LOCUS       NM_052804               4189 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fragile X messenger ribonucleoprotein 1 (Fmr1),
            mRNA.
ACCESSION   NM_052804
VERSION     NM_052804.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4189)
  AUTHORS   Ntoulas,G., Brakatselos,C., Nakas,G., Asprogerakas,M.Z., Delis,F.,
            Leontiadis,L.J., Trompoukis,G., Papatheodoropoulos,C., Gkikas,D.,
            Valakos,D., Vatsellas,G., Politis,P.K., Polissidis,A. and
            Antoniou,K.
  TITLE     Multi-level profiling of the Fmr1 KO rat unveils altered behavioral
            traits along with aberrant glutamatergic function
  JOURNAL   Transl Psychiatry 14 (1), 104 (2024)
   PUBMED   38378836
  REMARK    GeneRIF: Multi-level profiling of the Fmr1 KO rat unveils altered
            behavioral traits along with aberrant glutamatergic function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4189)
  AUTHORS   Leontiadis,L.J., Trompoukis,G., Tsotsokou,G., Miliou,A.,
            Felemegkas,P. and Papatheodoropoulos,C.
  TITLE     Rescue of sharp wave-ripples and prevention of network
            hyperexcitability in the ventral but not the dorsal hippocampus of
            a rat model of fragile X syndrome
  JOURNAL   Front Cell Neurosci 17, 1296235 (2023)
   PUBMED   38107412
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4189)
  AUTHORS   Anadolu,M.N., Sun,J., Kailasam,S., Chalkiadaki,K., Krimbacher,K.,
            Li,J.T., Markova,T., Jafarnejad,S.M., Lefebvre,F., Ortega,J.,
            Gkogkas,C.G. and Sossin,W.S.
  TITLE     Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are
            Consensus Sites for FMRP Association
  JOURNAL   J Neurosci 43 (14), 2440-2459 (2023)
   PUBMED   36849416
  REMARK    GeneRIF: Ribosomes in RNA Granules Are Stalled on mRNA Sequences
            That Are Consensus Sites for FMRP Association.
REFERENCE   4  (bases 1 to 4189)
  AUTHORS   D'Elia,A., Schiavi,S., Manduca,A., Rava,A., Buzzelli,V., Ascone,F.,
            Orsini,T., Putti,S., Soluri,A., Galli,F., Soluri,A., Mattei,M.,
            Cicconi,R., Massari,R. and Trezza,V.
  TITLE     FMR1 deletion in rats induces hyperactivity with no changes in
            striatal dopamine transporter availability
  JOURNAL   Sci Rep 12 (1), 22535 (2022)
   PUBMED   36581671
  REMARK    GeneRIF: FMR1 deletion in rats induces hyperactivity with no
            changes in striatal dopamine transporter availability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4189)
  AUTHORS   Asiminas,A., Booker,S.A., Dando,O.R., Kozic,Z., Arkell,D.,
            Inkpen,F.H., Sumera,A., Akyel,I., Kind,P.C. and Wood,E.R.
  TITLE     Experience-dependent changes in hippocampal spatial activity and
            hippocampal circuit function are disrupted in a rat model of
            Fragile X Syndrome
  JOURNAL   Mol Autism 13 (1), 49 (2022)
   PUBMED   36536454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4189)
  AUTHORS   Feng,Y., Gutekunst,C.A., Eberhart,D.E., Yi,H., Warren,S.T. and
            Hersch,S.M.
  TITLE     Fragile X mental retardation protein: nucleocytoplasmic shuttling
            and association with somatodendritic ribosomes
  JOURNAL   J Neurosci 17 (5), 1539-1547 (1997)
   PUBMED   9030614
REFERENCE   7  (bases 1 to 4189)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
REFERENCE   8  (bases 1 to 4189)
  AUTHORS   Siomi,H., Choi,M., Siomi,M.C., Nussbaum,R.L. and Dreyfuss,G.
  TITLE     Essential role for KH domains in RNA binding: impaired RNA binding
            by a mutation in the KH domain of FMR1 that causes fragile X
            syndrome
  JOURNAL   Cell 77 (1), 33-39 (1994)
   PUBMED   8156595
REFERENCE   9  (bases 1 to 4189)
  AUTHORS   Siomi,H., Siomi,M.C., Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The protein product of the fragile X gene, FMR1, has
            characteristics of an RNA-binding protein
  JOURNAL   Cell 74 (2), 291-298 (1993)
   PUBMED   7688265
REFERENCE   10 (bases 1 to 4189)
  AUTHORS   Kremer,E.J., Pritchard,M., Lynch,M., Yu,S., Holman,K., Baker,E.,
            Warren,S.T., Schlessinger,D., Sutherland,G.R. and Richards,R.I.
  TITLE     Mapping of DNA instability at the fragile X to a trinucleotide
            repeat sequence p(CCG)n
  JOURNAL   Science 252 (5013), 1711-1714 (1991)
   PUBMED   1675488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_052804.3.
            
            On Nov 27, 2020 this sequence version replaced NM_052804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY240947.1, SRR26643290.56678.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000021.1  152284930-152285161
            233-285             JAXUCZ010000021.1  152293184-152293236
            286-379             JAXUCZ010000021.1  152296613-152296706
            380-451             JAXUCZ010000021.1  152299165-152299236
            452-600             JAXUCZ010000021.1  152299638-152299786
            601-694             JAXUCZ010000021.1  152301132-152301225
            695-811             JAXUCZ010000021.1  152301308-152301424
            812-982             JAXUCZ010000021.1  152303533-152303703
            983-1061            JAXUCZ010000021.1  152303820-152303898
            1062-1171           JAXUCZ010000021.1  152306844-152306953
            1172-1303           JAXUCZ010000021.1  152308288-152308419
            1304-1390           JAXUCZ010000021.1  152311050-152311136
            1391-1586           JAXUCZ010000021.1  152313572-152313767
            1587-1733           JAXUCZ010000021.1  152315255-152315401
            1734-1816           JAXUCZ010000021.1  152316041-152316123
            1817-4189           JAXUCZ010000021.1  152320309-152322681
FEATURES             Location/Qualifiers
     source          1..4189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..4189
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /note="fragile X messenger ribonucleoprotein 1"
                     /db_xref="GeneID:24948"
                     /db_xref="RGD:2623"
     exon            1..232
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1927
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /note="protein FMR-1; synaptic functional regulator FMR1;
                     FMRP translational regulator 1"
                     /codon_start=1
                     /product="fragile X messenger ribonucleoprotein 1"
                     /protein_id="NP_434691.1"
                     /db_xref="GeneID:24948"
                     /db_xref="RGD:2623"
                     /translation="MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPF
                     HDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDAT
                     YNEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVT
                     YDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASR
                     FHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKAR
                     SFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKSVPQEEENLP
                     PSSLPSNNSRVGSNSSEEKKHLDTKENTHFSQPNSTKVQRGMVPFVFVGTKDSIANAT
                     VLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKGYVTDDGQGMGRG
                     SRPYRNRGHGRRGPGYTSESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQG
                     GRGRGGGFKGNDDHSRTDNRPRNPRETKGRTTDGSLQSTSSEGSRLRTGKDRNQKKEK
                     PDSVDGLQPLVNGVP"
     exon            233..285
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            286..379
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            380..451
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            452..600
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            601..694
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            695..811
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            812..982
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1061
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1171
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1303
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1390
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1586
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1733
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1816
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..4189
                     /gene="Fmr1"
                     /gene_synonym="FMRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccgcgcc tgagagggcg ggcagtgaag ccaacggacg gcgagcgcgg gcggtgtcag
       61 tgacggcggc gccgctgccg gggggcgtgc ggtaacgcgg cggcggcggc gacggctggg
      121 cctcgagcgc ctgcagccca cctctcggag gcgggctccc ggcgcgagga aggacgagaa
      181 gatggaggag ctggtggtgg aagtgcgggg ctccaatggc gctttctaca aggcatttgt
      241 aaaagatgtc catgaagatt ctataacagt tgcttttgaa aacaactggc agccagagag
      301 acagattcct ttccatgatg tgagattccc accacctgta ggttataata aagatataaa
      361 cgaaagtgat gaagttgagg tttattccag agcaaatgaa aaagagcctt gctgttggtg
      421 gttagctaaa gtgaggatga taaagggtga gttttatgtg atagaatatg cagcatgtga
      481 tgctacatac aatgaaattg tcacaattga gcgtctacga tctgttaatc ccaacaaacc
      541 tgctacaaaa gatactttcc ataagatcaa gctggaagtg ccagaagatt tacgacaaat
      601 gtgtgccaaa gaatcggcac ataaggattt taaaaaggca gttggtgcct tctctgtaac
      661 ttatgatcca gaaaattatc agctggtaat tttgtccatc aatgaagtca cctcaaagcg
      721 agcccacatg ttaattgaca tgcactttcg aagtctgcgc accaagttgt ctcttatact
      781 gagaaatgaa gaagccagta aacaactgga gagttcaagg cagcttgcct caagatttca
      841 tgaacagttt atcgtacgag aagatctgat gggtctagct attggtactc atggtgctaa
      901 tattcagcaa gctagaaaag tacctggggt cactgctatt gatttagatg aggatacctg
      961 cacatttcat atttatggag aggatcaaga tgcagtcaaa aaggctagaa gctttctgga
     1021 atttgctgaa gatgtcatac aagttccacg aaatttagta ggcaaagtaa taggaaaaaa
     1081 tggaaaactg attcaagaga ttgtggacaa gtcaggagtt gtgagggtga ggatcgaagc
     1141 tgaaaatgag aaaagtgtcc cacaagaaga ggaaaatttg ccaccaagtt ccctaccttc
     1201 caataattca agggttggat ctaattcctc tgaagaaaag aaacatttag atacaaagga
     1261 aaacacccat ttttctcaac ctaacagtac aaaagtccag agggggatgg taccatttgt
     1321 ttttgtggga acaaaagaca gcatcgctaa tgccactgtt cttttggatt atcacctgaa
     1381 ctacttaaag gaagtagacc agttgcgttt ggagagatta caaattgatg agcagttgcg
     1441 acaaattgga gctagttcta gaccaccacc aaatcgtaca gataaggaaa aaggctatgt
     1501 gactgatgat ggtcaaggaa tgggtcgagg tagtagacct tacagaaata gggggcacgg
     1561 cagacgcggt cctggatata cttcagaatc tgaccacaga gacgaactca gtgattggtc
     1621 attagctcca acagaggaag agagggagag cttcctgcgc agaggagacg gacggcggcg
     1681 tggaggaggc ggaagaggac aaggaggaag aggaagagga ggaggtttca aaggaaatga
     1741 cgatcattcc cgaacagata atcgtccacg taatccaaga gagactaaag gaagaacaac
     1801 tgatggatcc ctgcagagca cctccagtga agggagccgg ctgcgcaccg ggaaagatcg
     1861 gaaccagaag aaggaaaagc cagacagcgt ggatgggctg caaccactcg tgaatggagt
     1921 accctaaact acataattct gaagttatat ttcctctact gtttccgtaa ttcttactcc
     1981 attttagaaa actttattag gccaaagaca aatagtaggc aagatggcac agggcatgag
     2041 gtgaacacaa attctgcaaa gaattttttg gatattggcc ataatcaaca atcttccaag
     2101 tttgcacaaa aagatcttga aatttgaagc ataactttta agtacactta acacttcagg
     2161 gcaggatttt actttatttt ttaaaaatac taagcagtga tctttattaa ctaggaccat
     2221 tttcctgcat tgggctatat aactcagcag tacgtttcag tctttctggg taaatcacat
     2281 ttgtggtaat catactagat ctctgtcttc agtcccattt aaagtctcca tgaagtgctg
     2341 tgccatttca tgtcctgtgt cagtttatgt tttggtccgc ttttccagta ttttagtgga
     2401 ccctgaaatg tgtgtgatgt gacatttgtt atttttgtta gcaaaaaagt tgtatgatct
     2461 gtgccttttt tatatcttgg caggtaggaa tattatattt ggatgcagag ttcagggaag
     2521 ataagttgga aacactaaat gttaaagatg tagcaaaccc tgtcaaacat tagtacttta
     2581 tagaagaatg catgctttcc atattttttt ccttacataa acatcagctt aggcagtata
     2641 aagaatagga cttgtttttc gtttttgttt tgttgcactg aagtatgaca aatagtgtta
     2701 ttggaaggga tgtgtaattt ttctgtatag acaggaaaag aaataactat cttttcgttt
     2761 gggagaggct aaagatgttt tcagctactt gcaaatcttc ctggtcgaaa gttagtagga
     2821 tatgcctgct ctttggcctg atgacgaatt tcaacttaga acctttttct tttgtcctcc
     2881 ccaagttttg tcaagttttt cattcatatt ttacattaaa gcttattttg gggagatatg
     2941 aaggtcatct tcataaatac ataataaccc tcaaaagtat ataggtactt tgtttgagaa
     3001 acattgaaag caggttaaat gttttgtagc tttgaaatac gaagtctaat gtataagcag
     3061 aactgaaaaa caggcctaca attagttaaa aataattcat ttttttcctt ttgatgtgtc
     3121 aagtcttatt ttttgttttt tttctctttt taatgaatga aatttactga agaaaaatat
     3181 gtgaaggacc ttcactctga gatgttatat ttttcttaaa aaataactcc gagtaggggt
     3241 accactgaaa ctgtacagag ccgtacaaac cgaagttctg cctctgatgt actttgtgaa
     3301 tttgtttctt tgaatttttc atttttcatt tagttttcct tgcatacaaa taagcatata
     3361 aaatggcaac aaactgcaca tgatttcaca aatattaaaa tgtcttttaa aaagtattgc
     3421 caaacattta atgttgattt ctagttattt attctgggaa tgtatagtat ttgaaaacag
     3481 aaattggtac cttgcacaca tcatctgtaa gctgttcagt ttaaaatact gtagataatt
     3541 aaccaaggta gaatgacctt gtaatgtaac tgctcttggg caatattctc tgtacatatt
     3601 agcgacaaca gattggattt tatgttgaca tttgtttggt tatagtgcaa tatattttgt
     3661 atgcaagcag tttcaataaa gtttgatctt cctctgctaa attgatgttg atgcaatctt
     3721 tacaatgatt gcttttaaaa attttaagat aggaaagaaa tctatagaaa gtgttctgtt
     3781 acaaaatgta actgttacca ttggaaattt cacatgtcat aggagattag ccgttattta
     3841 ccaactttca agatcgtaat cttgtttaat aaggtgaaat atcaacaatt ggtacacagt
     3901 cacaatgtac cggttaaaat atgcactaag tctctttttt acaaaggctg aattcagcaa
     3961 ggcgctaact tgcttaaatg tgaattacta acttctaaaa ctgtaatttg attcacatgt
     4021 tttcaaatgg agttggagtt gattcatatt acaatatttg tgtgcaaaat gtgtatgttt
     4081 ttcagttcaa agtcatgttt ttaaaatctt attaaagttt caaaaatctg gagattgttt
     4141 atcttatcta gatgtaaatt tttattaaaa agttgcactt atgaaaaag
//
