LOCUS       NP_653338                535 aa            linear   ROD 03-APR-2024
DEFINITION  dimethylaniline monooxygenase [N-oxide-forming] 2 [Rattus
            norvegicus].
ACCESSION   NP_653338
VERSION     NP_653338.2
DBSOURCE    REFSEQ: accession NM_144737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 535)
  AUTHORS   Hugonnard,M., Benoit,E., Longin-Sauvageon,C. and Lattard,V.
  TITLE     Identification and characterization of the FMO2 gene in Rattus
            norvegicus: a good model to study metabolic and toxicological
            consequences of the FMO2 polymorphism
  JOURNAL   Pharmacogenetics 14 (10), 647-655 (2004)
   PUBMED   15454729
  REMARK    GeneRIF: FMO2 genetic polymorphism was associated with major
            differences in the S-oxidative metabolism.
REFERENCE   2  (residues 1 to 535)
  AUTHORS   Henderson,M.C., Krueger,S.K., Stevens,J.F. and Williams,D.E.
  TITLE     Human flavin-containing monooxygenase form 2 S-oxygenation:
            sulfenic acid formation from thioureas and oxidation of glutathione
  JOURNAL   Chem Res Toxicol 17 (5), 633-640 (2004)
   PUBMED   15144220
REFERENCE   3  (residues 1 to 535)
  AUTHORS   Lattard,V., Longin-Sauvageon,C., Krueger,S.K., Williams,D.E. and
            Benoit,E.
  TITLE     The FMO2 gene of laboratory rats, as in most humans, encodes a
            truncated protein
  JOURNAL   Biochem Biophys Res Commun 292 (2), 558-563 (2002)
   PUBMED   11906197
REFERENCE   4  (residues 1 to 535)
  AUTHORS   Krueger,S.K., Martin,S.R., Yueh,M.F., Pereira,C.B. and
            Williams,D.E.
  TITLE     Identification of active flavin-containing monooxygenase isoform 2
            in human lung and characterization of expressed protein
  JOURNAL   Drug Metab Dispos 30 (1), 34-41 (2002)
   PUBMED   11744609
REFERENCE   5  (residues 1 to 535)
  AUTHORS   Karoly,E.D. and Rose,R.L.
  TITLE     Sequencing, expression, and characterization of cDNA expressed
            flavin-containing monooxygenase 2 from mouse
  JOURNAL   J Biochem Mol Toxicol 15 (6), 300-308 (2001)
   PUBMED   11835629
REFERENCE   6  (residues 1 to 535)
  AUTHORS   Dolphin,C.T., Beckett,D.J., Janmohamed,A., Cullingford,T.E.,
            Smith,R.L., Shephard,E.A. and Phillips,I.R.
  TITLE     The flavin-containing monooxygenase 2 gene (FMO2) of humans, but
            not of other primates, encodes a truncated, nonfunctional protein
  JOURNAL   J Biol Chem 273 (46), 30599-30607 (1998)
   PUBMED   9804831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070904.1 and CK365136.1.
            
            On Oct 28, 2005 this sequence version replaced NP_653338.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070904.1, AF458414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     Protein         1..535
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     2"
                     /EC_number="1.14.13.8"
                     /note="FMO 2; dimethylaniline oxidase 2; pulmonary
                     flavin-containing monooxygenase 2; flavin containing
                     monooxygenase 2"
                     /calculated_mol_wt=60814
     Region          3..532
                     /region_name="FMO-like"
                     /note="Flavin-binding monooxygenase-like; pfam00743"
                     /db_xref="CDD:395602"
     Site            510..530
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IRI9.3)"
     CDS             1..535
                     /gene="Fmo2"
                     /coded_by="NM_144737.2:97..1704"
                     /db_xref="GeneID:246245"
                     /db_xref="RGD:628600"
ORIGIN      
        1 mvkkvaviga gvsglislkc cvdegleptc fertediggl wrfkenvedg rasiyhsvit
       61 ntskemscfs dfpmpedfpn flhnsklley frifakkfdl lkyiqfqttv isvkkrpdfa
      121 ssgqwdvyvq sngkeqravf davmvcsghh iqphlplksf pgierfqgqy fhsrqykhpv
      181 gyegkrilvv gignsaadia selskraaqv fvstrhgswv lsrisedgyp wdmvfhtrfs
      241 smlrnvlprt vvkwmmerqm nrwfnhenyg lvpqnkylmk epvlnddlps rllygaikvk
      301 trvkelteta vvfedgtvee dvdvivfatg ytfsfpfled slvkvednkv slykamfpph
      361 lekptlacig liqplgsifp tvelqarwat rvfkgvcrlp settmmadia ernekridlf
      421 gksqsqilqt nyidyldela leigakpdfi sllfkdpkla vklyfgpcns yqyrlvgpgq
      481 wegarnailt qkqrilkplk trtlqtsasa pvsflikvlg llaivlafff klhgf
//
