LOCUS       NM_001271167            4298 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus folliculin interacting protein 2 (Fnip2), mRNA.
ACCESSION   NM_001271167 XM_002725984 XM_227287
VERSION     NM_001271167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Woodford,M.R., Dunn,D.M., Blanden,A.R., Capriotti,D., Loiselle,D.,
            Prodromou,C., Panaretou,B., Hughes,P.F., Smith,A., Ackerman,W.,
            Haystead,T.A., Loh,S.N., Bourboulia,D., Schmidt,L.S., Marston
            Linehan,W., Bratslavsky,G. and Mollapour,M.
  TITLE     The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and
            enhance drug binding
  JOURNAL   Nat Commun 7, 12037 (2016)
   PUBMED   27353360
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Goberdhan,D.C., Wilson,C. and Harris,A.L.
  TITLE     Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the
            Spot
  JOURNAL   Cell Metab 23 (4), 580-589 (2016)
   PUBMED   27076075
  REMARK    Review article
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   Hasumi,H., Baba,M., Hasumi,Y., Lang,M., Huang,Y., Oh,H.F.,
            Matsuo,M., Merino,M.J., Yao,M., Ito,Y., Furuya,M., Iribe,Y.,
            Kodama,T., Southon,E., Tessarollo,L., Nagashima,K., Haines,D.C.,
            Linehan,W.M. and Schmidt,L.S.
  TITLE     Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles
            in kidney tumor suppression in cooperation with Flcn
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), E1624-E1631 (2015)
   PUBMED   25775561
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Dunlop,E.A., Seifan,S., Claessens,T., Behrends,C., Kamps,M.A.,
            Rozycka,E., Kemp,A.J., Nookala,R.K., Blenis,J., Coull,B.J.,
            Murray,J.T., van Steensel,M.A., Wilkinson,S. and Tee,A.R.
  TITLE     FLCN, a novel autophagy component, interacts with GABARAP and is
            regulated by ULK1 phosphorylation
  JOURNAL   Autophagy 10 (10), 1749-1760 (2014)
   PUBMED   25126726
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Hong,S.B., Oh,H., Valera,V.A., Baba,M., Schmidt,L.S. and
            Linehan,W.M.
  TITLE     Inactivation of the FLCN tumor suppressor gene induces TFE3
            transcriptional activity by increasing its nuclear localization
  JOURNAL   PLoS One 5 (12), e15793 (2010)
   PUBMED   21209915
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Wang,L., Kobayashi,T., Piao,X., Shiono,M., Takagi,Y., Mineki,R.,
            Taka,H., Zhang,D., Abe,M., Sun,G., Hagiwara,Y., Okimoto,K.,
            Matsumoto,I., Kouchi,M. and Hino,O.
  TITLE     Serine 62 is a phosphorylation site in folliculin, the
            Birt-Hogg-Dube gene product
  JOURNAL   FEBS Lett 584 (1), 39-43 (2010)
   PUBMED   19914239
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Komori,K., Takagi,Y., Sanada,M., Lim,T.H., Nakatsu,Y., Tsuzuki,T.,
            Sekiguchi,M. and Hidaka,M.
  TITLE     A novel protein, MAPO1, that functions in apoptosis triggered by
            O6-methylguanine mispair in DNA
  JOURNAL   Oncogene 28 (8), 1142-1150 (2009)
   PUBMED   19137017
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Takagi,Y., Kobayashi,T., Shiono,M., Wang,L., Piao,X., Sun,G.,
            Zhang,D., Abe,M., Hagiwara,Y., Takahashi,K. and Hino,O.
  TITLE     Interaction of folliculin (Birt-Hogg-Dube gene product) with a
            novel Fnip1-like (FnipL/Fnip2) protein
  JOURNAL   Oncogene 27 (40), 5339-5347 (2008)
   PUBMED   18663353
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Hasumi,H., Baba,M., Hong,S.B., Hasumi,Y., Huang,Y., Yao,M.,
            Valera,V.A., Linehan,W.M. and Schmidt,L.S.
  TITLE     Identification and characterization of a novel
            folliculin-interacting protein FNIP2
  JOURNAL   Gene 415 (1-2), 60-67 (2008)
   PUBMED   18403135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Sep 7, 2012 this sequence version replaced
            XM_002725984.3, XM_227287.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.7941.1,
                                           SRR26643294.9128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000002.1  167005896-167006055 c
            161-287             JAXUCZ010000002.1  166953820-166953946 c
            288-440             JAXUCZ010000002.1  166950904-166951056 c
            441-541             JAXUCZ010000002.1  166948529-166948629 c
            542-613             JAXUCZ010000002.1  166948360-166948431 c
            614-714             JAXUCZ010000002.1  166945320-166945420 c
            715-786             JAXUCZ010000002.1  166943530-166943601 c
            787-916             JAXUCZ010000002.1  166938534-166938663 c
            917-1118            JAXUCZ010000002.1  166932495-166932696 c
            1119-1207           JAXUCZ010000002.1  166931535-166931623 c
            1208-1354           JAXUCZ010000002.1  166927705-166927851 c
            1355-1524           JAXUCZ010000002.1  166927419-166927588 c
            1525-2854           JAXUCZ010000002.1  166919120-166920449 c
            2855-3011           JAXUCZ010000002.1  166917957-166918113 c
            3012-3212           JAXUCZ010000002.1  166903979-166904179 c
            3213-3328           JAXUCZ010000002.1  166900426-166900541 c
            3329-4298           JAXUCZ010000002.1  166897064-166898033 c
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q33"
     gene            1..4298
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /note="folliculin interacting protein 2"
                     /db_xref="GeneID:310538"
                     /db_xref="RGD:1562174"
     exon            1..160
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3407
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /codon_start=1
                     /product="folliculin-interacting protein 2"
                     /protein_id="NP_001258096.1"
                     /db_xref="GeneID:310538"
                     /db_xref="RGD:1562174"
                     /translation="MAPTLLQKLFNKRGGGAASAQARPPKEEPAFSWSCSEFDLSDIR
                     LIVYQDCERRGRQVMFDSRAVQKVEETAAQKAEDVPIKMSARCCQESGSVSSSSSSSS
                     NSSSSQSSGGSSQHAKEQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKIHYIRS
                     PPQLMISKVFSARMGSFCGSTNNLQDSFEYINQDPQAGKLNTNQNSLGPCRTGSNLAH
                     STPVDMPSRGQNEDRDSGIARSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTTSL
                     ENGIFPRRSTDETFSLAEETCSSNPSIVRRKKIAISIIFSLCEREAAQRDFQDFFFSH
                     FPLFESHMNRLKSAIEKAMISCRKISESSLRVQFYVSRLMEALGEFRGTIWNLYSVPR
                     IAEPVWLTMMSNTLEKNQLCQRFLKEFILLIEQVNKNQFFAALLTAVLTYHLAWVPTV
                     MPVDHPPIKTFSEKRTSQSVNMLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVIGKQ
                     KDLVQRILYVLTYFLRCSELQENQLTWSGNHSDDDQVINGSKIVTALEKGEVEESEYV
                     VVTVSNEPALVPPVLPPGTSERTSPEPTVVAEIPEGINTELGHKPERNRCKRPEQYSE
                     ASSMGFQEAETDNSWTPRGMFCEDKQNDQQVAQDCSSGPPSCEVPRVKRRMDQQTFHE
                     ELHGEMLKKRAERSAAWPCPDRHSQEGPPVEKVTFHIGSSISPESDFESRTKRMEERL
                     KACGHFHGASASARSSMDTGLTQDQQASGCSFKADFQKDITPQDHCLGEEGVSENRGL
                     RANIRANMAHAVGQLSQADGPLAPSTCTAESGWRQLEQTRDVQLKGNKGPSSEPVPNR
                     CRQQGDLLIAADVPYGDASGKANYRSEGDIPRNESLDSALGDSDDEACVLALLELGHN
                     CDRTEGSFEVELPLPRSQSTSKPNVRNFGRSLLAGYCATYMPDLVLHGTSSDEKLKQC
                     LAADLVHTVHHPVLDEPIAEAVCIIADTDKWTVQVATSQRKVTDAMKLGQDVLVSNQV
                     SSLLQSILQLHKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVKELSVVLG
                     IESSDLPLLTAIASTHSPYVAQILL"
     exon            161..287
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            288..440
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            441..541
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            542..613
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            614..714
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            715..786
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            787..916
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1118
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1207
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1354
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1524
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2854
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3011
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3212
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3328
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..4298
                     /gene="Fnip2"
                     /gene_synonym="RGD1562174"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttgggctg cgcgctgagc cgtcgggtcc cggagcgtgg ccgcccgggc agccgcgtgc
       61 acgccatggc cccgaccctg ctccagaagc tcttcaacaa aaggggcggc ggcgcagcgt
      121 ccgcccaggc ccggccgccc aaggaggagc cggccttcag ttggtcgtgt tcggagtttg
      181 atttgagtga cattcgcctg atagtgtacc aggactgcga gaggagaggc agacaagtca
      241 tgtttgactc cagagccgtg cagaaggtgg aagagacagc agctcagaaa gcagaggacg
      301 tccctattaa aatgtcagcg agatgctgtc aggaaagcgg cagtgtcagc agcagcagca
      361 gcagcagcag caacagcagc tcttctcaga gctctggggg atcttcacag cacgctaagg
      421 agcagcttcc aaagtaccaa tacacgagac cagcatctga tgtcaacatg cttggggaaa
      481 tgatgttcgg ctctgtcgca atgagttaca aaggctccac cctgaagata cactacatac
      541 gatctcctcc acaactgatg attagtaaag tcttctctgc tagaatgggc agcttctgtg
      601 gaagtacaaa taatctgcag gacagcttcg aatacatcaa ccaagatcct caggctggaa
      661 aactgaacac aaatcagaac agtttgggtc cttgtcgtac tggaagtaac ctagcacaca
      721 gcacacctgt tgatatgcca agcagagggc agaatgaaga cagggacagt ggcattgctc
      781 gatcagcttc actgagcagc ctgctgatca cacccttccc atctccgagc tcctctacat
      841 cctcctccag cagttaccag cgccgctggc ttcgaagtca gaccacgagt ttggaaaatg
      901 gcatctttcc aaggaggtca acagatgaaa catttagctt ggctgaagaa acctgtagct
      961 ctaatccatc catagttaga cggaagaaaa ttgccatcag tatcatcttt tccttgtgtg
     1021 agagagaggc cgcacagcgg gatttccagg acttcttttt ctcccacttc cccctgtttg
     1081 aatctcacat gaacaggctg aagagtgcaa ttgaaaaggc catgatctcc tgtaggaaga
     1141 tctctgaatc aagtctccgt gtccagtttt atgtgagccg tctgatggaa gccctgggag
     1201 aattcagagg gactatctgg aacttatatt ctgttccaag gatagctgaa ccagtgtggc
     1261 ttaccatgat gtccaacacc ttggaaaaaa accaactctg ccagcgcttt ctcaaggaat
     1321 ttatacttct gattgaacag gtcaacaaaa accagttttt cgctgcctta ctgactgcgg
     1381 tgttaaccta ccacctggcc tgggtaccaa ctgtcatgcc tgttgaccat cctcccatta
     1441 aaaccttctc ggagaagcgc acctctcagt cagtgaacat gctggccaaa acacatccat
     1501 ataatcctct ctgggcacag ctgggtgatc tttatggagc tataggctct ccagtgagac
     1561 tgactcgcac cgtggtgatt gggaagcaga aggatttggt ccagcgcatt ctttatgttc
     1621 taacctactt tctccgttgc tctgaactgc aagagaatca actgacctgg agtgggaatc
     1681 acagtgacga tgaccaggtt ataaatggga gcaagattgt aactgccttg gaaaaaggag
     1741 aggtagaaga gtctgagtat gtggtagtta cagtgagcaa tgagcctgct ctggtaccac
     1801 cagtcctacc accagggaca tctgagagga cgagccctga gcctacagta gtagctgaga
     1861 tcccagaagg cattaatacc gaactgggcc acaaacctga aagaaacaga tgcaagaggc
     1921 cagagcaata ttctgaggcc agcagcatgg ggttccaaga ggccgaaact gacaattcat
     1981 ggacacctcg aggcatgttc tgtgaggaca aacagaatga ccaacaggta gcccaggatt
     2041 gttcttcagg acctcccagc tgtgaggtgc ccagggtaaa aaggaggatg gaccaacaaa
     2101 ctttccatga agagctgcat ggcgagatgc taaagaaacg agcagagcgc tcagcagcct
     2161 ggccctgccc tgacagacat tcccaggagg gtcctcctgt tgaaaaggtc actttccaca
     2221 ttggaagttc catctctcca gagtctgact ttgaaagccg caccaaaaga atggaggagc
     2281 ggttaaaggc ctgtggacat tttcatgggg caagtgcctc tgccaggtct agcatggaca
     2341 ctggcctgac tcaagaccag caggcctctg ggtgctcctt caaagctgac tttcagaagg
     2401 acatcacacc tcaggaccac tgtttagggg aagaaggtgt ctctgagaac agaggcctcc
     2461 gagccaacat ccgagccaac atggcacatg ccgtgggaca gctgagccaa gctgatggcc
     2521 cccttgcacc ttccacttgt acagcagaaa gtggctggag acagctggaa cagactagag
     2581 atgtgcaatt aaaaggcaac aaaggacctt catcagagcc tgttccaaac agatgtagac
     2641 agcagggtga cctgctgatt gctgcagatg tcccctatgg ggatgccagt ggtaaggcca
     2701 actacaggag cgaaggagac attcccagga atgaaagctt ggatagtgct cttggagaca
     2761 gtgacgatga agcgtgtgtt ttagccctgc tagaacttgg tcacaattgt gacaggactg
     2821 aagggtcctt tgaagtggaa ctgcctctac caaggtctca gagtaccagc aagccaaatg
     2881 ttagaaattt tggccgctca cttctggcag gttactgcgc cacgtatatg cctgacttgg
     2941 tgctgcacgg aaccagcagc gatgagaagc tgaagcagtg cctggcagcc gatctggtcc
     3001 acacggtgca tcacccagtg ctcgatgagc ccatagccga agccgtctgc atcattgcag
     3061 acactgacaa gtggactgtc caggtggcca caagtcagag gaaagtgacg gacgccatga
     3121 agctgggcca ggatgtcctg gtctctaatc aggtgtccag tttactccag tccatcttac
     3181 agctccataa gcttcacctc cccgctgatt tttgcatcat gcatctggaa gacagactac
     3241 aggagatgta cctcaaaagt aaaatgcttt cagagtatct ccggggacac acacgtgtgc
     3301 acgtgaaaga gctgagcgtg gtgctgggga ttgaatccag tgacctgcct ctgctgactg
     3361 ccatcgccag cactcactct ccgtatgtgg ctcagatcct cttatagccg actgcaggac
     3421 cagaaggagg aagctctctc gatgatggca gaggcctgag aacacggacc agtcgcccgc
     3481 tcgcctgccg gcccgcccgt ccgcctgccc ctcgttattc attcgtgtgg ctgctgccta
     3541 gtggctggta cattgggagg cttgtgttta ctccatgcag tggcacattg tgattgttct
     3601 ggaacactct gagccattgt ctcccaggaa ccaaaagaaa gtagcctttc tgtgggaggg
     3661 aagcaccaca gtcaaactag gcagacaccc ccatgctgtt gagtagaata ctgagggctg
     3721 actctggagt agagggtaac cgatatctag aacattccag caggaagtgt ttcctgttca
     3781 agcagctact gttggacaca ggatgtggaa gaggatcgcc tgttgaggag agagtgctca
     3841 ggagacccgt gctcatccct tctcagagct tcctgtcatt ccagtacagc cacaggaggt
     3901 ctgaggggga ttgctggtgc agtaagccca gcagtcaggc agcatgctgt tcggagggtg
     3961 ttttggagta ctgcgtagtc cgacactggg cgctcctctc tggattccgt gtctttaggc
     4021 ttctccagag agaccattta ccaaagctgt ttccatgagc tcaggctcag gctcttctgt
     4081 ggctgagctc gtccagccca agcctctttc ctgctaacag tcagcgctga tgcctgttga
     4141 ttctgtaagg tgcagctgcc cgctggggag ggaaccctgc agctccgaca aggacagcag
     4201 gcagctcaaa cattcagaag caatccatgt gcgatctcag ttcttacatg atcagttctg
     4261 cactttttaa tccctttcat gttctttaaa aaaaaaaa
//
