LOCUS       NM_001393677            4724 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus formin binding protein 1 (Fnbp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001393677
VERSION     NM_001393677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Wakita,Y., Kakimoto,T., Katoh,H. and Negishi,M.
  TITLE     The F-BAR protein Rapostlin regulates dendritic spine formation in
            hippocampal neurons
  JOURNAL   J Biol Chem 286 (37), 32672-32683 (2011)
   PUBMED   21768103
  REMARK    GeneRIF: F-BAR protein Rapostlin, whose activity is regulated by
            Rnd2, plays a key role in spine formation through the regulation of
            membrane dynamics.
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Shimada,A., Niwa,H., Tsujita,K., Suetsugu,S., Nitta,K.,
            Hanawa-Suetsugu,K., Akasaka,R., Nishino,Y., Toyama,M., Chen,L.,
            Liu,Z.J., Wang,B.C., Yamamoto,M., Terada,T., Miyazawa,A.,
            Tanaka,A., Sugano,S., Shirouzu,M., Nagayama,K., Takenawa,T. and
            Yokoyama,S.
  TITLE     Curved EFC/F-BAR-domain dimers are joined end to end into a
            filament for membrane invagination in endocytosis
  JOURNAL   Cell 129 (4), 761-772 (2007)
   PUBMED   17512409
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Nakamura,K., Yamashita,Y., Tamamaki,N., Katoh,H., Kaneko,T. and
            Negishi,M.
  TITLE     In vivo function of Rnd2 in the development of neocortical
            pyramidal neurons
  JOURNAL   Neurosci Res 54 (2), 149-153 (2006)
   PUBMED   16303198
  REMARK    GeneRIF: Rnd2 functions in vivo as a regulator of the migration and
            morphological changes associated with the development of pyramidal
            neurons
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Houdart,F., Girard-Nau,N., Morin,F., Voisin,P. and Vannier,B.
  TITLE     The regulatory subunit of PDE6 interacts with PACSIN in
            photoreceptors
  JOURNAL   Mol Vis 11, 1061-1070 (2005)
   PUBMED   16357825
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   Kamioka,Y., Fukuhara,S., Sawa,H., Nagashima,K., Masuda,M.,
            Matsuda,M. and Mochizuki,N.
  TITLE     A novel dynamin-associating molecule, formin-binding protein 17,
            induces tubular membrane invaginations and participates in
            endocytosis
  JOURNAL   J Biol Chem 279 (38), 40091-40099 (2004)
   PUBMED   15252009
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Kakimoto,T., Katoh,H. and Negishi,M.
  TITLE     Identification of splicing variants of Rapostlin, a novel RND2
            effector that interacts with neural Wiskott-Aldrich syndrome
            protein and induces neurite branching
  JOURNAL   J Biol Chem 279 (14), 14104-14110 (2004)
   PUBMED   14732713
  REMARK    GeneRIF: functionally different splicing variants of Rapostlin have
            different responses to Rnd2 in association with N-WASP.
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Morin,F., Vannier,B., Houdart,F., Regnacq,M., Berges,T. and
            Voisin,P.
  TITLE     A proline-rich domain in the gamma subunit of phosphodiesterase 6
            mediates interaction with SH3-containing proteins
  JOURNAL   Mol Vis 9, 449-459 (2003)
   PUBMED   14502124
  REMARK    Erratum:[Mol Vis. 2003 Sep 18;9:449]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Fujita,H., Katoh,H., Ishikawa,Y., Mori,K. and Negishi,M.
  TITLE     Rapostlin is a novel effector of Rnd2 GTPase inducing neurite
            branching
  JOURNAL   J Biol Chem 277 (47), 45428-45434 (2002)
   PUBMED   12244061
  REMARK    GeneRIF: Data show that rapostlin is the first effector of Rnd2,
            regulating neurite branch formation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760393
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000003.1  34821942-34822117   c
            177-292             JAXUCZ010000003.1  34784330-34784445   c
            293-349             JAXUCZ010000003.1  34775864-34775920   c
            350-497             JAXUCZ010000003.1  34774847-34774994   c
            498-560             JAXUCZ010000003.1  34762228-34762290   c
            561-665             JAXUCZ010000003.1  34761194-34761298   c
            666-794             JAXUCZ010000003.1  34740257-34740385   c
            795-941             JAXUCZ010000003.1  34736605-34736751   c
            942-1136            JAXUCZ010000003.1  34735167-34735361   c
            1137-1319           JAXUCZ010000003.1  34734085-34734267   c
            1320-1334           JAXUCZ010000003.1  34726171-34726185   c
            1335-1444           JAXUCZ010000003.1  34721475-34721584   c
            1445-1577           JAXUCZ010000003.1  34717444-34717576   c
            1578-1699           JAXUCZ010000003.1  34716809-34716930   c
            1700-1836           JAXUCZ010000003.1  34716407-34716543   c
            1837-1995           JAXUCZ010000003.1  34713776-34713934   c
            1996-4724           JAXUCZ010000003.1  34706814-34709542   c
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..4724
                     /gene="Fnbp1"
                     /note="formin binding protein 1"
                     /db_xref="GeneID:192348"
                     /db_xref="RGD:621350"
     exon            1..176
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2003
                     /gene="Fnbp1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     formin-binding protein 17; rapostlin; formin-binding
                     protein 1-like"
                     /codon_start=1
                     /product="formin-binding protein 1 isoform 2"
                     /protein_id="NP_001380606.1"
                     /db_xref="GeneID:192348"
                     /db_xref="RGD:621350"
                     /translation="MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAK
                     QLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNELNDYAGQHEVISENMTSQITVDL
                     VRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDA
                     DINVTKADVEKARQQAQMRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQE
                     MEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGF
                     EPPGDIEFEDYTQPMKRTVSDNSLSSSKEGKPELKFGGKSRGKLWPFIKKNKLMTLLT
                     SPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSL
                     KLGVTPEDFSNFPPEQRRKKLQQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDP
                     ASLDHKLAEVTQNIEKLRLEAHKFEAWLAEVEGRLPARSEQARRQSGLYDGQTHQTVT
                     NCAQDRESPDGSYTEEQSQESEHKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEG
                     TISVVEGETLSVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKGS"
     exon            177..292
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..349
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..497
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..560
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..665
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..794
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..941
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1136
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1319
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1334
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1444
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1577
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1699
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1836
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1995
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..4724
                     /gene="Fnbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattttgctc cgcgcggagc gacgagaggt ggcgagccgg ggctagaggc gcgagccgga
       61 ggaagcggcg ggctttccgc attctcaggg tccggaggac cgcagcgatc gccggcgaag
      121 ggggtcgggg gccccttccc ggtccctgca ccatgagctg gggcactgag ctctgggatc
      181 agtttgacaa cttggaaaaa cacacacagt ggggaatcga cattcttgag aaatacatca
      241 agttcgtcaa ggagagaacg gagattgagc tcagctatgc caaacagctc aggaatcttt
      301 caaagaaata ccaacccaag aagaactcga aggaagaaga ggaatacaag tacacggcgt
      361 gtaaagcgtt tctttccacc ctgaatgagt tgaatgacta cgccgggcag catgaggtca
      421 tctccgagaa catgacgtca cagatcacgg tggacctggt gcgctacgta caggagctga
      481 agcaggagag gaaatcgaat ttccatgatg gacggaaggc tcagcagcac atagagacgt
      541 gctggaagca gctggagtcg agtaagagga ggtttgagcg ggactgtaag gaggccgacc
      601 gtgcacagca gtactttgag aaaatggacg ccgacatcaa tgtgaccaag gcggatgtgg
      661 aaaaggcgcg acaacaagct cagatgcgcc agcaaatggc agaggacagc aaagctgatt
      721 actccttaat cctgcagagg ttcaaccagg agcagtggga gtactaccac acccacatcc
      781 ccaacatctt ccagaaaatc caagagatgg aggagaggag gattgtgcgc attggagagt
      841 ccatgaagac gtatgcagag gtggaccggc aggtgatacc catcatcggg aagtgcctgg
      901 acggtatagt gaaggcggcc gagtctattg accagaaaaa cgactcccag ctagtcgtag
      961 aagcctataa gtcaggattc gagcctcccg gagacattga attcgaagat tacacacagc
     1021 ccatgaaacg cacggtgtca gacaacagcc tttccagttc caaagaaggc aagcccgagc
     1081 tcaagtttgg aggcaagtcc agaggcaagc tctggccgtt catcaagaaa aacaagctta
     1141 tgaccctttt aacatccccc caccagcctc cccctcctcc ccctgcctct gcctcaccct
     1201 ctgctgttcc caacggcccc cagtctccca agcagcaaaa ggaacccctc tcccaccgct
     1261 tcaacgagtt catgacctcc aaacccaaaa tccactgctt ccggagccta aagcgtgggc
     1321 tttcgctcaa gctgggtgtc accccggaag acttcagcaa cttcccgcct gagcagagaa
     1381 ggaaaaaact acaacagaaa gtggacgatc tcaataaaga gatccaaaag gagaccgacc
     1441 agagagacgc catcactaaa atgaaagatg tgtacctaaa gaaccctcag atgggagacc
     1501 cggccagctt ggaccacaaa ctcgccgaag tcacccagaa catagaaaaa ctgcggctgg
     1561 aggctcacaa gttcgaggcc tggctggctg aggtggaagg cagactccca gctcggagtg
     1621 agcaggcacg ccggcaaagt gggctgtacg acggccagac acaccagacg gtcactaact
     1681 gcgcccagga ccgggagagc ccagatggta gttacacaga agagcaaagc caggagagcg
     1741 agcacaaggt gctggccacg gacttcgacg atgagttcga cgatgaggag ccgcttcctg
     1801 ccatcgggac ctgcaaggcc ctctacacct ttgaaggtca gaacgaaggc accatttcgg
     1861 tagttgaagg agaaacgctg agcgtgattg aggaggacaa aggcgatggg tggacacgca
     1921 tccgcagaaa cgaagacgag gagggttacg tccccacttc ctacgtcgaa gtctatttag
     1981 acaaaaacgc caaaggttcc taatggcggt gcacaaggcc agagtccccc ccggagcctc
     2041 ccaggagcca ccgtcgtcca gcccgattgt ccccacaggc ctccagcgac actcaggctg
     2101 gctgggcatc ctcaaaccca cctgcgagtt gggtccccac ctccccctct ccttcacagc
     2161 atgctcccgt ggctccgcca ttccctctgc ctactgtatg gcacgggtgt ttctcttcca
     2221 aagcctccca cgggggctgt gtgcttcact ctgctccctt cccacacagg ccaccaaggc
     2281 agctggactt gtgccctgtg tccccgctcc ttctgggctc ccagtccacc tgctcaccac
     2341 ccagccactc cttgcacatc tcacactgtg cctttgtcaa ccgtcaccgc tggtttcctg
     2401 gtgactaaca gaatcctgac aagggggggc cggcggtgca tcaggtggac tgagcgccca
     2461 cctgtcatct atgtgtctct cgggactcat tgtcaaatgc gtccttctct ccagaggctg
     2521 ctgcctcggg tcctccccac catccagcac tgttaccttc cattgcgtcc ttctctccag
     2581 aggctgctgc ctcgggtcct ccccaccatc cagcactgta cttcagtact ccatcctagg
     2641 ggatcgatgg taggactggg gcgcccaacc cacatccact cccactctgg ttctaaatca
     2701 tctacctggc ccaaggaggt ccgtatcgaa gtcccaaatc caacttgtgg gccaaccctg
     2761 ctgtcttgcc tgggtctacc ttctgtgagc cttgtctgcc tgttcccggt accctgtgat
     2821 ggagggcctc acacccgctc tagctcatta ctgtaaggcg ggcctgccga gtcccgtagg
     2881 tagcatttga ggactctcct atgttcccac caaagacctt gtgcctcctg tggtccctct
     2941 gatggctctg aacactgctt ctgcattgga tcctattctc cagaagcccc ggagaatgga
     3001 tggagcttgc ttttgaaact gtttccctcc tagaatggtg gagcttttgg gggagaaccg
     3061 aggtggtcct tcgaacctta gagccgcgct ttctctcctt tcccagtaca aaagcactca
     3121 aggcttggcc acaagccccc gtgaagggca ccccacaagc ttgaacttga ggagattggc
     3181 atcttcctcc aggcagttgg tagcttagct aacatcgtca gaggatcaaa gacatgggag
     3241 tcttacaaaa ccagaaatag ggacaaagag gcaggttctc agggtcgggc ctgtgctttg
     3301 tggaaatgca gacattctcc tcttgtggca ctggtgtacc accctgcaga acagcactgt
     3361 caacctcaca gcagaggaga gggagagtac cacagtgggg agcagccgac aagggcctga
     3421 ctttgggttt caagagcaag caaggattag ttttgaggca ttcttcaccc tgccttctcc
     3481 caaggaaggc ctagccccgg gtccaacaca ctgccctctg gggcccctgt gaggctgttc
     3541 aggactcaca tgaggaagac ctagggacgg tatggaagcc tggtgcctaa gagtgaagat
     3601 tgtctcagct ctgacacagt tactccacca ggttactggc catctatctc cagaacctgt
     3661 gatttttcac caagttgggc cgaccactgt cccctccatg aggagccaga gtggttttta
     3721 ctggtctgtt cacagatctc attagtgcat gaaggacgga gaaaggctct tgccacaaag
     3781 gtaacatgga gaagctgcca atcttcctcg aatgactgtt taagcctgtg cctgtctccc
     3841 cgcatcccct cacttctttt ttaacttcct gtaccaccta catccagaaa ggatggaggt
     3901 gagcgtcttc aggccgttcc ctgagcgaga tggtctgccg tggaaaccct gtggaattgt
     3961 accggctgtg gggggaaggg aatgcaggat ttccctagaa gcgctacact ccctgtcccc
     4021 aggacccact gcctgtcact cctagctgct agtgtgctga tacaagaatg actcactgta
     4081 aaagaacctg ccctgcaaat gacttagaga cgagaaataa aaggaacttg acatttactg
     4141 cttttttttt cctatgcagg atgtgaagcc gcagtggctc ctccctctgg gctgagcgta
     4201 ctcagccagt gggagcagcc caagtaacac acggggaggc cgctaaagcc ttctggtgac
     4261 acctgtagtt atagtagaat gtccacacga agtttaaaaa acaaaagttc cgttcctgcc
     4321 ggtatttttc cagaaactgc agttttgtga tttttttttt tttaattttt gtgtctgtac
     4381 atataacata tggagtgtct ctaataatgg ccccgacttc tcttttagcc tgacatcaag
     4441 caccttttaa gtcatgcctg tgcgtgtgtg cgtgcgtgtg tgtgtgtgtg tgtgtgtgtg
     4501 tgtgtgtgtg agagagagag agagagagag agctcgagct agttctaagc cttgagggcg
     4561 tggcactgtt ggaaaggccc tcacagctgt caggtcttgg acttgcctgt gtctctggag
     4621 gtggaattaa gaccaaacaa agagctttcg gtagaaaagc tctcttaccc tggtaattaa
     4681 atgttagtcc tttcgatgtt aaataaagta taacttctag tgta
//
