LOCUS       NM_001305939            1108 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Fms related receptor tyrosine kinase 3 ligand
            (Flt3lg), mRNA.
ACCESSION   NM_001305939
VERSION     NM_001305939.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Kokonozaki M, Tsirakis G, Devetzoglou M, Kyriakaki S, Antonakis A,
            Vyzoukaki R, Pappa CA, Tzardi M and Alexandrakis MG.
  TITLE     Potential role of FLT3-ligand in the angiogenic process of multiple
            myeloma
  JOURNAL   Leuk Res 39 (12), 1467-1472 (2015)
   PUBMED   26521986
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Pfister O, Lorenz V, Oikonomopoulos A, Xu L, Hauselmann SP, Mbah C,
            Kaufmann BA, Liao R, Wodnar-Filipowicz A and Kuster GM.
  TITLE     FLT3 activation improves post-myocardial infarction remodeling
            involving a cytoprotective effect on cardiomyocytes
  JOURNAL   J Am Coll Cardiol 63 (10), 1011-1019 (2014)
   PUBMED   24184252
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Satpathy AT, Briseno CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X,
            Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C,
            Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS,
            Gommerman JL, Nussenzweig MC, Colonna M, Kopan R and Murphy KM.
  TITLE     Notch2-dependent classical dendritic cells orchestrate intestinal
            immunity to attaching-and-effacing bacterial pathogens
  JOURNAL   Nat Immunol 14 (9), 937-948 (2013)
   PUBMED   23913046
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD and Chen J.
  TITLE     RNAi screen reveals potentially novel roles of cytokines in
            myoblast differentiation
  JOURNAL   PLoS One 8 (7), e68068 (2013)
   PUBMED   23844157
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Desterke C, Bilhou-Nabera C, Guerton B, Martinaud C, Tonetti C,
            Clay D, Guglielmelli P, Vannucchi A, Bordessoule D, Hasselbalch H,
            Dupriez B, Benzoubir N, Bourgeade MF, Pierre-Louis O, Lazar V,
            Vainchenker W, Bennaceur-Griscelli A, Gisslinger H, Giraudier S and
            Le Bousse-Kerdiles MC.
  CONSRTM   French Intergroup of Myeloproliferative Disorders,; French INSERM;
            European EUMNET Networks on Myelofibrosis
  TITLE     FLT3-mediated p38-MAPK activation participates in the control of
            megakaryopoiesis in primary myelofibrosis
  JOURNAL   Cancer Res 71 (8), 2901-2915 (2011)
   PUBMED   21487043
  REMARK    Erratum:[Cancer Res. 2011 Jun 1;71(11):4049-50]
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Lyman SD, Seaberg M, Hanna R, Zappone J, Brasel K, Abkowitz JL,
            Prchal JT, Schultz JC and Shahidi NT.
  TITLE     Plasma/serum levels of flt3 ligand are low in normal individuals
            and highly elevated in patients with Fanconi anemia and acquired
            aplastic anemia
  JOURNAL   Blood 86 (11), 4091-4096 (1995)
   PUBMED   7492765
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Brasel K, Escobar S, Anderberg R, de Vries P, Gruss HJ and Lyman
            SD.
  TITLE     Expression of the flt3 receptor and its ligand on hematopoietic
            cells
  JOURNAL   Leukemia 9 (7), 1212-1218 (1995)
   PUBMED   7630197
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Lavagna C, Marchetto S, Birnbaum D and Rosnet O.
  TITLE     Identification and characterization of a functional murine FLT3
            isoform produced by exon skipping
  JOURNAL   J Biol Chem 270 (7), 3165-3171 (1995)
   PUBMED   7531700
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS,
            Downey H, Splett RR, Beckmann MP and McKenna HJ.
  TITLE     Cloning of the human homologue of the murine flt3 ligand: a growth
            factor for early hematopoietic progenitor cells
  JOURNAL   Blood 83 (10), 2795-2801 (1994)
   PUBMED   8180375
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Lyman SD, James L, Vanden Bos T, de Vries P, Brasel K, Gliniak B,
            Hollingsworth LT, Picha KS, McKenna HJ, Splett RR et al.
  TITLE     Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase
            receptor: a proliferative factor for primitive hematopoietic cells
  JOURNAL   Cell 75 (6), 1157-1167 (1993)
   PUBMED   7505204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ226639.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1108              FQ226639.1         4-1111
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1108
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /note="Fms related receptor tyrosine kinase 3 ligand"
                     /db_xref="GeneID:103691134"
                     /db_xref="RGD:2322792"
     exon            1..73
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            74..140
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..800
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /note="rCG54594-like; fms-related tyrosine kinase 3
                     ligand"
                     /codon_start=1
                     /product="fms-related tyrosine kinase 3 ligand precursor"
                     /protein_id="NP_001292868.1"
                     /db_xref="GeneID:103691134"
                     /db_xref="RGD:2322792"
                     /translation="MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISSNFHM
                     RISELTDYLLKDYPVTVAINLQDEKHCKALWSLFLAHRWIEQLKTVAGSKMQKLLEDV
                     NTEIHFVTSCTFQPLPECLRFVQTNISHLLQDTCSQLLALKPCIGKACQNFSRCLEVQ
                     CQPDSSTLLPPESPGALGATELPKPLPRQLWLLLVLPFSVVLLAAAWCLRWQRTRRRV
                     ELRPGVPLPSHP"
     exon            141..254
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            255..308
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            309..452
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            453..597
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            598..776
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            777..845
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1089
                     /gene="Flt3lg"
                     /gene_synonym="Gm45713"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcttcct ttcactttcg gtctttggct gtcatccagt tcggtctttc cacacccagc
       61 tggggcaagc ctgaccctgc cacaggcatg aggggtctcc agccgagatg acagtgctgg
      121 cgccagcctg gagcccaaat tcctccttgt tgctgttgct gctgctgctg agcccttgcc
      181 tgcgggggac acctgactgt tacttcagcc acagtcccat ctcctccaac ttccacatga
      241 ggattagcga gttgactgac tacctgctta aagattaccc agtcactgtg gccatcaatc
      301 ttcaggacga gaaacactgc aaggccttgt ggagcctctt cctggcccat cgctggatag
      361 agcaactgaa gactgtggca gggtctaaaa tgcaaaagct tctggaggat gtcaatacgg
      421 agatacattt tgtcacctcg tgtaccttcc agcccctacc agaatgtctt cgattcgtcc
      481 agaccaacat ctcccacctc ctgcaggaca cctgctcaca gctgttagct ctgaagccct
      541 gtatcgggaa agcctgccag aatttctctc ggtgcctgga ggtgcagtgc cagccggact
      601 cctccaccct gcttccccca gagagtcctg gagcccttgg agccacggag cttccaaagc
      661 ctctgcccag gcagctgtgg ctcctgctgg tactgccttt ctcagtggtg ttgctggcag
      721 ccgcctggtg ccttcgctgg caaaggacaa gaaggagggt ggagctccgc cctggggtgc
      781 ccctcccctc ccatccctag gatgtgagac ttgtgcgtcg ctgactcagc cagggtcttc
      841 tctcgggttg ggaaccaaaa caaggaacaa gctaggcaaa tgctgtgctg agctacatcc
      901 ccagcccaga ggacacactg tctgggcctg gcgatggaca tgtgtaattc cagagcttct
      961 ggattggaga tgctgaaact ggaggatact gactttatga aaaacagaaa ggaagaaggg
     1021 gatgcattgt cgccctgtgt ggtcgcttct gtcacctccg ccccttaaaa taaaaacaac
     1081 tgccgggtaa aaaaaaaaaa aaaaaaaa
//
