LOCUS       NM_080698               2960 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus fibromodulin (Fmod), mRNA.
ACCESSION   NM_080698
VERSION     NM_080698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Jiang,Q.L., Xu,J.Y., Yao,Q.P., Jiang,R., Xu,Q., Zhang,B.T., Li,T.
            and Jiang,J.
  TITLE     Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal
            formation via inhibition of fibromodulin
  JOURNAL   Cell Mol Biol Lett 29 (1), 2 (2024)
   PUBMED   38172726
  REMARK    GeneRIF: Transfer RNA-derived small RNA tRF-Glu-CTC attenuates
            neointimal formation via inhibition of fibromodulin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Liang,Y., Zhou,Y., Wang,J. and He,Y.
  TITLE     Downregulation of fibromodulin attenuates inflammatory signaling
            and atrial fibrosis in spontaneously hypertensive rats with atrial
            fibrillation via inhibiting TLR4/NLRP3 signaling pathway
  JOURNAL   Immun Inflamm Dis 11 (10), e1003 (2023)
   PUBMED   37904680
  REMARK    GeneRIF: Downregulation of fibromodulin attenuates inflammatory
            signaling and atrial fibrosis in spontaneously hypertensive rats
            with atrial fibrillation via inhibiting TLR4/NLRP3 signaling
            pathway.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Zheng,Z., Zhang,X., Dang,C., Beanes,S., Chang,G.X., Chen,Y.,
            Li,C.S., Lee,K.S., Ting,K. and Soo,C.
  TITLE     Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound
            Healing
  JOURNAL   Am J Pathol 186 (11), 2824-2832 (2016)
   PUBMED   27665369
  REMARK    GeneRIF: The fibromodulin (Fm)-transforming growth factor
            (TGF)-beta1 nexus plays a crucial in fetal-type scarless skin
            repair.
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Qian,H., Xiao,Y. and Bartold,P.M.
  TITLE     Immunohistochemical localization and expression of fibromodulin in
            adult rat periodontium and inflamed human gingiva
  JOURNAL   Oral Dis 10 (4), 233-239 (2004)
   PUBMED   15196146
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Matias,M.A., Li,H., Young,W.G. and Bartold,P.M.
  TITLE     Immunohistochemical localization of fibromodulin in the
            periodontium during cementogenesis and root formation in the rat
            molar
  JOURNAL   J Periodontal Res 38 (5), 502-507 (2003)
   PUBMED   12941075
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Schaefer,L., Raslik,I., Grone,H.J., Schonherr,E., Macakova,K.,
            Ugorcakova,J., Budny,S., Schaefer,R.M. and Kresse,H.
  TITLE     Small proteoglycans in human diabetic nephropathy: discrepancy
            between glomerular expression and protein accumulation of decorin,
            biglycan, lumican, and fibromodulin
  JOURNAL   FASEB J 15 (3), 559-561 (2001)
   PUBMED   11259366
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Soo,C., Hu,F.Y., Zhang,X., Wang,Y., Beanes,S.R., Lorenz,H.P.,
            Hedrick,M.H., Mackool,R.J., Plaas,A., Kim,S.J., Longaker,M.T.,
            Freymiller,E. and Ting,K.
  TITLE     Differential expression of fibromodulin, a transforming growth
            factor-beta modulator, in fetal skin development and scarless
            repair
  JOURNAL   Am J Pathol 157 (2), 423-433 (2000)
   PUBMED   10934147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X82152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2960
                     /gene="Fmod"
                     /note="fibromodulin"
                     /db_xref="GeneID:64507"
                     /db_xref="RGD:619769"
     exon            1..46
                     /gene="Fmod"
                     /inference="alignment:Splign:2.1.0"
     exon            47..1032
                     /gene="Fmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1184
                     /gene="Fmod"
                     /note="FM; KSPG fibromodulin; collagen-binding 59 kDa
                     protein; keratan sulfate proteoglycan fibromodulin"
                     /codon_start=1
                     /product="fibromodulin precursor"
                     /protein_id="NP_542429.1"
                     /db_xref="GeneID:64507"
                     /db_xref="RGD:619769"
                     /translation="MQWASILLLRGLCSLSQGQYEEDSHWWLQYLRNQQSTYYDPYDT
                     YPYETSDPYPYEVEEGPAYAYGAPPPPEPRDCPQECDCPPNFPTAMYCDNRNLKYLPF
                     VPSRMKYVYFQNNQIAAIQEGVFDNATGLLWIALHGNQITSDKIGRKVFSKLRHLERL
                     YLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLHHNEIQEVGSS
                     MRGLRSLILLDLSYNHLRRVPDGLPSALEQLYLEHNNVYTVPDSYFRGSPKLLYVRLS
                     HNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFC
                     TVVDVMNFSKLQVLRLDGNEIKRSAMPVDAPLCLRLASLIEI"
     exon            1033..2944
                     /gene="Fmod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggccaaac agaaggacgt ggtcactctg aacggttcaa cccaagggac aacatgcagt
       61 gggcctccat cctgctgctg cgcgggctct gctcgctttc ccagggccag tatgaagaag
      121 actctcactg gtggctccaa tacctccgaa accagcagtc cacctactac gacccctacg
      181 acacttaccc ctacgagacc tccgaccctt acccctatga agtagaggag ggcccagcct
      241 atgcctatgg tgccccacct ccaccagagc cccgtgattg tccccaagaa tgcgactgtc
      301 cccccaactt ccccacagcc atgtactgtg acaaccgcaa cctcaagtac ctgccctttg
      361 tgccctcccg catgaagtac gtctacttcc agaacaacca gatcgctgcc atccaggaag
      421 gtgtctttga caatgccacc ggcctcctct ggattgctct gcatggcaac cagattacca
      481 gtgacaagat aggcaggaag gtcttctcca agctgaggca cttggagagg ctgtacctgg
      541 accacaacaa cctgacccgg atgcccggac cactgcctcg gtccctgaga gagctccacc
      601 tggaccacaa ccagatctct cgggtcccca acaacgctct ggagggcctg gagaacctca
      661 cagcattata tctccatcac aatgagatcc aagaagtggg aagttccatg aggggcctcc
      721 ggtccctgat cctactagac ctgagttata accaccttcg aagggttccc gacggtctgc
      781 cctcagccct ggagcagctg tacctagaac acaacaacgt ctacaccgtc cctgacagct
      841 acttccgggg ctcacccaag ctgctgtatg tccggctgtc tcacaacagt ctcactaaca
      901 atggccttgc taccaacacc ttcaattcca gcagccttct ggagctagac ttgtcctaca
      961 accagctgca gaagatccct cccgtcaaca ccaacctgga gaatctttac ctccaaggca
     1021 acaggatcaa tgagttctcc atcagcagtt tctgcacggt ggtggacgtc atgaacttct
     1081 ccaagctgca ggtgctacgc ctggatggga acgagatcaa gcgcagcgct atgccggtgg
     1141 acgccccact ctgcctgcgc cttgccagcc tcatcgagat ctgaggggct tcgccttggg
     1201 ctcggggctc cgccttggac tccgggctcc gccttgggat cggagatcgg ggctcagggc
     1261 tccgggctcc gggctccggg cactggactc cgggctccag gcatcgggta ccgggcaccg
     1321 gggtcccggc atatgccctg ccacctgcta cactcagctt gaaggtctgg tttggctttt
     1381 gctggatggt ctgggacaag cacgtgacag aagtccacag gatcttattc agtctccttc
     1441 cgataggcaa agttaggtgg gatcaggggc caggccagtt tctgcagggg atgaaagtgg
     1501 tggtaaaaga aatggccgca gagtctagcc cccaaatctt actatccctc aacccttccc
     1561 catgacctag tctggcagac catccccttg cttggataat agcatataac cagacaatct
     1621 gacttcagct gtgctcactc aatggcttgg ccagttgctt ctgcagtcgc tctgggctcc
     1681 tactccttgc tcctcaaaac atcaaaacgt acttcctgcc cagccacttc ctctaggccc
     1741 agctcatccc ctctgccctc tttcattgag gcctcttcta aggtcttaga caatcaggag
     1801 acacccacac cccaaggttg gtggggagct gtccaacaac ctgtggagga agaccacaca
     1861 ttattatctg aggttaaaag gatatctaaa accatcacac acacacacac acacacacac
     1921 acacacacac acacacacaa cgtcacctgt ttaaagtcag cgtattgaac agtataatgg
     1981 tgactgatag tcatgactta attacaaggg gataaccagc cctataatgg aggatccatc
     2041 agaggagaga agggtcaaat gctcattttt aggatccaca ataagatggg gaagagtcac
     2101 acctcagaat ggcaggactg aaggggcagc cccccttcca gcttcacctg accaacatga
     2161 tctgtgcccc ttcttgggct tttagtatca aaggggccag tgtggtttcc aaaccatgag
     2221 aaagagcctc tgcccatcct tggatccagg tatggaggtt tgttacacag aggcagaggc
     2281 agactgtgcc agccgtggac ccacccacta acccagacaa gggtgtgatc tccataactg
     2341 gtttgtccct aaagctagag tttaaggtac cagctcttct ggagatggtc actggggtac
     2401 aggaagccct agccaggccc aaggcttacc tacactagac atagtttcct ctgcttccac
     2461 actgtgggac cacaccttat actgatggtg cctgtgacgt gtagcttgtc tgagagcaac
     2521 cctgtcttct cctttttaaa ggtgatgttg cctaggtaca gccatcgggt tctctagact
     2581 cactgggaaa gagccacggg tagccagtgg caagaaccag ttgtgagatg ttagcctgag
     2641 gtaggtccct tcccagatgc cttagaccca tgactctgtg tgcacttagg agcaagcttc
     2701 cctgaaaagg acagggtggg gtggggtgct tagactgtgc catgggttcc agatcctgaa
     2761 atccacaaaa gccaaaccag cttgtttgaa ccagggagtg ccacatgtgg agcaaggctg
     2821 ccctgcccag agctcttgag aagcacctgc atgcagatac catctggcct ctataaaggg
     2881 tcctcagcaa gaagcaagca tgagtggtgg ccaacctgac caataaagtt attttataag
     2941 tgcaaaaaaa aaaaaaaaaa
//
