LOCUS       NM_001107288            8861 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus filamin B (Flnb), mRNA.
ACCESSION   NM_001107288 XM_001071051 XM_224561
VERSION     NM_001107288.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8861)
  AUTHORS   Yang,H., Zheng,Z., Cai,H., Li,H., Ye,X., Zhang,X., Wang,Z. and
            Fu,Q.
  TITLE     Three novel missense mutations in the filamin B gene are associated
            with isolated congenital talipes equinovarus
  JOURNAL   Hum Genet 135 (10), 1181-1189 (2016)
   PUBMED   27395407
REFERENCE   2  (bases 1 to 8861)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8861)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 8861)
  AUTHORS   Folgueras,A.R., Guo,X., Pasolli,H.A., Stokes,N., Polak,L., Zheng,D.
            and Fuchs,E.
  TITLE     Architectural niche organization by LHX2 is linked to hair follicle
            stem cell function
  JOURNAL   Cell Stem Cell 13 (3), 314-327 (2013)
   PUBMED   24012369
REFERENCE   5  (bases 1 to 8861)
  AUTHORS   Bouvard,D., Pouwels,J., De Franceschi,N. and Ivaska,J.
  TITLE     Integrin inactivators: balancing cellular functions in vitro and in
            vivo
  JOURNAL   Nat Rev Mol Cell Biol 14 (7), 430-442 (2013)
   PUBMED   23719537
  REMARK    Review article
REFERENCE   6  (bases 1 to 8861)
  AUTHORS   Farrington-Rock,C., Firestein,M.H., Bicknell,L.S.,
            Superti-Furga,A., Bacino,C.A., Cormier-Daire,V., Le Merrer,M.,
            Baumann,C., Roume,J., Rump,P., Verheij,J.B., Sweeney,E.,
            Rimoin,D.L., Lachman,R.S., Robertson,S.P., Cohn,D.H. and Krakow,D.
  TITLE     Mutations in two regions of FLNB result in atelosteogenesis I and
            III
  JOURNAL   Hum Mutat 27 (7), 705-710 (2006)
   PUBMED   16752402
REFERENCE   7  (bases 1 to 8861)
  AUTHORS   Bicknell,L.S., Morgan,T., Bonafe,L., Wessels,M.W., Bialer,M.G.,
            Willems,P.J., Cohn,D.H., Krakow,D. and Robertson,S.P.
  TITLE     Mutations in FLNB cause boomerang dysplasia
  JOURNAL   J Med Genet 42 (7), e43 (2005)
   PUBMED   15994868
REFERENCE   8  (bases 1 to 8861)
  AUTHORS   Krakow,D., Robertson,S.P., King,L.M., Morgan,T., Sebald,E.T.,
            Bertolotto,C., Wachsmann-Hogiu,S., Acuna,D., Shapiro,S.S.,
            Takafuta,T., Aftimos,S., Kim,C.A., Firth,H., Steiner,C.E.,
            Cormier-Daire,V., Superti-Furga,A., Bonafe,L., Graham,J.M. Jr.,
            Grix,A., Bacino,C.A., Allanson,J., Bialer,M.G., Lachman,R.S.,
            Rimoin,D.L. and Cohn,D.H.
  TITLE     Mutations in the gene encoding filamin B disrupt vertebral
            segmentation, joint formation and skeletogenesis
  JOURNAL   Nat Genet 36 (4), 405-410 (2004)
   PUBMED   14991055
REFERENCE   9  (bases 1 to 8861)
  AUTHORS   Sheen,V.L., Feng,Y., Graham,D., Takafuta,T., Shapiro,S.S. and
            Walsh,C.A.
  TITLE     Filamin A and Filamin B are co-expressed within neurons during
            periods of neuronal migration and can physically interact
  JOURNAL   Hum Mol Genet 11 (23), 2845-2854 (2002)
   PUBMED   12393796
REFERENCE   10 (bases 1 to 8861)
  AUTHORS   van der Flier,A., Kuikman,I., Kramer,D., Geerts,D., Kreft,M.,
            Takafuta,T., Shapiro,S.S. and Sonnenberg,A.
  TITLE     Different splice variants of filamin-B affect myogenesis,
            subcellular distribution, and determine binding to integrin [beta]
            subunits
  JOURNAL   J Cell Biol 156 (2), 361-376 (2002)
   PUBMED   11807098
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474010.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_001107288.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071051.1, XM_224561.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..8861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..8861
                     /gene="Flnb"
                     /note="filamin B"
                     /db_xref="GeneID:306204"
                     /db_xref="RGD:1311915"
     exon            1..417
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..7862
                     /gene="Flnb"
                     /note="filamin, beta; filamin B, beta; filamin-B-like"
                     /codon_start=1
                     /product="filamin-B"
                     /protein_id="NP_001100758.1"
                     /db_xref="GeneID:306204"
                     /db_xref="RGD:1311915"
                     /translation="MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDL
                     SDGLRLIALLEVLSQKRMHHKYHQRPTFRQMKLENVSVALEFLDHESIKLVSIDSKAI
                     VDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITN
                     FNQNWQDGKALGALVDSCAPGLCPDWESWDPRKPVDNAREAMQQADDWLGVPQVITPE
                     EIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIESTGNMVKQPAK
                     FTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFA
                     GQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKPTYFDIYTAGAGVGDIGVE
                     VEDPQGKNSVELLVEDRGNQVYRCVYKPLQPGPHVVKVSFAGDAIPKSPFGVQIGEAC
                     NPNACRASGRGLQPKGVRIRETADFKVDTKAAGSGELAVTVKGPKGLEELVKQKGFLD
                     GVYSFEYYPSTPGKYSIAVTWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGR
                     SADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDD
                     EDIKDSPYMAFIHPATGDYNPDLVQAYGPGLEKTGCTINNPAEFIVDPKDAGNAPLKI
                     LAQDGEGQPIDIQMKSRMDGTYVCSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQGS
                     HPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFD
                     IIHNANDTFTVKYVPPAPGRYTIKVLFASEEIPASPFRVKVDPSHDASKVKAEGPGLS
                     KAGVENGKPTHFTVHTKGAGKAPLNVQFSSPVPGEAVKDLDIIDNYDYSHTVKYTPTQ
                     QGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKINGLENRVEVGKDQEFAIDTNGAG
                     GQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPY
                     TVEASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECS
                     DNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHG
                     KVGEPGILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGSYAVTYVPLTAGMYTL
                     TMKYGGELVPQFPTWVKVEPTVDTSGIKAFGPGIEGKDVFREATTDFTVDARPLTQVG
                     GDHIKAHIANPSGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDAPIPNSPFKV
                     AVNEGCQPSRVHAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDN
                     KDGSCSAEYIPFAPGDYDVNITYGGVHIPGSPFRVPSKDVVDPSKVKIAGPGLSSCVR
                     ACIPQSFTVDTSKAGLAPLEVRVMGPRGLVEPVDVVDNGDGTHTVTYTPSQEGPYIVS
                     VKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSAYGVPASLPVEFAIDARDAGEGLL
                     AVQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQ
                     TGDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENE
                     DGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMVTEEAYVPVSDMNGLGFKPFDLV
                     IPFAVRKGEITGQVHMPSGKKATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIP
                     ESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEI
                     SCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKLGSAA
                     DFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNG
                     NHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVE
                     GPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKES
                     ITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGHVTEAEIVPVGKNSHCVR
                     FVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGIPAEF
                     SIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIP
                     DSPYLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAV
                     EECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVS
                     AYGAGLEAGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMA
                     PGNYLISVKYGGPNHISRSPFKAKVTGQRLVTPGSANETSSILVESVTRSSTETCYSA
                     IPKSSSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMK
                     HVGKQQYNVTYVVKEKGDYVLAVKWGEEHIPGSPFHVTVP"
     exon            418..666
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            667..764
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            765..912
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1031
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1109
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1272
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1470
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1608
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1735
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1872
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2066
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2180
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2324
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2448
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2609
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2700
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2870
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2988
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3251
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3849
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..4023
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4186
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4347
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4515
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4639
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4796
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4986
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5234
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5337
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5338..5478
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5479..5607
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5608..5781
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5782..5940
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            5941..6144
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6145..6297
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6298..6420
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6421..6687
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6688..6825
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6826..6941
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            6942..7074
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            7075..7251
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            7252..7470
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            7471..7674
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
     exon            7675..8861
                     /gene="Flnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctagtg tagcaacgct ttcgagcccc cttcccactt gcctcagttc cccttccccg
       61 ggcccttagg gcttttcatc tcagtccctg aagctcgttg cctccgctca ctctctgcct
      121 ccaggatgcc ggtgaccgag aaagacctgg cggaggacgc gccgtggaag aagattcagc
      181 agaacacgtt cacgcgctgg tgcaacgagc acctcaagtg tgtgaacaaa cgcatcggga
      241 acctgcagac cgacctgagc gacgggctgc ggctcatcgc gttgcttgag gtgctcagcc
      301 agaagcgcat gcaccacaag taccatcagc ggcccacctt ccgacagatg aagctggaga
      361 atgtgtctgt ggctctggag ttcctagacc acgaaagcat taagctcgtg tccattgaca
      421 gtaaagccat cgtggatggg aatctgaagc tcatcttggg cctggtatgg actttgatcc
      481 ttcactactc catctccatg cccgtgtggg aagacgaggg ggatgatgac gccaagaagc
      541 agaccccgaa acagaggctg ctgggatgga ttcagaacaa gatcccatac ttgcccatca
      601 ccaacttcaa ccagaactgg caagacggca aagccttagg agccctggta gacagctgtg
      661 ctccgggtct gtgcccggac tgggaatcct gggacccacg aaagccggtg gataatgctc
      721 gagaagccat gcagcaggcc gacgactggc tgggcgtccc acaggtcatc acgcccgagg
      781 agattattca cccggatgtg gacgagcact ctgtgatgac ctacctgtct cagttcccca
      841 aagccaagct caagccaggt gctcctctta aacccaaact caacccgaag aaagccagag
      901 cctatggcag aggaatcgag tccactggaa acatggtgaa gcagccagcc aaattcacgg
      961 tagataccat cagcgctgga caaggggatg tgatggtgtt tgttgaggac ccagaaggaa
     1021 acaaggaaga ggctcgtgtg accccagaca gtgataagaa caagacatac tctgtggagt
     1081 atctgcccaa agtcaccggg cttcacaaag tcatagtcct gtttgcagga cagcacattt
     1141 ccaagagccc atttgaagtg aacgttgaca aagcccaagg agatgccagc aaagtcactg
     1201 ctaaaggccc agggttggaa actacaggga acattgccaa taagcccacc tactttgaca
     1261 tctacacagc tggtgctggt gtgggtgaca ttggcgttga ggtagaggat ccccagggca
     1321 agaacagtgt ggagctcctg gtagaagaca gaggcaatca ggtgtataga tgtgtctaca
     1381 agccactgca gcctggcccc catgtggtca aggtctcctt tgctggggac gccattccca
     1441 agagcccctt tggtgtacaa attggtgaag cctgtaaccc aaatgcttgc agggccagtg
     1501 gccgaggcct gcagcccaaa ggcgtccgga tccgggagac tgcagacttt aaggtggaca
     1561 ccaaggcggc tggaagcgga gagcttgctg taaccgtgaa gggccctaag ggcctggagg
     1621 agctggtcaa gcagaagggc tttctggatg gggtctactc gtttgagtac taccccagca
     1681 caccagggaa atacagcatt gcagttactt gggggggaca ccacattcca aagagcccct
     1741 ttgaagttca agttggccct gaggcaggca tgcagaaagt ccgtgcatgg ggccctggac
     1801 tccacggtgg cattgttggt cggtcagcag actttgtggt ggaatccatt ggttctgagg
     1861 tcgggactct gggttttgcc atcgaaggtc cttcccaggc aaaaatcgag tatgacgatc
     1921 agaacgatgg ctcatgtgac gtcaaatact ggcccaagga acctggagaa tatgccgttc
     1981 acatcatgtg cgacgacgaa gacatcaagg acagcccata catggctttc atccatcctg
     2041 ccacaggaga ctacaaccca gatctagtcc aagcatatgg gccaggtctg gagaaaactg
     2101 gttgtactat caacaaccca gctgagttca tcgtagatcc taaggatgcc gggaacgctc
     2161 ccttaaagat actggctcag gatggggaag gccagcccat tgacatccag atgaaaagcc
     2221 ggatggatgg cacctatgtc tgctcctata ccccggtcaa agctatcaag cacaccatag
     2281 ctgtggtctg gggaggggtg aacataccac acagccccta cagggtcaac attggacaag
     2341 gtagccatcc ccaaaaggtc aaagtgtttg gaccgggcgt ggagaggagt ggtctgaagg
     2401 caaacgagcc tactcacttc acagtggatt gcacggaggc tggggaaggt gatgtcagtg
     2461 ttggtatcaa gtgtgatgcc cgagtgttaa gtgatgatga ggaagacgtc gatttcgaca
     2521 ttattcacaa tgccaacgac acgttcacag tcaaatacgt gcctcccgcc cctgggcgat
     2581 atactatcaa ggttctcttc gcatcggagg aaatccctgc cagccctttc agagtcaaag
     2641 ttgacccttc ccatgacgcc agcaaggtga aggcggaagg ccctgggttg agtaaagcag
     2701 gtgtggaaaa tgggaagccg acccacttca ctgttcacac caagggagcc ggaaaagccc
     2761 cgctcaatgt gcagttctcc agcccggtcc ctggggaggc agtgaaggac ttggatatca
     2821 ttgacaacta tgactactcc catactgtta aatacacccc aacccagcag ggcaacatgc
     2881 aggtcctggt gacttatggt ggcgacccca ttcccaaaag tcctttcact gtgggcgttg
     2941 ccgcgccgct ggatctgagc aagataaaaa tcaacggact agaaaacaga gttgaggttg
     3001 ggaaggacca ggaatttgcc attgacacca acggggcagg aggccagggg aagctggatg
     3061 tgacgatcct gagcccttct cggaaggtgg tgccatgctt ggtagcacca gtggctggca
     3121 gagaatgcag cacagccaaa ttcatccctc gggaagaggg gctgtttgct gtagacgtga
     3181 cctatgacgg acacccagtg ccggggagcc cctacactgt ggaggcctca ctgccaccag
     3241 atcccaccaa ggtgaaggcc cacggtcctg gccttgaagg aggtcttgta ggcaagcccg
     3301 cagagttcac cattgacact aaaggagctg gaactggagg tttgggcctc actgtggaag
     3361 gtccgtgtga ggccaaaatc gaatgctctg ataacggcga tgggacctgc tccgtctctt
     3421 accttcccac gaaacctgga gaatactttg tcaacattct tttcgaagaa gtccatattc
     3481 ccgggtctcc cttcaaagcc gacattgaga tgccatttga cccctctaag gttgtagcct
     3541 caggaccagg actcgaacat ggaaaagtgg gtgaacctgg aatcctttgc gttgattgtt
     3601 cagaagcagg gcctgggact ctgggccttg aagcggtctc agactcaggt gcgaaagccg
     3661 aggtgtccat ccagaacaac aaagatggca gctacgctgt gacctatgtg cctctgacgg
     3721 ccggcatgta caccctgacc atgaagtatg gtggtgagct tgtaccacaa ttccccacct
     3781 gggtcaaggt ggagcccacc gtcgacacga gtgggatcaa agcctttggg ccaggaatcg
     3841 aaggcaaaga tgtgttccgg gaggccacaa cagacttcac agttgatgct aggcccctta
     3901 cccaggttgg aggtgaccac atcaaagctc acattgccaa cccgtcaggg gcctcaaccg
     3961 agtgcttcgt caaggacaat gctgatggga cctatcaagt agaatacaca ccatttgaga
     4021 aaggtttcca tgtagtagag gtgacatacg atgatgcgcc catcccaaac agcccattca
     4081 aagtggctgt caatgaaggc tgccagccat ctcgggtcca tgcccaaggc cctgggctga
     4141 aagaggcttt caccaacaag cctaatgtct tcacagtggt gaccagggga gcggggatcg
     4201 gtgggcttgg catcactgtg gaggggccgt cggagtcaaa gataaactgc agagacaaca
     4261 aagacggcag ctgcagcgcg gagtacatcc cgtttgcgcc tggggattac gacgttaata
     4321 tcacatacgg aggcgtccac atccctggca gccccttcag agtgccttcg aaagatgtcg
     4381 tggatcccag caaggtcaaa attgctggcc ccggtctgag ctcctgtgtc cgagcatgca
     4441 tcccacagtc cttcacggtg gacaccagca aggctggcct ggctccactg gaagtgaggg
     4501 tcatgggccc aagaggcctc gtggagccgg tggatgtggt ggataatggg gatggcaccc
     4561 acacagtgac ctacacgcca tctcaggagg ggccctacat tgtttctgtc aaatacgctg
     4621 atgaagagat cccccgaagt ccctttaagg tcaaggtcct tcccacatac gatgcgagca
     4681 aagtgaccgc ctccgggcct ggcctcagtg cctatggggt gcccgccagc ttacctgtgg
     4741 agtttgccat tgatgccaga gatgccggcg aaggcctact tgctgtccag atcacggacc
     4801 aagaaggaaa gcctcaaaga gccaccgtcc acgacaataa ggatggcacc tacgccgtta
     4861 cctatatccc tgataagacc ggacgctata tgattggggt cacctatggt ggagacaaca
     4921 tcccactttc tccttatcgt atccgggcca cgcagaccgg cgatgccagc aagtgtttgg
     4981 ccacaggtcc tggcattgcc cccactgtga aaactggcga ggaagtgggc ttcgtagtgg
     5041 atgctaagac tgcagggaag gggaaagtca cctgcgtgat cctcacccca gatggcacgg
     5101 aggctgaagc tgacgtcatt gaaaatgaag atggcaccta tgacattttc tacactgccg
     5161 ccaagccagg cacctacgtg atctatgtgc gctttggtgg cgttgatatt cccaatagcc
     5221 ccttcacagt catggttacg gaagaggcct atgtcccagt gagtgacatg aacggactag
     5281 gcttcaagcc ctttgacttg gtgattccgt ttgccgtcag gaaaggagaa atcacaggcc
     5341 aggtgcatat gccgtctggg aagaaagcta cccctgagat tgtggacaac aaggacggca
     5401 cggtcactgt gagatatgcc cccactgaag ttggcctcca cgagatgcac atcaagtaca
     5461 tgggcagcca catccctgag agccccctcc agttctacgt gaactacccc aacagtggga
     5521 gtgtgtctgc gtacggtcca ggccttgtgt atggagtagc caacaaaacc gccaccttca
     5581 ccatcgtcac ggaggatgct ggagaaggtg gtctggactt ggctattgaa gggccctcaa
     5641 aagcagagat cagctgcatt gacaacaaag acgggacatg tacagtgacc tacctgccca
     5701 ccttgccagg ggactatagc attctggtca agtacaatga caagcacatc cctggcagcc
     5761 ccttcactgc caagatcaca gatgatagca gacgctgctc ccaagtgaag ctgggctcgg
     5821 ctgctgactt ccttctggac atcagtgaga ccgacctcag caccctgaca gccagtatca
     5881 aggccccatc tggacgtgat gagccctgtc tgctaaagag actacccaac aaccacattg
     5941 gcatttcctt catcccccga gaggtgggtg aacatctagt cagcatcaag aagaacggca
     6001 accacgtggc caatagccct gtatccatca tggtggtcca gtctgagatt ggtgatgcac
     6061 gccgtgccaa agtctatggc cgaggcctgt cagaaggccg gactttcgag atgtctgact
     6121 tcatcgtgga cacgagagat gcaggctatg gtggcatatc cttggcagta gaaggaccca
     6181 gcaaggtgga catccagaca gaggacctgg aggacggtac ctgcaaggtg tcctacttcc
     6241 ccactgtgcc tggggtctat atcgtctcca ccaaatttgc tgacgagcat gtgcctggaa
     6301 gcccattcac tgtgaagatc agcggtgagg gaagagtcaa ggagagcatc acccggacga
     6361 gccgggctcc atctgtggcc acggttggca gtatctgtga cctgaacctg aagatcccag
     6421 agatcaacag cagtgacatg tctgcccatg tcaccagccc ctctggtcat gtcaccgagg
     6481 cagagatcgt ccctgtggga aagaactctc actgtgtcag atttgtgccc caggagatgg
     6541 gcgtccacac agtcagcgtc aagtaccgtg gacagcacgt aacaggaagc cccttccagt
     6601 tcaccgtggg gccccttgga gaagggggtg cccacaaggt ccgagcagga ggccctggtc
     6661 tggagagggg agaagcaggt atcccagccg agttcagcat ctggacccgg gaagcaggtg
     6721 ctggtggcct ctccattgct gtcgagggcc ctagtaaggc cgagatcaca ttcgatgacc
     6781 ataaaaatgg gtcatgcggt gtgtcttata ttgcccaaga gcctggtaac tacgaggtgt
     6841 ctatcaagtt caacgatgag cacatccctg acagccctta cctggtgccc gtcatcgcgc
     6901 cctcagacga cgcccgctgc ctcactgttc tgagccttca ggagtcagga ttaaaagtta
     6961 accagccagc atcctttgct ataaggttga atggcgccaa aggaaagatt gacgcaaagg
     7021 tgcacagccc ctcgggagcc gtggaggaat gccacgtgtc tgaactggag ccagataagt
     7081 acgctgtgcg cttcatcccc catgagaatg gcatccacac gatcgacgtc aaatttaatg
     7141 gcagccacgt ggtcgggagc cctttcaaag tgcgtgttgg agagccaggc caagcaggga
     7201 atcctgctct ggtgtcggcc tacggggctg ggcttgaggc aggtaccaca ggtatccagt
     7261 cagaattctt catcaacacc actcaggcag gcccggggac actgtctgtc accattgaag
     7321 gaccatccaa ggtcaaaatg gattgccagg aaatcccaga agggtacaaa gtcatgtata
     7381 ctcccatggc tcctggaaat tacctgatca gtgtcaaata tggcgggccc aaccacatct
     7441 cgaggagtcc attcaaggcc aaggtgacag gccaacgtct ggttacccca ggctcagcca
     7501 acgagacctc gtccatcttg gtggaatcag taaccagatc ctcaacggaa acatgctata
     7561 gcgccatccc caagtcgtcc tcagatgcca gcaaagtgac ctccaagggg gcggggctgt
     7621 caaaggcctt tgtgggccag aagagttcct tcctggtgga ctgcagcaaa gctgggtcca
     7681 acatgctgtt gattggggtc catgggccca ccaccccctg tgaagaggtc tccatgaagc
     7741 acgtgggcaa gcaacagtac aatgtcacat acgttgtcaa ggagaaggga gattacgttc
     7801 tggctgtgaa gtggggggaa gagcacatcc ccggtagccc ctttcatgtc actgtgcctt
     7861 aaaacaccct gtatcctgtg ctggacgtgt cccttccagt tgcttttgtt gctagtttgt
     7921 aattcatttt tttacaatgt ccgcagcctg ctggtgggcc agaaaacccc gtcccaaaaa
     7981 aaaaaccttg ccactcattc caagtgcctt tagtgccctt agactcttga ggacatgtgg
     8041 gacatcttcg gaaagcaagc tgcggccaaa aacgtgcaga gcactctgcc caaatcgaga
     8101 ggctcttgag ttccaaggtc actccaggca gaaagcaaga gcatggatag gactgactgg
     8161 ctctcctaag cttctggtct actcaagtgt ttaccaaaca agaatgtcat tgcagaaggg
     8221 ggtcctgcac cccacttgcc aaagaacctt gcaccccact tccctcaaga ctaaagtctg
     8281 acccagatcg ttctccatgt ctgcgccctg accactttga cttcatcgca aagccagctc
     8341 tggagtagga gggattctgc tcttgcctac tttcttgaag acatgtggtc atggccaaat
     8401 gcagagcctc tgtcagctgc ccccagagtc cattgcttct gctaaatggc agagaccact
     8461 gataaattac tgtaggacct cctccttgca aaagctggaa ggggtggata cccacccctg
     8521 ttatgaccca tgagaggcct taaggaccaa ggcactaaca catgcaccta gggtctcttt
     8581 aaaggctttg gtgtaagcat ttccaggctg tcaaataccc cttccccctc aaaatcgggt
     8641 gttgtggctg ttgtcgtgga tatggtaggg gtgaagtagg tgtcccgcac caaggcacgg
     8701 cagccagaga ggtgtgggtg ctaaaagcca cccgttagga cccagagcag ctgaagctgg
     8761 atgcgaaagg gatacaggct tagtagccat ggagaccaaa ctggaacaaa tgccgactgg
     8821 aaagtgtatc ttataactta ttaaataaaa tgtttgctcc a
//
