LOCUS       NM_001109051            1038 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus fructosamine 3 kinase (Fn3k), mRNA.
ACCESSION   NM_001109051 XM_001081842 XM_006247907 XM_573235
VERSION     NM_001109051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Sanghvi,V.R., Leibold,J., Mina,M., Mohan,P., Berishaj,M., Li,Z.,
            Miele,M.M., Lailler,N., Zhao,C., de Stanchina,E., Viale,A.,
            Akkari,L., Lowe,S.W., Ciriello,G., Hendrickson,R.C. and Wendel,H.G.
  TITLE     The Oncogenic Action of NRF2 Depends on De-glycation by
            Fructosamine-3-Kinase
  JOURNAL   Cell 178 (4), 807-819 (2019)
   PUBMED   31398338
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Veiga da-Cunha,M., Jacquemin,P., Delpierre,G., Godfraind,C.,
            Theate,I., Vertommen,D., Clotman,F., Lemaigre,F., Devuyst,O. and
            Van Schaftingen,E.
  TITLE     Increased protein glycation in fructosamine 3-kinase-deficient mice
  JOURNAL   Biochem J 399 (2), 257-264 (2006)
   PUBMED   16819943
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Delplanque,J., Delpierre,G., Opperdoes,F.R. and Van Schaftingen,E.
  TITLE     Tissue distribution and evolution of fructosamine 3-kinase and
            fructosamine 3-kinase-related protein
  JOURNAL   J Biol Chem 279 (45), 46606-46613 (2004)
   PUBMED   15331600
  REMARK    GeneRIF: fructosamine 3-kinase and fructosamine 3-kinase-related
            protein have roles in repairing damage caused by ribose 5-phosphate
            [FN3K, FN3K-RP]
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Delpierre,G., Collard,F., Fortpied,J. and Van Schaftingen,E.
  TITLE     Fructosamine 3-kinase is involved in an intracellular deglycation
            pathway in human erythrocytes
  JOURNAL   Biochem J 365 (Pt 3), 801-808 (2002)
   PUBMED   11975663
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Szwergold,B.S., Howell,S. and Beisswenger,P.J.
  TITLE     Human fructosamine-3-kinase: purification, sequencing, substrate
            specificity, and evidence of activity in vivo
  JOURNAL   Diabetes 50 (9), 2139-2147 (2001)
   PUBMED   11522682
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Delpierre,G., Rider,M.H., Collard,F., Stroobant,V., Vanstapel,F.,
            Santos,H. and Van Schaftingen,E.
  TITLE     Identification, cloning, and heterologous expression of a mammalian
            fructosamine-3-kinase
  JOURNAL   Diabetes 49 (10), 1627-1634 (2000)
   PUBMED   11016445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jan 10, 2022 this sequence version replaced
            XM_006247907.4, NM_001109051.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212922.1, SRR26360194.556070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000010.1  107198952-107199166
            216-367             JAXUCZ010000010.1  107201473-107201624
            368-459             JAXUCZ010000010.1  107203445-107203536
            460-542             JAXUCZ010000010.1  107204431-107204513
            543-665             JAXUCZ010000010.1  107212769-107212891
            666-1038            JAXUCZ010000010.1  107213804-107214176
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1038
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /note="fructosamine 3 kinase"
                     /db_xref="GeneID:498034"
                     /db_xref="RGD:1559983"
     exon            1..215
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1004
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /codon_start=1
                     /product="fructosamine-3-kinase"
                     /protein_id="NP_001102521.2"
                     /db_xref="GeneID:498034"
                     /db_xref="RGD:1559983"
                     /translation="MEQLLRAQLHTKTLRAFGSSGGGCISEGYAYYTDTGPVFVKVNR
                     RAQARQMFEGEMASLEALRNTGLVRVPKPMKVIDLPGGGAVFVMEHLKMKSLGSQASK
                     LGEQMADLHLYNQKLREKSKAQQNTVGCGAEDAEPRGVTKFGFHTVTCCGFIPQVNEW
                     QDDWPTFFTRHRLQAQLDLIEKDYADRETQELWSRLQVKIPELFSGIEIVPALLHGDL
                     WSGNVAEDEQGPIIYDPASFYGHSEFELAIASMFGGFPRSFFTAYHQKIPKAPGFDKR
                     LLLYQLFNYLNHWNHFGREYRSPSLGMMRKLLR"
     exon            216..367
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
     exon            368..459
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
     exon            460..542
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
     exon            543..665
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
     exon            666..1038
                     /gene="Fn3k"
                     /gene_synonym="Fnsk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcgtgtt tccttctggt ccccagcacc cctcctctgc gtcatctctc ccgcattctg
       61 gtcctcaact ctccatggag cagctgctgc gcgcccagct tcacaccaag acactgcggg
      121 cctttggaag ctccggaggg ggctgcatca gcgagggtta tgcctactac actgacactg
      181 gccccgtgtt tgtcaaggtc aaccgcaggg cgcaggcccg acagatgttt gagggagaga
      241 tggcgagcct ggaggccctc cgcaacactg gcctggtgag agtacctaag cccatgaagg
      301 tgattgacct gccaggaggt ggggctgttt ttgtgatgga gcatttgaag atgaagagcc
      361 ttggcagtca ggcatcaaag cttggagaac agatggcaga tttgcacctt tacaaccaga
      421 aactcaggga gaagtccaag gctcagcaga acacagtggg ctgtggggcg gaggatgctg
      481 agccccgggg tgtgaccaag ttcggctttc acacagtgac gtgctgtggc ttcatcccac
      541 aggtgaatga atggcaggat gactggccaa cctttttcac tcgacatcgg ctccaagctc
      601 agttggatct catagaaaag gactatgctg accgagagac acaagaactg tggtcaaggc
      661 tacaggtgaa gatcccagag ctgttttctg gtatagagat tgtccctgcc ctgctccatg
      721 gagacctctg gtctggaaac gtggctgagg atgagcaggg ccccattatt tatgacccag
      781 cctccttcta cggccattct gagtttgaac tggcaattgc atcgatgttt ggggggttcc
      841 ccagatcctt cttcactgcc taccatcaga agatcccaaa ggctccaggg ttcgacaaac
      901 gcctgctgct ctaccagctc tttaactacc taaaccattg gaaccacttt gggcgggagt
      961 atagaagccc atccctgggg atgatgagga aactgctcag gtagcagagg gctggaccta
     1021 ataaaacgtc aaactgga
//
