LOCUS       NM_001191862            9049 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus filamin C (Flnc), mRNA.
ACCESSION   NM_001191862 XM_342653
VERSION     NM_001191862.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9049)
  AUTHORS   Valdes-Mas,R., Gutierrez-Fernandez,A., Gomez,J., Coto,E.,
            Astudillo,A., Puente,D.A., Reguero,J.R., Alvarez,V., Moris,C.,
            Leon,D., Martin,M., Puente,X.S. and Lopez-Otin,C.
  TITLE     Mutations in filamin C cause a new form of familial hypertrophic
            cardiomyopathy
  JOURNAL   Nat Commun 5, 5326 (2014)
   PUBMED   25351925
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9049)
  AUTHORS   Bouvard,D., Pouwels,J., De Franceschi,N. and Ivaska,J.
  TITLE     Integrin inactivators: balancing cellular functions in vitro and in
            vivo
  JOURNAL   Nat Rev Mol Cell Biol 14 (7), 430-442 (2013)
   PUBMED   23719537
  REMARK    Review article
REFERENCE   3  (bases 1 to 9049)
  AUTHORS   Maiweilidan,Y., Klauza,I. and Kordeli,E.
  TITLE     Novel interactions of ankyrins-G at the costameres: the
            muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds
            plectin and filamin C
  JOURNAL   Exp Cell Res 317 (6), 724-736 (2011)
   PUBMED   21223964
REFERENCE   4  (bases 1 to 9049)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 9049)
  AUTHORS   Holmes,W.B. and Moncman,C.L.
  TITLE     Nebulette interacts with filamin C
  JOURNAL   Cell Motil Cytoskeleton 65 (2), 130-142 (2008)
   PUBMED   17987659
REFERENCE   6  (bases 1 to 9049)
  AUTHORS   Dalkilic,I., Schienda,J., Thompson,T.G. and Kunkel,L.M.
  TITLE     Loss of FilaminC (FLNc) results in severe defects in myogenesis and
            myotube structure
  JOURNAL   Mol Cell Biol 26 (17), 6522-6534 (2006)
   PUBMED   16914736
REFERENCE   7  (bases 1 to 9049)
  AUTHORS   Lypowy,J., Chen,I.Y. and Abdellatif,M.
  TITLE     An alliance between Ras GTPase-activating protein, filamin C, and
            Ras GTPase-activating protein SH3 domain-binding protein regulates
            myocyte growth
  JOURNAL   J Biol Chem 280 (27), 25717-25728 (2005)
   PUBMED   15886195
  REMARK    GeneRIF: physical interaction between RasGAP and FLN-C facilitates
            an interaction between G3BP and cdk7 mRNA
REFERENCE   8  (bases 1 to 9049)
  AUTHORS   Pudas,R., Kiema,T.R., Butler,P.J., Stewart,M. and Ylanne,J.
  TITLE     Structural basis for vertebrate filamin dimerization
  JOURNAL   Structure 13 (1), 111-119 (2005)
   PUBMED   15642266
REFERENCE   9  (bases 1 to 9049)
  AUTHORS   Sheen,V.L., Feng,Y., Graham,D., Takafuta,T., Shapiro,S.S. and
            Walsh,C.A.
  TITLE     Filamin A and Filamin B are co-expressed within neurons during
            periods of neuronal migration and can physically interact
  JOURNAL   Hum Mol Genet 11 (23), 2845-2854 (2002)
   PUBMED   12393796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_342653.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.18668.1,
                                           SRR26643294.17490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               JAXUCZ010000004.1  58999547-59000090
            545-793             JAXUCZ010000004.1  59004662-59004910
            794-891             JAXUCZ010000004.1  59006366-59006463
            892-1042            JAXUCZ010000004.1  59006579-59006729
            1043-1161           JAXUCZ010000004.1  59006820-59006938
            1162-1239           JAXUCZ010000004.1  59007060-59007137
            1240-1402           JAXUCZ010000004.1  59007314-59007476
            1403-1603           JAXUCZ010000004.1  59007624-59007824
            1604-1741           JAXUCZ010000004.1  59009130-59009267
            1742-1868           JAXUCZ010000004.1  59009604-59009730
            1869-2005           JAXUCZ010000004.1  59009875-59010011
            2006-2199           JAXUCZ010000004.1  59010223-59010416
            2200-2313           JAXUCZ010000004.1  59010514-59010627
            2314-2457           JAXUCZ010000004.1  59011249-59011392
            2458-2581           JAXUCZ010000004.1  59011625-59011748
            2582-2742           JAXUCZ010000004.1  59011888-59012048
            2743-2833           JAXUCZ010000004.1  59012297-59012387
            2834-3003           JAXUCZ010000004.1  59012480-59012649
            3004-3121           JAXUCZ010000004.1  59012851-59012968
            3122-3384           JAXUCZ010000004.1  59013052-59013314
            3385-3982           JAXUCZ010000004.1  59013670-59014267
            3983-4156           JAXUCZ010000004.1  59014808-59014981
            4157-4319           JAXUCZ010000004.1  59015080-59015242
            4320-4480           JAXUCZ010000004.1  59015367-59015527
            4481-4648           JAXUCZ010000004.1  59016148-59016315
            4649-4772           JAXUCZ010000004.1  59016396-59016519
            4773-4929           JAXUCZ010000004.1  59016958-59017114
            4930-5119           JAXUCZ010000004.1  59017195-59017384
            5120-5143           JAXUCZ010000004.1  59017556-59017579
            5144-5391           JAXUCZ010000004.1  59017691-59017938
            5392-5490           JAXUCZ010000004.1  59018465-59018563
            5491-5590           JAXUCZ010000004.1  59018866-59018965
            5591-5731           JAXUCZ010000004.1  59019281-59019421
            5732-5860           JAXUCZ010000004.1  59019692-59019820
            5861-6034           JAXUCZ010000004.1  59019909-59020082
            6035-6196           JAXUCZ010000004.1  59020673-59020834
            6197-6400           JAXUCZ010000004.1  59020912-59021115
            6401-6553           JAXUCZ010000004.1  59021566-59021718
            6554-6676           JAXUCZ010000004.1  59021811-59021933
            6677-6919           JAXUCZ010000004.1  59022068-59022310
            6920-7189           JAXUCZ010000004.1  59022515-59022784
            7190-7327           JAXUCZ010000004.1  59022879-59023016
            7328-7443           JAXUCZ010000004.1  59023209-59023324
            7444-7576           JAXUCZ010000004.1  59024453-59024585
            7577-7753           JAXUCZ010000004.1  59024685-59024861
            7754-7972           JAXUCZ010000004.1  59025026-59025244
            7973-8182           JAXUCZ010000004.1  59026041-59026250
            8183-9049           JAXUCZ010000004.1  59026374-59027240
FEATURES             Location/Qualifiers
     source          1..9049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..9049
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /note="filamin C"
                     /db_xref="GeneID:362332"
                     /db_xref="RGD:1308807"
     exon            1..544
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..8370
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /note="filamin C, gamma (actin binding protein 280);
                     filamin-2; gamma-filamin; ABP-280-like protein;
                     actin-binding-like protein"
                     /codon_start=1
                     /product="filamin-C"
                     /protein_id="NP_001178791.1"
                     /db_xref="GeneID:362332"
                     /db_xref="RGD:1308807"
                     /translation="MMNNSNYSDASGLGLLDEADEMPSTEKDLAEDAPWKKIQQNTFT
                     RWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVS
                     VALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQ
                     TPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQN
                     AREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNP
                     KKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKD
                     RTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNV
                     ANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHT
                     VHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSG
                     ELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVIPGKYVVTITWGGYAIPRSPFEVQV
                     SPEAGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDRGD
                     GSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTG
                     CIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHT
                     VIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQG
                     DVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPAS
                     PFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGE
                     AVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKV
                     QGLNSKVAVGEEQAFLVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGSGAEAQAVRYM
                     PPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDT
                     KGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPF
                     KATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVL
                     IHNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVE
                     PHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAY
                     EEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRG
                     AGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYVPFTPGDYDVNITFGGQPIPGSPFRV
                     PVKDVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEV
                     RDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNA
                     SGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGR
                     YTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVIT
                     VDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHI
                     PNSPFHVLACDPLPHVEEPAEVLQLHQPYAPLRPGTCPTHWATEEPVVPVEPLESMLR
                     PFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYD
                     GNHIPGSPLQFYVDAINSGHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGP
                     SKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQL
                     NVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVV
                     SVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGG
                     LGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGE
                     GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTE
                     RTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASS
                     QDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFT
                     VGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFED
                     RKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGL
                     KVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSID
                     VKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGA
                     LSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGP
                     RLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQK
                     NSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWG
                     DESVPGSPFKVNVP"
     exon            545..793
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            794..891
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1042
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1161
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1239
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1402
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1603
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1741
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1868
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2005
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2199
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2313
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2457
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2581
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2742
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2833
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3003
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3121
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3384
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3982
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4156
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4319
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4480
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4648
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..4772
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4929
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4930..5119
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5143
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5144..5391
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5392..5490
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5491..5590
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5591..5731
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5732..5860
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            5861..6034
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6035..6196
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6197..6400
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6401..6553
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6554..6676
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6677..6919
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            6920..7189
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7190..7327
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7328..7443
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7444..7576
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7577..7753
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7754..7972
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            7973..8182
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
     exon            8183..9049
                     /gene="Flnc"
                     /gene_synonym="ABP-L; FLN-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctccgccc cgagagggag atagagccct agccggacag cccagcagca cagcccagga
       61 ggcccacgag cccgccactc agagcgctag agaagtctcc gagagagctc agtgtcccgc
      121 cgtcccgccc cgacagcgcc cacagcccga cccccaggcc gtacgtcccc ggccccgcgc
      181 cgcgccacca tgatgaacaa cagcaactac tccgacgcct ccggcctcgg cctgcttgac
      241 gaggcggacg agatgccgtc caccgagaag gacctagcgg aggacgcgcc gtggaagaag
      301 atccagcaaa acacattcac gcggtggtgc aacgagcatc tcaagtgtgt gggcaagcgg
      361 ctgaccgacc tgcagcgaga cctcagcgac gggctgcgcc tcatcgcgct gctcgaagtg
      421 ctcagccaga agcgcatgta ccgcaagttc cacccgcgcc ccaacttccg ccagatgaag
      481 ctggaaaatg tgtctgtggc cctggagttc ctggagcgcg aacacatcaa gctcgtgtcc
      541 atcgacagca aggccatcgt ggatgggaac ctgaagctaa tcctgggcct gatctggaca
      601 ctgatccttc actactccat ctctatgccc atgtgggagg atgaagacga tgaggatgcc
      661 cgcaaacaga cgcccaagca gcgactgctc ggctggatcc agaacaaagt gccccagctg
      721 cccattacca actttaacag ggactggcag gacggcaagg ctctgggtgc cctggtggac
      781 aactgtgccc ctggtctctg ccctgactgg gaagcctggg accccaacca gcctgtgcag
      841 aatgccagag aagccatgca gcaagccgat gactggctcg gggtgcccca ggtgattgcc
      901 cctgaagaga tcgtggatcc caacgtggat gagcactctg tcatgaccta cctgtcccag
      961 ttccccaagg ccaagctcaa acccggtgcc cctgtccgct ctaagcagct gaatcccaag
     1021 aaagccattg cctacgggcc cggcattgag ccccagggca acaccgtgct gcagcctgcc
     1081 cacttcactg tgcagacagt agatgctggt gtgggtgagg tgctggtcta catcgaggac
     1141 cccgagggtc acactgagga ggccaaagtg gttcccaaca acgacaagga ccgcacatac
     1201 gcagtctcct atgtgcccaa ggttgctggg ttacacaagg tgacggtcct cttcgctggc
     1261 cagaacatcg agcgtagtcc ctttgaggtg aatgtgggca tggctctcgg ggatgccaac
     1321 aaggtatcag cccgtggccc tggtctggaa cctgtgggta atgtggccaa caaacccacc
     1381 tactttgaca tctatactgc tggggctggc actggtgatg ttgccgtggt gatcgtggac
     1441 ccacaggggc ggcgagatac agtagaggtg gccctggagg acaaaggtga caacacattc
     1501 cgatgcacat acaggcccgt gatggaaggg ccacacaccg tgcatgtggc ctttgccggt
     1561 gcacccatca cccggagtcc cttccccgtc catgtggcag aagcttgtaa tcccaacgcc
     1621 tgcagagcct ctgggcgagg cctgcagccc aaaggtgtgc gtgtgaagga ggtggctgac
     1681 ttcaaggtgt tcaccaaggg tgctggcagc ggggaactca aggtcacagt caagggtcca
     1741 aagggcacag aggagccagt gaaggttcgg gaggctggag acggtgtgtt cgagtgcgag
     1801 tactacccag tgatacctgg gaagtatgtg gtgaccatca cttggggtgg ctatgccatc
     1861 ccccgcagtc cttttgaggt ccaggtgagc ccagaggccg gagcccagaa agtacgggca
     1921 tggggtcctg gtttggagac tggccaggtg ggcaagtcag ctgacttcgt ggtggaagcc
     1981 attggcacag aagtggggac gctgggcttc tctattgagg ggccctcgca agccaagatc
     2041 gagtgtgatg acaggggtga tggctcctgt gacgtgcggt actggcccac ggagcccggg
     2101 gagtatgctg tgcacgtcat ctgtgacgat gaagacatcc gggactcacc tttcatcgcc
     2161 cacattcagc cagccccacc agactgcttc ccagacaagg tgaaagcctt cggacctggt
     2221 ctggagccca ctggctgcat cgtagacagg cctgcggagt tcaccattga tgcccgtgct
     2281 gctggcaagg gagatttgaa gctctatgcc caggatgcag atggctgccc catcgacatc
     2341 aaggtgatcc ccaatggtga tggcaccttc cgctgctcct acgtgcctac caagcccatt
     2401 aagcataccg tcattatctc ttggggaggt gtcaacgtgc ccaagagccc cttcagggtg
     2461 aatgtaggag aaggcagcca tcctgagcgg gtaaaagtat atggccctgg agtggagaag
     2521 acaggcctga aagccaacga acccacctat ttcacagtgg actgcagtga agctgggcaa
     2581 ggtgatgtga gcattggcat caaatgtgcc cctggcgtgg tggggcccgc ggaagctgac
     2641 atcgattttg acatcatcaa gaatgacaat gacaccttca cagtcaagta cacaccccca
     2701 ggggccggcc actacacgat catggtgctg tttgccaacc aggaaatccc tgccagtccc
     2761 ttccacatca aggtggaccc gtcccacgat gctagcaagg tcaaggctga gggccctggg
     2821 ctgagccgca caggtgtgga agtcggaaag ccaactcact tcactgtgct gaccaaggga
     2881 gctggcaagg ccaaactgga cgtgcacttc gctggggcag ccaagggcga ggctgtgcga
     2941 gactttgaaa tcatcgacaa ccatgactat tcgtatactg tcaagtacac tgctgtccag
     3001 cagggcaaca tggcagtaac ggtgacctac ggtggagacc ctgtccccaa aagtcccttc
     3061 gtggtgaatg tggcaccccc actggacctc agcaaagtca aagtccaagg cctgaacagc
     3121 aaggtagctg tgggagagga acaagcgttc ttggtgaaca ccagaggggc tggtggtcag
     3181 ggccaactag atgtgcggat gacctcaccc tcccgacggc ctatcccctg caagctggaa
     3241 cctgggagtg gagcagaagc ccaggctgtc cgctacatgc cccctgaaga aggaccttac
     3301 aaggtggaca tcacctatga tggtcaccca gtgcctggca gcccctttgc tgtggaaggc
     3361 gtcctgcccc ctgacccctc caaggtctgc gcgtatggcc ctggtctcaa gggtgggcta
     3421 gtaggcaccc cggcaccatt ctccattgac accaaggggg ccggcacagg aggcctgggg
     3481 ctgactgtcg agggcccctg cgaagccaag atcgagtgcc aagacaatgg tgatggatct
     3541 tgtgcagtta gctacctgcc cacagagcca ggcgagtaca ccatcaatat cctgttcgct
     3601 gaagcccaca tccctggctc acccttcaag gccaccatcc agcctgtgtt cgacccaagc
     3661 aaggtgaggg ccagtgggcc aggcctggag cgtggcaagg ccggagaggc agccaccttc
     3721 actgtggact gctcggaagc gggcgaggcc gagctgacca tcgagatcct gtcagacgct
     3781 ggtgtcaaag cggaggtgct gatccacaac aacgcggatg gcacctacca catcacctac
     3841 agtcctgcct tcccaggcac ctacaccatc accatcaagt atggcggcca ccccataccc
     3901 aagttcccca cccgtgtcca cgtgcagcct gcagttgata ccagtggcat caaggtctct
     3961 gggcctggtg tggaaccaca tggtgtcctg cgggaggtga ccaccgaatt tactgtggat
     4021 gcaagatctc tgacagctac aggtggcaac cacgtgacag ctcgtgtgct caacccctcg
     4081 ggtgctaaga cagataccta tgtgacagac aacggggatg gcacctaccg ggtgcagtac
     4141 acggcctacg aagagggtgt gcatttggtg gaggtgctgt atgacgaagt agccgtgccc
     4201 aagagcccct tccgagtggg tgtgacggag ggctgtgacc ccacccgagt ccgggccttc
     4261 ggaccaggcc tagagggtgg cttggtcaac aaggccaacc gcttcactgt ggaaactagg
     4321 ggtgctggca caggaggcct tggcctagcc atcgagggcc cctcagaagc taagatgtcc
     4381 tgcaaggaca acaaagatgg cagttgcact gtggagtacg tccccttcac tcctggggac
     4441 tatgatgtca acatcacctt tgggggacaa cccatcccag gaagcccatt ccgagttcct
     4501 gtgaaggatg ttgtggaccc tgggaaggtg aagtgttcag ggccagggct agggactggc
     4561 gtcagggctc gggtacctca gaccttcaca gtggactgca gtcaagctgg ccgggcccct
     4621 ctacaggtgg cagtgctggg acccacaggt gtggctgagc ctgtggaggt gcgtgacaat
     4681 ggcgacggta cccacactgt ccactacacg cctgccactg acggacccta tacagtagct
     4741 gtcaagtatg ctgaccagga ggtgccacgc agccctttca agatcaaagt gcttccggcc
     4801 cacgatgcca gcaaagtgcg ggccagtggc cctggcctca atgcctccgg catccccgcc
     4861 agcctgcccg tggagttcac cattgatgct cgtgatgctg gtgaggggct tctcacagtc
     4921 cagatcctgg atcccgaggg taaacccaag aaggccaaca tccgagacaa tggggatggc
     4981 acatacaccg tgtcctacct gccagacatg agtggtcggt acaccatcac catcaagtat
     5041 ggcggcgatg agatccctta ctcacccttc cgtatccacg ccctgcctac aggggatgcc
     5101 agcaagtgcc ttgttacagt atccattgga ggccatggac tgggtgcctg cctgggtccc
     5161 agaatccaga ttggagagga gactgtgatt acagtggatg ccaaggcagc aggcaagggg
     5221 aaggtgacct gcacagtatc cacacctgac ggggcagagc tcgatgtgga tgtagttgag
     5281 aaccacgatg gtacctttga tatctactac acagcacctg agccgggcaa atatgtcatc
     5341 accatccgct ttgggggtga acacattccc aacagcccct tccatgtgct ggcatgtgac
     5401 ccgctgcctc atgtggagga gcctgcggaa gtgctgcagc tgcaccagcc atatgcccca
     5461 cttcggcctg gcacctgccc cacacactgg gccacagagg agcccgtggt tcctgtggag
     5521 cctttggagt ccatgctgag gcctttcaac ttggtcatcc cattcactgt gcagaaaggg
     5581 gagctgacag gggaggtccg gatgccctct ggtaaaacag cacgtcccaa catcactgac
     5641 aacaaggacg gtaccatcac agtgagatac gcacctacag agaaaggcct gcaccagatg
     5701 ggaatcaagt acgatggcaa ccatatccct gggagccctc tgcagttcta tgtggatgcc
     5761 atcaacagcg ggcatgtcag tgcctatggg ccaggtctga gccatggcat ggtcaacaag
     5821 cctgccacct tcacaattgt caccaaagac gctggggaag gggggctgtc actggctgtg
     5881 gagggcccat ccaaggcgga gatcacctgc aaggacaaca aagatggcac ctgtaccgtg
     5941 tcctacctac ccacagcacc tggagactac agcatcattg tgcgctttga cgacaagcat
     6001 atcccaggga gccccttcac ggccaagatc acaggtgacg actcaatgag aacgtcccag
     6061 cttaatgtgg gcacctccac cgatgtgtca ctgaagatca cagagggtga cctcagccag
     6121 ctgacagcca gtatccgtgc tccttcaggc aatgaggagc cttgcctgct gaagcgcttg
     6181 cccaacaggc acattgggat ctcctttacc cccaaggagg tcggtgagca tgtggtgagc
     6241 gtacgcaaga gtggcaagca cgtcaccaac agccccttta agattttggt tgggccttcg
     6301 gagatcggcg atgccagcaa agttcgagtc tggggcaagg gcctttccga gggacagacc
     6361 ttccaagtgg cagagttcat tgtggacact cgcaatgcag gctacggagg cctggggctg
     6421 agcatcgaag gtcctagcaa ggtggacatt aactgtgagg atatggaaga cggtacctgc
     6481 aaagtcacct actgtccaac tgaacctggc acctacatca tcaacattaa gtttgctgac
     6541 aaacacgtgc ctggaagtcc cttcaccgtg aaggtgactg gcgagggacg catgaaggag
     6601 agcatcaccc ggcgcagaca ggcgccttcc atcgccacca ttggtagcac ctgtgacctc
     6661 aacctcaaga tcccaggaaa ctggtttcag atggtgtccg cccaggagcg cctgactcgc
     6721 accttcacgc gtagcagtca cacgtacacc cgcacggagc ggacagagat cagcaagact
     6781 cggggtgggg agaccaagcg tgaagtccgg gtggaggagt ccacccaggt cggcggagac
     6841 cctttccctg ctgttttcgg cgattttctc ggccgggaac gcctgggctc ctttggaagc
     6901 atcacccgac agcaggaagg tgaggccagc tctcaggaca tgacagccca ggtgaccagt
     6961 ccatctggca agacagaagc cgcagagatc gttgagggag aagacagcgc atacagtgtg
     7021 cgctttgtgc cccaggagat gggcccccac acagtcgctg tcaagtaccg gggccaacat
     7081 gtgcctggaa gcccttttca gttcaccgtg ggtccgctag gtgaaggtgg tgcccacaag
     7141 gtgcgggctg gaggcacagg gctggagcga ggtgtagctg gtgtgccagc tgagtttagc
     7201 atctggaccc gagaagctgg agctgggggc ctgtccattg ctgtggaagg tcccagcaag
     7261 gcagagatcg cattcgaaga ccgcaaagat ggttcttgtg gtgtctccta tgttgtccag
     7321 gagccaggtg actatgaggt ctccatcaag ttcaatgatg agcacatccc agacagcccc
     7381 tttgtggtgc ctgtggcctc cctctcagat gatgctcgcc gcctcaccgt caccagcctc
     7441 caggagacag ggcttaaggt gaaccagcca gcatctttcg cggtgcagct taatggggca
     7501 cgtggcgtga tcgatgcccg ggtacacaca ccctcaggag ctgtggagga gtgctatgtc
     7561 tctgaactgg acagtgataa gcataccatc cgcttcatcc cccatgagaa cggtgtccac
     7621 tcaattgatg tcaagttcaa cggtgcccac atccctggaa gccccttcaa gatccgcgtt
     7681 ggggagcaga gccaagctgg ggacccaggc ttggtgtcag cttatgggcc tgggcttgaa
     7741 ggaggcacta cgggtgtatc gtcagagttc attgttaaca cccagaatgc aggctcgggg
     7801 gccttgtctg tcaccatcga tgggccttcc aaggtgcagc tggactgtcg ggagtgtcct
     7861 gagggccatg tagtcactta cacgcccatg gctcctggca actacctcat tgccatcaag
     7921 tatggcggcc ctcagcacat tgtgggcagt cccttcaaag caaaggtcac aggtccccgg
     7981 ttgtctggag gccacagcct tcacgaaaca tccacagttc tggtggagac tgtgacaaag
     8041 tcctcctcga gccgcggcgc cagctacagt tccatcccca agttctcctc agatgccagc
     8101 aaggtggtga caaggggccc cggcctgtcc caggcctttg tgggtcagaa gaactccttc
     8161 accgtggact gcagcaaagc aggtaccaac atgatgatgg tgggtgtgca cgggcccaag
     8221 accccctgcg aagaggtata tgtgaagcac atggggaacc gggtctacaa tgtcacctac
     8281 actgtcaagg agaaaggaga ctacatcctc attgtcaagt ggggtgatga aagtgtccct
     8341 ggaagcccct tcaaggtcaa tgtgccctga atctcagaag cgcctccctc agcccaggcc
     8401 cccacttcct gccaaagtca tacccacaca gatgtgccac ccccctatcc acactcacag
     8461 aatcagacac taaaacacct gccttaggtg tgacggggtg atacaatccc ccgtacccca
     8521 ctgtgccact tggtgggtgg ggggccgggc ctttatctgt tttgtttcag tgtccctcaa
     8581 aggtgtcctg agggaagact tggtgaagct gggggccgag actgtgatat aaggggttaa
     8641 acgggttggg gggaagccct ggggatcata gtggggctga tgccagtggg caagcactga
     8701 gttggggtat ctgtgtgtga aagaagtcat cctcacaaac caccatgcct gaggactctg
     8761 tcaggccgtc tggtggccat agccctagag taaggggctt ggaaaagaaa gaacaatcag
     8821 aagaaagcag ttccagaaca aacagcacac cgcatgcgga ctggccctga gtgacatgct
     8881 ccacccaagc caggcctcct gggaaactga tttctcttac tatttttttt ttatggttac
     8941 acagctctgc cccattgggg gtctttttta cacattgtgg ggcccaactc tctgggaaac
     9001 ttttgcacat gtggaaaaca ccaaataaag catagctgtt gcgaaggct
//
