LOCUS       NM_133527               1279 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus folate receptor alpha (Folr1), mRNA.
ACCESSION   NM_133527
VERSION     NM_133527.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Naz,N., Moshkdanian,G., Miyan,S., Eljabri,S., James,C. and Miyan,J.
  TITLE     A Paternal Methylation Error in the Congenital Hydrocephalic Texas
            (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements
  JOURNAL   Int J Mol Sci 24 (2), 1638 (2023)
   PUBMED   36675153
  REMARK    GeneRIF: A Paternal Methylation Error in the Congenital
            Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural
            Folate Supplements.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Silhavy,J., Krijt,J., Sokolova,J., Zidek,V., Mlejnek,P.,
            Simakova,M., Skop,V., Trnovska,J., Oliyarnyk,O., Markova,I.,
            Huttl,M., Malinska,H., Kazdova,L., Liska,F., Kozich,V. and
            Pravenec,M.
  TITLE     Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of
            metabolic syndrome in spontaneously hypertensive rats
  JOURNAL   Physiol Res 67 (4), 657-662 (2018)
   PUBMED   30113208
  REMARK    GeneRIF: Folr1 plays an important role in folate and sulfur amino
            acid levels and affects glucose and lipid metabolism in the rat.
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Sequeira,J.M., Desai,A., Berrocal-Zaragoza,M.I., Murphy,M.M.,
            Fernandez-Ballart,J.D. and Quadros,E.V.
  TITLE     Exposure to Folate Receptor Alpha Antibodies during Gestation and
            Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study
  JOURNAL   PLoS One 11 (3), e0152249 (2016)
   PUBMED   27011008
  REMARK    GeneRIF: These observations have implications in the pathology of
            FRa-autoantibodies associated with neural tube defect pregnancy,
            preterm birth and neurodevelopmental disorders including autism
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Pravenec,M., Kozich,V., Krijt,J., Sokolova,J., Zidek,V., Landa,V.,
            Mlejnek,P., Silhavy,J., Simakova,M., Skop,V., Trnovska,J.,
            Kazdova,L., Kajiya,T., Wang,J. and Kurtz,T.W.
  TITLE     Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1)
            Gene Predisposes Spontaneously Hypertensive Rats to Metabolic
            Syndrome
  JOURNAL   Hypertension 67 (2), 335-341 (2016)
   PUBMED   26667416
  REMARK    GeneRIF: inherited variation in the expression of Folr1 in the
            kidney influences the development of the metabolic syndrome
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Chen,C., Ke,J., Zhou,X.E., Yi,W., Brunzelle,J.S., Li,J., Yong,E.L.,
            Xu,H.E. and Melcher,K.
  TITLE     Structural basis for molecular recognition of folic acid by folate
            receptors
  JOURNAL   Nature 500 (7463), 486-489 (2013)
   PUBMED   23851396
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Chancy,C.D., Kekuda,R., Huang,W., Prasad,P.D., Kuhnel,J.M.,
            Sirotnak,F.M., Roon,P., Ganapathy,V. and Smith,S.B.
  TITLE     Expression and differential polarization of the reduced-folate
            transporter-1 and the folate receptor alpha in mammalian retinal
            pigment epithelium
  JOURNAL   J Biol Chem 275 (27), 20676-20684 (2000)
   PUBMED   10787414
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   da Costa,M., Rothenberg,S.P., Sadasivan,E., Regec,A. and Qian,L.
  TITLE     Folate deficiency reduces the GPI-anchored folate-binding protein
            in rat renal tubules
  JOURNAL   Am J Physiol Cell Physiol 278 (4), C812-C821 (2000)
   PUBMED   10751329
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Orr,R.B. and Kamen,B.A.
  TITLE     UMSCC38 cells amplified at 11q13 for the folate receptor synthesize
            a mutant nonfunctional folate receptor
  JOURNAL   Cancer Res 54 (14), 3905-3911 (1994)
   PUBMED   8033114
REFERENCE   9  (bases 1 to 1279)
  AUTHORS   Birn,H., Selhub,J. and Christensen,E.I.
  TITLE     Internalization and intracellular transport of folate-binding
            protein in rat kidney proximal tubule
  JOURNAL   Am J Physiol 264 (2 Pt 1), C302-C310 (1993)
   PUBMED   8447363
REFERENCE   10 (bases 1 to 1279)
  AUTHORS   Lacey,S.W., Sanders,J.M., Rothberg,K.G., Anderson,R.G. and
            Kamen,B.A.
  TITLE     Complementary DNA for the folate binding protein correctly predicts
            anchoring to the membrane by glycosyl-phosphatidylinositol
  JOURNAL   J Clin Invest 84 (2), 715-720 (1989)
   PUBMED   2527252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, FM060472.1 and FM059473.1.
            
            On Sep 3, 2015 this sequence version replaced NM_133527.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN06680425 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                JAXUCZ010000001.1  165642647-165642669 c
            24-637              FM060472.1         1-614
            638-968             FM059473.1         313-643
            969-1279            JAXUCZ010000001.1  165631462-165631772 c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1279
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /note="folate receptor alpha"
                     /db_xref="GeneID:171049"
                     /db_xref="RGD:71032"
     exon            1..115
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..241
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..389
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..559
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1165
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /note="folate binding protein 1; folate receptor 1
                     (adult)"
                     /codon_start=1
                     /product="folate receptor alpha precursor"
                     /protein_id="NP_598211.2"
                     /db_xref="GeneID:171049"
                     /db_xref="RGD:71032"
                     /translation="MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEK
                     PGPEDKLHDQCSPWKTNACCSTNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDT
                     CLYECSPNLGPWIQQVDQSWRKERILDVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNW
                     TSGHNECPVGASCHPFTFYFPTPAVLCEKIWSHSYKLSNYSRGSGRCIQMWFDPAQGN
                     PNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFWVLS"
     exon            560..748
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..884
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1279
                     /gene="Folr1"
                     /gene_synonym="Fbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttccccaa tcagcaggct gatctggaag cataaacaag aactgaagct gaaggctcta
       61 ggggttccca acctgtgatc tccagcagac actcctggtg tgtcaccgga ttcaggctcc
      121 tgggataaag aaagcaaagg aagtctggag tggagacgaa gaaaccccag gcactctgag
      181 agctgctacc ttttccatgt gtgctgccag acacttctcg tcagggacca aataccccaa
      241 gggagtggag agaggcctgg gctgggccag acttcctggg ctttaacctg tgctccaagt
      301 aggtgggtca cattttcccc agcgggagtt gaagagtcac ctggtgcttc aacgggactg
      361 atttcctggg cctggagttg gagatcagag gtctgacatg gctcacctga tggctgggca
      421 gtggttgctc ctgctgatgt ggatggccga atgtgcccag tccagagcta ctcgggccag
      481 gaccgaactt ctcaatgtct gcatggatgc caagcaccac aaagaaaagc caggcccaga
      541 ggacaagtta cacgaccagt gcagcccctg gaagacgaat gcctgctgct ccaccaacac
      601 aagccaggaa gcacataagg acatttccta cctgtaccga ttcaactgga atcactgtgg
      661 aactatgacc ccggagtgca aacgtcactt tatccaagac acctgcctct atgagtgttc
      721 cccgaacttg ggaccctgga tccagcaggt ggaccagagc tggcgcaaag agcggatcct
      781 tgatgttccc ctgtgcaaag aagactgtgt gctgtggtgg gaggactgca agagctcttt
      841 tacctgcaag agcaactggc acaagggatg gaactggacc tcggggcata atgagtgccc
      901 tgtgggagcc tcctgccatc ccttcacttt ctacttccct acacctgctg ttctgtgtga
      961 gaaaatctgg agtcactcct acaagctcag caactacagc cgagggagcg gccgctgcat
     1021 ccagatgtgg ttcgacccag cccaaggcaa ccccaacgag gaagtggcga ggttctatgc
     1081 cgaggtcatg agtggagctg ggcttcgcga ggcctggctg ctggtgtgca gcctgtcctt
     1141 agtgctgttc tgggtgctca gctgagttcc tgttactcct tgtctggagc tccaccctgc
     1201 ccggcttagc ctcccagctc ccagcctcct ttgtggtggg gctctgacag cctgtttagt
     1261 aaaccagaca ttctacatg
//
