LOCUS       NM_001039609            5429 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus formin binding protein 1-like (Fnbp1l), mRNA.
ACCESSION   NM_001039609 XM_227658
VERSION     NM_001039609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5429)
  AUTHORS   Chander,H., Brien,C.D., Truesdell,P., Watt,K., Meens,J., Schick,C.,
            Germain,D. and Craig,A.W.
  TITLE     Toca-1 is suppressed by p53 to limit breast cancer cell invasion
            and tumor metastasis
  JOURNAL   Breast Cancer Res 16 (6), 3413 (2014)
   PUBMED   25547174
  REMARK    GeneRIF: Loss of p53 tumor suppressor function in breast cancers
            leads to upregulation of Toca-1, and results in enhanced risk of
            developing metastatic disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5429)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5429)
  AUTHORS   Cao,J., Shen,Y., Zhu,L., Xu,Y., Zhou,Y., Wu,Z., Li,Y., Yan,X. and
            Zhu,X.
  TITLE     miR-129-3p controls cilia assembly by regulating CP110 and actin
            dynamics
  JOURNAL   Nat Cell Biol 14 (7), 697-706 (2012)
   PUBMED   22684256
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5429)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5429)
  AUTHORS   Giuliani,C., Troglio,F., Bai,Z., Patel,F.B., Zucconi,A.,
            Malabarba,M.G., Disanza,A., Stradal,T.B., Cassata,G.,
            Confalonieri,S., Hardin,J.D., Soto,M.C., Grant,B.D. and Scita,G.
  TITLE     Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics
            and membrane trafficking during Caenorhabditis elegans oocyte
            growth and embryonic epidermal morphogenesis
  JOURNAL   PLoS Genet 5 (10), e1000675 (2009)
   PUBMED   19798448
REFERENCE   6  (bases 1 to 5429)
  AUTHORS   Takano,K., Toyooka,K. and Suetsugu,S.
  TITLE     EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane
            curvature-dependent actin polymerization
  JOURNAL   EMBO J 27 (21), 2817-2828 (2008)
   PUBMED   18923421
  REMARK    GeneRIF: N-WASP-WIP complex-mediated actin polymerization is
            activated by phosphatidylserine-containing membranes depending on
            membrane curvature in the presence of Toca-1 or FBP17 and in the
            absence of Cdc42 and phosphatidylinositol (4,5)-bisphosphate.
            Erratum:[EMBO J. 2008 Dec 17;27(24):3332. Takano, Kazunari
            [corrected to Takano, Kazunori]]
REFERENCE   7  (bases 1 to 5429)
  AUTHORS   Kakimoto,T., Katoh,H. and Negishi,M.
  TITLE     Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein
            that induces plasma membrane invagination
  JOURNAL   J Biol Chem 281 (39), 29042-29053 (2006)
   PUBMED   16885158
  REMARK    GeneRIF: a vesicle trafficking regulator Toca-1 regulates different
            aspects of neuronal morphology from N-WASP
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_001039609.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760389, SAMEA5760393
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000002.1  213422857-213423051 c
            196-311             JAXUCZ010000002.1  213385828-213385943 c
            312-365             JAXUCZ010000002.1  213364355-213364408 c
            366-513             JAXUCZ010000002.1  213363171-213363318 c
            514-576             JAXUCZ010000002.1  213362334-213362396 c
            577-681             JAXUCZ010000002.1  213357425-213357529 c
            682-810             JAXUCZ010000002.1  213354368-213354496 c
            811-957             JAXUCZ010000002.1  213352631-213352777 c
            958-1161            JAXUCZ010000002.1  213351438-213351641 c
            1162-1320           JAXUCZ010000002.1  213350014-213350172 c
            1321-1335           JAXUCZ010000002.1  213345647-213345661 c
            1336-1445           JAXUCZ010000002.1  213342780-213342889 c
            1446-1578           JAXUCZ010000002.1  213340536-213340668 c
            1579-1673           JAXUCZ010000002.1  213339970-213340064 c
            1674-1822           JAXUCZ010000002.1  213337791-213337939 c
            1823-5429           JAXUCZ010000002.1  213331871-213335477 c
FEATURES             Location/Qualifiers
     source          1..5429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..5429
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /note="formin binding protein 1-like"
                     /db_xref="GeneID:310839"
                     /db_xref="RGD:1305386"
     exon            1..195
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2001
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /note="Cdc42 effector; transducer of Cdc42-dependent actin
                     assembly protein 1"
                     /codon_start=1
                     /product="formin-binding protein 1-like"
                     /protein_id="NP_001034698.1"
                     /db_xref="GeneID:310839"
                     /db_xref="RGD:1305386"
                     /translation="MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAK
                     QLRNLVKKYCPKRSSKDEEPRFTSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELM
                     RYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDND
                     TNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEM
                     DERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFE
                     PPGDFPFEDYSQHIYRTVSDGTISASKQEGGKMDSKSTAGKAKGKLWLFGKKPKPQSP
                     PLTPTSLFTSSPPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSMKMGPAL
                     EDFSHLPPEQRRKKLQQRIDELNRGLQKESDQKEALNKMKDVYEKNPQMGDPGSLQPK
                     LAETMNNIDRLRMEIHKNEAWLSEVEGKTGVRGDRRHSSDINHLVTQGRESPEGSYTD
                     DANQEVRGPPQQHGHHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLY
                     IIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLEKNSKGAVTYI"
     exon            196..311
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..365
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..513
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..576
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..681
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..810
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..957
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1161
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1320
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1335
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1445
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1578
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1673
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1822
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..5429
                     /gene="Fnbp1l"
                     /gene_synonym="RGD1305386; Toca-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggacgcg gcggcagctc gcttcagtcg tgtctctctc actcactggg gaacccggtg
       61 gtggcggcag ctttcgaggc agacacttgc cggcccggtc ctgagaaggg aaagtcgggg
      121 cgagcggaca gcgggagcag cctgccggcg ccagtcgcct taggttccgc catgagctgg
      181 ggcaccgagc tgtgggatca gttcgatagc ttagataagc atacccaatg gggaattgac
      241 ttcttggaaa gatacgccaa gtttgttaaa gagagaattg aaattgaaca gaactatgcg
      301 aaacaattga gaaatttggt taagaagtac tgtcccaaac gctcgtccaa agatgaagag
      361 ccaaggttta cttcatgtat cgcctttttt aacatcctta atgagttaaa cgactatgca
      421 ggacagcgag aggtagtagc agaagaaatg gcacacagag tatatggtga actaatgaga
      481 tatgcccatg acctgaaaac ggaaagaaaa atgcatcttc aagaaggacg aaaagctcaa
      541 caatacctag acatgtgttg gaaacagatg gataatagta aaaagaaatt tgaaagagaa
      601 tgtagagagg ctgagaaagc acagcagagt tatgaaagac tggataatga tacaaatgca
      661 accaaggcag atgttgaaaa ggccaagcag cagctgaacc tccgcacgca catggctgac
      721 gagaataaaa acgaatacgc cgcgcagctg cagaacttca acggggagca gcacaagcat
      781 ttctacgtgg tgattcctca gatttacaag caactacaag aaatggatga acgaaggaca
      841 attaaactca gtgaatgtta cagagggttt gcagactcag aacgcaaagt tatccccatc
      901 atctcgaaat gtctagaagg aatgattctt gcagcaaaat cagttgatga gagaagagac
      961 tctcaaatgg tagtagactc gttcaagtct ggctttgaac ccccaggaga ctttccattt
     1021 gaagattata gtcagcacat ttacaggacc gtttctgatg ggaccatcag tgcctccaaa
     1081 caggagggtg gcaagatgga ttccaagtcc acagcaggga aggccaaggg caaactgtgg
     1141 ctctttggaa agaagccaaa gccacagtcc ccacccttaa cccctactag tttattcaca
     1201 tccagtcctc ctaatgggtc ccagtttctc acactctcca ttgagcccgt gcattattgt
     1261 atgaatgaaa taaaaacagg gaagcccaga attccttctt tcagaagcct caaaagaggg
     1321 tggtcgatga agatgggccc agcactagaa gatttcagtc atttgccacc agagcagagg
     1381 cgtaagaagt tacagcaacg gattgatgag cttaaccgag ggctgcagaa agaatcagac
     1441 caaaaagaag cactcaacaa aatgaaagat gtatatgaga aaaatccaca aatgggggat
     1501 ccaggaagtc tgcagcctaa attagcagag accatgaata acattgaccg cttacgaatg
     1561 gaaatccaca agaatgaggc atggctctct gaagtggaag gcaaaacagg tgtgagagga
     1621 gacagaagac acagcagtga cataaaccat ctcgtgacac aggggcgaga aagccctgag
     1681 ggaagttata ctgatgatgc aaaccaagaa gttcgtgggc caccgcaaca acatggtcac
     1741 cacagtgagt ttgatgacga gtttgaagat gatgatcccc tgcctgctat tggacactgc
     1801 aaagctatct acccttttga tgggcacaat gaaggtactc tggcaatgaa agaaggggag
     1861 gtgctgtaca ttattgagga ggacaaaggt gatggatgga caagagcccg gagacagaac
     1921 ggcgaagaag gctacgttcc cacaacatac atagatgtaa ctctagagaa aaacagtaaa
     1981 ggtgcagtaa cttatatcta aactaaccag gcagctttgt gccatgtaca cataaaatga
     2041 caacacattc aacaggtcag aaaaaccaaa acgttaaggc atcctgacgc atgttcactg
     2101 tgtgagctga gtgcaggctt ggtcagagag agagaattct gccaccagag actctttgac
     2161 gccttactgt tcaagggatg ctggtgtgga agcttaatcg atgcctttcg ctttctgtcc
     2221 tgcctaagtg tgtgtaaagg atgtgtgctt ttctgcctta taaataatag atttgattat
     2281 taggcaagaa tcataggtag aatgttccct gcccccttca cctcagaaac aacagtgact
     2341 gatgaataaa ataaacaaac cttctctgag cgcagaaagc tgatccccag gagcagctca
     2401 gcctaggagc ttgggtttat agcttcaggt tccaggaaga aaagtaatgg ttagataatt
     2461 aggtaaaata acagtcattt tccttgctat tcttaacttg gtttcctaca gaaagaaaac
     2521 gaatacctgg tatataattt atttaatatg agctcatctg gggtcgcagg ataagtcacc
     2581 tggtggagct tgtatgtgaa taaaacagca ttgagacctg gaaatatttt caggtttact
     2641 ggtaattttc aatgttgtac aaagttcatt ccaagctaag ctcatgcttg tacttctcac
     2701 tcgacagtct tagggacatt agtgcttatt tagtttctgc gttacagcag agattggctc
     2761 tcactcagta gacgttaagg acagtctgca atggaggaag aaagggctga tggtggtgac
     2821 tgttagagga gaaacaggaa acagttttct cctgagagga agcaagctct ctaccaccat
     2881 cgagggcttc actttagctg gatcgttgac tgtcagagta gctacttgtc cagggttgcc
     2941 aagggcatct gttggaatca ttgcccaacc aggagctgtg cagtgcagtg cagcagtcgt
     3001 gtgaccacat cctccttagt tgagcgagga gacaaaggga ggaggcagta ccactggcct
     3061 ttgatcagct tgtttcggag ttccctggtg tttttagtag ctggctataa agttatttta
     3121 ggtacatttg ggacagacac tttaaactga atgccccttt tggtcttacc aaaggtcttc
     3181 agtaattgtt tttttctttt tcctcctgga ctgcaggttc ctgaagaggg tttctgagga
     3241 aatgggcaag atgttgaagg aggttacatg cagctgcttg ggggagggta ttagacttgt
     3301 caggctgaga gagagtgaga aaagcaagtc gcatgaatgc atgcagattg ttttactaac
     3361 gtcattagca tttccataca ttaaaaagtc attatagtac cagtccttaa atccctagtt
     3421 cacagttgtt cacgtggaag aaggaaaaga aaagccagca atggctgatc tcttttttca
     3481 ttaactgata ccaagtcaga aaaaatgcag agctgtctta aagtttgtct tatttgggct
     3541 gtccagtcgg actgtcttca tcgagctctg ttttgattgg cttttagact ccttgtctgt
     3601 tagaaccctt gccatttgtc agtgtctgcc tgcaccacct ctgtgcttgc ttaacatcct
     3661 gttgcatgtc tagagtgctc tgggcttaga gttttcaggc atgtctctgt attcccctgt
     3721 tcttgtcaaa gcttttgttt cgtttcgcat ttgtagcgca gatcactttg tcagccacct
     3781 cagcactaat gtcccatctt agtgtttgtg tatgctgcta aaactcccca ccgcaaacat
     3841 tccagttttc acatgaagac atagtctgtg aacctgaagt atttatgata agaaaaagaa
     3901 aacatctctg ctctagcctg cagcccagtt aaagactctg tgaaatgtga cacatcttca
     3961 gcacctcagt ctgggagaat ctggtcagca ctgaagtcct ggcataataa caccgaaggg
     4021 accgttgtca aaagtcagct gcttccattc aaatgctgcc ttaaaatcga gtgcctaaac
     4081 ctgtccttgc caacactacc actacagtat cccaccaagg gcttagtgca gctcagtgct
     4141 cgcctctaac cggcacctcc gcagctgtga tgtagcctcg gtcggtggct tctagagctg
     4201 ccatgtgcag tggtgcatct tcaattcacg gatcaaacta agacctgtct gagtccattt
     4261 tactttcatc agtgtactta ggagaagttg gatggacctt cccccttcac cttttaccag
     4321 agtggtgatg atctcctttg attgttttaa tggtagtctg tttccaagtg acgcttttgt
     4381 ttgaaccaga tacaatttag tgaaactttg taatgatctc tgtgcacttt tacttgtaaa
     4441 atggaaactt ctgtatgttt atacttgtaa atacgattgt ctgtcttagt gccctcattg
     4501 ctcctgttgt cctgccccgc agcattcgtg attctgttaa tgacttgtat ctgaactaat
     4561 ttcttagtgg tcttgtaaca gggaggtggg agggctggga gggcgatttg taccactgaa
     4621 gctctaataa tttggttctt tactgttttg gggggagaag aacaatgtga agtgttctgt
     4681 gtattatcgg atttcaagca atattttaga aaccgtgtga ctgctttaat aattttttcc
     4741 aatgctattt gaatcatgct atcagttata ctaaagctga atgacaattg tgtgaacatt
     4801 aatgccttca taagatcaag tacaccactg tacgcagctg acatatagta tattaccttc
     4861 gaggctagta aactatacag ttttagatat taaatctcgt tacagggtta tttatataat
     4921 gtgacattat tctatactga cagactacat ggagtagttt taaaaagtag tgctattttt
     4981 atttcagaag ttagcaatga gaaggaaatg tgacctgcct gtgtttgtct tctgtacaaa
     5041 gactgaagtg cttatgtttt tctgactaac aatggcagag ggcagagttc aaagcttcct
     5101 tgtaaagact gttcttttcg ggctactgtg tgttttctaa tgctgacgtg tgcttccata
     5161 gcgggcaagt tccttcatgt ggagtagtgc gacctgttta tgggttgtaa catttgaaaa
     5221 aagacacctg tgcttgcaca gtttttagtc attcttaaat cattcttaaa ctctgaacat
     5281 gtgagctgtc taaaagaatc tcttaatttc acagtaattt ccactttgtg cacatattga
     5341 tttcttaatg gtaaaaagcc ttgtttatga tagtgttctc tgttgaggat attttcatgg
     5401 aataaagcaa tcttttcatg gtcagttaa
//
