LOCUS       NM_001412560            6349 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fibronectin type III domain containing 1 (Fndc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001412560 XM_006227871
VERSION     NM_001412560.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6349)
  AUTHORS   Deng,A.Y., Chauvet,C. and Menard,A.
  TITLE     Alterations in Fibronectin Type III Domain Containing 1 Protein
            Gene Are Associated with Hypertension
  JOURNAL   PLoS One 11 (4), e0151399 (2016)
   PUBMED   27064407
  REMARK    GeneRIF: Mutations in Fndc1 gene is associated with Hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6349)
  AUTHORS   Sato,M., Jiao,Q., Honda,T., Kurotani,R., Toyota,E., Okumura,S.,
            Takeya,T., Minamisawa,S., Lanier,S.M. and Ishikawa,Y.
  TITLE     Activator of G protein signaling 8 (AGS8) is required for
            hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma
            and connexin 43 (CX43)
  JOURNAL   J Biol Chem 284 (45), 31431-31440 (2009)
   PUBMED   19723622
  REMARK    GeneRIF: AGS8 is required for hypoxia-induced apoptosis of
            ardiomyocytes.
REFERENCE   3  (bases 1 to 6349)
  AUTHORS   Sato,M., Cismowski,M.J., Toyota,E., Smrcka,A.V., Lucchesi,P.A.,
            Chilian,W.M. and Lanier,S.M.
  TITLE     Identification of a receptor-independent activator of G protein
            signaling (AGS8) in ischemic heart and its interaction with
            Gbetagamma
  JOURNAL   Proc Natl Acad Sci U S A 103 (3), 797-802 (2006)
   PUBMED   16407149
  REMARK    GeneRIF: Activator of G protein signaling 8 (AGS8, KIAA1866) has
            been isolated from a rat heart model of repetitive transient
            ischemia. AGS8 appears to promote G protein signaling by a
            mechanism that involves direct interaction with G-protein betagamma
            [AGS8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 6, 2022 this sequence version replaced XM_006227871.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.561.1, SRR26643295.592.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000001.1  49686856-49687154
            300-494             JAXUCZ010000001.1  49707688-49707882
            495-581             JAXUCZ010000001.1  49710948-49711034
            582-650             JAXUCZ010000001.1  49711667-49711735
            651-857             JAXUCZ010000001.1  49720976-49721182
            858-956             JAXUCZ010000001.1  49724477-49724575
            957-1074            JAXUCZ010000001.1  49726433-49726550
            1075-1262           JAXUCZ010000001.1  49729231-49729418
            1263-1370           JAXUCZ010000001.1  49730262-49730369
            1371-1559           JAXUCZ010000001.1  49733216-49733404
            1560-3971           JAXUCZ010000001.1  49735102-49737513
            3972-4072           JAXUCZ010000001.1  49739036-49739136
            4073-4184           JAXUCZ010000001.1  49742430-49742541
            4185-4631           JAXUCZ010000001.1  49743453-49743899
            4632-4700           JAXUCZ010000001.1  49750117-49750185
            4701-4844           JAXUCZ010000001.1  49752146-49752289
            4845-5075           JAXUCZ010000001.1  49755182-49755412
            5076-5184           JAXUCZ010000001.1  49757523-49757631
            5185-5264           JAXUCZ010000001.1  49761608-49761687
            5265-5294           JAXUCZ010000001.1  49764803-49764832
            5295-5456           JAXUCZ010000001.1  49765946-49766107
            5457-5579           JAXUCZ010000001.1  49767042-49767164
            5580-6349           JAXUCZ010000001.1  49768494-49769263
FEATURES             Location/Qualifiers
     source          1..6349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..6349
                     /gene="Fndc1"
                     /note="fibronectin type III domain containing 1"
                     /db_xref="GeneID:308099"
                     /db_xref="RGD:1310640"
     exon            1..299
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..5695
                     /gene="Fndc1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibronectin type III domain-containing protein
                     1; activator of G-protein signaling 8; fibronectin type
                     III domain containing 1 protein"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001399489.1"
                     /db_xref="GeneID:308099"
                     /db_xref="RGD:1310640"
                     /translation="MAPEARASPRLLLRAALLLLAALLPVASSAGPPVDHPLKPRHVK
                     LLSANMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGV
                     VYFVLVTAENHSGVSRPVYRAESPPGGEWIKIDGFPNKGPGPFNETITEKEVPNKPLR
                     MRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERSHEIKK
                     LASESVYVVSLQSTNSQGQSQPVYRAALTKRKNAEEDELDVPEDISVRVMSSQSVLVA
                     WVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRALVDSLIPDTVYEFAVRI
                     SQGERDGKWSASVFQRTPESAPTTAPENLRVWPVNGKPTVVTVSWDALPESEGKVKEY
                     ILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGQGPHSKAFIVA
                     IPTTSSTEASVQPNGRDNGKPEKPQQPSSSAPKVAASSQHMPPAKNVKDALSDLKNKI
                     QTNGVAPGRTQLHSKVGELDPQSTEVTGEEELDSLENPRSSRLETLNQKQPLRVPSRS
                     GHGALAPGRTPARAGLPVLSRKEGMDRRGPSLDPHPHPRVEPSASSAYHQLSSTDNDS
                     VDRKEDDQAGSPDPKAASSGSSPKNPGRSRPTSAPSRHAASNMLRDKSRVHPGTKAAS
                     SSTSRQSHSSTSEEDSSAQPSRHFPLHRGSSTSPLSRGWKDRQDTHASSSHTTSRTAS
                     SSHPSALTEGSEEEDGGADSDRAAEDTIRRAEATAQIQQTRPGLGHFSLIRNKPFTPH
                     SRNPNRFPRLRGPRLQPSVSPQSTSASKVLTRSPSLPASHTRPGSDVYGDGEDEEPLP
                     ATVINDRTPSYPRHPISGSSDTLRRGPQRGASLYRKEPIPENSKAAGADVPPGGRSPL
                     SSKAQGFQQSTTDEGAPQTSPASTSRQPSPARPPASRSQPSPGSTVPRRMTPDRSSEL
                     SSSQSKDRSLSQPKLSVAHAGHDHPHTANSRGVLPSAPQNQNEGAQSTYEDNSTEIEG
                     PDSRTPTHSARAKDTTPPILKPRQVGSQSWSSDNRPQPSQAGASERPIRPGSTHPRAQ
                     VPGRAGVQATSVKKVSPSKRPLPLESQQSVFAEEEEENEGMLKGKEDSLSTSVKKWPS
                     SSSPRDKYADRNLDKDKAAIGLLVQEENTVPGRRPPGSPAIASHPSTRHQPRNPATAS
                     PIANTHSWPRYTTRAPSSYSSTTPMLSLRQRMQRRFRTPVSRQPPPPRPVLTPGYNGR
                     PNAEENIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL
                     GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLEVVRTT
                     TQVPTTTMPPSTTTTTVPPTTTLPPTTTTTRRTTTTRRTTTTRRPTTTTRATRRTTTT
                     TTTPEPTTPSPTCPPGTLEHRDEAGNLIMGSNGIPECYPEEDDFSGLEIDTALPTEED
                     YVVYDDDYGLETTRPPTSTMPSTTAATPKVVPEQGTVSSFPEEEFDLAGKRRFVAPYV
                     TYLSKDPAAPCSLTDALDHFQVESLDELIPNDLTKNDLPPQHAPRNITVVAMEGCHSF
                     VIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQ
                     AKNPHGYGPVSPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPGYTDCHGRQYVKR
                     TWYKKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQS
                     YVEALPTIQGYYRQYRQEPVSFGHIGFGTPYYYVGWYECGVSIPGKW"
     exon            300..494
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..581
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..650
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..857
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..956
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1074
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1262
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1370
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1559
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..3971
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4072
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4184
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4631
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4700
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4844
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4845..5075
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5184
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5264
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5265..5294
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5295..5456
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5579
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5580..6349
                     /gene="Fndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcagcg ggtggcctca gtggcggagc gcggccgcgg tgcgtgaccg ggagcggtcg
       61 ccgaggggct gcagcgccgc tggcacagga caccggacgc ccggccacgg gcacccgacg
      121 cgttgctctg cacttccctc actgcggtcc gcgccctgcc cgccacccac gctcggtccc
      181 cacgcattcc gggctcccga tggcccccga ggccagggcg tccccgcgcc tgctgctcag
      241 ggcggcgctg cttctcctgg cggcgctgct ccctgtagct tcctcagcgg gacccccagt
      301 tgaccaccca ctgaagccaa ggcatgtgaa actgctgtcc gctaacatgg gcctgaaggt
      361 cacatgggac ccacccaaag acgctaccag tagacccgtg gaacattaca acattgccta
      421 tgggaagtca ctgaaaagtc ttaagtccat caaggtgaat gcggagacac actccttcct
      481 tattaaagac gtggagccag gggtggtgta ctttgtgctg gttaccgcag agaaccacag
      541 cggagtgagc cgccctgttt acagagctga gagcccaccc ggaggtgaat ggatcaagat
      601 agatggtttt cccaacaagg gtccaggacc atttaatgag accattacag aaaaggaagt
      661 gcccaacaag cccttgcgta tgcgcgtccg agcctcagat gacaggctgt ctgttgcatg
      721 gaaggcacca cgtctgtctg gagccaagag cccacggaga tctcggggtt ttcttctggg
      781 ctacggggaa agtggccgga agatgaatta tgtcccactg accagagatg agagatcgca
      841 tgaaattaaa aagcttgcct ctgagtcggt gtatgtggtc tccctgcagt ccacaaactc
      901 ccaggggcag agtcagcccg tctatagagc tgccctcaca aagcgcaaga atgcagaaga
      961 ggatgaactg gatgtacctg aagacattag tgtccgggtc atgtcgtctc agtccgtgct
     1021 cgtggcctgg gtggatcctc ttgtggaaaa acagaagaga gttgttgcat caagacagta
     1081 cactgtgcgc taccgtgaga agggggagtc ggccaggtgg gattacaagc aagtctccaa
     1141 caggcgtgca ctggtggaca gcctgatccc agacaccgtg tatgaatttg cggtccgtat
     1201 ttcacaagga gagcgagatg gcaagtggag cgcatctgtc ttccagagaa cgccggaatc
     1261 ggctcccacc acagcgcctg agaacctgag agtctggcca gtcaacggca agcccacggt
     1321 tgtcaccgta tcctgggatg cattgccaga gtctgagggg aaagtgaaag aatacattct
     1381 ttcatatgcc ccggctctca aaccgtttgg agcaaagtcc ctcaccttct ctggacatac
     1441 tacttctgcc ctcgtggacg gtctgcagcc tggggaacgc tatctgttca aaatccgggc
     1501 cacaaacagg agaggccagg ggccacactc caaagccttc attgtcgcta taccaacaac
     1561 cagttctact gaagccagtg tccagccgaa tgggagagac aatgggaaac ctgagaaacc
     1621 acagcaacct tcttcctctg ctcccaaagt tgcagcctcc tcacaacaca tgcccccagc
     1681 caaaaatgtc aaggatgctc tctcggactt aaagaacaaa atccagacta atggtgtggc
     1741 gcccggaaga acccagcttc actctaaagt gggtgagctg gatcctcagt ccacagaagt
     1801 cactggcgag gaggaactgg attcccttga aaatcctcgt tcatcacggt tggagaccct
     1861 aaaccagaag caacccttga gggtaccaag tagatctggt catggggctc tggctcctgg
     1921 caggactcca gccagggctg gcctgccagt gctgtcccgc aaggaaggga tggacaggcg
     1981 tggcccctca ctggaccccc atcctcatcc tagggttgaa ccttcagctt cttctgccta
     2041 ccaccagctc agctctacag acaatgattc tgtggaccga aaggaggatg atcaagcagg
     2101 atcccctgac cctaaagctg cctcttccgg gtcatctccc aagaatccag gcaggtccag
     2161 gccaacctct gcccctagcc gccatgcggc ttctaacatg ctcagagaca aaagccgggt
     2221 acacccaggt acaaaggcag catcatcatc tacgtcgagg cagtctcatt cttccaccag
     2281 tgaggaagac tccagtgccc aaccctcgag acatttccca ctgcatagag gatcttctac
     2341 atccccgctt tctaggggct ggaaggaccg ccaggatacc catgcctcta gttcccatac
     2401 gacttcccgg accgccagct cttctcatcc ctctgccctg acagagggct ctgaggaaga
     2461 ggatggcggc gctgatagtg acagagctgc agaagacacc atcaggcggg ctgaggccac
     2521 tgctcagatc caacagaccc ggcctggctt gggtcacttt agtttgatac ggaataaacc
     2581 cttcactcct cacagcagaa atccaaacag attccccagg ctccgtggac caaggcttca
     2641 gccttctgtg tctcctcagt ctacctcagc ctcgaaagtc ctcaccaggt ctccttcgct
     2701 gccagcatcc cacactaggc ctggctctga tgtctatgga gatggtgagg atgaagagcc
     2761 tcttccagcc actgtgatca atgaccgtac accttcctat cccaggcacc caatctctgg
     2821 cagctcagac actctgagaa gaggtcccca gagaggggcc agcttgtacc ggaaggagcc
     2881 catcccagaa aactccaaag ctgctggagc ggatgtacct cctgggggca gatcccctct
     2941 gtcctccaag gctcagggct ttcaacagag caccaccgat gaaggtgctc ctcaaacatc
     3001 cccagcatcc accagccgcc agccgtcgcc tgctagacct ccagcatcaa gatcacagcc
     3061 ctcccccggg tccactgttc ccagaagaat gacacccgat cgcagctcag aactctctag
     3121 ttctcagagc aaggatcggt cactttccca gcccaagctg tccgtcgctc acgcagggca
     3181 tgaccaccct cacactgcaa actcccgtgg ggtgctcccc tcagctcccc agaatcagaa
     3241 tgagggtgcc cagagcacct acgaggacaa cagcactgaa attgagggtc cagactcccg
     3301 gactcccact cattcagctc gagccaagga taccactcca cccattctca aacctcggca
     3361 ggtgggctcc cagtcatgga gcagtgacaa cagacctcag cccagccagg caggagcctc
     3421 tgaaagaccc atccggcctg gcagcaccca cccacgggcc caggttcctg gcagggctgg
     3481 ggtccaggcc acgtcagtga agaaggtctc accttccaag cggcccctgc cactcgaatc
     3541 tcagcaatcg gtcttcgctg aggaggaaga ggaaaacgaa ggaatgttaa aaggcaaaga
     3601 agattctctg tctacctcag ttaaaaagtg gccttcttcc tcctccccgc gggacaagta
     3661 cgcagacagg aaccttgaca aagacaaggc tgccattggc ctccttgtac aggaagagaa
     3721 caccgtcccc ggaaggcgac caccaggcag ccccgcaata gcctcacacc catctacccg
     3781 gcaccagcct cgaaatcccg ccactgcaag tcccatcgca aacacacact cctggccaag
     3841 gtataccacc cgggcccctt ccagctactc ctccaccaca ccgatgctct ccttgcggca
     3901 gcggatgcag cggaggttta ggacgccagt ctcgcgccag cctccaccgc ccagacccgt
     3961 gcttacacca ggttataatg gaagaccaaa tgcagaagag aacatacctc ctggtagtat
     4021 tggaaaacca aacggacaga gaattattaa tggtcctcaa ggaacaaagt gggttgtaga
     4081 cctggatcgt ggcttggtgt tgaatgcaga agggcggtac ctccaagact cccacggcaa
     4141 tcctctccgg gtgagactcg ggggagacgg tcgcaccatc gtggatcttg gaggaacccc
     4201 tatggtgagt cccgatggcc tccccctgtt tgggcaggga agacatggca aacctgtggc
     4261 cagtgcccag gataaaccca tcttgagtct tggagggaag cccttagtgg gcttggaagt
     4321 ggtcagaaca accacccaag ttcctaccac aaccatgccg ccaagcacaa cgaccaccac
     4381 tgtgccgccc accacaaccc tgccgcccac aaccaccacc acccgccgga ccaccaccac
     4441 ccgccggacc accaccacca ggcgtcccac aaccacaacc cgagctactc gcaggacaac
     4501 taccactacc accactccgg aacctaccac cccctctcct acctgtcctc ctgggaccct
     4561 ggaacaccgg gatgaagctg gcaacctcat aatgggctca aatgggatcc cagagtgcta
     4621 ccccgaggaa gatgacttct ccggcctgga gatagacaca gcactaccca cggaagagga
     4681 ttatgttgtg tacgatgacg attatggact tgagaccaca aggccaccga ccagcaccat
     4741 gccctcaacc actgctgcca caccgaaggt cgtcccagag cagggcactg tcagctcctt
     4801 cccagaggaa gaatttgacc ttgccggaaa gaggcggttt gttgctcctt acgtgaccta
     4861 cctcagtaaa gacccagcag ccccgtgctc actgactgat gccctggacc acttccaagt
     4921 ggaaagcctg gatgaactta ttccaaatga cttgacaaag aacgatctcc ctcctcagca
     4981 tgctccccgg aacattactg tggtcgccat ggaaggctgc cactcctttg tcattgtgga
     5041 ctggaacaaa gccatccctg gagatgtggt aacaggatac ctggtctaca gcgcctctta
     5101 tgaggacttc atcaggaata aatggtcaac tcagacctcg tcagtgaccc atttgcccat
     5161 tgagaacctg aagccaaaca caaggtatta cttcaaagtt caagcgaaaa accctcacgg
     5221 ctatgggcct gtcagccctt cagtctcatt tgtcacagaa tcagacaatc ctctgctggt
     5281 tgtgaggcca ccaggtggtg agcccatctg gatcccgttt gctttcaagc atgaccccgg
     5341 ctacactgac tgccatggtc ggcagtatgt gaaacggacg tggtacaaaa agtttgtggg
     5401 agttgttctt tgtaattctc taaggtacaa gatctacctc agtgacaatc tcaaagacac
     5461 attctacagc attggggaca gctggggaag gggtgaagac cattgtcagt ttgtggattc
     5521 gcacctggat ggaagaacgg ggcctcagtc ttatgtagaa gccctcccca ccattcaagg
     5581 ctactatcgc cagtaccgtc aggagcccgt cagctttgga cacattggat ttggaacccc
     5641 ctattactat gtgggctggt acgagtgtgg agtctccatc ccaggaaagt ggtaaccaca
     5701 ggatgggcct gctgcaagtt catcttccca gcctgtgtga ctaacccaca ctagggactc
     5761 tgggcaaaag aaagacagtg ctccaagccc actgtcccgg tgcatcagga ggccacacgg
     5821 tggacatggc attttgtcct cttcagttgg aatttggcca catttcttgg tctggattat
     5881 acatgcaatt ccgttttgct gaaacttcac ttcttgtttg cactttgtct gtaatcacac
     5941 attccagaga catcaaccct gcagaggatc cagggtgatt tccagactct tcaggcacaa
     6001 aacctggatg ctccgggatc tccagggaac agcattggtg tgctctgtcc gcctcacaga
     6061 atgctctctg cttctctctt cttcaaagca gccaagttta agcttcaccc atctttgtat
     6121 gaagtagaat tgaatcgctg aaatcactga cggaagtaca acctctttga gatttatcct
     6181 aaagacttat ccaccactgg gctaagtgcc tcaaatctta tttgtaaatt ctcaattttg
     6241 atatatatat gtgtgtgtat atatgcatat acatgttcac actcatcaag aatatcgatt
     6301 aaacttgtgc taaatttata gttgttcttt agataaatgc gtgcaagac
//
