LOCUS       NM_019143               8331 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus fibronectin 1 (Fn1), mRNA.
ACCESSION   NM_019143
VERSION     NM_019143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8331)
  AUTHORS   Yao,J., Ma,R., Wang,C. and Zhao,G.
  TITLE     LncRNA-HOTAIR Inhibits H9c2 Apoptosis After Acute Myocardial
            Infarction via miR-206/FN1 Axis
  JOURNAL   Biochem Genet 60 (5), 1781-1792 (2022)
   PUBMED   35092560
  REMARK    GeneRIF: LncRNA-HOTAIR Inhibits H9c2 Apoptosis After Acute
            Myocardial Infarction via miR-206/FN1 Axis.
REFERENCE   2  (bases 1 to 8331)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8331)
  AUTHORS   Soltani,M., Rahmati,M., Nikravesh,M.R., Saeidinejat,S. and
            Jalali,M.
  TITLE     Evaluation of Sertoli cell autophagy associated with laminin,
            fibronectin, and caspase-3 proteins' alteration, following
            testicular torsion rat
  JOURNAL   Andrologia 54 (1), e14272 (2022)
   PUBMED   34729793
  REMARK    GeneRIF: Evaluation of Sertoli cell autophagy associated with
            laminin, fibronectin, and caspase-3 proteins' alteration, following
            testicular torsion rat.
REFERENCE   4  (bases 1 to 8331)
  AUTHORS   Nakakura,T., Suzuki,T., Tanaka,H., Arisawa,K., Miyashita,T.,
            Nekooki-Machida,Y., Kurosawa,T., Tega,Y., Deguchi,Y. and
            Hagiwara,H.
  TITLE     Fibronectin is essential for formation of fenestrae in endothelial
            cells of the fenestrated capillary
  JOURNAL   Cell Tissue Res 383 (2), 823-833 (2021)
   PUBMED   32910242
  REMARK    GeneRIF: Fibronectin is essential for formation of fenestrae in
            endothelial cells of the fenestrated capillary.
REFERENCE   5  (bases 1 to 8331)
  AUTHORS   Coelho,N.R., Tomkiewicz,C., Correia,M.J., Goncalves-Dias,C.,
            Barouki,R., Pereira,S.A., Coumoul,X. and Monteiro,E.C.
  TITLE     First evidence of aryl hydrocarbon receptor as a druggable target
            in hypertension induced by chronic intermittent hypoxia
  JOURNAL   Pharmacol Res 159, 104869 (2020)
   PUBMED   32416216
REFERENCE   6  (bases 1 to 8331)
  AUTHORS   Hagege,J., Peraldi,M.N., Rondeau,E., Adida,C., Delarue,F.,
            Medcalf,R., Schleuning,W.D. and Sraer,J.D.
  TITLE     Plasminogen activator inhibitor-1 deposition in the extracellular
            matrix of cultured human mesangial cells
  JOURNAL   Am J Pathol 141 (1), 117-128 (1992)
   PUBMED   1632457
REFERENCE   7  (bases 1 to 8331)
  AUTHORS   Heine,U.I., Munoz,E.F., Flanders,K.C., Roberts,A.B. and Sporn,M.B.
  TITLE     Colocalization of TGF-beta 1 and collagen I and III, fibronectin
            and glycosaminoglycans during lung branching morphogenesis
  JOURNAL   Development 109 (1), 29-36 (1990)
   PUBMED   2209468
REFERENCE   8  (bases 1 to 8331)
  AUTHORS   Patel,R.S., Odermatt,E., Schwarzbauer,J.E. and Hynes,R.O.
  TITLE     Organization of the fibronectin gene provides evidence for exon
            shuffling during evolution
  JOURNAL   EMBO J 6 (9), 2565-2572 (1987)
   PUBMED   3119323
REFERENCE   9  (bases 1 to 8331)
  AUTHORS   Schwarzbauer,J.E., Patel,R.S., Fonda,D. and Hynes,R.O.
  TITLE     Multiple sites of alternative splicing of the rat fibronectin gene
            transcript
  JOURNAL   EMBO J 6 (9), 2573-2580 (1987)
   PUBMED   2445560
REFERENCE   10 (bases 1 to 8331)
  AUTHORS   Odermatt,E., Tamkun,J.W. and Hynes,R.O.
  TITLE     Repeating modular structure of the fibronectin gene: relationship
            to protein structure and subunit variation
  JOURNAL   Proc Natl Acad Sci U S A 82 (19), 6571-6575 (1985)
   PUBMED   3863113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 30, 2008 this sequence version replaced NM_019143.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15906.1, SRR26643288.37932.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000009.1  80713778-80714137   c
            361-489             JAXUCZ010000009.1  80712529-80712657   c
            490-627             JAXUCZ010000009.1  80711628-80711765   c
            628-759             JAXUCZ010000009.1  80710314-80710445   c
            760-897             JAXUCZ010000009.1  80709125-80709262   c
            898-1053            JAXUCZ010000009.1  80706389-80706544   c
            1054-1245           JAXUCZ010000009.1  80704020-80704211   c
            1246-1425           JAXUCZ010000009.1  80703291-80703470   c
            1426-1602           JAXUCZ010000009.1  80702493-80702669   c
            1603-1755           JAXUCZ010000009.1  80701380-80701532   c
            1756-1884           JAXUCZ010000009.1  80699785-80699913   c
            1885-2028           JAXUCZ010000009.1  80698636-80698779   c
            2029-2150           JAXUCZ010000009.1  80693222-80693343   c
            2151-2328           JAXUCZ010000009.1  80690575-80690752   c
            2329-2505           JAXUCZ010000009.1  80690224-80690400   c
            2506-2634           JAXUCZ010000009.1  80689309-80689437   c
            2635-2724           JAXUCZ010000009.1  80688991-80689080   c
            2725-2919           JAXUCZ010000009.1  80688066-80688260   c
            2920-3192           JAXUCZ010000009.1  80686765-80687037   c
            3193-3459           JAXUCZ010000009.1  80684994-80685260   c
            3460-3554           JAXUCZ010000009.1  80681197-80681291   c
            3555-3723           JAXUCZ010000009.1  80679606-80679774   c
            3724-3810           JAXUCZ010000009.1  80678800-80678886   c
            3811-4002           JAXUCZ010000009.1  80675826-80676017   c
            4003-4275           JAXUCZ010000009.1  80674249-80674521   c
            4276-4458           JAXUCZ010000009.1  80672960-80673142   c
            4459-4548           JAXUCZ010000009.1  80671090-80671179   c
            4549-4818           JAXUCZ010000009.1  80669684-80669953   c
            4819-4935           JAXUCZ010000009.1  80668232-80668348   c
            4936-5100           JAXUCZ010000009.1  80666972-80667136   c
            5101-5256           JAXUCZ010000009.1  80666132-80666287   c
            5257-5370           JAXUCZ010000009.1  80664810-80664923   c
            5371-5640           JAXUCZ010000009.1  80663712-80663981   c
            5641-5828           JAXUCZ010000009.1  80662407-80662594   c
            5829-5916           JAXUCZ010000009.1  80661114-80661201   c
            5917-6093           JAXUCZ010000009.1  80660205-80660381   c
            6094-6183           JAXUCZ010000009.1  80659503-80659592   c
            6184-6363           JAXUCZ010000009.1  80659115-80659294   c
            6364-6453           JAXUCZ010000009.1  80658083-80658172   c
            6454-6920           JAXUCZ010000009.1  80657003-80657469   c
            6921-7059           JAXUCZ010000009.1  80655988-80656126   c
            7060-7224           JAXUCZ010000009.1  80653048-80653212   c
            7225-7350           JAXUCZ010000009.1  80650703-80650828   c
            7351-7457           JAXUCZ010000009.1  80650032-80650138   c
            7458-7571           JAXUCZ010000009.1  80646812-80646925   c
            7572-8331           JAXUCZ010000009.1  80645507-80646266   c
FEATURES             Location/Qualifiers
     source          1..8331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..8331
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /note="fibronectin 1"
                     /db_xref="GeneID:25661"
                     /db_xref="RGD:2624"
     exon            1..360
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..7643
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /note="FN; fibronectin 2; fibronectin 3"
                     /codon_start=1
                     /product="fibronectin precursor"
                     /protein_id="NP_062016.2"
                     /db_xref="GeneID:25661"
                     /db_xref="RGD:2624"
                     /translation="MLRGPGPGRLLLLAVLCLGTSVRCTETGKSKRQAQQIVQPPSPV
                     AVSQSKPGCFDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKY
                     TGNTYKVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHE
                     TGGYMLECLCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLG
                     EGNGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHVL
                     QSASAGSGSFTDVRTAIYQPQTHPQPAPYGHCVTDSGVVYSVGMQWLKSQGDKQMLCT
                     CLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNY
                     EQDQKYSFCTDHAVLVQTRGGNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQ
                     NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC
                     IPYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQCQDSET
                     RTFYQIGDSWEKFVHGVRYQCYCYGRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPN
                     SHPIQWNAPEPSHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLI
                     SIQQYGHQEVTRFDFTTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWV
                     SASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQ
                     SLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELN
                     LPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGVPRSDDVPAPKDLQF
                     VEVTDVKVTIMWTPPNSAVTGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTY
                     LFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTV
                     GLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGNQQSPKATGVFTTLQPLR
                     SIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGV
                     EYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITG
                     YRITTTPTNGQQGTALEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV
                     IPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVG
                     YYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWA
                     PPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHE
                     SIPLRGRQKTGLDSPTGFDSSDVTANSFTVHWVAPRAPITGYIIRHHAEHSAGRPRQD
                     RVPPSRNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDVPRDLEVIASTPT
                     SLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYA
                     VTGRGDSPASSKPVSINYQTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTAP
                     KNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTNIDRPK
                     GLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRP
                     GSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLTGY
                     RVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT
                     LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPVQRTISPDVRSY
                     TITGLQPGTDYKIHLYTLNDNARSSPVVIDASTAIDAPSNLRFLTTTPNSLLVSWQAP
                     RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEP
                     LIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTNPGYDTENGIQLPGTSHQ
                     QPSVGQQMIFEEHGFRRTTPPTAATPVRLRPRPYLPNVDEEVQIGHVPRGDVDYHLYP
                     HVPGLNPNASTGQEALSQTTISWTPFQESSEYIISCQPVGTDEEPLQFQVPGTSTSAT
                     LTGLTRGVTYNIIVEALHNQRRHKVREEVVTVGNTVNEGLNQPTDDSCFDPYTVSHYA
                     VGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQRM
                     SCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDN
                     CRRPGAAEPSPDGTTGHTYNQYTQRYHQRTNTNVNCPIECFMPLDVQADRDDSRE"
     exon            361..489
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..627
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..759
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..897
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1053
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1245
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1425
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1602
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1755
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1884
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2028
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2150
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2328
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2505
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2634
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2724
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2919
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3192
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3459
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3554
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3723
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3810
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..4002
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4275
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4458
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4548
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4818
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4935
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5100
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5101..5256
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5370
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5371..5640
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5828
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..5916
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6093
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6094..6183
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6184..6363
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6453
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6454..6920
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6921..7059
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7060..7224
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7225..7350
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7351..7457
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7458..7571
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7572..8331
                     /gene="Fn1"
                     /gene_synonym="FIBNEC; fn-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcacccg ctgcactgca caggggaaga aaaggagccc agggtgtgag ccgggccagc
       61 ggccacaact tctggtcctc tcccgtgtcc tccttccatc ttcttacagg cgtccccacc
      121 tcaggacttt tcctgcaggc tgcgagggga accacacttc gtggccacta gcctcctgga
      181 gagggcgact ctcctcccat ccactcaaga tgctcagggg tccgggaccc gggcggctgc
      241 tgctgctagc agtcctgtgc ctggggacat cggtgcgctg caccgaaacc gggaagagca
      301 agaggcaggc tcagcaaatc gtgcagcctc cgtccccggt ggctgtcagt cagagcaagc
      361 ctggctgttt tgacaacggg aagcattatc agataaatca gcagtgggaa cggacctacc
      421 taggcaacgc cctggtttgt acctgctatg gaggaagcag aggttttaac tgcgagagca
      481 agcctgaacc tgaagagacc tgttttgaca aatacactgg aaacacttac aaagtgggtg
      541 acacttatga gcgccctaaa gattccatga tctgggactg tacctgcatt ggggctgggc
      601 gaggcaggat cagctgtacc attgcaaatc gctgccatga agggggtcag tcctacaaga
      661 ttggtgacaa gtggaggagg ccacatgaga ctggtggcta tatgttggag tgtttgtgtc
      721 tggggaatgg aaaaggggaa tggacctgca agccaatagc tgagaaatgt tttgatcacg
      781 ctgctgggac ttcctacgtc gtgggggaga cctgggaaaa gccctaccaa ggctggatga
      841 tggtggactg tacttgtctg ggcgaaggca atgggcgtat cacctgcacc tcccggaaca
      901 gatgcaatga tcaggacacc aggacgtcct acagaattgg agacacatgg agcaagaagg
      961 acaacagagg gaacctgctc cagtgtgtct gcacaggcaa cggcagaggg gagtggaagt
     1021 gtgagcgaca tgttctacag agtgcttcag ctggatctgg ctccttcaca gatgtccgaa
     1081 cagctattta ccaaccccag acccaccccc agcccgcacc gtacggccac tgtgtcacag
     1141 acagcggtgt ggtctactct gtgggaatgc agtggctgaa gtctcaagga gacaagcaga
     1201 tgctgtgcac ttgcctgggc aatggcgtca gctgccagga gacagctgtg acccagactt
     1261 acggtggcaa ctcaaacggg gagccctgtg ttctcccgtt cacctacaac ggtaggacct
     1321 tctactcctg caccaccgaa gggcggcaag acggacatct gtggtgtagc acaacttcaa
     1381 attatgaaca agaccagaag tattctttct gcacagacca cgcggttttg gttcagactc
     1441 gaggtgggaa ttccaatggt gccttgtgcc acttcccctt cctgtacaac aaccggaatt
     1501 acaccgactg tacttctgag ggtaggcggg acaacatgaa atggtgcggc accacccaga
     1561 actacgatgc cgatcagaag tttggattct gcccaatggc tgcccatgag gagatctgca
     1621 cgaccaacga aggggtcatg tatcgcattg gggaccagtg ggataagcag catgacctgg
     1681 gccacatgat gaggtgcacg tgtgttggga acggccgtgg agaatgggcc tgcatcccct
     1741 actcccagct ccgagatcag tgcatcgttg atgacattac ttacaacgtc aacgacacgt
     1801 tccacaagcg tcacgaggag ggacatatgc tgaactgtac ctgcttcggt cagggccggg
     1861 gcagatggaa atgtgacccc atcgaccagt gccaagattc agagacccgg acattttacc
     1921 agattggtga ctcctgggag aagtttgtgc atggtgtcag ataccagtgt tactgttacg
     1981 gccgtggcat tggggagtgg cactgccagc ctctgcagac ctacccaggc acaactggac
     2041 ctgttcaagt aattatcacg gagaccccca gccagcccaa ttcccacccc atccagtgga
     2101 atgccccgga gccttcacac atcaccaagt acattctcag gtggagacct aaaacctcta
     2161 cgggtcgctg gaaggaagct accattccag gccaccttaa ctcctatacc atcaaaggcc
     2221 tgaccccagg tgtgatctac gagggacagc tcatcagcat ccagcagtac gggcaccaag
     2281 aagtgactcg ctttgacttc accaccagcg ccagcacacc tgtgaccagc aacacagtga
     2341 ctggagagac tgcgcccttt tctcctgttg tggccacttc cgaatctgtc actgaaatca
     2401 cagccagcag cttcgtggtc tcctgggtct cagcttccga cacggtgtca ggattccgag
     2461 tggagtacga actgagcgag gaaggagatg agcctcagta ccttgatctt ccaagcacag
     2521 ccacttctgt gaacattcct gacctgctcc cgggcagaaa gtacatcgtc aacgtctatc
     2581 agatatctga agagggaaag cagagcttga tcctgtctac atcacagact acagcacctg
     2641 atgcgcctcc agaccctact gtggaccagg ttgatgacac ttccattgtt gttcgatgga
     2701 gcagacccca ggcacctatc acagggtaca ggattgtcta ttcaccttca gtagaaggca
     2761 gtagcacaga actcaacctt cctgaaacgg ccaactccgt caccctcagc gacctgcagc
     2821 ccggtgttca gtacaacatc actatctatg ctgtggagga gaaccaggag agcacacccg
     2881 ttttcatcca gcaggagact actggcgtcc cacgatccga tgatgttccc gctccaaagg
     2941 acctacagtt tgtggaagtg accgacgtga aagtcaccat catgtggaca cctcctaata
     3001 gcgcagtgac tggataccgt gtggatgtcc tgcctgtcaa cctgccaggg gaacatgggc
     3061 agaggctgcc tgtcaacagg aacacctttg ctgaagtcac cggactgtcc ccaggggtca
     3121 cgtacctctt caaagtcttt gctgtgcatc agggcaggga aagcaagcct ctgacagcac
     3181 aacagaccac caaactcgat gctcccacta acctccagtt tgtcaatgaa acggacagaa
     3241 cagttctggt aacttggact ccacctcgag cccggatagc aggctaccga ctgacagtgg
     3301 gcctcacccg aggaggccag cccaagcagt acaatgtggg acccatggct tccaagtatc
     3361 ccctgagaaa tctgcagcct gggtctgagt acactgtgac cttgatggct gtgaaaggca
     3421 accagcagag tcccaaagcc accggagtct ttactaccct gcagcctctg cgctccattc
     3481 caccttataa caccgaggtg acagagacca caatcgtgat cacctggacc cccgctccaa
     3541 ggattggctt caagctgggt gtacgaccaa gccagggagg tgaagcaccc cgagaagtga
     3601 cttcagactc aggaagcatc gttgtgtctg gcttgactcc aggcgtggaa tacacgtaca
     3661 ccatccaagt cctgagggac ggccaggaga gagatgcacc aattgtcaac cgagtagtga
     3721 caccgctgtc tcccccaacc aacttgcacc tggaggccaa tcctgacact ggagtgctta
     3781 ccgtctcctg ggagaggagc accaccccag atattactgg ctacagaata accaccaccc
     3841 ccacaaacgg gcagcaggga accgctttgg aagaagtggt tcatgccgat cagagttcct
     3901 gcacttttga aaacctgaat cctggcctgg agtacaatgt cagtgtttac actgtcaaag
     3961 atgacaagga aagtgcccct atctctgata ccgtcatccc agaggtgccc cagctcactg
     4021 acctaagctt tgttgatata actgactcaa gcatcggcct gaggtggacc ccgctaaact
     4081 cttccaccat tatcgggtac cgaatcacag tagttgcggc aggagaaggg atccccattt
     4141 ttgaagattt tgtggactcc tcagtaggat actacacagt tacagggctg gaacccggca
     4201 ttgactatga catcagcgtt atcactctca ttaatggcgg agagagtgcc cctactacac
     4261 tgacacagca aacggccgtc cctcctccca cggatctgcg attcaccaat atcggtccgg
     4321 acactatgcg ggtcacttgg gccccgcctc cgtccattga gctaaccaac ctcttggtgc
     4381 gctactcacc tgtgaagaac gaggaggatg tggcagagct gtccatttca ccctcagaca
     4441 acgccgtggt cctaacaaat ctcctgcctg ggactgagta cttagtcagt gtctccagcg
     4501 tgtacgaaca gcatgagagc atccctctca gaggaagaca gaaaacaggt ctggactccc
     4561 caactggttt tgattcttct gatgtcaccg ccaactcatt caccgtccac tgggtggctc
     4621 ctcgggcccc catcaccggc tacatcatcc gccatcacgc cgagcattct gccggaagac
     4681 ccaggcaaga ccgagtgccg ccctcaagga attctatcac cctcaccaac cttaatccgg
     4741 gcacggagta cattgtcacc atcattgctg ttaatggcag agaggagagc cccccactga
     4801 ttggccagca atccacggtt tccgatgtcc cgagagatct ggaggtcatc gcttccaccc
     4861 ccaccagcct gctcatcagt tgggaacccc ccgccgtctc tgtgcgctat tacagaatca
     4921 cctatggaga gacaggagga aatagccctg tccaggaatt cactgtgccc ggaagcaagt
     4981 ccaccgccac catcaacaac attaaaccag gagcagacta caccatcacc ctgtatgctg
     5041 tcactggccg tggggacagt ccagccagca gcaagccagt ttccatcaat tatcaaacag
     5101 aaattgacaa gccatcccag atgcaggtga cggatgtcca ggacaacagc atcagtgtca
     5161 ggtggctgcc ttcaacttct cctgtgacag gttacagagt gaccaccgct cccaaaaatg
     5221 gcctaggacc aacaaaatct caaactgtca gtccagatca aacagaaatg accattgaag
     5281 gtttgcaacc caccgtggag tatgtggtta gtgtctatgc tcagaaccgg aacggagaaa
     5341 gccagcccct ggttcagact gcagtgacca acattgaccg ccctaaagga ctggcattca
     5401 ctgatgtgga tgtcgattcc atcaaaattg cctgggaaag cccacagggg caagtttcca
     5461 ggtacagggt gacctactca agccctgagg atggaatcca tgagcttttc cctgcgcctg
     5521 atggtgacga ggacacggca gagctgcacg gcctcaggcc gggttctgag tacacagtca
     5581 gtgtggttgc cttgcacggt ggcatggaga gccagcccct gattggagtc cagtccacag
     5641 ccattcctgc gccaaccaat ctgaagttca ctcaggtgtc acccaccacc ttgactgccc
     5701 agtggacagc acccagtgtt aagctcactg gctaccgagt gcgggtgacc ccgaaggaga
     5761 agacaggacc aatgaaagaa atcaaccttt ctccagacag cacctccgtg attgtgtcag
     5821 ggctcatggt ggccaccaag tatgaagtca gcgtctatgc tctcaaggac acattgacaa
     5881 gcagaccagc tcagggagtc gtcacgactc tggagaatgt cagccctcca agaagggccc
     5941 gtgtgaccga cgctacagaa actaccatca ctattagctg gagaacgaag acagagacga
     6001 tcactggctt ccaagtcgat gccattccag ccaatggcca gaccccggtt cagaggacca
     6061 tcagcccgga tgtcagaagc tatactatta caggtttaca gccaggcact gactacaaga
     6121 tccacctgta cacgctcaac gacaatgccc ggagctctcc tgtggtcatt gatgcctcca
     6181 cggccattga tgccccatcc aacctgcggt tcctgaccac cacacccaac tccttgctgg
     6241 tatcatggca ggcaccccgt gccaggatta ctggctacat tatcaagtat gagaagcctg
     6301 gatcccctcc cagagaagtg gtccctcggc cccgccctgg tgtcacggag gccaccatca
     6361 ctggtctgga gccaggaacc gagtacacca tctatgtcat cgcactgaag aacaatcaga
     6421 agagtgagcc cctgattggg aggaaaaaga cagatgagct tccccaactg gttacccttc
     6481 cacaccccaa tcttcatgga ccagagatct tggatgttcc ctccacagtt caaaagaccc
     6541 ccttcgtcac caaccctggg tatgacaccg aaaatggtat tcagcttcct ggcacatccc
     6601 accaacaacc cagtgttggg caacaaatga tctttgagga acatggcttt aggcgaacca
     6661 cgccacccac tgcggccacc cccgtcaggc ttaggccaag accatacctg ccgaatgtag
     6721 atgaggaggt ccaaatcggt catgttccca ggggagacgt agactaccac ctctatcctc
     6781 atgttccggg gctcaatcca aatgcctcta caggacaaga agctctctct cagacaacca
     6841 tctcttggac gccattccag gagagttctg agtacatcat ttcatgccaa cctgttggca
     6901 ctgacgaaga gcccttacag ttccaagttc ctggaacttc taccagtgcg actctgactg
     6961 gccttaccag aggggtcacc tacaacatca tagtggaggc cctgcacaac cagaggaggc
     7021 acaaggtccg agaagaggtt gttactgtag gcaacactgt caacgaaggc ctgaaccagc
     7081 ctacggatga ctcatgcttt gacccttaca cggtttccca ttacgccgtt ggagaggaat
     7141 gggagcggtt atctgactct ggctttaagc tcacttgcca gtgcttgggc tttggcagtg
     7201 gtcatttcag atgcgattca tctaaatggt gccatgacaa cggtgtcaac tacaagatcg
     7261 gagagaagtg ggatcgtcag ggagaaaatg gccagcggat gagctgcaca tgtctcggga
     7321 atggaaaggg agaattcaaa tgcgatcccc atgaagcaac gtgttatgac gacgggaaga
     7381 cctaccacgt aggagaacag tggcagaaag agtatctcgg agccatttgc tcctgcacgt
     7441 gtttcggggg ccagcggggc tggcgctgtg acaactgccg cagacctggg gctgctgaac
     7501 ccagtcccga tggtaccact ggccacacct acaaccagta tacacagaga taccatcaga
     7561 gaacgaacac taatgtaaat tgcccaattg aatgcttcat gccgttggac gtgcaggctg
     7621 acagagatga ttccagagag taatctttcc atccagccca agccaacaag tgtctctcta
     7681 ccaaggtcaa tccacacccc agtgatgtta gcagaccctc catttctgag tggtcatttc
     7741 acccttaagc cttctgctct ggagtcaagt tctcagcttc agctcaactt acagcttctc
     7801 caagcatcgc cccgcgggat gttttgagac ttccctctta aatggtgaca gttggttgcc
     7861 ctgttctgct tcagggtatt cagtactgct cagtattatt gtctaagaga atcaaaagtt
     7921 cttgtgattt ggtctgggat caaagggaaa cacaggtagc caaccacgat gcaatgaatt
     7981 gaatggtagt acccaagagc gggagcagga agttaaacca gacagttctg ctttcttttg
     8041 ccgtctgatc tgcagcactg tcaggaggcc tgtcctgtgg ctgtgtccaa acaccccaca
     8101 ggactcactg tcccaacaat cctaattgcc tagaaatatc tttctcttac ctgttattta
     8161 tcaatttttc ccagtatttt tatacggaaa aaattgtatt gaagacactt tgtatgcagt
     8221 tgataagagg aattcagtat aattatggtt ggtgactatt tttatatgta catgccaaca
     8281 ctttactact gtggaaagac aagtgtttta ataaaaagat ttacattcca t
//
