LOCUS       NM_144737               2040 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus flavin containing dimethylaniline monoxygenase 2
            (Fmo2), mRNA.
ACCESSION   NM_144737
VERSION     NM_144737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Hugonnard,M., Benoit,E., Longin-Sauvageon,C. and Lattard,V.
  TITLE     Identification and characterization of the FMO2 gene in Rattus
            norvegicus: a good model to study metabolic and toxicological
            consequences of the FMO2 polymorphism
  JOURNAL   Pharmacogenetics 14 (10), 647-655 (2004)
   PUBMED   15454729
  REMARK    GeneRIF: FMO2 genetic polymorphism was associated with major
            differences in the S-oxidative metabolism.
REFERENCE   2  (bases 1 to 2040)
  AUTHORS   Henderson,M.C., Krueger,S.K., Stevens,J.F. and Williams,D.E.
  TITLE     Human flavin-containing monooxygenase form 2 S-oxygenation:
            sulfenic acid formation from thioureas and oxidation of glutathione
  JOURNAL   Chem Res Toxicol 17 (5), 633-640 (2004)
   PUBMED   15144220
REFERENCE   3  (bases 1 to 2040)
  AUTHORS   Lattard,V., Longin-Sauvageon,C., Krueger,S.K., Williams,D.E. and
            Benoit,E.
  TITLE     The FMO2 gene of laboratory rats, as in most humans, encodes a
            truncated protein
  JOURNAL   Biochem Biophys Res Commun 292 (2), 558-563 (2002)
   PUBMED   11906197
REFERENCE   4  (bases 1 to 2040)
  AUTHORS   Krueger,S.K., Martin,S.R., Yueh,M.F., Pereira,C.B. and
            Williams,D.E.
  TITLE     Identification of active flavin-containing monooxygenase isoform 2
            in human lung and characterization of expressed protein
  JOURNAL   Drug Metab Dispos 30 (1), 34-41 (2002)
   PUBMED   11744609
REFERENCE   5  (bases 1 to 2040)
  AUTHORS   Karoly,E.D. and Rose,R.L.
  TITLE     Sequencing, expression, and characterization of cDNA expressed
            flavin-containing monooxygenase 2 from mouse
  JOURNAL   J Biochem Mol Toxicol 15 (6), 300-308 (2001)
   PUBMED   11835629
REFERENCE   6  (bases 1 to 2040)
  AUTHORS   Dolphin,C.T., Beckett,D.J., Janmohamed,A., Cullingford,T.E.,
            Smith,R.L., Shephard,E.A. and Phillips,I.R.
  TITLE     The flavin-containing monooxygenase 2 gene (FMO2) of humans, but
            not of other primates, encodes a truncated, nonfunctional protein
  JOURNAL   J Biol Chem 273 (46), 30599-30607 (1998)
   PUBMED   9804831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070904.1 and CK365136.1.
            
            On Oct 28, 2005 this sequence version replaced NM_144737.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070904.1, AF458414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BC070904.1         1-153
            154-801             CK365136.1         89-736
            802-2040            BC070904.1         802-2040
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2040
                     /gene="Fmo2"
                     /note="flavin containing dimethylaniline monoxygenase 2"
                     /db_xref="GeneID:246245"
                     /db_xref="RGD:628600"
     exon            1..90
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..228
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1704
                     /gene="Fmo2"
                     /EC_number="1.14.13.8"
                     /note="FMO 2; dimethylaniline oxidase 2; pulmonary
                     flavin-containing monooxygenase 2; flavin containing
                     monooxygenase 2"
                     /codon_start=1
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     2"
                     /protein_id="NP_653338.2"
                     /db_xref="GeneID:246245"
                     /db_xref="RGD:628600"
                     /translation="MVKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGLWRFK
                     ENVEDGRASIYHSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLK
                     YIQFQTTVISVKKRPDFASSGQWDVYVQSNGKEQRAVFDAVMVCSGHHIQPHLPLKSF
                     PGIERFQGQYFHSRQYKHPVGYEGKRILVVGIGNSAADIASELSKRAAQVFVSTRHGS
                     WVLSRISEDGYPWDMVFHTRFSSMLRNVLPRTVVKWMMERQMNRWFNHENYGLVPQNK
                     YLMKEPVLNDDLPSRLLYGAIKVKTRVKELTETAVVFEDGTVEEDVDVIVFATGYTFS
                     FPFLEDSLVKVEDNKVSLYKAMFPPHLEKPTLACIGLIQPLGSIFPTVELQARWATRV
                     FKGVCRLPSETTMMADIAERNEKRIDLFGKSQSQILQTNYIDYLDELALEIGAKPDFI
                     SLLFKDPKLAVKLYFGPCNSYQYRLVGPGQWEGARNAILTQKQRILKPLKTRTLQTSA
                     SAPVSFLIKVLGLLAIVLAFFFKLHGF"
     exon            229..417
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..580
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..723
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..923
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1279
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1352
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2017
                     /gene="Fmo2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaact cccatctctc tgcacacaac cctcagggga aactcctctg ccaaagggag
       61 agaggacagt gctaaaaagc acaaataaag gggacaatgg tgaagaaggt tgccgtgatt
      121 ggagcagggg tcagtggcct gatctctcta aagtgctgcg tggacgaggg tctggagccc
      181 acctgctttg aaaggactga ggatatcgga ggactgtgga ggttcaaaga aaacgtggaa
      241 gatggccgag ccagcatcta ccactctgtc atcaccaaca ctagcaaaga aatgtcctgc
      301 ttcagtgact tcccaatgcc ggaggatttc cccaacttcc tgcacaactc taaactcctg
      361 gaatacttca ggatctttgc caagaaattt gatctcctaa aatatattca gtttcagaca
      421 accgtcatta gtgtgaagaa acgcccagat ttcgcatctt ctgggcagtg ggacgtgtat
      481 gttcagagca atggcaagga gcagcgtgct gtctttgacg ccgttatggt ctgcagcggc
      541 catcacatcc agccccacct gccactcaag tcgtttccag gtatcgagag gttccaaggc
      601 cagtatttcc atagccgcca atacaagcac ccagtggggt atgaggggaa acgcatccta
      661 gtggttggaa taggaaactc cgccgcagac attgcctctg aactgagtaa gagggccgcg
      721 caggtgtttg tcagcaccag acatggttcc tgggtattga gccgaatctc tgaagatggc
      781 tacccttggg acatggtgtt ccacactaga tttagctcca tgctccggaa tgtcctgccc
      841 cgcacggtcg tcaagtggat gatggaacga cagatgaatc gatggttcaa ccatgagaat
      901 tacggcctgg tgcctcagaa caaatacctt atgaaagaac ctgtattaaa cgacgacctc
      961 cccagccgcc tgctgtacgg agccatcaaa gtaaaaacac gggtaaagga gctcacggag
     1021 acagctgtgg tcttcgagga tggcacggtg gaggaagacg tggatgtcat tgtctttgcc
     1081 acagggtata cgttctcttt tcctttcctg gaagactcgc ttgttaaagt agaggataat
     1141 aaggtctcgc tgtacaaagc catgtttccc cctcacctgg agaagccaac ccttgcgtgc
     1201 ataggtctca tccagcctct gggctccatc ttcccaaccg tagagcttca ggcgcggtgg
     1261 gcgacaagag ttttcaaagg cgtgtgtcgc ttgccttcgg agacgacgat gatggcagac
     1321 attgctgaaa gaaatgagaa aagaattgac ctgtttggaa aaagccagag ccagattctg
     1381 cagaccaatt acattgatta cctggatgaa ctcgccttgg agataggtgc gaagccggac
     1441 ttcatctctc tccttttcaa agaccctaaa ctggctgtga aactctactt cggaccctgc
     1501 aattcctacc agtaccgcct agttggacct gggcagtggg aaggagccag gaatgccatc
     1561 ctcacccaga agcagcggat cctgaagccg ttaaagactc gcactctcca gacctcagct
     1621 agtgccccag tgtctttcct gattaaggtc ctggggctgc ttgctattgt tctggccttc
     1681 tttttcaagc ttcatgggtt ctaatctgtc ccatgacact tttctccatc accgcctctt
     1741 tgaaagggag actaaagaaa ttacatcctc attataattt tacttcaggg gaacaagtag
     1801 ggggactgat tgtagggaga tcagaagaat taggtctaga tataaagcta aattaaggtc
     1861 acaggatgct gttatcattc tactatctcc tccaattcat cagtcttcac gtggtattct
     1921 gtaataacac cagcacaggt agatagtgcc accagtcatg gcaagttttg agttacaatg
     1981 ataaaaaaaa tctcaataaa attatgcagg ataaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
