LOCUS       NM_057185               3009 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus folate hydrolase 1 (Folh1), mRNA.
ACCESSION   NM_057185
VERSION     NM_057185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Silhavy,J., Krijt,J., Sokolova,J., Zidek,V., Mlejnek,P.,
            Simakova,M., Skop,V., Trnovska,J., Oliyarnyk,O., Markova,I.,
            Huttl,M., Malinska,H., Kazdova,L., Liska,F., Kozich,V. and
            Pravenec,M.
  TITLE     Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of
            metabolic syndrome in spontaneously hypertensive rats
  JOURNAL   Physiol Res 67 (4), 657-662 (2018)
   PUBMED   30113208
  REMARK    GeneRIF: Folh1 gene plays an important role in folate and sulfur
            amino acid levels and affects glucose and lipid metabolism in the
            rat.
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Navratil,M., Ptacek,J., Sacha,P., Starkova,J., Lubkowski,J.,
            Barinka,C. and Konvalinka,J.
  TITLE     Structural and biochemical characterization of the
            folyl-poly-gamma-l-glutamate hydrolyzing activity of human
            glutamate carboxypeptidase II
  JOURNAL   FEBS J 281 (14), 3228-3242 (2014)
   PUBMED   24863754
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Zuo,D., Bzdega,T., Olszewski,R.T., Moffett,J.R. and Neale,J.H.
  TITLE     Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on
            release of glutamate and dopamine in prefrontal cortex and nucleus
            accumbens in phencyclidine model of schizophrenia
  JOURNAL   J Biol Chem 287 (26), 21773-21782 (2012)
   PUBMED   22570482
  REMARK    GeneRIF: NAAG peptidase inhibition has a role in release of
            glutamate and dopamine in prefrontal cortex and nucleus accumbens
            in phencyclidine model of schizophrenia
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Collard,F., Vertommen,D., Constantinescu,S., Buts,L. and Van
            Schaftingen,E.
  TITLE     Molecular identification of beta-citrylglutamate hydrolase as
            glutamate carboxypeptidase 3
  JOURNAL   J Biol Chem 286 (44), 38220-38230 (2011)
   PUBMED   21908619
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Blom,H.J. and Smulders,Y.
  TITLE     Overview of homocysteine and folate metabolism. With special
            references to cardiovascular disease and neural tube defects
  JOURNAL   J Inherit Metab Dis 34 (1), 75-81 (2011)
   PUBMED   20814827
  REMARK    Review article
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Luthi-Carter,R., Berger,U.V., Barczak,A.K., Enna,M. and Coyle,J.T.
  TITLE     Isolation and expression of a rat brain cDNA encoding glutamate
            carboxypeptidase II
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 3215-3220 (1998)
   PUBMED   9501243
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Bzdega,T., Turi,T., Wroblewska,B., She,D., Chung,H.S., Kim,H. and
            Neale,J.H.
  TITLE     Molecular cloning of a peptidase against N-acetylaspartylglutamate
            from a rat hippocampal cDNA library
  JOURNAL   J Neurochem 69 (6), 2270-2277 (1997)
   PUBMED   9375657
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Pinto,J.T., Suffoletto,B.P., Berzin,T.M., Qiao,C.H., Lin,S.,
            Tong,W.P., May,F., Mukherjee,B. and Heston,W.D.
  TITLE     Prostate-specific membrane antigen: a novel folate hydrolase in
            human prostatic carcinoma cells
  JOURNAL   Clin Cancer Res 2 (9), 1445-1451 (1996)
   PUBMED   9816319
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Carter,R.E., Feldman,A.R. and Coyle,J.T.
  TITLE     Prostate-specific membrane antigen is a hydrolase with substrate
            and pharmacologic characteristics of a neuropeptidase
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 749-753 (1996)
   PUBMED   8570628
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Israeli,R.S., Powell,C.T., Fair,W.R. and Heston,W.D.
  TITLE     Molecular cloning of a complementary DNA encoding a
            prostate-specific membrane antigen
  JOURNAL   Cancer Res 53 (2), 227-230 (1993)
   PUBMED   8417812
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF513486.2, U75973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  149913852-149914035 c
            185-293             JAXUCZ010000001.1  149912175-149912283 c
            294-480             JAXUCZ010000001.1  149910781-149910967 c
            481-582             JAXUCZ010000001.1  149906803-149906904 c
            583-708             JAXUCZ010000001.1  149900510-149900635 c
            709-895             JAXUCZ010000001.1  149899290-149899476 c
            896-989             JAXUCZ010000001.1  149884257-149884350 c
            990-1088            JAXUCZ010000001.1  149881774-149881872 c
            1089-1174           JAXUCZ010000001.1  149881112-149881197 c
            1175-1294           JAXUCZ010000001.1  149878083-149878202 c
            1295-1377           JAXUCZ010000001.1  149875987-149876069 c
            1378-1441           JAXUCZ010000001.1  149861930-149861993 c
            1442-1509           JAXUCZ010000001.1  149855679-149855746 c
            1510-1601           JAXUCZ010000001.1  149853388-149853479 c
            1602-1692           JAXUCZ010000001.1  149849317-149849407 c
            1693-1957           JAXUCZ010000001.1  149846693-149846957 c
            1958-2039           JAXUCZ010000001.1  149845353-149845434 c
            2040-2132           JAXUCZ010000001.1  149843597-149843689 c
            2133-3009           JAXUCZ010000001.1  149840760-149841636 c
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3009
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /note="folate hydrolase 1"
                     /db_xref="GeneID:85309"
                     /db_xref="RGD:70963"
     exon            1..184
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2322
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /EC_number="3.4.17.21"
                     /note="FGCP; mGCP; GCPII; NAALADase I; glutamate
                     carboxypeptidase II; membrane glutamate carboxypeptidase;
                     folylpoly-gamma-glutamate carboxypeptidase;
                     prostate-specific membrane antigen homolog;
                     pteroylpoly-gamma-glutamate carboxypeptidase;
                     N-acetylated-alpha-linked acidic dipeptidase I;
                     N-acetylated alpha-linked acidic dipeptidase"
                     /codon_start=1
                     /product="glutamate carboxypeptidase 2"
                     /protein_id="NP_476533.2"
                     /db_xref="GeneID:85309"
                     /db_xref="RGD:70963"
                     /translation="MWNAQQDSDSAEALRRRQRWFCAGTLVLAFTGTFIIGFLFGWFI
                     KPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQW
                     KEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVV
                     PPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKN
                     AQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPA
                     NEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPG
                     FAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQS
                     GAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVA
                     YINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEF
                     IGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKTNKVSSYPLYHSVYETYELVEK
                     FYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEM
                     KAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLG
                     LPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFT
                     VQAAAETLREVD"
     exon            185..293
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            294..480
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            481..582
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            583..708
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            709..895
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            896..989
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1088
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1174
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1294
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1377
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1441
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1509
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1601
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1692
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1957
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2039
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2132
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..3009
                     /gene="Folh1"
                     /gene_synonym="Naalad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggctgcag actctgcagt agagccgcag tagaactgct gagaaagacc aaagttgcca
       61 gagatgtgga acgctcagca ggacagcgac tccgcggagg ccctgagacg ccgtcaacgc
      121 tggttctgtg ctggaacact ggtgctggct ttcactggaa ccttcatcat tggcttcctc
      181 tttgggtggt ttataaaacc ctccaatgat tctactagca gtgtttccta tcctggcatg
      241 aagaaggcat ttttgcaaga attgaaggct gagaacatca aaaaattttt atacaatttc
      301 acacggacac cacatttggc agggacacaa cacaattttg agcttgcaaa gcaaattcat
      361 gcccagtgga aagaatttgg cctggatttg gttgagttat ctgattatga tgtcctgttg
      421 tcctacccaa ataagaccca tcccaactat atctcaataa ttaatgaaga tggaaatgag
      481 attttcaaaa catcattagc tgaactgtca cccccgggat atgagaacat atcagatgta
      541 gtgccaccat acagtgcctt ctctccacaa gggacaccag agggggatct agtatatgtt
      601 aactatgcac ggactgaaga cttctttaaa ctggaacggg tcatgaagat caattgttct
      661 gggaagattg tcatcgccag atatgggcaa gtgttcagag gaaataaggt taaaaatgct
      721 cagctggcag gtgcaaaagg aatcattctg tactcagacc ctgctgatta ctttgttcct
      781 ggggtgaagt cctatccaga tggttggaac ctccctggag gtggtgttca gcgtggaaat
      841 gtcttaaatc ttaatggtgc aggtgatcca ctcacaccag gttatccagc aaatgaatat
      901 gcctacaggc atgaattcac agaagctgtc ggtcttccaa gtattcctgt ccatccaatt
      961 ggatatgatg atgcacagaa actattagaa catatgggtg gctccgcacc ccctgacagc
     1021 agctggaagg gaggactaaa agtgccttac aacgtgggac ctggctttgc tggaaacttt
     1081 tcaaaacaaa aggtcaagct gcatattcac tcctacaata aagtgacaag aatctacaat
     1141 gttattggta ccctcaaagg agctgtggaa ccagacagat atgttattct tggagggcac
     1201 agagatgctt gggtgtttgg tggcattgac cctcagagtg gagcagctgt tgttcatgaa
     1261 attgtcagga cctttggaac tctgaagaag aaaggttgga ggcctagaag aactattttg
     1321 tttgcaagct gggatgctga agaatttggc cttcttggtt ctactgagtg ggcagaggaa
     1381 cattcaagac tcttacaaga acgtggtgtg gcttatatca acgctgattc ttccatagaa
     1441 ggaaactaca ctctcagagt tgattgcaca ccactgatgc acagcttagt atacaaccta
     1501 acaaaagagc tgccaagccc ggatgaaggc tttgaaggca aatctcttta tgacagctgg
     1561 aaagaaaaaa gtccttcaac tgagttcatt ggaatgccaa ggattagcaa gctggggtct
     1621 ggcaatgatt ttgaagtgtt tttccaaaga cttggaattg cttcaggcag agcccggtat
     1681 actaaaaatt ggaaaaccaa caaagtcagc agctatcctc tctatcacag tgtctatgaa
     1741 acatacgaat tggtagaaaa attctatgat ccgacattta aatatcacct cactgtggcc
     1801 caggttcgag gagcaatggt atttgaattg gccaattcta tagtgcttcc ctttgactgc
     1861 caaagttatg ctgtagctct gaagaaacat gctgagacta tctacaacat ttcaatgaat
     1921 catccacagg agatgaaggc gtacatgata tcatttgatt cgctgttttc tgcagtaaat
     1981 aattttacag atgttgcatc caagttcaat cagagactgc aagacttaga caagagcaac
     2041 cccatattac tgagaatttt gaatgatcag ctaatgtatc tggaacgtgc attcattgat
     2101 cctttaggat taccaggaag gcctttctac aggcatatca tctatgctcc aagcagccac
     2161 aacaagtatg caggagaatc attcccaggg atttatgatg ccctttttga tattaataac
     2221 aaagtcgaca cttctaaggc ctggagagaa gtgaagagac agatttctat tgcagccttc
     2281 acagtgcaag ctgcagcaga gactctgaga gaagtagact aagcagtctt tacagaattc
     2341 ataaaaaact gatttgtgga tcaaaagaca aaagtgaata atttcataat gacttataat
     2401 tttggcatgt attactaaaa tttaaaattc aataggtatt aaaactaatg taaacagcct
     2461 aataaaatga cacatttgac agtattagat aattatccga aatctaatac acccttccca
     2521 aatctaccct gtagttttac ttcattatgg aatacatctt ggatagttca caattctgct
     2581 ctacctgggg gcctatatgc tctctggtca ccaaaggctg ggaggatcat tatagtcacc
     2641 ctagcagacg agttctaatt tattctctct tcttgtaaac ctaattcctc tttattgaaa
     2701 agtttaagta tataggccaa ggtcttgtct gtggctccct atggaggatc ctgataaaaa
     2761 gcggcagtcc atggttttaa ggtatttatg atctaaaact ctataaattg taaaagtaca
     2821 actactaatt aacatctata gtctcagtaa ctgaacttct gaacaaatgc attatttata
     2881 tgaaatataa tcatggtctt gaattttatg tttataatgt ctctttttat atagaattac
     2941 atgtgtttta tattcattac atgtcttgaa atatatgtaa ttttctattt ttcattgtta
     3001 tcttctatt
//
