LOCUS       NM_144739               2690 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus flavin containing dimethylaniline monoxygenase 5
            (Fmo5), mRNA.
ACCESSION   NM_144739 XM_346630
VERSION     NM_144739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Fiorentini,F., Romero,E., Fraaije,M.W., Faber,K., Hall,M. and
            Mattevi,A.
  TITLE     Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug
            Metabolism
  JOURNAL   ACS Chem Biol 12 (9), 2379-2387 (2017)
   PUBMED   28783300
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Fiorentini,F., Geier,M., Binda,C., Winkler,M., Faber,K., Hall,M.
            and Mattevi,A.
  TITLE     Biocatalytic Characterization of Human FMO5: Unearthing
            Baeyer-Villiger Reactions in Humans
  JOURNAL   ACS Chem Biol 11 (4), 1039-1048 (2016)
   PUBMED   26771671
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Gonzalez Malagon,S.G., Melidoni,A.N., Hernandez,D., Omar,B.A.,
            Houseman,L., Veeravalli,S., Scott,F., Varshavi,D., Everett,J.,
            Tsuchiya,Y., Timms,J.F., Phillips,I.R. and Shephard,E.A.
  TITLE     The phenotype of a knockout mouse identifies flavin-containing
            monooxygenase 5 (FMO5) as a regulator of metabolic ageing
  JOURNAL   Biochem Pharmacol 96 (3), 267-277 (2015)
   PUBMED   26049045
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Lai,W.G., Farah,N., Moniz,G.A. and Wong,Y.N.
  TITLE     A Baeyer-Villiger oxidation specifically catalyzed by human
            flavin-containing monooxygenase 5
  JOURNAL   Drug Metab Dispos 39 (1), 61-70 (2011)
   PUBMED   20947616
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Wu,C.C., MacCoss,M.J., Mardones,G., Finnigan,C., Mogelsvang,S.,
            Yates,J.R. 3rd and Howell,K.E.
  TITLE     Organellar proteomics reveals Golgi arginine dimethylation
  JOURNAL   Mol Biol Cell 15 (6), 2907-2919 (2004)
   PUBMED   15047867
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Cherrington,N.J., Cao,Y., Cherrington,J.W., Rose,R.L. and
            Hodgson,E.
  TITLE     Physiological factors affecting protein expression of
            flavin-containing monooxygenases 1, 3 and 5
  JOURNAL   Xenobiotica 28 (7), 673-682 (1998)
   PUBMED   9711811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_144739.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF458413.1, BC070883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000002.1  187910964-187911276
            314-490             JAXUCZ010000002.1  187911394-187911570
            491-679             JAXUCZ010000002.1  187917968-187918156
            680-842             JAXUCZ010000002.1  187919807-187919969
            843-985             JAXUCZ010000002.1  187921169-187921311
            986-1185            JAXUCZ010000002.1  187925635-187925834
            1186-1538           JAXUCZ010000002.1  187929033-187929385
            1539-1611           JAXUCZ010000002.1  187936295-187936367
            1612-2690           JAXUCZ010000002.1  187937382-187938460
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2690
                     /gene="Fmo5"
                     /note="flavin containing dimethylaniline monoxygenase 5"
                     /db_xref="GeneID:246248"
                     /db_xref="RGD:628602"
     exon            1..313
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            314..490
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1957
                     /gene="Fmo5"
                     /EC_number="1.14.13.8"
                     /EC_number="1.6.3.1"
                     /note="dimethylaniline monooxygenase [N-oxide-forming] 5;
                     FMO 5; dimethylaniline oxidase 5; hepatic
                     flavin-containing monooxygenase 5; flavin containing
                     monooxygenase 5; NADPH oxidase; NAPDH oxidase"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 5"
                     /protein_id="NP_653340.2"
                     /db_xref="GeneID:246248"
                     /db_xref="RGD:628602"
                     /translation="MAKKRIAVIGSGASGLTCIKCCLEEGLEPVCFEMSDDIGGLWRY
                     QENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNSQVLEYFRMYAKEFGLL
                     KYIQFKTTVCSVKKQPDFSTSGQWQVVTEHEGKEQVDVFDGVLVCTGHHTDPHLPLDS
                     FPGIEKFKGKYFHSREYKNPVEFTGKRVIVIGIGNSGGDLAVEISHTAKQVFLSTRRG
                     AWILNRVGKHGYPIDILLSSRITNYLSKICGSALKNRYMEKQLNQRFDHEMFGLKPKH
                     SALGQHPTINDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDVVIFATGYSF
                     AFPFLEDSVKVVQNKVSLYKKVFPPNLEKPTLAIIGLIQPLGAIMPISELQGRWATQV
                     FKGLKKLPSQSEMMAEINKTREEMAKRYVDSQRHTIQGDYIDTMEEIADLVGVRPNLL
                     SLAFTDPKLAFQLLVGPCTPVQYRLQGPGKWAGARKTILTTEDRIRKPLMTRVVERDS
                     SGTSLVTVRVLMLAVTFLAVILAYF"
     exon            491..679
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            680..842
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..985
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1185
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1538
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1611
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..2690
                     /gene="Fmo5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgggaagt tgaaagtgaa ccctgaagga aaagtaggaa gggatggagc ctggagggtc
       61 gctctccctg tgggagtgct gctgagaagc tatagattaa aacatatata atgttattgt
      121 tttcttccca aaacattctg agctgtttcc tttgcgttta cggaagaagg gtgcacgccc
      181 ttaggagggc gggataggag gtgggacggc acagcccctc cccattggcc agtgtttatc
      241 tgaggcactg ctgctctgcc aggagttgta gcccccgctt agtcccgagc tagtggagca
      301 gtgccctgag caggacaagt gactctaacc caaccagtga agctttctgg cgaccatggc
      361 caagaaaagg atcgctgtaa ttggatcagg agccagcggg ctcacctgca tcaagtgctg
      421 cctagaagag ggtttggaac ctgtctgctt tgaaatgtct gatgacatcg gaggactgtg
      481 gaggtaccag gaaaaccctg aggaaggaag ggccagtatt tataagtctg tgatcatcaa
      541 cacttccaag gagatgatgt gtttcagtga ctaccctatt ccagatcatt accctaactt
      601 catgcacaac tcccaggtcc tggagtattt caggatgtac gccaaagagt ttggccttct
      661 caaatatatc caattcaaga ccacagtgtg cagcgtgaag aagcagcctg atttctctac
      721 ctcaggccag tggcaagtgg tcactgagca tgaagggaaa gagcaggtag acgtcttcga
      781 tggagtcctg gtttgcacag gtcatcacac ggaccctcac ctgcccctgg acagctttcc
      841 tggaattgaa aagttcaaag gaaagtactt ccacagtcga gaatataaga acccagtgga
      901 atttaccggg aaaagggtca ttgtcattgg cattgggaat tctggaggag atctggccgt
      961 agagatcagc cacacagcca agcaggtgtt cctcagtacc aggagaggag cttggatctt
     1021 gaaccgcgta gggaaacatg gatatcctat tgatattctg ctttcttctc gaattaccaa
     1081 ctatctgtca aagatctgtg gctcagccct gaaaaacaga tatatggaaa aacagttgaa
     1141 ccaaaggttt gatcatgaaa tgtttggcct gaagcctaag cacagtgctc tgggtcagca
     1201 tccaacgata aacgatgacc tgcccaatcg tatcatttct ggcttggtga aggtgaaagg
     1261 caatgtgaag gaattcacag agacggccgc catatttgaa gatggctcca gggaggatga
     1321 cattgatgtg gtcatctttg ccacaggcta cagctttgcc tttccttttc ttgaggactc
     1381 tgtcaaagta gtccaaaaca aggtctcctt gtataaaaag gtctttcccc ctaacctgga
     1441 aaaaccaact cttgcaatca tcggtttaat tcagcccttg ggagccatta tgcctatttc
     1501 agagctccaa ggacgctggg ccactcaggt gttcaaaggg ctaaagaaat tgccctccca
     1561 aagtgaaatg atggcagaaa taaataagac tcgagaggaa atggcaaaaa ggtatgtgga
     1621 cagccagcgt cataccatcc agggagacta tatagacacc atggaagaga ttgcagattt
     1681 ggtgggtgtc aggcccaatc tcctgtctct ggccttcacc gaccctaagc tggcattcca
     1741 gttacttgta ggaccctgta ctccggtcca gtatcgtcta cagggcccgg ggaagtgggc
     1801 tggagcccga aaaactattc tcaccacaga agatcgtata cgaaagcctc tgatgacaag
     1861 agtggtggaa agggacagct ctgggacgtc actggtgact gtgcgtgtcc tcatgctggc
     1921 tgtcactttc ctggctgtca tcctggctta tttttagatg tggcagctca atgctcccgc
     1981 ttccactgga aagcgccatc tagcgacacc ttcagaaatg acaagactga acactcagct
     2041 tcatactgca caggaatcaa tcacaatcag tcaatcaatc aatcaatcaa tctctctctg
     2101 cctccctcct cttctctccc ttcctccccc tctctctcct ccatcaatca ttaatctttc
     2161 ttgtttttcc ttctgtgata ctgggttttc attaattaat tcatctcctc tcttgagcct
     2221 ctaatttctc ccggtagttt ccaggccgtg agctcagacc tctcttgtca tctttgtatg
     2281 tcattagcag agttctctta gtgcttgact ctgttgtgtt tctaatattg cacagctaga
     2341 cctcgttgga tgacaacacc tcttgaaaag actgctcaca tcatcaagcg cttactggct
     2401 agaacttgac cttgtaagca gagcccatgt gcctattcct ggaatcccca cagagggaca
     2461 gttcagaaag aagaacatct ggtgctgagg gctggaagtc caagatcaag ggtgcagaca
     2521 gtgaggaact tctggcctcg tgattaatac agtgagggta tcatatgggc aagacagaaa
     2581 atacattgtt agctaagttc cgacatgtgg cacatgctaa ataaatgttc attgatgttt
     2641 atgaaataag gtggcatctc taagtcaatc taataaataa gtggctgact
//
