LOCUS       NM_001126291            2846 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus fibronectin leucine rich transmembrane protein 3
            (Flrt3), mRNA.
ACCESSION   NM_001126291 XM_001080226 XM_345441
VERSION     NM_001126291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Yamada,M., Fujita,Y., Hayano,Y., Hayakawa,H., Baba,K., Mochizuki,H.
            and Yamashita,T.
  TITLE     Increased Expression of Fibronectin Leucine-Rich Transmembrane
            Protein 3 in the Dorsal Root Ganglion Induces Neuropathic Pain in
            Rats
  JOURNAL   J Neurosci 39 (38), 7615-7627 (2019)
   PUBMED   31346030
  REMARK    GeneRIF: These findings suggest that FLRT3 is produced by injured
            DRG neurons and increases neuronal excitability in the dorsal horn,
            leading to pain sensitization. Neuropathic pain induction is a
            novel function of FLRT3.
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Lu,Y.C., Nazarko,O.V., Sando,R. 3rd, Salzman,G.S., Li,N.S.,
            Sudhof,T.C. and Arac,D.
  TITLE     Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell
            Adhesion
  JOURNAL   Structure 23 (9), 1678-1691 (2015)
   PUBMED   26235030
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Leyva-Diaz,E., del Toro,D., Menal,M.J., Cambray,S., Susin,R.,
            Tessier-Lavigne,M., Klein,R., Egea,J. and Lopez-Bendito,G.
  TITLE     FLRT3 is a Robo1-interacting protein that determines Netrin-1
            attraction in developing axons
  JOURNAL   Curr Biol 24 (5), 494-508 (2014)
   PUBMED   24560577
REFERENCE   5  (bases 1 to 2846)
  AUTHORS   O'Sullivan,M.L., de Wit,J., Savas,J.N., Comoletti,D., Otto-Hitt,S.,
            Yates,J.R. 3rd and Ghosh,A.
  TITLE     FLRT proteins are endogenous latrophilin ligands and regulate
            excitatory synapse development
  JOURNAL   Neuron 73 (5), 903-910 (2012)
   PUBMED   22405201
REFERENCE   6  (bases 1 to 2846)
  AUTHORS   Yamagishi,S., Hampel,F., Hata,K., Del Toro,D., Schwark,M.,
            Kvachnina,E., Bastmeyer,M., Yamashita,T., Tarabykin,V., Klein,R.
            and Egea,J.
  TITLE     FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive
            neurons
  JOURNAL   EMBO J 30 (14), 2920-2933 (2011)
   PUBMED   21673655
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2846)
  AUTHORS   Maretto,S., Muller,P.S., Aricescu,A.R., Cho,K.W., Bikoff,E.K. and
            Robertson,E.J.
  TITLE     Ventral closure, headfold fusion and definitive endoderm migration
            defects in mouse embryos lacking the fibronectin leucine-rich
            transmembrane protein FLRT3
  JOURNAL   Dev Biol 318 (1), 184-193 (2008)
   PUBMED   18448090
REFERENCE   8  (bases 1 to 2846)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
REFERENCE   9  (bases 1 to 2846)
  AUTHORS   Robinson,M., Parsons Perez,M.C., Tebar,L., Palmer,J., Patel,A.,
            Marks,D., Sheasby,A., De Felipe,C., Coffin,R., Livesey,F.J. and
            Hunt,S.P.
  TITLE     FLRT3 is expressed in sensory neurons after peripheral nerve injury
            and regulates neurite outgrowth
  JOURNAL   Mol Cell Neurosci 27 (2), 202-214 (2004)
   PUBMED   15485775
  REMARK    GeneRIF: Study concludes that FLRT3 codes for a putative cell
            surface receptor implicated in both the development of the nervous
            system and in the regeneration of the peripheral nervous system.
REFERENCE   10 (bases 1 to 2846)
  AUTHORS   Tsuji,L., Yamashita,T., Kubo,T., Madura,T., Tanaka,H., Hosokawa,K.
            and Tohyama,M.
  TITLE     FLRT3, a cell surface molecule containing LRR repeats and a FNIII
            domain, promotes neurite outgrowth
  JOURNAL   Biochem Biophys Res Commun 313 (4), 1086-1091 (2004)
   PUBMED   14706654
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160843.1.
            
            On or before May 7, 2008 this sequence version replaced
            XM_001080226.1, XM_345441.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160843.1, DY319128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2846
                     /gene="Flrt3"
                     /gene_synonym="RGD1566005"
                     /note="fibronectin leucine rich transmembrane protein 3"
                     /db_xref="GeneID:366205"
                     /db_xref="RGD:1566005"
     exon            1..188
                     /gene="Flrt3"
                     /gene_synonym="RGD1566005"
                     /inference="alignment:Splign:2.1.0"
     exon            189..389
                     /gene="Flrt3"
                     /gene_synonym="RGD1566005"
                     /inference="alignment:Splign:2.1.0"
     exon            390..2828
                     /gene="Flrt3"
                     /gene_synonym="RGD1566005"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2384
                     /gene="Flrt3"
                     /gene_synonym="RGD1566005"
                     /note="leucine-rich repeat transmembrane protein FLRT3;
                     fibronectin-like domain-containing leucine-rich
                     transmembrane protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT3
                     precursor"
                     /protein_id="NP_001119763.1"
                     /db_xref="GeneID:366205"
                     /db_xref="RGD:1566005"
                     /translation="MISPAWSLFLIGTKIGLFFQVAPLSVMAKSCPSVCRCDAGFIYC
                     NDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNL
                     PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLF
                     LSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGD
                     KVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRL
                     DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMC
                     QAPEKVRGMAIKDLSAELFDCKDSGIVSTVQITTAIPNTAYPAQGQWPAPVTKQPDIK
                     NPKLTKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFG
                     SITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYN
                     PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYS
                     KGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYK
                     NNLSESSSNRSYRDSGIPDLDHSHS"
ORIGIN      
        1 ctcgcgcgca gtcctcagcg caggagtgat ctgaagcagg acgggctcag gctgcagctg
       61 ctgtggcttt gtgtgcactg gatgccgcgc tccggagacg ggggagggtt tttacttcaa
      121 ctcacaggca atggaattac agctgtagca gcagggtata aaggattgct ttttccctcg
      181 tcttcctgga ggtgctcagt ccggcccact gtaaggaagg aagagaaata aaaagggaat
      241 ttcgtgtgct tccttctccc tccatgagga ctgcttgcac tgtgtccttt gctccttaaa
      301 agagagtcca cccgttctag tagaagggga ctgaaacgga aatactgaga aagcagcaag
      361 aagcagaaga catagctatt tcacagcagt aacagaagct gcctgctata ataaagacct
      421 caacactgct gaccatgatc agcccagcct ggagcctctt cctcattggg acgaaaattg
      481 ggctattctt ccaagtggca cctctgtctg ttatggctaa atcctgtcca tctgtgtgtc
      541 gctgtgacgc aggtttcatt tactgtaatg atcgctctct gacatccatt ccagtgggaa
      601 ttccggagga tgctacaaca ctctaccttc agaacaacca aataaacaat gttgggattc
      661 cttcagattt gaagaacttg ctgaaagtgc aaagaatata cctgtaccac aacagtttag
      721 atgaatttcc taccaacctt ccaaagtatg tgaaagagtt acatttgcag gagaataaca
      781 taagaactat cacgtacgat tcactttcga aaattcccta tctggaagag ttacacttgg
      841 atgataattc agtctcggct gttagcatag aagagggagc atttcgagac agcaactatc
      901 tgcggctgct ttttctgtcc cgtaaccacc ttagcacaat cccgggaggc ttgcccagga
      961 ctattgagga attacgccta gatgacaatc gcatatcaac tatctcttcc ccatcgcttc
     1021 acggtctcac aagcctgaaa cgcctggttt tagatggaaa cttgttgaac aaccacggtt
     1081 tgggtgacaa agttttcttc aacttagtaa acttaacaga actgtccctg gtgaggaatt
     1141 ccttgacagc cgcacccgtg aaccttcccg gcacgagcct gaggaagctt taccttcaag
     1201 acaaccatat caaccgggta cccccaaatg ctttttctta tttaaggcag ctgtatcgac
     1261 tcgatatgtc caataataac ctaagcaatt tacctcaggg tatctttgat gatttggaca
     1321 atataaccca actgattctt cgcaacaatc cttggtattg tgggtgcaag atgaaatggg
     1381 tacgagactg gttgcagtca ctacctgtga aggtcaatgt gcgtgggctc atgtgccaag
     1441 ctccagaaaa ggtccgtgga atggctatca aggacctcag tgcagaactg tttgattgta
     1501 aagacagtgg gattgtgagc accgttcaga taaccaccgc aatacctaac acagcatatc
     1561 ctgctcaagg acagtggcca gctcctgtga ccaaacaacc agatattaaa aaccccaagc
     1621 tcactaagga tcagcgaact acaggcagtc cctcacgaaa aacaattttg attactgtga
     1681 agtctgtcac ccctgacaca atccacatat cctggagact tgctctgcct atgactgctt
     1741 tgcgactcag ctggcttaaa ctgggccaca gcccagcctt tggatctata acggaaacca
     1801 tcgtaacagg agaacgtagt gaatacttgg tcacagctct agaacctgaa tcaccctata
     1861 gagtatgcat ggttcccatg gaaaccagta acctttacct gtttgatgaa actcctgttt
     1921 gtattgagac tcaaactgcc cctcttcgaa tgtacaaccc cacaaccacc ctcaatcgag
     1981 agcaagagaa agaaccttac aaaaatccaa atttaccttt ggccgccatc attggtgggg
     2041 ctgtggccct ggtaagcatc gccctccttg ctttggtgtg ttggtatgtg cataggaatg
     2101 ggtccctgtt ctcacggaac tgcgcgtaca gcaaagggag gaggagaaag gatgactatg
     2161 cagaagctgg cactaagaaa gacaactcca tcctggaaat cagggaaact tctttccaga
     2221 tgctaccgat aagcaatgaa cccatctcca aggaggagtt tgtaatacac accatatttc
     2281 ctccgaatgg gatgaatctg tacaaaaaca acctcagtga gagcagtagt aaccggagct
     2341 acagagacag tgggattcca gacttggacc actcacactc atgatgcgag gaggtcccac
     2401 accagactct tcctgggttt ttttttccaa aaacctaaga aaggtgatag taggaactct
     2461 gttctactgc gaaacactgg aaaaaagaga ctgagaaaag caatgtactg tacatttgcc
     2521 atataattta tatttaagaa ctttttatta aaagtttcag atttcaggtt gctgctgcgc
     2581 ttgatgtagt ggggaggcct gaacacagtt ctatatttta gtatttttta gtaatttgta
     2641 ctgtattttt ccttgcagat attgaagtta tgaaccattt actttgtgtt ctactgagta
     2701 agatgacttg ttgactgtga aagtgaattt tcttgctgtg ttgaacaatc aggactgcgt
     2761 tcacttgaga tccttgtaga ataagcacag gccgtttttc actttggtat tgatacaatg
     2821 taaaaaaaaa aaaaaaaaaa aaaaaa
//
