LOCUS       NM_019306               6848 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus Fms related receptor tyrosine kinase 1 (Flt1),
            transcript variant 1, mRNA.
ACCESSION   NM_019306
VERSION     NM_019306.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6848)
  AUTHORS   Meng,J., Yang,X.M., Scheer,O., Lange,J., Muller,H., Burger,S.,
            Rothemund,S., Younis,R., Unterlauft,J.D. and Eichler,W.
  TITLE     Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1)
            Increases the Survival of Retinal Neurons
  JOURNAL   Invest Ophthalmol Vis Sci 65 (10), 27 (2024)
   PUBMED   39167401
  REMARK    GeneRIF: Pigment Epithelium-Derived Factor Binding to VEGFR-1
            (Flt-1) Increases the Survival of Retinal Neurons.
REFERENCE   2  (bases 1 to 6848)
  AUTHORS   Zhang,H., Zhang,Y., Xu,K., Wang,L., Zhou,X., Yang,M., Xie,J. and
            Li,H.
  TITLE     Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and
            Cognitive Impairment in Offspring Caused by Maternal Prenatal
            Stress
  JOURNAL   Appl Biochem Biotechnol 196 (8), 4900-4913 (2024)
   PUBMED   37979086
  REMARK    GeneRIF: Inhibition of FLT1 Attenuates Neurodevelopmental
            Abnormalities and Cognitive Impairment in Offspring Caused by
            Maternal Prenatal Stress.
REFERENCE   3  (bases 1 to 6848)
  AUTHORS   Jiangxue,H., Liling,Y., Fang,X., Shumei,Y., Gengying,L., Xuejun,R.,
            Yao,Y., Chuan,N., Jie,Y. and Zhuxiao,R.
  TITLE     Wnt5a-Flt1 activation contributes to preterm altered cerebral
            angiogenesis after prenatal inflammation
  JOURNAL   Pediatr Neonatol 64 (5), 528-537 (2023)
   PUBMED   36922327
  REMARK    GeneRIF: Wnt5a-Flt1 activation contributes to preterm altered
            cerebral angiogenesis after prenatal inflammation.
REFERENCE   4  (bases 1 to 6848)
  AUTHORS   Bayat,M., Chien,S. and Chehelcheraghi,F.
  TITLE     Co- localization of Flt1 and tryptase of mast cells in skin wound
            of rats with type I diabetes: Initial studies
  JOURNAL   Acta Histochem 123 (2), 151680 (2021)
   PUBMED   33444982
  REMARK    GeneRIF: Co- localization of Flt1 and tryptase of mast cells in
            skin wound of rats with type I diabetes: Initial studies.
REFERENCE   5  (bases 1 to 6848)
  AUTHORS   Bayraktar,B., Turkoz,D., Turkoz,A. and Karkucak,A.
  TITLE     Effects of Cerebral Ischemia on Levels of Vascular Endothelial
            Growth Factor (VEGF) and Its Soluble Receptors: A Possible Link to
            Angiogenesis in Arteriovenous Malformations
  JOURNAL   Turk Neurosurg 31 (6), 907-912 (2021)
   PUBMED   34169992
  REMARK    GeneRIF: Effects of Cerebral Ischemia on Levels of Vascular
            Endothelial Growth Factor (VEGF) and Its Soluble Receptors: A
            Possible Link to Angiogenesis in Arteriovenous Malformations.
REFERENCE   6  (bases 1 to 6848)
  AUTHORS   Fong,G.H., Rossant,J., Gertsenstein,M. and Breitman,M.L.
  TITLE     Role of the Flt-1 receptor tyrosine kinase in regulating the
            assembly of vascular endothelium
  JOURNAL   Nature 376 (6535), 66-70 (1995)
   PUBMED   7596436
REFERENCE   7  (bases 1 to 6848)
  AUTHORS   Brown,L.F., Olbricht,S.M., Berse,B., Jackman,R.W., Matsueda,G.,
            Tognazzi,K.A., Manseau,E.J., Dvorak,H.F. and Van de Water,L.
  TITLE     Overexpression of vascular permeability factor (VPF/VEGF) and its
            endothelial cell receptors in delayed hypersensitivity skin
            reactions
  JOURNAL   J Immunol 154 (6), 2801-2807 (1995)
   PUBMED   7876550
REFERENCE   8  (bases 1 to 6848)
  AUTHORS   Yamane,A., Seetharam,L., Yamaguchi,S., Gotoh,N., Takahashi,T.,
            Neufeld,G. and Shibuya,M.
  TITLE     A new communication system between hepatocytes and sinusoidal
            endothelial cells in liver through vascular endothelial growth
            factor and Flt tyrosine kinase receptor family (Flt-1 and
            KDR/Flk-1)
  JOURNAL   Oncogene 9 (9), 2683-2690 (1994)
   PUBMED   8058332
REFERENCE   9  (bases 1 to 6848)
  AUTHORS   Quinn,T.P., Peters,K.G., De Vries,C., Ferrara,N. and Williams,L.T.
  TITLE     Fetal liver kinase 1 is a receptor for vascular endothelial growth
            factor and is selectively expressed in vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7533-7537 (1993)
   PUBMED   8356051
REFERENCE   10 (bases 1 to 6848)
  AUTHORS   de Vries,C., Escobedo,J.A., Ueno,H., Houck,K., Ferrara,N. and
            Williams,L.T.
  TITLE     The fms-like tyrosine kinase, a receptor for vascular endothelial
            growth factor
  JOURNAL   Science 255 (5047), 989-991 (1992)
   PUBMED   1312256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jun 8, 2015 this sequence version replaced NM_019306.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28498.1, SRR26643289.31754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000012.1  12333430-12333728
            300-396             JAXUCZ010000012.1  12360271-12360367
            397-623             JAXUCZ010000012.1  12360726-12360952
            624-748             JAXUCZ010000012.1  12379522-12379646
            749-911             JAXUCZ010000012.1  12381428-12381590
            912-1048            JAXUCZ010000012.1  12381691-12381827
            1049-1223           JAXUCZ010000012.1  12385091-12385265
            1224-1341           JAXUCZ010000012.1  12386629-12386746
            1342-1511           JAXUCZ010000012.1  12389214-12389383
            1512-1671           JAXUCZ010000012.1  12390251-12390410
            1672-1786           JAXUCZ010000012.1  12407633-12407747
            1787-1895           JAXUCZ010000012.1  12415913-12416021
            1896-2204           JAXUCZ010000012.1  12423629-12423937
            2205-2351           JAXUCZ010000012.1  12428514-12428660
            2352-2483           JAXUCZ010000012.1  12449760-12449891
            2484-2590           JAXUCZ010000012.1  12459382-12459488
            2591-2723           JAXUCZ010000012.1  12464495-12464627
            2724-2828           JAXUCZ010000012.1  12469605-12469709
            2829-2942           JAXUCZ010000012.1  12474421-12474534
            2943-3031           JAXUCZ010000012.1  12476066-12476154
            3032-3188           JAXUCZ010000012.1  12481888-12482044
            3189-3286           JAXUCZ010000012.1  12482490-12482587
            3287-3409           JAXUCZ010000012.1  12484167-12484289
            3410-3521           JAXUCZ010000012.1  12486288-12486399
            3522-3621           JAXUCZ010000012.1  12488896-12488995
            3622-3727           JAXUCZ010000012.1  12495060-12495165
            3728-3870           JAXUCZ010000012.1  12495628-12495770
            3871-3955           JAXUCZ010000012.1  12497632-12497716
            3956-4050           JAXUCZ010000012.1  12499852-12499946
            4051-6848           JAXUCZ010000012.1  12501953-12504750
FEATURES             Location/Qualifiers
     source          1..6848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..6848
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /note="Fms related receptor tyrosine kinase 1"
                     /db_xref="GeneID:54251"
                     /db_xref="RGD:2621"
     exon            1..299
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..4246
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vascular endothelial growth factor receptor 1;
                     tyrosine-protein kinase receptor FLT; vascular endothelial
                     growth factor receptor 1-like; vascular endothelial growth
                     factor/vascular permeability factor receptor; Fms-related
                     tyrosine kinase 1 (vascular endothelial growth
                     factor/vascular permeability factor receptor); FMS-like
                     tyrosine kinase 1"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_062179.2"
                     /db_xref="GeneID:54251"
                     /db_xref="RGD:2621"
                     /translation="MVSCWDTAVLPCALLGCLLLTGYCSGSKLKGPELSLKGTQHVMQ
                     AGQTLFLKCRGEAAHSWSLPTTVSQEDKKLSVTRSACGRNNRQFCSTLTLNMAQANHT
                     GLYSCRYLPKSTSKEKKMESAIYIFVSDAGSPFIEMHSDIPKLVHMTEGRELIIPCRV
                     TSPNITVTLKKFPFDALTPDGQRIAWDSRRGFIIANATYKEIGLLTCEATVNGHLYQT
                     SYLTHRQTNTILDVQISPPSPVRFLRGQTLVLNCTVTTDLNTRVQMSWNYPGKATKRA
                     SIRQRIDQSNPHSNVFHSVLKINNVESRDKGLYTCRVKSGSSFRTFNTSVHVYEKGFI
                     SVKHRKQQVQETIAGKRSHRLSMKVKAFPSPEVVWLKDGVPATEKSARYSVHGYSLII
                     KDVTAEDAGDYTILLGIKQSKLFRNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQ
                     VLTCTVYGIPQPTIKWLWHPCHYNHSKERNDFCFGSEESFILDSSSNIGNRIEGITQR
                     MMVIEGTNKTVSTLVVADSRTPGIYSCKAFNKIGTVERDIRFYVTDVPNGFHVSLEKI
                     PTEGEDLKLSCVVSKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIK
                     NVSLEDSGTYACRARNIYTGEEILRKTEVLVRDLEAPLLLQNLSDHEVSISGSTTLDC
                     QARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEEDEGVYRCRATNQKGVV
                     ESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTDYLSII
                     MDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR
                     TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY
                     GNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEPDLEQDQKPRLDSVSSSESFTSSGFQ
                     EDKSVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL
                     SENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVL
                     LWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPR
                     FAELVEKLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSVPTFSEDFFKDGFTDPKFH
                     SGSSDDVRYVNAFKFMSLERIKTFEELSPNATSMFEDYHLDTSSLLTSPLLKRFTWTE
                     TKPKASMKIDLRITSKSKEAGLSDLPGPSFCFSSCGHIRPVRQEDEDDPELGKESCCS
                     PPPDYNSVVLYSSPPA"
     exon            300..396
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..623
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..748
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..911
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1048
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1223
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1341
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1511
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1671
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1786
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1895
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2204
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2351
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2483
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2590
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2723
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2828
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2942
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3031
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3188
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3286
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3409
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3521
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3621
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3727
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3870
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..3955
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4050
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..6848
                     /gene="Flt1"
                     /gene_synonym="FLT-1; VEGFR-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggtagt ggtggtagtg gtggcagcag ctccgagcgg gctccgggac tcaagcgcag
       61 cggctagcgg acgcgagact gggaggatcc cctccgcccc ccacaccacc tcggctgcag
      121 gcgcgagaag agctctcgcg gcgccatcag gagcaggagg ggaccggctc gggcggctgc
      181 tccgtcggcc tcggagagcg cgggcaccgg gccagcaggc cgcgtcgcgc tcaccatggt
      241 cagctgctgg gacaccgcgg tcctgccttg cgcgctgctc gggtgtctgc ttctcacagg
      301 atattgttca gggtcgaagt taaaaggacc agaactgagt ttaaaaggca cccagcacgt
      361 catgcaagcg ggccagactc tctttctcaa gtgcagaggg gaggcagccc actcctggtc
      421 tctgcctact acagtgagcc aggaggacaa aaagctgagc gtcactagat cagcctgtgg
      481 aaggaataac agacaattct gcagcacctt gaccttgaac atggcgcagg ccaaccacac
      541 gggcctctac tcctgcagat acctgcctaa atccacctcg aaggaaaaga aaatggaatc
      601 tgcaatctac atatttgtta gtgatgcagg gagtcctttc atagagatgc acagtgacat
      661 acccaaactc gtgcacatga cagaaggaag agagctcatc atcccctgcc gggtgacgtc
      721 tcccaacatc acagtcactc taaaaaagtt tccatttgac gctcttaccc ctgacgggca
      781 aagaatagcg tgggacagta ggagaggctt tataatagca aatgcaacgt acaaagagat
      841 aggactgctg acctgcgaag ccacagttaa cgggcacctg taccagacaa gttatctgac
      901 ccatcggcag accaatacaa tcctagatgt ccaaataagc ccaccgagcc ccgtgagatt
      961 cctccgtggt caaactcttg tcctcaactg caccgtcacc acggacctca atacaagggt
     1021 gcagatgagc tggaattacc ctggtaaagc aactaagaga gcatctatca ggcagcggat
     1081 tgaccaaagc aatccccaca gcaatgtgtt ccacagcgtt cttaagatca acaacgtgga
     1141 gagccgggac aagggactct acacttgtcg tgtgaagagt gggtcgtcat tccggacttt
     1201 caacacctct gtgcatgtgt atgaaaaggg atttatcagc gtgaagcatc ggaagcaaca
     1261 ggtgcaggaa accatagcag gaaaacggtc ccatcggctg tccatgaaag tgaaggcctt
     1321 cccctcgcca gaagtcgtat ggttaaaaga tggcgtaccc gcaacggaga aatctgctcg
     1381 ctattcggtg catggctact cgttaattat caaagatgta actgccgagg acgcagggga
     1441 ctatacaatc ttgctgggca taaaacagtc aaagctattt agaaacctca cagccactct
     1501 catcgtaaat gtgaaacctc agatctacga aaagtccgtg tcgtcccttc caagcccacc
     1561 tctctaccca ctgggcagca gacaagtcct cacttgcacc gtgtatggca tccctcagcc
     1621 taccatcaag tggctgtggc acccctgtca ctacaaccac tccaaagaaa ggaatgactt
     1681 ctgctttggg agtgaagaat ccttcatcct ggattccagc agcaacatag gaaacagaat
     1741 cgagggcatc actcagcgca tgatggtcat agaaggaacc aataagacgg ttagcacatt
     1801 ggtggtggct gactctcgga cccctggaat ctacagctgc aaggccttca ataaaatagg
     1861 gactgtggag agagacataa ggttttacgt cacagatgtg ccaaacggct ttcacgtttc
     1921 cttggaaaag ataccaaccg aaggagagga cctgaaactg tcctgtgtgg tcagtaaatt
     1981 cctgtacaga gacattacct ggatcctgct acggacagtt aacaacagga ccatgcacca
     2041 tagcatcagt aagcaaaaaa tggccaccac tcaggactac tccatcactc tgaaccttgt
     2101 catcaagaat gtgtctctgg aagactcggg cacctatgcc tgcagagcca ggaacatata
     2161 cacaggggaa gagatccttc ggaagacaga agttctcgtt agagatttgg aagcgccact
     2221 cctgcttcaa aacctcagtg accacgaggt gtccatcagt ggctccacga ccttagactg
     2281 tcaagctaga ggtgtccctg cgcctcagat cacttggttc aaaaacaacc acaaaataca
     2341 acaagaaccg ggaattattt taggaccagg aaacagcacg ctgtttattg aaagagtcac
     2401 agaagaggat gagggtgtct ataggtgccg agccaccaac cagaaggggg tcgtggaaag
     2461 ctcagcgtac ctcaccgtgc aaggaacctc agacaagtca aacctggagc tgatcaccct
     2521 cacgtgcacg tgtgtggctg cgacactctt ttggctcctt ctaactctct tcatccgaaa
     2581 actgaagcgg tcttcttccg aagtaaagac ggactacctg tcaatcatca tggacccaga
     2641 tgaagtcccc ctggatgagc agtgtgaacg gctgccctat gatgccagca agtgggagtt
     2701 tgcgcgggag agacttaaac taggcaaatc actcgggaga ggggcttttg ggaaggtggt
     2761 tcaggcctcg gcatttggca ttaagaaatc acccacctgc cggactgtgg ctgtgaagat
     2821 gttgaaagag ggggccacag ccagtgagta caaagctctg atgaccgaac tcaagatctt
     2881 gacccacatc ggccatcatc tgaatgtggt taacctcctg ggagcctgca ccaagcaagg
     2941 agggcctctg atggtgatcg tggaatactg caaatatgga aacctgtcca actaccttaa
     3001 gagcaaacgt gacttcttct gtctcaacaa ggatgcagcc ttgcatatgg agcccaagaa
     3061 agaaaagctg gagccagacc tggagcagga ccagaaaccc cgcctagaca gtgtcagcag
     3121 cagcgagagt ttcaccagct ccggcttcca ggaagataag agtgtgagcg atgtggaagg
     3181 aggcgaggat tacagtgaga tctccaagca gcccctcacc atggaagacc tgatctccta
     3241 cagtttccaa gtggccagag gcatggagtt tctgtcctcc agaaagtgca ttcatcgcga
     3301 cctggcagca cggaacatcc ttttatctga gaacaatgtt gtgaagattt gcgactttgg
     3361 cctggcccgg gatatttata agaaccctga ttacgtgagg agaggagata ctcgacttcc
     3421 cctaaaatgg atggctcccg aatccatctt tgacaaggtc tacagcacca agagtgacgt
     3481 gtggtcctac ggagtgttgc tgtgggagat cttttcctta gggggttctc catacccagg
     3541 agtgcaaatg gatgaagact tctgtagccg gctgaaggaa ggcatgcgca tgagaacacc
     3601 agagtatgcc acacctgaaa tctaccaaat catgctggat tgctggcaca aagaccccaa
     3661 agaaaggccc cggtttgctg aacttgtgga gaagctcggt gacctgcttc aagccaatgt
     3721 ccaacaggat ggtaaagact acatccccct caacgccata ctgactagaa acagtggctt
     3781 cacatactca gtccccacct tctcagagga ctttttcaag gatggtttca cggatccaaa
     3841 gtttcattct ggaagctctg atgatgtgag atacgtaaac gctttcaaat tcatgagcct
     3901 ggaaagaatc aaaacctttg aggagctttc accaaatgcc acctccatgt ttgaagacta
     3961 tcatctggat accagcagtc tgctgacctc ccccttgctg aagcgattca cctggactga
     4021 gaccaagccc aaggcctcaa tgaaaataga cctgagaatt actagtaaaa gcaaggaggc
     4081 ggggctttcc gatctgcccg gacccagctt ctgcttttcc agctgtggcc acatcaggcc
     4141 tgtgcgccag gaggatgaag acgaccctga gctggggaag gaatcctgct gctctccgcc
     4201 cccagactac aactccgtgg tgttgtactc ctccccgcct gcttagtgct tctcacaagc
     4261 cccagacaac agcctctgac agtattatac atatatgagt ttacacctat tccgctcctc
     4321 gggagccagc tgcttctcgt gacttttaat cgtgcttttt gttttgtttg ttgtcgctgt
     4381 tttgactaac aagaatgtaa cccccagata gagccacgtg aggaaaacac tattgttcaa
     4441 tcctcctgtg actccacgtt agagaaatcc tttctaagtc ccaacggctc ggctcacctg
     4501 cttcaacccc ccaaagcctc agggtaactt ggacaggaag gtgctggtgc cgccccgccc
     4561 acgctggcca tggccccacc caccctccct gcagctgtgg gaccagaccc agtaagtcat
     4621 tagctcaggg cagcgtgctc tgggtccctt tctgaggaaa gggagaacag caaacgagag
     4681 aggcacagga aaaggccgtg ggctgcatcc tgtggagccg gtgcaggaga gggctctgct
     4741 ctgctacttc agtgacttgt cacttctggc ctctgctttt tcaggccccc ttccaagagg
     4801 ttacagagca gaacgtgtgg ggtgtttccc agaccagggg gcacatgttc tcgggaacca
     4861 cagtaaatct taaatctttt cccgggagtc ttctgtctct gttcgccatc caaagcacgt
     4921 ttagtatgtg tcagtgaggg tggcgcttgg ctctgcggcc atacccacca tcagtttctc
     4981 tagcgagatg cactgaggtc agacccaagc ttggagtcct gaccttagca tactgctcac
     5041 acggggttaa gtggtccagt ttggcctagt aaggttgcct accaatgggc tcaaaagtca
     5101 ccttttaaac aggcttcatt tcaagtatta atatacagac aagacacttt tgcattacct
     5161 tgctttatat agttagctat ccagggaagc cggggtgact taagagtaat ggtctagaaa
     5221 agggttttct ctgtacccag acccggctcg atgggctaag acctggtaag acagagtggg
     5281 tgctccatgt ataatcgcca aaccacacac ctgaagttgg cacctcaccg ccttttactt
     5341 catcgtgtgt ttccccttct caaggcagtc tgagaggagc agaatagcat cagcccatgt
     5401 ttggtaagca ctttatgctc ctcgacagaa caggcggtgt tctctacggc tctctctaca
     5461 gctgcgactc aggttagtca gtgagccatc aaaaggaaaa aaaaatcttt tcatctgttt
     5521 cggaccttgc ctggggtcta acaatgatga ggacagggta gaaaagggaa gacagggtag
     5581 aaaagggtgc cctctctttg gagtctagag attgtgagcc ctgggtctct aaaatggctc
     5641 ttagaagctg tgtgtgcaaa ttgaggggtg gggtggtctg agtgtttagg tcgtgtgcac
     5701 ctgctggagc ctcgcggctg ggcagacgat gaatagctgc ttcgggagag cggaccacgc
     5761 ttgacgctaa gctctctgcc ctgaacggta gcacgtgagc ctgcttccca gtgtaccaca
     5821 tccttgaggt tctttgtctg atgagactgg agactcagcg caagccccat caaggtggtc
     5881 tgcaacccac ggtggccagg attagacacg aaagaaaggg cttccccagc cacactggag
     5941 ataaagaaat caggtagggc cgggcaaaga aatctttgtt caattagaaa agctcttgtc
     6001 cactgcggtg tgtaaatcag ggattagaca gagtctacca gagaaacgga tgctatagcc
     6061 agcatcctgt gatttctcag ccaaatatcc agcaattaga gggggatagc cagtcctgta
     6121 ttattccaat tttaatcatc taattcttaa tcattaagat gctttagtaa atgtcccttt
     6181 tccacaaaag taaagaaagc ctattgggat tctctggttc tgtttaagga cagctttgga
     6241 gcctatggaa gttgattagc cagaaaaaag gaaagaaagg aagaaagaaa atggttcctc
     6301 ctgagttttt aaggtaggaa gaaaaatgga aatctataaa gacagccata cctaggtgca
     6361 ctgtgcctgt tcaccaaagc cagcattgga tggtaagagt cttgacagtg acattaaaac
     6421 cctttgccat tcaaggccaa gcagttggaa ctaaggaaga gcgaacattt ctcctagtgt
     6481 ttgggactcg ccctgtgtga ctagggagct gaagcctcag gcaagtctaa gctagcccga
     6541 ggcggatcct taggagacag atctggtcga accccgttgc acaggtcttc gagcagtgaa
     6601 gggggggggg gcagctcagt gaagggagag ggcacctctg acccacagtg gtaggaactg
     6661 tacgtgtatg tgtgtatctg tatgttttgt gcataactat ttaaagaaac tggaattttg
     6721 aagttacttt tatatgagtc aagattattt gctacagacc tgagacatga tctggccaca
     6781 cctttctagt catgatgaat gtatttcata tattatcttc atttaataaa attaactttc
     6841 aaaaccaa
//
