LOCUS       NM_001106750            2900 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus fibronectin leucine rich transmembrane protein 2
            (Flrt2), mRNA.
ACCESSION   NM_001106750 XM_001064239 XM_234361
VERSION     NM_001106750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Hwang,H.J., Kang,D., Kim,J.R., Choi,J.H., Ryu,J.K., Herman,A.B.,
            Ko,Y.G., Park,H.J., Gorospe,M. and Lee,J.S.
  TITLE     FLRT2 prevents endothelial cell senescence and vascular aging by
            regulating the ITGB4/mTORC2/p53 signaling pathway
  JOURNAL   JCI Insight 9 (7), e172678 (2024)
   PUBMED   38587072
  REMARK    GeneRIF: FLRT2 prevents endothelial cell senescence and vascular
            aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Schroeder,A., Vanderlinden,J., Vints,K., Ribeiro,L.F.,
            Vennekens,K.M., Gounko,N.V., Wierda,K.D. and de Wit,J.
  TITLE     A Modular Organization of LRR Protein-Mediated Synaptic Adhesion
            Defines Synapse Identity
  JOURNAL   Neuron 99 (2), 329-344 (2018)
   PUBMED   29983322
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Yamagishi,S., Hampel,F., Hata,K., Del Toro,D., Schwark,M.,
            Kvachnina,E., Bastmeyer,M., Yamashita,T., Tarabykin,V., Klein,R.
            and Egea,J.
  TITLE     FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive
            neurons
  JOURNAL   EMBO J 30 (14), 2920-2933 (2011)
   PUBMED   21673655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Muller,P.S., Schulz,R., Maretto,S., Costello,I., Srinivas,S.,
            Bikoff,E. and Robertson,E.
  TITLE     The fibronectin leucine-rich repeat transmembrane protein Flrt2 is
            required in the epicardium to promote heart morphogenesis
  JOURNAL   Development 138 (7), 1297-1308 (2011)
   PUBMED   21350012
REFERENCE   7  (bases 1 to 2900)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234361.4, XM_001064239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM117735.1, CB732320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..2900
                     /gene="Flrt2"
                     /note="fibronectin leucine rich transmembrane protein 2"
                     /db_xref="GeneID:299236"
                     /db_xref="RGD:1308574"
     exon            1..372
                     /gene="Flrt2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..2900
                     /gene="Flrt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             765..2747
                     /gene="Flrt2"
                     /note="leucine-rich repeat transmembrane protein FLRT2;
                     fibronectin-like domain-containing leucine-rich
                     transmembrane protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT2
                     precursor"
                     /protein_id="NP_001100220.1"
                     /db_xref="GeneID:299236"
                     /db_xref="RGD:1308574"
                     /translation="MGLQTAKWPSHGTFVLKFWLIMSLGLYSHVSKLLACPSVCRCDR
                     NFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDE
                     FPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAIS
                     LKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN
                     KGIADGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLR
                     KLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNV
                     RGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTVSVPSPS
                     RGSVPPAPAPSKLPTIPDWDGRERATPPISERIQLSIHFVNDTSIQVSWLSLFTVMAY
                     KLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTI
                     CSEATTHASYLNNGSNTASSHEQTTSHTMGSPFLLAGLIGGAVIFVLVVLLSVFCWHM
                     HKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRL
                     QPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT"
ORIGIN      
        1 tttgaaagca gtcgccatca cttgtgagtt tggcgtcatc cattgtcacc accaaggaat
       61 gtgcgctggg agataacacc gagtgcaggg cttctcaaac acgcggagct cctctgcttc
      121 caggtgcgct cctagctggt ccttggcgcc gaatttccgg cacccggagg cagcaccgca
      181 gaaccggtca ccgagtcctc cgagcctcag gatcaagctg gtagttctca acgatgggca
      241 ggagggacct cagcggcgac ccctaaaaca ataccatgcc cggagagtcc ctctgctgcc
      301 gcaccagctt cttccctttc cacctccccg acccggtcgg cttcggatga gctaaggaga
      361 caaggctacc agattactga ctctgcttaa ccaagaaatt cctaggctgc tctaccctgg
      421 cctgactcat tatagaagaa ggaagatttg cctgcctggc tggacttctc ttgacagtac
      481 ttggcatcac gctttgcttg tgttgaaaat tcttcctgtt gagtcgtttt gcacaaggag
      541 gaccacttca tgagggcaac ctagggagat cagactgaaa acatcagaaa gattgtttta
      601 ccattgtccc ttggatcatt tcctctaaca gaagtgatag actttgacag aacctggtcc
      661 agtcatttgg attttgcttt ctggtttttg ctattgtttg ttgcgctttt gtttttgatt
      721 tttccccccc atatcacata gtattttatt tcttttcttc agaaatgggc ctgcagactg
      781 caaagtggcc cagccatggg acttttgttc taaaattttg gctcatcatg tccctgggac
      841 tgtactcaca tgtgtcaaaa ctcctggcct gccctagtgt gtgtcgatgt gacaggaact
      901 ttgtctactg taatgagaga agcttgacct cagtgcctct tgggatcccg gagggcgtaa
      961 ccgtactcta cctccacaac aaccaaatta ataatgctgg atttcctgca gagctgcaca
     1021 acgtacagtc agtgcacacg gtctaccttt acggcaacca actggatgaa ttccccatga
     1081 acctccccaa gaatgtcaga gttctccatc tgcaggaaaa caacattcag accatctcgc
     1141 gggctgctct tgctcagctc ctcaagctgg aagaactaca cctagatgac aactccatat
     1201 ctacagtggg agtggaagac ggggccttcc gggaggcaat aagcctcaaa ctgttgtttt
     1261 tatcaaagaa tcacctgagt agcgtgcctg ttgggctccc cgtagacttg caagagctga
     1321 gagtggatga aaaccgaatc gcggtcattt cagacatggc ctttcagaac ctcacaagct
     1381 tggagcgtct gatcgtggat gggaatcttc tgaccaacaa gggcattgct gacggtacct
     1441 tcagccatct caccaagctc aaggaatttt ccatagtccg gaactcgctc tcccacccgc
     1501 ctcccgacct cccaggtacg catctgatca ggctctactt acaggataac cagataaacc
     1561 atatcccatt gacagccttc gcaaacctcc gtaagctgga aaggctcgat atatccaata
     1621 accagctacg aatgttaact caaggagtct tcgatcatct ctccaacctg aaacaactca
     1681 ccgctcggaa taacccttgg ttttgcgact gcagcatcaa atgggtcacc gaatggctca
     1741 aatatatccc ttcttctctc aatgtgcgtg gtttcatgtg ccaaggtccc gagcaagtcc
     1801 gggggatggc tgtcagggag ttgaatatga atctcttgtc ttgtcccacc acgactcccg
     1861 gcctacctgt ctttacccca gctcccagta cagtgtctcc aacaactcag tctcccactg
     1921 tctctgttcc aagccccagc agaggctcgg tgcctccagc tcccgcccca tccaaacttc
     1981 ccaccatccc ggactgggat ggcagagaaa gagcgacccc acctatttct gaaaggatcc
     2041 aactttccat ccacttcgtt aatgatactt caattcaagt cagctggctg tctctcttta
     2101 cggtgatggc ctacaaactg acgtgggtga aaatgggcca cagtctcgta gggggaatcg
     2161 ttcaggaacg cattgtcagc ggtgagaagc agcacctgag cttggttaat ttagagccca
     2221 gatccacgta caggatttgt ttagtgccac tggacgcgtt caactaccgc actgtggaag
     2281 ataccatctg ttctgaggcc accacccacg cctcttattt gaacaatggc agcaacactg
     2341 cgtctagcca tgagcaaaca acttcccaca ccatggggtc cccttttctg ctcgcgggct
     2401 tgatcggggg tgcggtgatt tttgtgctcg tggtcttgct cagtgtcttt tgctggcaca
     2461 tgcacaaaaa gggacgctac acctcccaga agtggaaata caaccggggc cgacggaaag
     2521 atgactattg tgaggcaggt accaaaaagg acaactccat cttggagatg acagaaacaa
     2581 gttttcagat tgtctcttta aataacgatc agctccttaa aggagatttc agactgcagc
     2641 ccatttatac cccaaatggg ggcattaatt acacagactg ccacatcccc aacaacatga
     2701 gatactgcaa cagcagtgtg ccagatctgg agcattgtca cacgtaacag cctagaggtc
     2761 cagcgttaga aaggtggaca accgaactct caagaacaca cacacgtgtg cacacaaaga
     2821 catgcaaatt acatttgata aatgttaccc agatgcattt gtgcatttga atactctgta
     2881 atttatacgg tgtactatat
//
