LOCUS       NM_012792               2042 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus flavin containing dimethylaniline monoxygenase 1
            (Fmo1), mRNA.
ACCESSION   NM_012792
VERSION     NM_012792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Li,B., Yuan,Y., Zhang,W., He,W., Hu,J. and Chen,N.
  TITLE     Flavin-containing monooxygenase, a new clue of pathological
            proteins in the rotenone model of parkinsonism
  JOURNAL   Neurosci Lett 566, 11-16 (2014)
   PUBMED   24440618
  REMARK    GeneRIF: FMO, whose dysfunction could be a reason for the apoptosis
            of dopaminergic neurons in rotenone model, might be a new clue of
            pathological proteins in rotenone model of parkinsonism
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Ekuni,D., Firth,J.D., Nayer,T., Tomofuji,T., Sanbe,T., Irie,K.,
            Yamamoto,T., Oka,T., Liu,Z., Vielkind,J. and Putnins,E.E.
  TITLE     Lipopolysaccharide-induced epithelial monoamine oxidase mediates
            alveolar bone loss in a rat chronic wound model
  JOURNAL   Am J Pathol 175 (4), 1398-1409 (2009)
   PUBMED   19779138
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Rodriguez-Fuentes,G., Coburn,C., Curras-Collazo,M., Guillen,G. and
            Schlenk,D.
  TITLE     Effect of hyperosmotic conditions on flavin-containing
            monooxygenase activity, protein and mRNA expression in rat kidney
  JOURNAL   Toxicol Lett 187 (2), 115-118 (2009)
   PUBMED   19429252
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Novick,R.M., Mitzey,A.M., Brownfield,M.S. and Elfarra,A.A.
  TITLE     Differential localization of flavin-containing monooxygenase (FMO)
            isoforms 1, 3, and 4 in rat liver and kidney and evidence for
            expression of FMO4 in mouse, rat, and human liver and kidney
            microsomes
  JOURNAL   J Pharmacol Exp Ther 329 (3), 1148-1155 (2009)
   PUBMED   19307449
  REMARK    GeneRIF: Data show a compelling visual demonstration of the
            isoform-specific localization patterns of FMO1, -3, and -4 in the
            rat liver and kidney and the first evidence for expression of FMO4
            at the protein level in mouse and human liver and kidney
            microsomes.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Hernandez,D., Janmohamed,A., Chandan,P., Omar,B.A., Phillips,I.R.
            and Shephard,E.A.
  TITLE     Deletion of the mouse Fmo1 gene results in enhanced pharmacological
            behavioural responses to imipramine
  JOURNAL   Pharmacogenet Genomics 19 (4), 289-299 (2009)
   PUBMED   19262426
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Ryu,S.D., Kang,J.H., Yi,H.G., Nahm,C.H. and Park,C.S.
  TITLE     Hepatic flavin-containing monooxygenase activity attenuated by
            cGMP-independent nitric oxide-mediated mRNA destabilization
  JOURNAL   Biochem Biophys Res Commun 324 (1), 409-416 (2004)
   PUBMED   15465034
  REMARK    GeneRIF: results suggest that nitric oxide acts directly in a
            cyclic GMP-independent mechanism by decreasing the half-life of
            flavin-containing monooxygenase 1 (FMO1) mRNA, thereby inducing
            impairment of FMO-related functions in endotoxemia
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Henderson,M.C., Krueger,S.K., Stevens,J.F. and Williams,D.E.
  TITLE     Human flavin-containing monooxygenase form 2 S-oxygenation:
            sulfenic acid formation from thioureas and oxidation of glutathione
  JOURNAL   Chem Res Toxicol 17 (5), 633-640 (2004)
   PUBMED   15144220
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Lattard,V., Lachuer,J., Buronfosse,T., Garnier,F. and Benoit,E.
  TITLE     Physiological factors affecting the expression of FMO1 and FMO3 in
            the rat liver and kidney
  JOURNAL   Biochem Pharmacol 63 (8), 1453-1464 (2002)
   PUBMED   11996886
  REMARK    GeneRIF: the relationship between gender and development in the
            expression of FMO1 in the liver and kidney was determined
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Itoh,K., Kimura,T., Yokoi,T., Itoh,S. and Kamataki,T.
  TITLE     Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and
            expression in yeast
  JOURNAL   Biochim Biophys Acta 1173 (2), 165-171 (1993)
   PUBMED   8504165
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M84719.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M84719.1, FQ218919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2042
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /note="flavin containing dimethylaniline monoxygenase 1"
                     /db_xref="GeneID:25256"
                     /db_xref="RGD:2622"
     exon            1..38
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            39..176
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1643
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /EC_number="1.14.13.8"
                     /EC_number="1.14.13.148"
                     /note="dimethylaniline monooxygenase [N-oxide-forming] 1;
                     FMO 1; dimethylaniline oxidase 1; flavin containing
                     monooxygenase 1; hepatic flavin-containing monooxygenase
                     1; trimethylamine monooxygenase"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 1"
                     /protein_id="NP_036924.1"
                     /db_xref="GeneID:25256"
                     /db_xref="RGD:2622"
                     /translation="MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSCDLGGLWRFT
                     EHVEEGRASLYNSVVSNSSKEMSCYSDFPFPEDYPNFVPNSLFLEYLQLYATQFNLLR
                     CIYFNTKVCSITKRPDFAVSGQWEVVTVCQGKQSSDTFAAVMVCTGFLTNPHLPLDSF
                     PGIQTFKGQYFHSRQYKHPDVFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGA
                     WVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPVVSWLISKKMNSWFNHVNYGVAPEDR
                     TQLREPVLNDELPGRIITGKVLIKPSIKEVKENSVVFNNTPKEEPIDVIVFATGYSFA
                     FPFLDESIVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMIPTGETQARWVVQV
                     LKGATTLPPPSVMMKEVNERKKNKHSGFGLCYCKALQSDYITYIDDLLTSINAKPDLR
                     AMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVNVTKTRTVQETP
                     STFETLLKLFSFLALLVAVFFIFL"
     exon            177..365
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            366..528
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            529..671
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            672..871
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1227
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..2042
                     /gene="Fmo1"
                     /gene_synonym="RFMO1A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacataaag tcagattgct aaacttctgt gtcgactgaa aaacatggtg aagcgagttg
       61 caattgtggg agctggggtc agtggcctgg cctccatcaa gtgctgcctg gaagaaggac
      121 tagaacccac ctgcttcgag agaagctgtg acttgggagg actttggaga ttcacggaac
      181 atgttgaaga aggaagagcc agcctttaca actcagtggt ttctaacagc agcaaggaga
      241 tgtcttgtta ctccgatttc ccttttccag aagactaccc aaactttgtg ccaaattctc
      301 tgttcctgga atatctccag ctgtatgcaa cccagttcaa ccttctgaga tgcatctatt
      361 tcaacaccaa agtgtgcagt ataacaaaac gcccagattt cgctgtctct ggacaatggg
      421 aagtggtcac tgtctgtcaa gggaagcaaa gctcagacac ctttgctgct gtcatggtct
      481 gcactgggtt tctaactaac ccacatctgc ccctggattc ctttccaggc atacaaactt
      541 ttaaggggca gtacttccac agccggcagt ataaacatcc agacgtattt aaggacaagc
      601 gagtccttgt ggttggaatg ggaaattctg gtacagacat tgccgtggag gccagtcact
      661 tagcgaaaaa ggtgtttctc agcaccaccg gaggggcatg ggtgatcagc cgagtctttg
      721 attcagggta cccctgggac atgatattca tgacgcgatt tcagaacatg ctcagaaatc
      781 ttctcccaac tccagttgtg agttggttga tatcaaagaa gatgaacagc tggttcaacc
      841 acgtgaatta cggtgtggct ccagaagaca ggactcagct gagagagcct gtgctgaatg
      901 atgagctccc aggccgcatc atcactggga aagtgttgat caagcccagc atcaaggagg
      961 tgaaagaaaa ctctgtcgtc tttaacaata caccgaagga ggagcctatt gacgtcatcg
     1021 tctttgccac tggatactcc tttgcgttcc ccttcctcga tgaatcaata gtgaaagttg
     1081 aggatggcca ggcatcactg tacaagtaca tcttcccggc acatctgcca aaaccaactc
     1141 tggccgtgat tggcctcatc aaacccctgg gttccatgat acccacagga gagacacaag
     1201 ctcgatgggt tgttcaggtc ctgaaaggtg cgactacatt accacccccg agtgtcatga
     1261 tgaaagaagt caatgaacgg aagaagaaca agcatagcgg atttggcttg tgctactgca
     1321 aggctttgca atccgattac ataacgtaca tagatgacct cctgacctcg atcaacgcaa
     1381 aaccggacct gcgggccatg ctcctgactg acccacgcct ggctctgagc atcttcttcg
     1441 gcccatgcac accttaccat ttccgcctga ctggtccagg aaagtgggaa ggagccagaa
     1501 aggccatctt gacccagtgg gaccgaacag tgaacgtcac caaaactcga accgtacaag
     1561 aaaccccatc tacctttgaa actttgctta aactctttag ttttctggct ttgcttgtgg
     1621 ctgttttctt tattttcctg taagtgaaag atctaactgg ctttccaaat gtgtggagta
     1681 taaccttcca acttctctaa tgtaacaatt tcaccttcgt aattgtaaac cacgtccaga
     1741 gacacccaac ccctacctct ccccaactca cctcattggc accttcattg ctgggtctct
     1801 tgctagtcca tcaggtttag tgcaagaaaa taatgtccag caattctgtt cacttaaaat
     1861 gttggaagga tccaggcccc ctttcaggaa gaatctgccc ccagagagga ctctgagcat
     1921 tctttcaatc taaaaaactg ctttccctag atcttaatga aaagcccaac ttcgcggaat
     1981 attggtctgc actaaaatag ttctctgtgt attagttgac tacaaataaa atggaagaaa
     2041 ct
//
