LOCUS       NM_022701               1718 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus flotillin 1 (Flot1), mRNA.
ACCESSION   NM_022701
VERSION     NM_022701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Kessler,E.L., van Stuijvenberg,L., van Bavel,J.J.A., van
            Bennekom,J., Zwartsen,A., Rivaud,M.R., Vink,A., Efimov,I.R.,
            Postma,A.V., van Tintelen,J.P., Remme,C.A., Vos,M.A., Banning,A.,
            de Boer,T.P., Tikkanen,R. and van Veen,T.A.B.
  TITLE     Flotillins in the intercalated disc are potential modulators of
            cardiac excitability
  JOURNAL   J Mol Cell Cardiol 126, 86-95 (2019)
   PUBMED   30452906
  REMARK    GeneRIF: the presence of Flotillin-1, in addition to Flotillin-2 in
            the cardiac intercalated disc, is reported.
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Luo,Y., Akama,T., Okayama,A., Yoshihara,A., Sue,M., Oda,K.,
            Hayashi,M., Ishido,Y., Hirano,H., Hiroi,N., Katoh,R. and Suzuki,K.
  TITLE     A Novel Role for Flotillin-Containing Lipid Rafts in
            Negative-Feedback Regulation of Thyroid-Specific Gene Expression by
            Thyroglobulin
  JOURNAL   Thyroid 26 (11), 1630-1639 (2016)
   PUBMED   27676653
  REMARK    GeneRIF: Data suggest that flotillin-1 and flotillin-2 function as
            thyroglobulin-binding proteins in lipid rafts of thyrocytes; these
            interactions appear to exert negative-feedback effects on gene
            expression in thyrocytes.
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Hwangbo,C., Tae,N., Lee,S., Kim,O., Park,O.K., Kim,J., Kwon,S.H.
            and Lee,J.H.
  TITLE     Syntenin regulates TGF-beta1-induced Smad activation and the
            epithelial-to-mesenchymal transition by inhibiting
            caveolin-mediated TGF-beta type I receptor internalization
  JOURNAL   Oncogene 35 (3), 389-401 (2016)
   PUBMED   25893292
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Nakadate,K.
  TITLE     Developmental changes in the flotillin-1 expression pattern of the
            rat visual cortex
  JOURNAL   Neuroscience 292, 101-111 (2015)
   PUBMED   25732136
  REMARK    GeneRIF: Study illustrates early developmental changes in the
            cellular and subcellular localization of flotillin-1 in the rat
            visual cortex and suggests that flotillin-1 was transported mainly
            into presynaptic terminals
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Morrow,I.C., Rea,S., Martin,S., Prior,I.A., Prohaska,R.,
            Hancock,J.F., James,D.E. and Parton,R.G.
  TITLE     Flotillin-1/reggie-2 traffics to surface raft domains via a novel
            golgi-independent pathway. Identification of a novel membrane
            targeting domain and a role for palmitoylation
  JOURNAL   J Biol Chem 277 (50), 48834-48841 (2002)
   PUBMED   12370178
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Marchand,S., Devillers-Thiery,A., Pons,S., Changeux,J.P. and
            Cartaud,J.
  TITLE     Rapsyn escorts the nicotinic acetylcholine receptor along the
            exocytic pathway via association with lipid rafts
  JOURNAL   J Neurosci 22 (20), 8891-8901 (2002)
   PUBMED   12388596
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Baumann,C.A., Ribon,V., Kanzaki,M., Thurmond,D.C., Mora,S.,
            Shigematsu,S., Bickel,P.E., Pessin,J.E. and Saltiel,A.R.
  TITLE     CAP defines a second signalling pathway required for
            insulin-stimulated glucose transport
  JOURNAL   Nature 407 (6801), 202-207 (2000)
   PUBMED   11001060
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Lang,D.M., Lommel,S., Jung,M., Ankerhold,R., Petrausch,B.,
            Laessing,U., Wiechers,M.F., Plattner,H. and Stuermer,C.A.
  TITLE     Identification of reggie-1 and reggie-2 as
            plasmamembrane-associated proteins which cocluster with activated
            GPI-anchored cell adhesion molecules in non-caveolar micropatches
            in neurons
  JOURNAL   J Neurobiol 37 (4), 502-523 (1998)
   PUBMED   9858255
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Bickel,P.E., Scherer,P.E., Schnitzer,J.E., Oh,P., Lisanti,M.P. and
            Lodish,H.F.
  TITLE     Flotillin and epidermal surface antigen define a new family of
            caveolae-associated integral membrane proteins
  JOURNAL   J Biol Chem 272 (21), 13793-13802 (1997)
   PUBMED   9153235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK359020.1, DY569467.1, CB326388.1 and CB324456.1.
            
            On Oct 25, 2007 this sequence version replaced NM_022701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC064652.1, U60976.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN11044071, SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               CK359020.1         1-723
            724-1014            DY569467.1         406-696
            1015-1134           CB326388.1         583-702             c
            1135-1718           CB324456.1         1-584               c
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1718
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /note="flotillin 1"
                     /db_xref="GeneID:64665"
                     /db_xref="RGD:70991"
     exon            1..165
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            166..216
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1460
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /note="REG-2; reggie-2"
                     /codon_start=1
                     /product="flotillin-1"
                     /protein_id="NP_073192.2"
                     /db_xref="GeneID:64665"
                     /db_xref="RGD:70991"
                     /translation="MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLN
                     TLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALE
                     TLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDY
                     LHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYEL
                     KKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE
                     KELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAVGARARAE
                     AEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAK
                     VTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA"
     exon            217..292
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            293..383
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            384..527
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            528..647
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            648..743
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            744..896
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1078
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1124
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1262
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1427
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1700
                     /gene="Flot1"
                     /gene_synonym="Rareg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggggtc gcgtctgttg ctgcaacagg gtgcggccgg gtcgggggcg caagtgcagt
       61 ttccactaag ccgggtgttc aagcagtctc cacccagttt tggggctctg cgggtctccg
      121 cgcttcccta gaccccagtg gggttgctta ccggcattcc ggaagcctca actatgtttt
      181 tcacttgtgg cccaaatgag gccatggtgg tctccgggtt ctgcaggagc cccccagtca
      241 tggtggccgg aggccgagtg tttgtcctac cctgcattca acaaatccaa aggatctctc
      301 tcaacacact gaccctcaat gtcaagagtg agaaggttta tacccgccac ggggtcccca
      361 tctcagtcac gggcattgcc caggtgaaaa tccaggggca aaacaaggag atgctggcag
      421 ctgcctgcca gatgttcctg gggaagacag aggcagagat cgcccacatt gccctggaga
      481 cgctggaagg ccaccagagg gcaatcatgg cccacatgac tgtggaggag atctataagg
      541 acagacagaa gttctcagag caggttttca aggtggcctc ctccgacctg gtcaacatgg
      601 gtatcagtgt ggttagctac actttgaagg acattcacga tgaccaggat tacttacact
      661 ctttggggaa ggctcgcaca gcacaagtgc agaaagatgc tcggattgga gaagcagagg
      721 ccaagagaga tgcggggata cgggaggcta aggccaagca ggagaaggta tccgcacagt
      781 gcctcagtga aatagagatg gccaaggccc agagggacta tgagctgaag aaagccacct
      841 acgacattga ggtcaacacc cggcgagcac aggcagacct ggcctatcag ctgcaggtgg
      901 ccaagacgaa gcagcagatc gaggagcagc gggtacaggt gcaggtggtg gagcgcgccc
      961 agcaggtggc agtgcaggag caggagatag caaggcgcga gaaggagctg gaggcccggg
     1021 tgcgcaagcc agcggaggct gagcgctaca ggctggagcg cctggcggaa gcagagaagg
     1081 cccagctgat catgcaggca gaagctgaag ctgagtctgt gcggatgcga ggggaagctg
     1141 aggcctttgc cgtaggggcc cgcgctcgtg ctgaggctga gcaaatggcc aagaaggcag
     1201 aagccttcca gatgtaccag gaggccgccc agctggacat gctgctggag aaactgcccc
     1261 aggtggcaga agagatcagt ggccccctga cctcagccaa taagatcacg ctggtgtcta
     1321 gcggaagcgg aaccatgggg gccgccaaag ttactgggga agtactggac atcttaagcc
     1381 gtctgccaga gagtgtggag agactcacag gcgtcagcat ctcccaggtg aatcacaaca
     1441 agcctttaag gacggcgtga gccctcagtt cccaatggta cctggacatg tggcccaatg
     1501 gtctcattgc atgcgcctca gttggcctcc ctgagcatga ccccctgcca agggtgcaca
     1561 tctctccttg ccaaatagtc tgtgccttgc cttggagggc ttgctctccg cccatttgcc
     1621 agtgccctgc accaagactt tggttatctt acttcacccc aactatttaa cttcctgatt
     1681 aaacgagact gagccctctg aaaaaaaaaa aaaaaaaa
//
