LOCUS       NM_012847               1682 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus farnesyltransferase, CAAX box, subunit alpha
            (Fnta), mRNA.
ACCESSION   NM_012847
VERSION     NM_012847.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Blanden,M.J., Suazo,K.F., Hildebrandt,E.R., Hardgrove,D.S.,
            Patel,M., Saunders,W.P., Distefano,M.D., Schmidt,W.K. and
            Hougland,J.L.
  TITLE     Efficient farnesylation of an extended C-terminal C(x)3X sequence
            motif expands the scope of the prenylated proteome
  JOURNAL   J Biol Chem 293 (8), 2770-2785 (2018)
   PUBMED   29282289
  REMARK    GeneRIF: Data suggest that substrate specificity of protein
            farnesyltransferase (subunits Fnta plus Fntb) is extensive; these
            results expand the scope of the potential prenylated proteome in
            this species. (Fnta = farnesyltransferase CAAX box alpha protein;
            Fntb = farnesyltransferase CAAX box beta protein)
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Li,Z., Sun,C., Zhang,T., Mo,J., Shi,Q., Zhang,X., Yuan,M., Chen,L.,
            Mao,X., Yu,R. and Zhou,X.
  TITLE     Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis
  JOURNAL   J Neurochem 125 (5), 698-712 (2013)
   PUBMED   23534605
  REMARK    GeneRIF: GGTase-1 mediates brain derived neurotrophic factor
            (BDNF)-induced neuronal synaptogenesis in the hippocampus.
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Zhou,J., Vos,C.C., Gjyrezi,A., Yoshida,M., Khuri,F.R., Tamanoi,F.
            and Giannakakou,P.
  TITLE     The protein farnesyltransferase regulates HDAC6 activity in a
            microtubule-dependent manner
  JOURNAL   J Biol Chem 284 (15), 9648-9655 (2009)
   PUBMED   19228685
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Zhou,X.P., Wu,K.Y., Liang,B., Fu,X.Q. and Luo,Z.G.
  TITLE     TrkB-mediated activation of geranylgeranyltransferase I promotes
            dendritic morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (44), 17181-17186 (2008)
   PUBMED   18957540
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Veluthakal,R., Kaur,H., Goalstone,M. and Kowluru,A.
  TITLE     Dominant-negative alpha-subunit of farnesyl- and geranyltransferase
            inhibits glucose-stimulated, but not KCl-stimulated, insulin
            secretion in INS 832/13 cells
  JOURNAL   Diabetes 56 (1), 204-210 (2007)
   PUBMED   17192483
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Long,S.B., Casey,P.J. and Beese,L.S.
  TITLE     Cocrystal structure of protein farnesyltransferase complexed with a
            farnesyl diphosphate substrate
  JOURNAL   Biochemistry 37 (27), 9612-9618 (1998)
   PUBMED   9657673
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Finder,J.D., Litz,J.L., Blaskovich,M.A., McGuire,T.F., Qian,Y.,
            Hamilton,A.D., Davies,P. and Sebti,S.M.
  TITLE     Inhibition of protein geranylgeranylation causes a superinduction
            of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 272 (21), 13484-13488 (1997)
   PUBMED   9153192
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Park,H.W., Boduluri,S.R., Moomaw,J.F., Casey,P.J. and Beese,L.S.
  TITLE     Crystal structure of protein farnesyltransferase at 2.25 angstrom
            resolution
  JOURNAL   Science 275 (5307), 1800-1804 (1997)
   PUBMED   9065406
  REMARK    Erratum:[Science 1997 Apr 4;276(5309):21]
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Zhang,F.L., Moomaw,J.F. and Casey,P.J.
  TITLE     Properties and kinetic mechanism of recombinant mammalian protein
            geranylgeranyltransferase type I
  JOURNAL   J Biol Chem 269 (38), 23465-23470 (1994)
   PUBMED   8089111
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Chen,W.J., Andres,D.A., Goldstein,J.L. and Brown,M.S.
  TITLE     Cloning and expression of a cDNA encoding the alpha subunit of rat
            p21ras protein farnesyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11368-11372 (1991)
   PUBMED   1763049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012847.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81225.1, BC085758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000016.1  72767864-72768120
            258-343             JAXUCZ010000016.1  72770210-72770295
            344-458             JAXUCZ010000016.1  72772486-72772600
            459-563             JAXUCZ010000016.1  72775753-72775857
            564-690             JAXUCZ010000016.1  72777549-72777675
            691-839             JAXUCZ010000016.1  72780492-72780640
            840-902             JAXUCZ010000016.1  72783969-72784031
            903-1074            JAXUCZ010000016.1  72785207-72785378
            1075-1682           JAXUCZ010000016.1  72785586-72786193
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..1682
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /note="farnesyltransferase, CAAX box, subunit alpha"
                     /db_xref="GeneID:25318"
                     /db_xref="RGD:2625"
     exon            1..257
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1191
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /EC_number="2.5.1.59"
                     /EC_number="2.5.1.58"
                     /note="FTase-alpha; GGTase-I-alpha; CAAX
                     farnesyltransferase subunit alpha; ras proteins
                     prenyltransferase subunit alpha; type I protein
                     geranyl-geranyltransferase subunit alpha;
                     Farnesyltransferase, subunit alpha; farnesyltransferase,
                     CAAX box, alpha"
                     /codon_start=1
                     /product="protein
                     farnesyltransferase/geranylgeranyltransferase type-1
                     subunit alpha"
                     /protein_id="NP_036979.2"
                     /db_xref="GeneID:25318"
                     /db_xref="RGD:2625"
                     /translation="MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAG
                     EAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDY
                     FRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIE
                     EQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDN
                     ELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESA
                     WNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDIL
                     NKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV"
     exon            258..343
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            344..458
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            459..563
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            564..690
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            691..839
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            840..902
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1074
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1682
                     /gene="Fnta"
                     /gene_synonym="PFAS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggccgcg gagggggcgg ggcctccacc accacctcag ctgcggacgg aggcgagatg
       61 gcggccactg agggggtcgg ggaatctgcg ccaggcggtg agccgggaca gccagagcag
      121 ccgccgcccc cgcctcctcc gccgccagca cagcagccgc aggaagaaga gatggcggcc
      181 gaggccgggg aagcagcggc gtcccctatg gacgacgggt ttctgagcct ggactcgccc
      241 acctatgtct tgtacaggga cagggcagag tgggctgaca tagacccagt gccccagaat
      301 gatggcccca gtccagtggt ccagatcatc tacagtgaaa agtttagaga cgtctatgat
      361 tacttccgag ctgttctgca gcgcgatgaa agaagcgaac gagcctttaa gctcactcga
      421 gatgctattg agttaaacgc agccaactat acggtgtggc attttcggag agttctcttg
      481 aggtcgcttc agaaggatct gcaagaagaa atgaactaca tcactgcaat aattgaggaa
      541 cagcccaaaa actatcaagt ttggcaccat aggagagtat tagtggagtg gctgaaagat
      601 ccttctcaag agctcgagtt catcgccgat atccttaatc aggatgcaaa gaattaccat
      661 gcctggcagc atcgacagtg ggtcattcag gagtttcgac tttgggataa tgagctgcag
      721 tatgtggacc agcttctcaa agaggatgtg agaaataact ctgtgtggaa ccaaagacac
      781 ttcgtcattt ctaataccac tggctacagt gatcgcgctg tgttggagag agaagtccaa
      841 tatactctgg aaatgatcaa attagtgcca cacaatgaga gtgcgtggaa ctacttgaaa
      901 gggattttgc aggaccgtgg tctttccaga taccctaatc tattaaacca gttgcttgat
      961 ttacaaccaa gtcacagctc cccctaccta attgcctttc ttgtggatat ctatgaagac
     1021 atgctggaaa accagtgtga caacaaggag gacattctta ataaagcact agagttatgt
     1081 gagattctag ctaaagaaaa ggacactata agaaaggaat attggagata tattggacgg
     1141 tccctccaga gtaaacacag cagagaaagt gacataccgg cgagtgtata gcagcaagag
     1201 cggctggaag aagtggacaa tgctttctaa ggcctcttat tcgggagtgt agagcggtta
     1261 gagcggtcat ctcatgcctg tgagctaacg ttgtccaggt gctgtttcta acaagaacta
     1321 aggatgactc ctgtgtgctg acgctgttca gactagctaa gagtcgattt cctaaagcaa
     1381 ggtcattgga ggggagggtg aagaaaactt tcccgtaaag gaactactgc ttttgtagtc
     1441 ttcccaacat ttaatccaat cctgtagaat cagcatctcc tgaaagacat ggtgcacggc
     1501 tgtgtgctgg gcgtggctaa gggcagctgt gtcatgggtt tgcagtcatg ggaacctcgg
     1561 agcgctgccc gggactgcat tgatgattag ggctgctggc ctcacccaca ggatcttgct
     1621 atcactgtaa ccaactaatg ccaaaagaaa ggttttataa taaaatcaca ttatctacaa
     1681 ac
//
