LOCUS       NM_001270981            2179 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus fibronectin type III domain containing 5 (Fndc5),
            mRNA.
ACCESSION   NM_001270981 XM_002729542
VERSION     NM_001270981.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   Li,G., Jian,Z., Wang,H., Xu,L., Zhang,T. and Song,J.
  TITLE     Irisin Promotes Osteogenesis by Modulating Oxidative Stress and
            Mitophagy through SIRT3 Signaling under Diabetic Conditions
  JOURNAL   Oxid Med Cell Longev 2022, 3319056 (2022)
   PUBMED   36262283
  REMARK    GeneRIF: Irisin Promotes Osteogenesis by Modulating Oxidative
            Stress and Mitophagy through SIRT3 Signaling under Diabetic
            Conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Hu,S.L., Yang,W.C., Zuo,L.Y., Jiang,Q., Zhang,S.L. and Sun,J.Z.
  TITLE     [Effects of different types of exercise on contractile properties
            and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus muscle of
            unloaded rats]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (4), 356-360 (2022)
   PUBMED   36414561
  REMARK    GeneRIF: [Effects of different types of exercise on contractile
            properties and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus
            muscle of unloaded rats].
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Demirel,S., Sahinturk,S., Isbil,N. and Ozyener,F.
  TITLE     Irisin relaxes rat thoracic aorta through inhibiting signaling
            pathways implicating protein kinase C
  JOURNAL   Turk J Med Sci 52 (2), 514-521 (2022)
   PUBMED   36161624
  REMARK    GeneRIF: Irisin relaxes rat thoracic aorta through inhibiting
            signaling pathways implicating protein kinase C.
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Hu,C., Zhang,X., Hu,M., Teng,T., Yuan,Y.P., Song,P., Kong,C.Y.,
            Xu,S.C., Ma,Z.G. and Tang,Q.Z.
  TITLE     Fibronectin type III domain-containing 5 improves aging-related
            cardiac dysfunction in mice
  JOURNAL   Aging Cell 21 (3), e13556 (2022)
   PUBMED   35166002
  REMARK    GeneRIF: Fibronectin type III domain-containing 5 improves
            aging-related cardiac dysfunction in mice.
REFERENCE   5  (bases 1 to 2179)
  AUTHORS   Yu,Q., Li,G., Li,J., Sun,L., Yang,Y. and Tao,L.
  TITLE     Irisin Protects Cerebral Neurons from Hypoxia/Reoxygenation via
            Suppression of Apoptosis and Expression of Pro-Inflammatory
            Cytokines
  JOURNAL   Neuroimmunomodulation 29 (4), 425-432 (2022)
   PUBMED   35705003
  REMARK    GeneRIF: Irisin Protects Cerebral Neurons from
            Hypoxia/Reoxygenation via Suppression of Apoptosis and Expression
            of Pro-Inflammatory Cytokines.
REFERENCE   6  (bases 1 to 2179)
  AUTHORS   Roberts,M.D., Bayless,D.S., Company,J.M., Jenkins,N.T., Padilla,J.,
            Childs,T.E., Martin,J.S., Dalbo,V.J., Booth,F.W., Rector,R.S. and
            Laughlin,M.H.
  TITLE     Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF
            rats
  JOURNAL   Metabolism 62 (8), 1052-1056 (2013)
   PUBMED   23498898
  REMARK    GeneRIF: Further research is needed to examine whether other
            adipose tissue-derived factors up-regulate FNDC5 transcription
            and/or inhibit irisin biosynthesis from FNDC5
REFERENCE   7  (bases 1 to 2179)
  AUTHORS   Dun,S.L., Lyu,R.M., Chen,Y.H., Chang,J.K., Luo,J.J. and Dun,N.J.
  TITLE     Irisin-immunoreactivity in neural and non-neural cells of the
            rodent
  JOURNAL   Neuroscience 240, 155-162 (2013)
   PUBMED   23470775
  REMARK    GeneRIF: This immunohistochemical results demonstrate the
            expression of irisin immunoreactivity in three types of cells:
            skeletal, cardiac muscle, and Purkinje cells of the cerebellum.
REFERENCE   8  (bases 1 to 2179)
  AUTHORS   Bostrom,P., Wu,J., Jedrychowski,M.P., Korde,A., Ye,L., Lo,J.C.,
            Rasbach,K.A., Bostrom,E.A., Choi,J.H., Long,J.Z., Kajimura,S.,
            Zingaretti,M.C., Vind,B.F., Tu,H., Cinti,S., Hojlund,K., Gygi,S.P.
            and Spiegelman,B.M.
  TITLE     A PGC1-alpha-dependent myokine that drives brown-fat-like
            development of white fat and thermogenesis
  JOURNAL   Nature 481 (7382), 463-468 (2012)
   PUBMED   22237023
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2179)
  AUTHORS   Teufel,A., Malik,N., Mukhopadhyay,M. and Westphal,H.
  TITLE     Frcp1 and Frcp2, two novel fibronectin type III repeat containing
            genes
  JOURNAL   Gene 297 (1-2), 79-83 (2002)
   PUBMED   12384288
REFERENCE   10 (bases 1 to 2179)
  AUTHORS   Ferrer-Martinez,A., Ruiz-Lozano,P. and Chien,K.R.
  TITLE     Mouse PeP: a novel peroxisomal protein linked to myoblast
            differentiation and development
  JOURNAL   Dev Dyn 224 (2), 154-167 (2002)
   PUBMED   12112469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001270981.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001270981.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.24727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JACYVU010000162.1  56033002-56033099
            99-214              JACYVU010000162.1  56034700-56034815
            215-413             JACYVU010000162.1  56035500-56035698
            414-503             JACYVU010000162.1  56036006-56036095
            504-637             JACYVU010000162.1  56038004-56038137
            638-2179            JACYVU010000162.1  56038489-56040030
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2179
                     /gene="Fndc5"
                     /note="fibronectin type III domain containing 5"
                     /db_xref="GeneID:260327"
                     /db_xref="RGD:708525"
     exon            1..98
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..643
                     /gene="Fndc5"
                     /note="peroxisomal protein; fibronectin type III
                     domain-containing protein 5"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 5
                     precursor"
                     /protein_id="NP_001257910.1"
                     /db_xref="GeneID:260327"
                     /db_xref="RGD:708525"
                     /translation="MPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKA
                     NSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHV
                     QAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLF
                     MWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI"
     exon            99..214
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
     exon            215..413
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..503
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
     exon            504..637
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
     exon            638..2179
                     /gene="Fndc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtaggagcc gccatgcccc cagggccgtg cgcctggccg ccccgcgccg ctctccggct
       61 gtggctgggc tgcgtgtgct tcgcgctggt gcaggcggac agcccctcgg cccccgtgaa
      121 cgtaaccgtc aggcacctca aggccaactc ggcagtggtc agctgggacg tcctggagga
      181 cgaggttgtc atcggctttg ccatctctca gcagaagaag gatgtgagga tgctgcgctt
      241 cattcaggag gtgaacacca ccacccgatc ctgcgctctc tgggacctgg aggaggacac
      301 agagtatatc gtccacgtgc aggccatctc catccagggc cagagcccag ccagtgagcc
      361 cgtgctcttc aagaccccac gtgaggccga gaagatggcc tctaagaaca aagatgaggt
      421 gaccatgaag gagatgggga ggaaccagca gctgcggacg ggcgaggtgc tgatcatcgt
      481 cgtggtcctc ttcatgtggg caggtgtcat agctctcttc tgccgccagt atgacatcat
      541 caaggacaac gagcccaata acaacaagga aaaaaccaag agtgcatcag agaccagcac
      601 cccagagcac cagggtgggg gtctcctccg aagcaagata tgaaaccctt tcagtgcttg
      661 ctctgagcag ctcagaagta gaatgcgaga ggacctcact gttctgacga tgattgtcca
      721 acacacatcc ggccctctcc gtgtctcctc ccaccaccat cttctcctat caccgggctt
      781 actatcttct ctcctggctt tcctctttct gatggcggtt cctgaagcct ccaactaacc
      841 cctaactcgg ggagcgcctc gacagtgttt gtggctaagg ctacactcag agacagagtt
      901 gcagaatgag ggagacccag cccgagggac gccattgctg ggaggtagac tgggtgcgag
      961 ggcccttggc acaggactca catctgggct gttcagcttg accgaaggct gtgtgtgaaa
     1021 ggggaaaaag acaagattgc caggcagggc tgttgttttt gtggcttcga gggacaagaa
     1081 cctggctaaa aggcagcagc cctgctgttc tttttctcct ctgtcctgtt tcctacctta
     1141 caagaagtcc atgcaaccaa ccggggctct ggcacttttc ttgtttattt ccctcctggc
     1201 ttccaaacaa gccctctgtg gacatcatca aagcatggat aaccccctct gcaggggtgg
     1261 gcttcattct ccgctggtcc ctgtagcctt cctggacaca gggtgaaagt tgtaaaagtg
     1321 gtaggagtgc agctagccac aggttctcct tttccccatc tcagtctgac gaaggaggct
     1381 gaactacgaa cccaaattca gcaaaaaaaa aaaaaaaaaa aaaaaaaagt cacaaagtta
     1441 tttgcacaag gctgcacccc attctgaaga aggcacaagt ccgtgagaca gagccctgcc
     1501 ttacctcccc tggactggct tcctctttga gaaaaggcac aaagccctgg gagagagcaa
     1561 gcaccaagac tgactggagc tgtgtctgtc agactcatgg cactagggag gctgcagggc
     1621 cacctgcttt tcagggttcc gactccatca aacactttcc ggacccagac atcgagggca
     1681 tctgtgggat gaggtcccct ttgcaaatgt ggatgatacc ggtcatttga ctcttagaaa
     1741 acacaaccag agggctgctc tccagaacgc agagggctct gccaaggcct gagacggctg
     1801 cttgcatctg tctcgcacaa agatagatct ttgtggtgag atcatcagtg tggagttttg
     1861 agaagatctg gaaggtactg cccactttta aaggaagtgc ctcggctgtg gataactgaa
     1921 aacatctacg tcctacaccc tggaggctgc ggagcaagct gctgggacag gcagagagca
     1981 gccattgtca ctactggcct gggggggggg gggtctttgg atcttgccaa atgagaattc
     2041 ggggtcctct gaaagctacc cagggttctc atcttcccta gagcttgtag tgtaaagtga
     2101 cagctagtgt gtgcgcgcgc tctctcgctc tctctccttc tccctctctc tctccctatt
     2161 ccctcccctc ctctcctct
//
