LOCUS       NM_172034               2650 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus farnesyltransferase, CAAX box, subunit beta
            (Fntb), mRNA.
ACCESSION   NM_172034
VERSION     NM_172034.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   Blanden,M.J., Suazo,K.F., Hildebrandt,E.R., Hardgrove,D.S.,
            Patel,M., Saunders,W.P., Distefano,M.D., Schmidt,W.K. and
            Hougland,J.L.
  TITLE     Efficient farnesylation of an extended C-terminal C(x)3X sequence
            motif expands the scope of the prenylated proteome
  JOURNAL   J Biol Chem 293 (8), 2770-2785 (2018)
   PUBMED   29282289
  REMARK    GeneRIF: Data suggest that substrate specificity of protein
            farnesyltransferase (subunits Fnta plus Fntb) is extensive; these
            results expand the scope of the potential prenylated proteome in
            this species. (Fnta = farnesyltransferase CAAX box alpha protein;
            Fntb = farnesyltransferase CAAX box beta protein)
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Ibrahim,M.X., Sayin,V.I., Akula,M.K., Liu,M., Fong,L.G., Young,S.G.
            and Bergo,M.O.
  TITLE     Targeting isoprenylcysteine methylation ameliorates disease in a
            mouse model of progeria
  JOURNAL   Science 340 (6138), 1330-1333 (2013)
   PUBMED   23686339
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Zhou,J., Vos,C.C., Gjyrezi,A., Yoshida,M., Khuri,F.R., Tamanoi,F.
            and Giannakakou,P.
  TITLE     The protein farnesyltransferase regulates HDAC6 activity in a
            microtubule-dependent manner
  JOURNAL   J Biol Chem 284 (15), 9648-9655 (2009)
   PUBMED   19228685
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Long,S.B., Casey,P.J. and Beese,L.S.
  TITLE     Cocrystal structure of protein farnesyltransferase complexed with a
            farnesyl diphosphate substrate
  JOURNAL   Biochemistry 37 (27), 9612-9618 (1998)
   PUBMED   9657673
REFERENCE   7  (bases 1 to 2650)
  AUTHORS   Finder,J.D., Litz,J.L., Blaskovich,M.A., McGuire,T.F., Qian,Y.,
            Hamilton,A.D., Davies,P. and Sebti,S.M.
  TITLE     Inhibition of protein geranylgeranylation causes a superinduction
            of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 272 (21), 13484-13488 (1997)
   PUBMED   9153192
REFERENCE   8  (bases 1 to 2650)
  AUTHORS   Park,H.W., Boduluri,S.R., Moomaw,J.F., Casey,P.J. and Beese,L.S.
  TITLE     Crystal structure of protein farnesyltransferase at 2.25 angstrom
            resolution
  JOURNAL   Science 275 (5307), 1800-1804 (1997)
   PUBMED   9065406
  REMARK    Erratum:[Science 1997 Apr 4;276(5309):21]
REFERENCE   9  (bases 1 to 2650)
  AUTHORS   Zhang,F.L., Moomaw,J.F. and Casey,P.J.
  TITLE     Properties and kinetic mechanism of recombinant mammalian protein
            geranylgeranyltransferase type I
  JOURNAL   J Biol Chem 269 (38), 23465-23470 (1994)
   PUBMED   8089111
REFERENCE   10 (bases 1 to 2650)
  AUTHORS   Chen,W.J., Andres,D.A., Goldstein,J.L., Russell,D.W. and Brown,M.S.
  TITLE     cDNA cloning and expression of the peptide-binding beta subunit of
            rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1
  JOURNAL   Cell 66 (2), 327-334 (1991)
   PUBMED   1855253
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087675.1.
            
            On Dec 26, 2004 this sequence version replaced NM_172034.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087675.1, M69056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2650
                     /gene="Fntb"
                     /note="farnesyltransferase, CAAX box, subunit beta"
                     /db_xref="GeneID:64511"
                     /db_xref="RGD:620119"
     exon            1..189
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1359
                     /gene="Fntb"
                     /EC_number="2.5.1.58"
                     /note="FTase-beta; CAAX farnesyltransferase subunit beta;
                     ras proteins prenyltransferase subunit beta;
                     farnesyltransferase beta subunit; farnesyltransferase,
                     CAAX box, beta"
                     /codon_start=1
                     /product="protein farnesyltransferase subunit beta"
                     /protein_id="NP_742031.1"
                     /db_xref="GeneID:64511"
                     /db_xref="RGD:620119"
                     /translation="MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVT
                     SIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPW
                     LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNAL
                     CIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIIT
                     PDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQW
                     VTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQA
                     LQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPEN
                     VLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD"
     exon            190..254
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            255..327
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            328..419
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            420..566
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            567..650
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            651..737
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            738..867
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1000
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1112
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1227
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..2586
                     /gene="Fntb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggacgaag ctgagtccta tacagcgctc gcagctctcc cgatcatggc ttcttcgagt
       61 tccttcacct attattgtcc tccatcttct tcccctgttt ggtcagaacc gctgtatagt
      121 ctgagacctg agcacgcgcg ggagcggttg caagacgact cagtggaaac agtcacgtcc
      181 atagaacagg ccaaagtaga agaaaagatc caggaggtct tcagttctta caagtttaac
      241 cacctcgtac caaggcttgt tctgcagagg gagaagcact tccattatct gaaaagaggc
      301 cttcgacaac tgacagatgc ctatgagtgt ctggatgcca gccgcccctg gctctgctac
      361 tggatcctgc acagcttgga gctcctcgac gaacccatcc cccaaatagt ggctacagat
      421 gtgtgtcagt tcttggagct gtgtcagagt ccagacggtg gctttggagg gggccctggt
      481 cagtacccac acctcgctcc cacgtatgca gctgtcaacg cgctatgcat cattggcacg
      541 gaggaagcct acaacgtcat taacagagag aagctccttc agtacttgta ctccctaaag
      601 caaccggatg gctcttttct catgcacgtc ggaggagagg tggatgtaag aagtgcgtac
      661 tgtgctgcct cagtagcctc tctcaccaac atcatcactc ctgacctctt cgaaggcact
      721 gctgaatgga tagcaaggtg ccagaactgg gaaggcggca ttggcggggt gccagggatg
      781 gaagcccacg gtggctacac cttctgtggc ttggctgcgc tggtgatcct caagaaggaa
      841 cgttctttga acctgaagag cttgctacaa tgggtgacaa gccggcagat gcggttcgaa
      901 ggaggatttc agggccgctg caacaagctg gtggacggct gctactcctt ctggcaggca
      961 ggacttctgc ccctgttgca ccgggcactc cacgctcaag gtgaccctgc cctcagcatg
     1021 agccactgga tgttccatca gcaggcgctg caggagtaca tcctcatgtg ctgccagtgt
     1081 ccggctgggg gtctcctgga caaacctggc aagtcacgtg acttctacca tacttgctac
     1141 tgcctgagcg gcctgtccat tgcccagcat tttggaagtg gagccatgct gcacgatgtg
     1201 gtcatgggtg tgcctgaaaa tgttctgcag cccactcacc ctgtgtacaa catcggacct
     1261 gataaggtga tccaggccac cacacacttt ctgcagaagc cggtcccagg ctttgaggaa
     1321 tgcgaagatg cggtgacctc agatcctgcc actgactaga ggaccccatg gctcccccaa
     1381 atcccccgtc agacaaggtt tctccgtttg ggtacatagc acagtccgtg ctacttgagc
     1441 cttggccact gtggagttgt ggtttctttg tcctttcctg tcaaacaaaa caaagccatc
     1501 agctctgggt tggaatacac aatggtgtga ttttaaaaat tattttcata cctgtcaaac
     1561 caaaactctg ggagccgatg tagtaagcag ggttggagag caatgcatgc tgggaagcag
     1621 cagcctcctc cagcagccag gcccacaatg ctgaaatgga aggtgtctgt gagtatctcc
     1681 acatcacagc cactgctgtg cctcccacct acacaccatt cagtcagcag atgggctcct
     1741 ctctggtata aatgtcagct ctgtgcaagg gcggggctgt gggtccagcc aatacatgct
     1801 ctctggaaaa cagcactggg ctccagtggg catattcata cttgtctctt ttaccccagt
     1861 catttgcgaa ggacaggggc caggaatgaa gaagggtctt agattgagcc ttccccacaa
     1921 cctgaggaga actgatctca tatttctcca aggccatgtt tgtatgagca agacttgttt
     1981 tgccctaagt atgacgacta gacccaggta atcaattatg agtggaaaat caacctctag
     2041 gtgaactctg tgccagagga agcagcctcc ccagtgccca gcccctgcct ctccccatca
     2101 tgtaccagga gaggccctcc tcacggcagt gctgcagccc aggctccttc tagtcctttc
     2161 tccccaccca ccctccaaga cagtgctctt ttctcatcca gggtgttaac actactaagg
     2221 cttcaccgta atcgatcact caggatttac tcctgccctg cccactccag gctctctgaa
     2281 acacagtcaa gtgctaggca agctagctgc tgctgggaca gtgaccagca ggaaggcaag
     2341 tgctgtccgt gtgctgaatt ctggaactgc ctctgcaccg gctgagtttg ctcacctatc
     2401 cactgctaca gtcatagcaa gctcatgccg ctgtcccagc ctgtgcgagc aggcagacgg
     2461 gagcttggag atgcagcatg aggttcttcc ccaaaccact ggccatttgc tgcctctgat
     2521 tccccattgc tttggtgtac tgggctatgt attacctcct tgaaataata aaagagtaac
     2581 attttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaaa
//
