LOCUS       NM_001415752            3668 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Fms related receptor tyrosine kinase 3 (Flt3),
            mRNA.
ACCESSION   NM_001415752 XM_039089036
VERSION     NM_001415752.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3668)
  AUTHORS   Hasegawa,H., Taniguchi,H., Nakamura,Y., Kato,T., Fujii,S., Ebi,H.,
            Shiozawa,M., Yuki,S., Masuishi,T., Kato,K., Izawa,N., Moriwaki,T.,
            Oki,E., Kagawa,Y., Denda,T., Nishina,T., Tsuji,A., Hara,H.,
            Esaki,T., Nishida,T., Kawakami,H., Sakamoto,Y., Miki,I.,
            Okamoto,W., Yamazaki,K. and Yoshino,T.
  TITLE     FMS-like tyrosine kinase 3 (FLT3) amplification in patients with
            metastatic colorectal cancer
  JOURNAL   Cancer Sci 112 (1), 314-322 (2021)
   PUBMED   33075166
REFERENCE   2  (bases 1 to 3668)
  AUTHORS   Khongsti,S., Shunyu,B.N. and Ghosh,S.
  TITLE     Promoter-associated DNA methylation & expression profiling of genes
            (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell
            carcinoma in the Khasi & Jaintia population of Meghalaya, India
  JOURNAL   Indian J Med Res 150 (6), 584-591 (2019)
   PUBMED   32048621
REFERENCE   3  (bases 1 to 3668)
  AUTHORS   Aydin,M.M., Bayin,N.S., Acun,T., Yakicier,M.C. and Akcali,K.C.
  TITLE     Role of FLT3 in the proliferation and aggressiveness of
            hepatocellular carcinoma
  JOURNAL   Turk J Med Sci 46 (2), 572-581 (2016)
   PUBMED   27511526
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3668)
  AUTHORS   Rau,R., Magoon,D., Greenblatt,S., Li,L., Annesley,C.,
            Duffield,A.S., Huso,D., McIntyre,E., Clohessy,J.G., Reschke,M.,
            Pandolfi,P.P., Small,D. and Brown,P.
  TITLE     NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia
            recapitulating human disease
  JOURNAL   Exp Hematol 42 (2), 101-13 (2014)
   PUBMED   24184354
REFERENCE   5  (bases 1 to 3668)
  AUTHORS   Baker,S.D., Zimmerman,E.I., Wang,Y.D., Orwick,S., Zatechka,D.S.,
            Buaboonnam,J., Neale,G.A., Olsen,S.R., Enemark,E.J., Shurtleff,S.,
            Rubnitz,J.E., Mullighan,C.G. and Inaba,H.
  TITLE     Emergence of polyclonal FLT3 tyrosine kinase domain mutations
            during sequential therapy with sorafenib and sunitinib in
            FLT3-ITD-positive acute myeloid leukemia
  JOURNAL   Clin Cancer Res 19 (20), 5758-5768 (2013)
   PUBMED   23969938
REFERENCE   6  (bases 1 to 3668)
  AUTHORS   Brasel,K., Escobar,S., Anderberg,R., de Vries,P., Gruss,H.J. and
            Lyman,S.D.
  TITLE     Expression of the flt3 receptor and its ligand on hematopoietic
            cells
  JOURNAL   Leukemia 9 (7), 1212-1218 (1995)
   PUBMED   7630197
REFERENCE   7  (bases 1 to 3668)
  AUTHORS   Mackarehtschian,K., Hardin,J.D., Moore,K.A., Boast,S., Goff,S.P.
            and Lemischka,I.R.
  TITLE     Targeted disruption of the flk2/flt3 gene leads to deficiencies in
            primitive hematopoietic progenitors
  JOURNAL   Immunity 3 (1), 147-161 (1995)
   PUBMED   7621074
REFERENCE   8  (bases 1 to 3668)
  AUTHORS   Zeigler,F.C., Bennett,B.D., Jordan,C.T., Spencer,S.D.,
            Baumhueter,S., Carroll,K.J., Hooley,J., Bauer,K. and Matthews,W.
  TITLE     Cellular and molecular characterization of the role of the
            flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells
  JOURNAL   Blood 84 (8), 2422-2430 (1994)
   PUBMED   7919361
REFERENCE   9  (bases 1 to 3668)
  AUTHORS   Rottapel,R., Turck,C.W., Casteran,N., Liu,X., Birnbaum,D.,
            Pawson,T. and Dubreuil,P.
  TITLE     Substrate specificities and identification of a putative binding
            site for PI3K in the carboxy tail of the murine Flt3 receptor
            tyrosine kinase
  JOURNAL   Oncogene 9 (6), 1755-1765 (1994)
   PUBMED   8183574
REFERENCE   10 (bases 1 to 3668)
  AUTHORS   Small,D., Levenstein,M., Kim,E., Carow,C., Amin,S., Rockwell,P.,
            Witte,L., Burrow,C., Ratajczak,M.Z., Gewirtz,A.M. et al.
  TITLE     STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed
            in CD34+ human bone marrow cells and is involved in the
            proliferation of early progenitor/stem cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 459-463 (1994)
   PUBMED   7507245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 28, 2022 this sequence version replaced XM_039089036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.540157.1,
                                           SRR26643290.40380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000012.1  12660035-12660311
            278-399             JAXUCZ010000012.1  12676207-12676328
            400-602             JAXUCZ010000012.1  12687500-12687702
            603-718             JAXUCZ010000012.1  12688783-12688898
            719-848             JAXUCZ010000012.1  12694022-12694151
            849-976             JAXUCZ010000012.1  12696262-12696389
            977-1116            JAXUCZ010000012.1  12697207-12697346
            1117-1270           JAXUCZ010000012.1  12697431-12697584
            1271-1439           JAXUCZ010000012.1  12700218-12700386
            1440-1543           JAXUCZ010000012.1  12709362-12709465
            1544-1652           JAXUCZ010000012.1  12710406-12710514
            1653-1831           JAXUCZ010000012.1  12711080-12711258
            1832-1938           JAXUCZ010000012.1  12712355-12712461
            1939-2071           JAXUCZ010000012.1  12712542-12712674
            2072-2176           JAXUCZ010000012.1  12712760-12712864
            2177-2287           JAXUCZ010000012.1  12716933-12717043
            2288-2441           JAXUCZ010000012.1  12717925-12718078
            2442-2524           JAXUCZ010000012.1  12719493-12719575
            2525-2658           JAXUCZ010000012.1  12722702-12722835
            2659-2781           JAXUCZ010000012.1  12727985-12728107
            2782-2893           JAXUCZ010000012.1  12731735-12731846
            2894-2993           JAXUCZ010000012.1  12732209-12732308
            2994-3099           JAXUCZ010000012.1  12733430-12733535
            3100-3668           JAXUCZ010000012.1  12735016-12735584
FEATURES             Location/Qualifiers
     source          1..3668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3668
                     /gene="Flt3"
                     /note="Fms related receptor tyrosine kinase 3"
                     /db_xref="GeneID:140635"
                     /db_xref="RGD:61308"
     exon            1..277
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..3237
                     /gene="Flt3"
                     /EC_number="2.7.10.1"
                     /note="FL cytokine receptor; FMS-like tyrosine kinase 3;
                     receptor-type tyrosine-protein kinase FLT3; fms-related
                     tyrosine kinase 3"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein kinase FLT3
                     precursor"
                     /protein_id="NP_001402681.1"
                     /db_xref="GeneID:140635"
                     /db_xref="RGD:61308"
                     /translation="MRALARRSDRLPLLVVLSVMILETVTNQDLPVIKCVLIIHKNNG
                     SAAGKSSSHVMVPESPEDLRCAPKHRSEGVVYEAVTVEVAQSASFTLQVQLTTPGDVS
                     CLWVFKHSSLGCQPHFDLQNRRIVSMTILNVTETQAGEYLLHIQSEATNHTVLFTVNV
                     RDTQLYVLRRPSFRKMENQDALLCVSEGVPEPTVEWVVCSSHRDSCREEGSAVVKKEE
                     KVLHELFETDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIH
                     VNHGFGLTWELGNKVLEEGSYFEMSSYSTNRSMIRILLAFVSSVGRNNTGYYTCSSSK
                     HPSQTALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPQIRCKWTFSQTSFPC
                     EQSGLEDGYSISKFCDHKNNPGEYIFHGENDDAQFTKMFILNIRRKPQVLANASASQA
                     SCFSDGYPLPNWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGR
                     GFLVKCCAYNSMGTSCETILLNSPGPFLFIQDNISFYATIGLCPPFIVVLTVLICHKY
                     KKQFRYESQLQMIQVTGPLDNEYFYIDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRV
                     MNATAYGISKTGVSIQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACT
                     LSGPVYLIFEYCCHGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHSNSSMPGS
                     REVQIYPPVDQVSGFNGNSIHSEDEIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVA
                     KGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKW
                     MAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPF
                     YATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAAMYQNMGGDVPLEHPAIY
                     QNRRPASREAGSEPPSPQVQEKTHRERS"
     exon            278..399
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..602
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..718
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..848
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..976
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1116
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1270
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1439
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1543
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1652
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1831
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1938
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2071
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2176
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2287
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2441
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2524
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2658
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2781
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2893
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2993
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3099
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3668
                     /gene="Flt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcacgtgg gctcggccgc agcgctgcgc cagttcagcc cgcttggcag cccccgggct
       61 cgcgcggccg cggcctctgg ggagaggttc ctccccctct gctctgcacc agtccgaggg
      121 aatctgtggt cggtgacgcg cattcttcag cgagccacct gcagcccggg gagcgccgct
      181 gggaccgcat cacaggctgg gccggcggcc tgggtacccc gcgcaccgga ggccatgcgg
      241 gcgttggcgc ggcgcagcga ccggctgccg ctgcttgttg ttttgtcagt aatgattctc
      301 gagaccgtta caaaccaaga tctgcctgtg atcaagtgtg ttttaatcat tcataagaac
      361 aatggctcgg cggcgggaaa gtcatcgtcg cacgtcatgg ttccagaatc cccagaggac
      421 ctccggtgtg ccccgaagca tcggagtgaa ggggtggtct atgaagctgt cactgtggag
      481 gtggcccagt ctgcgtcctt cacattgcaa gtacagctca ccaccccggg ggatgtttct
      541 tgcctctggg tctttaagca cagctcgctg ggctgccagc cacactttga tttacagaac
      601 agaagaattg tttccatgac catcttgaac gttacagaga cccaggcagg agaataccta
      661 ctccatattc agagtgaagc caccaaccac acggtgctgt tcacagtgaa tgtaagagat
      721 acacagctgt acgtgctaag aagaccttcc ttcagaaaga tggagaacca ggacgccctg
      781 ctctgcgtct ctgagggtgt cccagagccc accgtggagt gggtggtctg cagttcccac
      841 agggacagct gtagagaaga aggctctgcc gttgtcaaaa aggaggaaaa ggtacttcac
      901 gagctatttg aaacagacat cagatgctgt gcgagaaatg cactgggccg agaatgcacc
      961 aagctgttca ccatagatct aaaccaggct cctcagagca cactgcccca gttatttctg
     1021 aaagtggggg agcccttgtg gataaggtgc aaggccatcc atgtgaacca tggattcggg
     1081 ctcacctggg agctgggaaa caaagtcctg gaggagggca gctactttga gatgagttcc
     1141 tactccacca acagatccat gatccggatt ctcttggctt ttgtgtcctc tgtgggaagg
     1201 aacaacaccg gatattacac ctgttcttcc tcaaagcatc ccagccagac agcgttggtg
     1261 accatcctag aaaaaggttt cataaatgct accagctcac aagaagagta tgaaattgac
     1321 ccgtatgaaa agttctgctt ctcggtcagg tttaaagcgt acccacaaat ccgatgcaag
     1381 tggaccttct ctcaaacatc gtttccttgt gaacaaagtg gcctggagga tgggtacagc
     1441 atttctaaat tttgcgatca taagaacaac ccaggagaat acatattcca tggagaaaat
     1501 gatgacgccc agttcaccaa aatgttcata ctgaatataa gaaggaaacc tcaagtgcta
     1561 gcaaatgcct cagccagcca ggcatcctgt ttctctgatg gctacccgtt acccaactgg
     1621 acctggaaga agtgttcgga caagtcaccc aactgcacgg aggaaatccc agaaggagtt
     1681 tggaataaaa aggctaacag aaaagtgttt ggacagtggg tgtcgagcag taccctgaat
     1741 atgagtgagg ccgggagagg gtttctggtc aaatgctgtg catacaattc tatgggcacg
     1801 tcttgcgaaa ccatcctttt aaactcacca ggccccttcc ttttcatcca agacaacatc
     1861 tccttctatg caaccatcgg gctttgcccg cctttcattg tcgtcctcac tgtgctgatc
     1921 tgtcacaaat acaaaaagca atttaggtac gaaagccagc tgcagatgat ccaagtgacc
     1981 ggccccctgg ataacgagta cttctacatt gacttcaggg actacgaata tgacctcaag
     2041 tgggagtttc caagggaaaa cttagagttt gggaaggtcc tggggtccgg cgcttttggg
     2101 agagtgatga atgccacggc ctacgggatt agtaaaacag gagtctcaat tcaggtggcg
     2161 gtgaagatgc taaaagagaa agctgacaga tgtgaaagag aggcgctcat ggctgagctc
     2221 aaaatgatga cccacctggg gcaccatgac aacatcgtga acctgctggg ggcatgcaca
     2281 ctgtcagggc cagtgtactt gatttttgaa tattgttgcc atggtgacct gctcaactac
     2341 ctaagaagca aaagagaaaa gtttcacagg acgtggacag agatttttaa ggaacataat
     2401 ttcagttttt accccacctt ccagtcacat tcaaactcca gtatgccggg ttcacgagaa
     2461 gttcagatat acccgcccgt ggatcaggtc tcagggttca atgggaattc aattcattct
     2521 gaagatgaga ttgagtatga aaaccagaag aggctggaag aagaggagga agaagatttg
     2581 aacgtgctga cgtttgaaga cctcctttgt tttgcgtatc aagtggccaa gggcatggag
     2641 ttcctggagt tcaagtcgtg tgttcacaga gacctggcag ccaggaacgt actggtcacc
     2701 cacgggaagg tggtgaagat ctgtgacttt ggactggccc gagacatcct gagtgactcc
     2761 agctacgtcg tcaggggcaa cgcacggctg ccagtgaagt ggatggcacc tgagagcttg
     2821 tttgaaggga tctatacaat caagagtgac gtctggtcct acggcatcct tctctgggag
     2881 atattttcat tgggtgtgaa cccttacccc ggtattcctg tcgatgctaa cttctataaa
     2941 ctgattcaga gtggatttaa aatggagcag ccgttctatg ctacggaaga gatatacttt
     3001 gtaatgcaat cctgctgggc ttttgactca aggaagcggc catccttccc caatctgacg
     3061 tcatttttag gctgtcagct cgcagaggca gaagcagcga tgtatcagaa catgggcggc
     3121 gatgtcccac tggagcaccc agccatctac caaaacaggc ggcctgccag cagagaggca
     3181 ggctcagagc cgccatcacc acaggttcag gagaagactc acagagaaag aagttagtga
     3241 ggccttggac cccgccaccc ctagacaggc tgtagatcgc agagccaagg ttagcttcac
     3301 ctcagaggaa gcaccctgcc ggctgctgct tcttcgctgg acttttctct agatgctgtc
     3361 tgccattact ccagagtgac ttctataaga ccaaaccgct cctcgcccag gcagaagaga
     3421 caataatgag gctgactggt gagcctgcct gccctggaga cctttccagg ctggcttgag
     3481 gggaaagcca tgtatcggaa atacagtata ttcctgtaaa tacataaaac aaaaacaaac
     3541 tcatttttgc taaggagaag ctaaatatga ttttttaaaa aaaaatctat gttttaaaat
     3601 aatatgtaac tttttcatct gcttagtgat atattttatg gacggaaata aactttctac
     3661 tatagaaa
//
