Akdag,M.B., Okan,A.,
            Akpolat,V. and Kullu,I.R.
  TITLE     The increase in c-fos expression in epileptic seizures is inhibited
            by magnetic field application, but not KCa1.1 channel expression
  JOURNAL   Electromagn Biol Med 42 (2), 81-97 (2023)
   PUBMED   37598353
  REMARK    GeneRIF: The increase in c-fos expression in epileptic seizures is
            inhibited by magnetic field application, but not KCa1.1 channel
            expression.
REFERENCE   6  (bases 1 to 1589)
  AUTHORS   Reghunath,R.
  TITLE     Eye injuries and foreign bodies
  JOURNAL   Nurs J India 83 (6), 157-160 (1992)
   PUBMED   1298921
REFERENCE   7  (bases 1 to 1589)
  AUTHORS   Stopera,S.A., Davie,J.R. and Bird,R.P.
  TITLE     Colonic aberrant crypt foci are associated with increased
            expression of c-fos: the possible role of modified c-fos expression
            in preneoplastic lesions in colon cancer
  JOURNAL   Carcinogenesis 13 (4), 573-578 (1992)
   PUBMED   1576709
REFERENCE   8  (bases 1 to 1589)
  AUTHORS   Abate,C., Luk,D., Gentz,R., Rauscher,F.J. 3rd and Curran,T.
  TITLE     Expression and purification of the leucine zipper and DNA-binding
            domains of Fos and Jun: both Fos and Jun contact DNA directly
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1032-1036 (1990)
   PUBMED   2105492
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1990 Jun;87(11):4411]
REFERENCE   9  (bases 1 to 1589)
  AUTHORS   Claycomb,W.C. and Lanson,N.A. Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   10 (bases 1 to 1589)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ089699.1.
            
            On May 25, 2007 this sequence version replaced NM_022197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ149169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1589
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /note="Fos proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:314322"
                     /db_xref="RGD:2626"
     exon            1..293
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1295
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /note="c-fos oncogene; v-fos FBJ murine osteosarcoma viral
                     oncogene homolog; proto-oncogene c-FOS; proto-oncogene
                     cFOS; FBJ osteosarcoma oncogene"
                     /codon_start=1
                     /product="protein c-Fos"
                     /protein_id="NP_071533.1"
                     /db_xref="GeneID:314322"
                     /db_xref="RGD:2626"
                     /translation="MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPV
                     NTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPS
                     TGAYARAGVVKTMSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRE
                     LTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSV
                     TSLDLTGGLPEATTPESEEAFTLPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPA
                     SSRPSGSETARSVPDVDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSC
                     TTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL"
     exon            294..545
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /inference="alignment:Splign:2.1.0"
     exon            546..653
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1589
                     /gene="Fos"
                     /gene_synonym="c-fos"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaccgcga ttgcagctag caactgagaa gactggatag agccggcgga gccgcgaacg
       61 agcagtgacc gcgctcccac ccagctctgc tctgcagctc ccaccagtgt ctacccctgg
      121 acccctcgcc gagctttgcc caaaccacga ccatgatgtt ctcgggtttc aacgcggact
      181 acgaggcgtc atcctcccgc tgcagtagcg cctccccggc cggggacagc ctttcctact
      241 accattcccc agccgactcc ttctccagca tgggctcccc tgtcaacaca caggactttt
      301 gcgcagatct gtccgtctct agtgccaact ttatccccac ggtgacagcc atctccacca
      361 gcccagacct gcagtggctg gtgcagccca ctctggtctc ctccgtggcc ccatcgcaga
      421 ccagagcgcc ccatccttac ggactcccca ccccgtcgac cggggcttac gccagagcgg
      481 gagtggtgaa gaccatgtca ggcggcagag cgcagagcat cggcagaagg ggcaaagtag
      541 agcagctatc tcctgaagag gaagagaaac ggagaatccg aagggaaagg aataagatgg
      601 ctgcagccaa gtgccggaat cggaggaggg agctgacaga tacgctccaa gcggagacag
      661 atcaacttga agacgagaag tctgcgttgc agaccgagat tgccaatcta ctgaaagaga
      721 aggaaaaact ggagtttatt ttggcagccc accgacctgc ctgcaagatc cccaatgacc
      781 tgggcttccc agaggagatg tctgtgacct ccctggactt gactgggggt ctgcctgagg
      841 ctaccacccc agagtctgag gaggccttca ccctgcctct tctcaatgac cctgagccca
      901 agccatcctt ggagccggtc aagaacatta gcaacatgga gctgaaggct gaaccctttg
      961 atgacttctt gtttccggca tcatctaggc ccagtggctc ggagactgcc cgctctgtgc
     1021 cagatgtgga cctgtctggt tccttctatg cagcagactg ggagcctctg cacagcagtt
     1081 ccctggggat ggggcccatg gtcacagagc tggagcccct gtgcactccc gttgtcacct
     1141 gcactcccag ctgcactacc tatacgtctt cctttgtctt cacctacccc gaggctgact
     1201 ccttccctag ctgcgcagct gcccaccgaa agggcagcag cagcaacgag ccctcctctg
     1261 actcactgag ctcgcccaca ctgctagccc tgtgagcagt cagagaaggc agggcagccg
     1321 gcactgactg agctggtgca ttacagagag aagaaacaag tcttccctcg aggggttccc
     1381 gtagacctag ggaggacctt atctgtgcgt gaaacacacc aggctgtgga cctcaaggac
     1441 ttgaaagcat ccacatctgg actccagtcc tcacctcttc cggagatgta gcaaaaaaac
     1501 aaaaaaacaa aacaaaaaaa aaacaaaaca aaaaatcaaa agcaaccgca tggagtgtat
     1561 tgtttgtagt gacacctgag agctggtag
//
