LOCUS       NM_053652               4358 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus Fms related receptor tyrosine kinase 4 (Flt4),
            mRNA.
ACCESSION   NM_053652 XM_346389
VERSION     NM_053652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4358)
  AUTHORS   He,H., Wang,J., Zhang,Y., Wang,Y., Liu,Y., Li,X., Zhang,Y.,
            Yang,J., Hao,X., Wang,H. and Liu,H.
  TITLE     miR-455-3p regulates lymphangiogenesis in silicosis by regulating
            VEGF-C/VEGFR3
  JOURNAL   Ecotoxicol Environ Saf 278, 116444 (2024)
   PUBMED   38728943
  REMARK    GeneRIF: miR-455-3p regulates lymphangiogenesis in silicosis by
            regulating VEGF-C/VEGFR3.
REFERENCE   2  (bases 1 to 4358)
  AUTHORS   Shuwen,H., Xi,Y., Miao,D., Jiamin,X., Jing,Z. and Weili,G.
  TITLE     Nine Genes Mediate the Therapeutic Effects of Iodine-131
            Radiotherapy in Thyroid Carcinoma Patients
  JOURNAL   Dis Markers 2020, 9369341 (2020)
   PUBMED   32626543
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4358)
  AUTHORS   Esposito,E., Ahn,B.J., Shi,J., Nakamura,Y., Park,J.H.,
            Mandeville,E.T., Yu,Z., Chan,S.J., Desai,R., Hayakawa,A., Ji,X.,
            Lo,E.H. and Hayakawa,K.
  TITLE     Brain-to-cervical lymph node signaling after stroke
  JOURNAL   Nat Commun 10 (1), 5306 (2019)
   PUBMED   31757960
  REMARK    GeneRIF: VEGF-C/VEGFR3 signaling activates lymphatic endothelium in
            cervical lymph nodes after ischemic stroke.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4358)
  AUTHORS   Ward,M.C. and Cunningham,A.M.
  TITLE     Developmental expression of vascular endothelial growth factor
            receptor 3 and vascular endothelial growth factor C in forebrain
  JOURNAL   Neuroscience 303, 544-557 (2015)
   PUBMED   25943477
  REMARK    GeneRIF: The findings of this study suggest an important role for
            VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain
            development, and ongoing functions with niche neurogenesis, glial
            and ependymal function in the maturing postnatal brain.
REFERENCE   5  (bases 1 to 4358)
  AUTHORS   Jakus,Z., Gleghorn,J.P., Enis,D.R., Sen,A., Chia,S., Liu,X.,
            Rawnsley,D.R., Yang,Y., Hess,P.R., Zou,Z., Yang,J., Guttentag,S.H.,
            Nelson,C.M. and Kahn,M.L.
  TITLE     Lymphatic function is required prenatally for lung inflation at
            birth
  JOURNAL   J Exp Med 211 (5), 815-826 (2014)
   PUBMED   24733830
REFERENCE   6  (bases 1 to 4358)
  AUTHORS   Achen,M.G., Jeltsch,M., Kukk,E., Makinen,T., Vitali,A., Wilks,A.F.,
            Alitalo,K. and Stacker,S.A.
  TITLE     Vascular endothelial growth factor D (VEGF-D) is a ligand for the
            tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 548-553 (1998)
   PUBMED   9435229
REFERENCE   7  (bases 1 to 4358)
  AUTHORS   Fitz,L.J., Morris,J.C., Towler,P., Long,A., Burgess,P., Greco,R.,
            Wang,J., Gassaway,R., Nickbarg,E., Kovacic,S., Ciarletta,A.,
            Giannotti,J., Finnerty,H., Zollner,R., Beier,D.R., Leak,L.V.,
            Turner,K.J. and Wood,C.R.
  TITLE     Characterization of murine Flt4 ligand/VEGF-C
  JOURNAL   Oncogene 15 (5), 613-618 (1997)
   PUBMED   9247316
REFERENCE   8  (bases 1 to 4358)
  AUTHORS   Kukk,E., Lymboussaki,A., Taira,S., Kaipainen,A., Jeltsch,M.,
            Joukov,V. and Alitalo,K.
  TITLE     VEGF-C receptor binding and pattern of expression with VEGFR-3
            suggests a role in lymphatic vascular development
  JOURNAL   Development 122 (12), 3829-3837 (1996)
   PUBMED   9012504
REFERENCE   9  (bases 1 to 4358)
  AUTHORS   Fournier,E., Dubreuil,P., Birnbaum,D. and Borg,J.P.
  TITLE     Mutation at tyrosine residue 1337 abrogates ligand-dependent
            transforming capacity of the FLT4 receptor
  JOURNAL   Oncogene 11 (5), 921-931 (1995)
   PUBMED   7675451
REFERENCE   10 (bases 1 to 4358)
  AUTHORS   Borg,J.P., deLapeyriere,O., Noguchi,T., Rottapel,R., Dubreuil,P.
            and Birnbaum,D.
  TITLE     Biochemical characterization of two isoforms of FLT4, a VEGF
            receptor-related tyrosine kinase
  JOURNAL   Oncogene 10 (5), 973-984 (1995)
   PUBMED   7898938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053652.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF402785.1, SRR26643289.27420.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000010.1  34414834-34414891
            59-155              JAXUCZ010000010.1  34429839-34429935
            156-400             JAXUCZ010000010.1  34430430-34430674
            401-513             JAXUCZ010000010.1  34430918-34431030
            514-676             JAXUCZ010000010.1  34431119-34431281
            677-816             JAXUCZ010000010.1  34431475-34431614
            817-985             JAXUCZ010000010.1  34431890-34432058
            986-1103            JAXUCZ010000010.1  34432329-34432446
            1104-1258           JAXUCZ010000010.1  34435210-34435364
            1259-1421           JAXUCZ010000010.1  34435458-34435620
            1422-1548           JAXUCZ010000010.1  34436779-34436905
            1549-1657           JAXUCZ010000010.1  34437911-34438019
            1658-2020           JAXUCZ010000010.1  34438809-34439171
            2021-2167           JAXUCZ010000010.1  34439482-34439628
            2168-2299           JAXUCZ010000010.1  34439723-34439854
            2300-2406           JAXUCZ010000010.1  34439992-34440098
            2407-2542           JAXUCZ010000010.1  34440403-34440538
            2543-2647           JAXUCZ010000010.1  34441024-34441128
            2648-2761           JAXUCZ010000010.1  34441460-34441573
            2762-2850           JAXUCZ010000010.1  34441773-34441861
            2851-3001           JAXUCZ010000010.1  34441992-34442142
            3002-3096           JAXUCZ010000010.1  34442562-34442656
            3097-3219           JAXUCZ010000010.1  34443054-34443176
            3220-3331           JAXUCZ010000010.1  34444707-34444818
            3332-3431           JAXUCZ010000010.1  34446483-34446582
            3432-3537           JAXUCZ010000010.1  34447645-34447750
            3538-3686           JAXUCZ010000010.1  34448489-34448637
            3687-3807           JAXUCZ010000010.1  34449970-34450090
            3808-3893           JAXUCZ010000010.1  34452054-34452139
            3894-4358           JAXUCZ010000010.1  34455414-34455878
FEATURES             Location/Qualifiers
     source          1..4358
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..4358
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /note="Fms related receptor tyrosine kinase 4"
                     /db_xref="GeneID:114110"
                     /db_xref="RGD:621737"
     CDS             1..4092
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /EC_number="2.7.10.1"
                     /note="vascular endothelial growth factor receptor 3;
                     VEGFR-3; tyrosine-protein kinase receptor FLT4; FLT-4;
                     FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 3
                     precursor"
                     /protein_id="NP_446104.2"
                     /db_xref="GeneID:114110"
                     /db_xref="RGD:621737"
                     /translation="MQPGAALNLRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTG
                     DSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTQVVQDCEGTEARPYCKVLSLAQTH
                     ANNTGSYYCYYKYIKARIEGTTAASTYVFVRDFEQPFINKPDTLLVNRKDSMWVPCLV
                     SIPGLNITLRSQSSVLHPDGQEVLWDDRRGMRVPTLLLRDALYLQCETTWGDQDFLSN
                     PFLVHITGNELYDIQLYPKKSLELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERA
                     KWVPERRSQQTHTELSSILTIHNVSQHDLGPYVCEANNGIQRFRESTEVIVHEKPFIS
                     VEWLKGPVLEATAGDEMVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEA
                     SAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTTYGV
                     PQPLSVQWHWRPWTPCKTFAQRSLRRRQPRDGMPQCRDWKEVTTQDAVNPIESLDTWT
                     ESVEGKNKTVSKLVIQDANVSAMYKCVVFNKVGQDERLIYFYVTTIPDGFSIESEPSE
                     DPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANL
                     EEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRNQDKHCHKKYLSVQALEAPRLTQ
                     NLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVRE
                     EDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFC
                     NMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAF
                     GKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLG
                     ACTKPNGPLMVIVEFCKYGNLSNFLRVKRETFDPYAEKSPEQRRRFRAMVEGAKADRR
                     RLGSTDRALFTRFLMGKGSARRAPFVQEAEDLWLSPLTMEDLVCYSFQVALGMEFLAS
                     RKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD
                     KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRH
                     IMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSEEDGFMQAST
                     TALHITEADAESSPPSMHCHSLAARYYNCVSFPGRLVRGTKAPGSSRMKTFEELPMTP
                     TTYKASVDNQTDSGMVLASEEFEQIESRHRQEGSFSRKDPGQHMDISRGHPDLQGRRR
                     RPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSNY"
     exon            1..58
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..155
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            156..400
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            401..513
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..676
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..816
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..985
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1103
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1258
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1421
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1548
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1657
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2020
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2167
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2299
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2406
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2542
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2647
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2761
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2850
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3001
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3096
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3219
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3331
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3431
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3537
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3686
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3807
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3893
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4358
                     /gene="Flt4"
                     /gene_synonym="Vegfr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcagccgg gcgctgcgct gaacctgcgc ctgtggctct gcctcggact cctccaaggc
       61 ctggcaaatg gctactccat gacccctcca actctgaaca tcacagagga ttcatatgtc
      121 attgacaccg gggacagcct atccatatcc tgcagggggc agcaccccct cgagtggacc
      181 tggccagggg cccaagaggt actgaccaca ggtgggaagg acagcgagga cacgcaggtt
      241 gtgcaagact gtgaaggcac agaagctagg ccctactgca aggtgctgtc gctggcccag
      301 actcacgcca acaacacagg cagctattac tgctactaca agtatatcaa ggcccggatt
      361 gagggcacca cagctgccag cacctatgtg tttgtaagag actttgaaca gcctttcatc
      421 aacaaacctg acacgctcct ggtcaacagg aaggactcga tgtgggtgcc ctgcttggtg
      481 tccattcccg ggctcaacat cacactgcgc tcgcaaagtt cggtgctgca ccctgatggg
      541 caggaggtgt tgtgggacga ccgccggggc atgcgggtgc ccactctact gttgcgtgac
      601 gccctgtacc tgcagtgcga gaccacctgg ggagaccagg acttcctttc caatcccttc
      661 ctcgtgcaca tcacaggcaa tgagctctat gacatccagc tgtaccccaa gaagtcactg
      721 gagctgttgg ttggagagaa gctggttttg aactgtacag tatgggctga gttcgactct
      781 ggtgtcacct tcgactggga ttacccagga aagcaggcag agcgtgctaa gtgggtacct
      841 gagcggcgtt cccagcagac ccacacggaa ctctccagca tcctgaccat ccacaatgtc
      901 agccagcacg acctgggccc ctatgtgtgt gaggccaaca atgggattca gcggttccgg
      961 gaaagcacgg aggtcattgt gcacgaaaag cccttcatca gtgtcgagtg gctcaaagga
     1021 cctgtcctgg aggccacagc cggtgacgag atggtgaagc tgcccgtgaa gcttgcagct
     1081 tatcccccac cggagttcca atggtacaag gacagaaagg cagtgactgg gcgccacaat
     1141 ccacatgctc tggtgctcaa agaggtgacc gaggccagtg caggcgtcta caccctcgcc
     1201 ctgtggaact ctgcagccgg tctgaggcag aatatcagtc tggagctggt ggtgaatgtg
     1261 ccgccccaca tccatgaaaa ggaagcttct tcacccagca tctactcccg ccacagccgc
     1321 cagaccctca cctgcaccac ctatggggta ccccaacctc tcagtgttca gtggcactgg
     1381 aggccctgga caccctgtaa gacatttgcc cagcgcagtc tccggaggcg gcagccgcgg
     1441 gatggcatgc cacagtgccg agactggaag gaggtgacca ctcaggacgc tgtgaacccc
     1501 atcgagagcc tggacacctg gaccgagtct gtggagggca agaacaagac ggtgagcaag
     1561 ctggtgattc aggatgccaa tgtgtcagcc atgtacaaat gcgtggtctt caacaaagtg
     1621 ggccaggacg agcggctcat ctacttctat gtgaccacca tccctgacgg cttcagtatc
     1681 gaatcagagc catccgagga tcccttagaa ggccagtccg tgcgcctcag ctgccgggcg
     1741 gacaactaca cgtatgagca tctgcgctgg taccggctca acctctccac gctgcacgac
     1801 gctcaaggga acccactact gctcgactgc aagaacgtgc acctgtttgc cacgccccta
     1861 gaggccaacc tagaggaggc ggagcctggg gcccgccacg ccaccctcag cttgaatatc
     1921 ccccgagtgg cgcccgagga cgagggtgac tacgtgtgtg aggtgcaaga taggcgcaac
     1981 caagacaagc actgccacaa gaaatacctg tccgtacagg ccctggaagc tcctcggctc
     2041 acgcagaact tgaccgacct cctggtgaac gtgagtgact ccctggagat gcgatgtccg
     2101 gtagccggag cacatgtgcc cagtattgtg tggtacaaag atgaaaggct cctggagaaa
     2161 gagtcgggaa tcgacctggc agactccaat cagaggctga gcatccaacg cgtgcgcgag
     2221 gaggacgcgg gtcgttacct gtgcagtgtg tgcaatgcca agggctgcgt aaactcctcc
     2281 gccagcgtgg ccgtagaagg ctcggaagat aaaggcagca tggagattgt gatactcatt
     2341 ggcactggcg tcatcgcagt cttcttctgg gtcctcctcc tgctcatctt ctgtaacatg
     2401 aaaaggcctg cccatgcaga catcaagacg ggctacctgt ccatcatcat ggaccccggg
     2461 gaggtgcctt tggaggagca gtgtgaatac ctgtcctatg acgtcagcca gtgggagttc
     2521 cccagggaaa ggttgcacct cgggagagtc ctaggccatg gggcttttgg gaaggtggtg
     2581 gaagcctcag cctttggcat caataaaggc agcagctgtg ataccgtggc ggtgaagatg
     2641 ctgaaagagg gcgctactgc cagcgaacac cgtgccctga tgtccgagct caagatccta
     2701 attcacatcg gtaaccacct caatgtggtc aacctcctag gggcgtgcac caagcccaat
     2761 ggccctctca tggtgatcgt ggagttttgc aaatacggca acctctccaa cttcttgcgt
     2821 gtcaagcggg agacgttcga cccctacgca gagaagtctc ccgagcaacg caggcgcttc
     2881 cgcgcgatgg tagaaggcgc caaggctgat aggaggagac ttggaagcac cgacagagcc
     2941 ctgtttacaa ggttcctgat gggcaaagga agtgcacggc gagccccatt tgtccaagaa
     3001 gctgaggacc tgtggttgag cccgctgacc atggaggacc ttgtctgcta cagtttccaa
     3061 gtggccctgg gaatggagtt cctggcttcc cgcaagtgca ttcacagaga cctggctgct
     3121 cggaacattt tactgtcaga aagtgacata gtgaagatct gtgactttgg cctcgctcgg
     3181 gacatctaca aagaccctga ctatgtccga aagggcagcg cccgactgcc tctgaaatgg
     3241 atggcccccg agagcatctt cgataaggtg tacaccacgc agagtgatgt gtggtccttc
     3301 ggagtgctgc tgtgggagat tttctcactg ggggcctctc cataccctgg ggtacagatc
     3361 aatgaggaat tctgccagcg gctgaaagac ggcacacgaa tgagggcccc agaactggcc
     3421 actcctgcca tacgccacat catgcagagt tgctggtctg gagaccctaa agcgaggcct
     3481 gctttctctg acctagtgga gatcctgggg gacctgcttc agggtggagg ctggcaggag
     3541 gaggaggagg aatgcatggc cctgcacagt tctcagagct cagaggagga tggcttcatg
     3601 caggcatcca ccacagctct acatatcacg gaggctgacg ctgagagcag tccacccagc
     3661 atgcattgcc acagcctggc agccagatat tacaactgtg tgtcctttcc tgggcgcctg
     3721 gtcaggggga ctaaggctcc aggttcctcc aggatgaaga cgtttgaaga attgcccatg
     3781 acccctacaa cctacaaagc ctctgtggat aaccaaacag acagcgggat ggtgctggcc
     3841 tcagaagagt ttgagcagat agaaagcagg catagacaag aaggcagctt cagccgtaaa
     3901 gatcctggcc agcacatgga tatttccaga ggacacccgg acctccaggg gaggcggcga
     3961 cggcccaccc agggggcaca aggaggcaag gtgttttaca acaacgagta tggggaggtc
     4021 tcccagccgt gtacagaagg tgactgctgc ccgtctgctg gctccacctt cttcgcagac
     4081 agcaactact aaggaacacg cggcaaggcc tcctgcccct ggctgcaacc cagctacgac
     4141 ggctgggctg gagagacatc cctagcaggg caaggctgga ggcccaggct gggaagtcaa
     4201 ctcctctagt tccagcccgg aggtgttttg tgtcccaccc ctaccccctg ccccttacag
     4261 cctccctatc caggaagagt caaactcaga cacgagggct cccttgaact cgatatcact
     4321 gggcagtcac cctcaccctc gcattcaatt cccttgta
//
