LOCUS       NM_053433               1916 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus flavin containing dimethylaniline monoxygenase 3
            (Fmo3), mRNA.
ACCESSION   NM_053433 XM_346448
VERSION     NM_053433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Novick,R.M., Mitzey,A.M., Brownfield,M.S. and Elfarra,A.A.
  TITLE     Differential localization of flavin-containing monooxygenase (FMO)
            isoforms 1, 3, and 4 in rat liver and kidney and evidence for
            expression of FMO4 in mouse, rat, and human liver and kidney
            microsomes
  JOURNAL   J Pharmacol Exp Ther 329 (3), 1148-1155 (2009)
   PUBMED   19307449
  REMARK    GeneRIF: Data show a compelling visual demonstration of the
            isoform-specific localization patterns of FMO1, -3, and -4 in the
            rat liver and kidney and the first evidence for expression of FMO4
            at the protein level in mouse and human liver and kidney
            microsomes.
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Novick,R.M. and Elfarra,A.A.
  TITLE     Purification and characterization of flavin-containing
            monooxygenase isoform 3 from rat kidney microsomes
  JOURNAL   Drug Metab Dispos 36 (12), 2468-2474 (2008)
   PUBMED   18775983
  REMARK    GeneRIF: Results demonstrate many similar properties between rat
            hepatic and renal FMO3 forms and suggest that renal FMO3 may play
            an important role in kidney metabolism of xenobiotics containing
            sulfur and selenium atoms.
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Krause,R.J., Glocke,S.C., Sicuri,A.R., Ripp,S.L. and Elfarra,A.A.
  TITLE     Oxidative metabolism of seleno-L-methionine to L-methionine
            selenoxide by flavin-containing monooxygenases
  JOURNAL   Chem Res Toxicol 19 (12), 1643-1649 (2006)
   PUBMED   17173378
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Dolan,C., Shields,D.C., Stanton,A., O'Brien,E., Lambert,D.M.,
            O'Brien,J.K. and Treacy,E.P.
  TITLE     Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene
            do not predispose to essential hypertension in Caucasians
  JOURNAL   BMC Med Genet 6, 41 (2005)
   PUBMED   16324215
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Lattard,V., Lachuer,J., Buronfosse,T., Garnier,F. and Benoit,E.
  TITLE     Physiological factors affecting the expression of FMO1 and FMO3 in
            the rat liver and kidney
  JOURNAL   Biochem Pharmacol 63 (8), 1453-1464 (2002)
   PUBMED   11996886
  REMARK    GeneRIF: the relationship between gender and development in the
            expression of FMO3 in the liver and kidney was determined
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Lattard,V., Buronfosse,T., Lachuer,J., Longin-Sauvageon,C.,
            Moulin,C. and Benoit,E.
  TITLE     Cloning, sequencing, tissue distribution, and heterologous
            expression of rat flavin-containing monooxygenase 3
  JOURNAL   Arch Biochem Biophys 391 (1), 30-40 (2001)
   PUBMED   11414682
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Treacy,E.P., Akerman,B.R., Chow,L.M., Youil,R., Bibeau,C., Lin,J.,
            Bruce,A.G., Knight,M., Danks,D.M., Cashman,J.R. and Forrest,S.M.
  TITLE     Mutations of the flavin-containing monooxygenase gene (FMO3) cause
            trimethylaminuria, a defect in detoxication
  JOURNAL   Hum Mol Genet 7 (5), 839-845 (1998)
   PUBMED   9536088
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087008.1.
            
            On Jun 3, 2007 this sequence version replaced NM_053433.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087008.1, AF286595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..1916
                     /gene="Fmo3"
                     /note="flavin containing dimethylaniline monoxygenase 3"
                     /db_xref="GeneID:84493"
                     /db_xref="RGD:619761"
     exon            1..220
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..358
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1822
                     /gene="Fmo3"
                     /EC_number="1.14.13.8"
                     /EC_number="1.14.13.148"
                     /EC_number="1.14.13.32"
                     /note="dimethylaniline monooxygenase [N-oxide-forming] 3;
                     FMO 3; dimethylaniline oxidase 3; hepatic
                     flavin-containing monooxygenase 3; trimethylamine
                     monooxygenase; flavin containing monooxygenase 3"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 3"
                     /protein_id="NP_445885.2"
                     /db_xref="GeneID:84493"
                     /db_xref="RGD:619761"
                     /translation="MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFS
                     DHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLK
                     YIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSF
                     PGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGS
                     WVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNG
                     TLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEGIDCVIFATGYGYA
                     YPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQV
                     IRGTCILPSVNDMMDDIDEKMGKKLKWFGNSTTIQTDYIVYMDELASFIGAKPNILWL
                     FLKDPRLAIEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRDVGGIQKP
                     CLYSHFLRLLAVPVLIALFLVLI"
     exon            359..547
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..710
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..853
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1053
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1409
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1482
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1890
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaatgacca gagaggtggc ccaaagacaa gcatgtcact gcagctggag tttgtgctct
       61 cttgctacag gatgaaggat taccccttta agagaagctc ctccctgttc caatgacact
      121 tctgcacaca gaaacataca aagtgcccag cattttctct ttcagacttt gaagaagact
      181 aggggtttag acacagagaa gaaaggaaga caaataaaag gccaccatga agaggaaagt
      241 ggccgtcatt ggggctggtg tcagtggtct ggctgccatc aggagctgtc tggaagaggg
      301 actggagccc acgtgctttg agaggagtga tgatgttggg ggcctgtgga aattttcaga
      361 ccacacagaa gagggcaggg ccagcattta ccaatcggtc ttcaccaact cttccaaaga
      421 aatgatgtgt ttcccagact tcccctatcc cgatgacttt cctaacttca tgcataacag
      481 caagctccaa gaatatatca cttcatttgc cacagaaaag aaccttctaa aatacataca
      541 gtttgagaca cttgtaacca gaatcaataa atgtcctgat ttctcaacca ctggcaaatg
      601 ggaagttacc actgaaaaga acagtaaaaa ggaaacagct gtctttgatg ctgtaatgat
      661 ttgttctggg caccatgtat atccccatct accaaaagac tcctttccag gtctgaaccg
      721 tttcaaaggc aaatgcttcc acagcaggga ctataaggag ccaggaacat ggaaaggaaa
      781 acgagtcctg gtgattggcc tggggaactc aggttgtgac atcgctgcgg aactcagtca
      841 cgtggctcag caggtcatca taagctccag aagtggttct tgggtgatga gccgggtctg
      901 gaatgatggc tacccttggg acatggtggt gatcacacga tttcaaacat ttctcaagaa
      961 caacttaccc acagccattt ctgactggtg gtatatgaag cagatgaacg caagattcaa
     1021 gcatgaaaac tacgggttga tgcctttaaa tggaacactc aggaaggagc ctgtgttcaa
     1081 tgatgagctt ccagcccgca tcctgtgtgg cactgtgtcc atcaagccta atgtgaagga
     1141 gttcacagag acctccgctg tgttcgagga tgggactgtg tttgagggca ttgactgtgt
     1201 catcttcgcc acaggctatg gttatgccta ccccttcctg gatgacagca tcatcaaaag
     1261 cagaaataat gaggtcacct tgtacaaagg catcttccct cctcaactag agaaaccaac
     1321 catggcagtg attggccttg tccagtccct gggtgctgcc atccccacaa ccgacctgca
     1381 ggcacgctgg gcagcacaag taataagagg aacttgcatt ttgccttctg taaacgacat
     1441 gatggatgat attgacgaga aaatggggaa gaagcttaaa tggtttggca acagcaccac
     1501 cattcagaca gattacattg tttatatgga tgaattggcc tccttcatcg gagcaaagcc
     1561 caatatccta tggctgtttc tcaaggaccc caggttggcc atagaagtgt tctttggccc
     1621 ttgcagcccc taccagttcc ggctggtagg cccagggaag tggtcaggag ccaggaacgc
     1681 catcctaacc cagtgggacc ggtcactgaa gcctatgaag acccgtgacg tcggtggtat
     1741 tcagaaacct tgcttgtatt cccattttct caggctcctg gctgttccag tgctcattgc
     1801 tttgttcctt gtgttgatct gattgagatt ccctctagaa tgtctgcgag tcaccgacaa
     1861 taaccagaca agaactttgc tatttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
