LOCUS       NM_001106283            1212 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus folate receptor beta (Folr2), mRNA.
ACCESSION   NM_001106283 XM_001067815 XM_215013
VERSION     NM_001106283.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Pridans,C., Irvine,K.M., Davis,G.M., Lefevre,L., Bush,S.J. and
            Hume,D.A.
  TITLE     Transcriptomic Analysis of Rat Macrophages
  JOURNAL   Front Immunol 11, 594594 (2021)
   PUBMED   33633725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Lu,Y., Parker,N., Kleindl,P.J., Cross,V.A., Wollak,K., Westrick,E.,
            Stinnette,T.W., Gehrke,M.A., Wang,K., Santhapuram,H.K., You,F.,
            Hahn,S.J., Vaughn,J.F., Klein,P.J., Vlahov,I.R., Low,P.S. and
            Leamon,C.P.
  TITLE     Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate
            of the mTOR Inhibitor Everolimus
  JOURNAL   Mol Med 21 (1), 584-596 (2015)
   PUBMED   26181632
  REMARK    GeneRIF: EC0565 forms micellar aggregates in physiological buffers
            and demonstrates good water solubility as well as strong
            multivalent FR-binding capacity. EC0565 inhibited mTOR signaling in
            rat macrophages at nanomolar concentrations
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Shen,J., Hilgenbrink,A.R., Xia,W., Feng,Y., Dimitrov,D.S.,
            Lockwood,M.B., Amato,R.J. and Low,P.S.
  TITLE     Folate receptor-beta constitutes a marker for human proinflammatory
            monocytes
  JOURNAL   J Leukoc Biol 96 (4), 563-570 (2014)
   PUBMED   25015955
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Watkins,D. and Rosenblatt,D.S.
  TITLE     Update and new concepts in vitamin responsive disorders of folate
            transport and metabolism
  JOURNAL   J Inherit Metab Dis 35 (4), 665-670 (2012)
   PUBMED   22108709
  REMARK    Review article
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   van der Heijden,J.W., Oerlemans,R., Dijkmans,B.A., Qi,H., van der
            Laken,C.J., Lems,W.F., Jackman,A.L., Kraan,M.C., Tak,P.P.,
            Ratnam,M. and Jansen,G.
  TITLE     Folate receptor beta as a potential delivery route for novel folate
            antagonists to macrophages in the synovial tissue of rheumatoid
            arthritis patients
  JOURNAL   Arthritis Rheum 60 (1), 12-21 (2009)
   PUBMED   19116913
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Page,S.T., Owen,W.C., Price,K. and Elwood,P.C.
  TITLE     Expression of the human placental folate receptor transcript is
            regulated in human tissues. Organization and full nucleotide
            sequence of the gene
  JOURNAL   J Mol Biol 229 (4), 1175-1183 (1993)
   PUBMED   8445646
  REMARK    Erratum:[J Mol Biol 1994 May 13;238(4):639]
REFERENCE   7  (bases 1 to 1212)
  AUTHORS   Antony,A.C., Kane,M.A., Portillo,R.M., Elwood,P.C. and
            Kolhouse,J.F.
  TITLE     Studies of the role of a particulate folate-binding protein in the
            uptake of 5-methyltetrahydrofolate by cultured human KB cells
  JOURNAL   J Biol Chem 260 (28), 14911-14917 (1985)
   PUBMED   4066659
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067815.1, XM_215013.4.
            
            ##Evidence-Data-START##
            CDS exon combination :: FQ211323.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN06621351,
                                    SAMN11044071 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1212
                     /gene="Folr2"
                     /note="folate receptor beta"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
     exon            1..100
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..267
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..420
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1032
                     /gene="Folr2"
                     /note="folate receptor 2 (fetal)"
                     /codon_start=1
                     /product="folate receptor beta precursor"
                     /protein_id="NP_001099753.1"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
                     /translation="MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPED
                     KLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYEC
                     SPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGIN
                     KCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEV
                     VKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD"
     exon            421..609
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..745
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1212
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgcggatc agggtgtagc tttcagctct ggttccagcc atgcctaccc caccttgttc
       61 cttgccatga tgattatgta ctaaacctct gaaactgtag attttttatt acagtctctc
      121 catgatggag ttcaccaact tggccaaact gaaagtctca gtgaactccc aggctggatc
      181 catctttctc cattcccaac agaaggcttg cagatggtca cctctccaga ttctcacatg
      241 ggtgctggaa aactaaacta aggcctgaga gacatggcct ggaaacagac accactcctg
      301 cttttggtct acatgatcac aacatgcagt gcccgggaca gaacagacct gctcaacgtt
      361 tgcatggatg ccaagcacca taagacaaag ccaggcccgg aggacaagct gcatgaccag
      421 tgtagtccat ggaagagaaa tgcctgctgc tcagtcaaca ccagccagga gctacacaag
      481 gacaactccc gtctgtacaa tttcaattgg gatcactgtg gtgagatgac gcccgcctgt
      541 aagcgtcact tcatccaaga cgcctgcctg tatgagtgtt cccccaatct tgggccttgg
      601 attcagcagg caggccagag ctggcgcaaa gagcgcttcc tggatgtgcc cttatgcaaa
      661 gaggactgtc aggagtggtg ggaagcctgt cgtacctcct ttacctgcaa gagagactgg
      721 cataaaggct gggactggac ctcaggcatt aacaagtgcc cagacacagc accctgccgc
      781 acatttcagt actatttccc gacaccagcc agcctttgtg agggtctctg gagtcactcc
      841 tacaaggtca gcaactatag cagagggagt ggccagtgca tccagatgtg gtttgactca
      901 acccagggca atcccaatga ggaagtggtg aagttctatg cttcctttat gacatctggg
      961 actgtgtacc atgcagcaat acttcttgtg cccagcctgg ccccagtgct gtcattatgg
     1021 ctccctgact gaggccagtc ttctcctcta gctacccttg gtctcggttg gttcaactct
     1081 tcaaagaata aggaagtctt gagcctgctt ccacccctct cctctgccat ccagttcctg
     1141 atccatgttg gggcttgggg tttctacaac aatcattttc aataaatcta tgacacatct
     1201 cggcctaatg aa
//
