LOCUS       NM_001134599            8412 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Rattus norvegicus filamin A (Flna), transcript variant 4, mRNA.
ACCESSION   NM_001134599 XM_001056685 XM_238167
VERSION     NM_001134599.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8412)
  AUTHORS   Shi,Y., Qiu,T., Wu,C., Yuan,W., Yao,X., Jiang,L., Wang,N., Wang,L.,
            Han,Q., Yang,G., Liu,X. and Sun,X.
  TITLE     Filamin A facilitates NLRP3 inflammasome activation during
            arsenic-induced nonalcoholic steatohepatitis
  JOURNAL   Environ Sci Pollut Res Int 30 (49), 107703-107715 (2023)
   PUBMED   37740811
  REMARK    GeneRIF: Filamin A facilitates NLRP3 inflammasome activation during
            arsenic-induced nonalcoholic steatohepatitis.
REFERENCE   2  (bases 1 to 8412)
  AUTHORS   Zou,M., Huang,C., Li,X., He,X., Chen,Y., Liao,W., Liao,Y., Sun,J.,
            Liu,Z., Zhong,L. and Bin,J.
  TITLE     Circular RNA expression profile and potential function of
            hsa_circRNA_101238 in human thoracic aortic dissection
  JOURNAL   Oncotarget 8 (47), 81825-81837 (2017)
   PUBMED   29137225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8412)
  AUTHORS   Segura,I., Lange,C., Knevels,E., Moskalyuk,A., Pulizzi,R.,
            Eelen,G., Chaze,T., Tudor,C., Boulegue,C., Holt,M., Daelemans,D.,
            Matondo,M., Ghesquiere,B., Giugliano,M., Ruiz de Almodovar,C.,
            Dewerchin,M. and Carmeliet,P.
  TITLE     The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via
            Modification of Filamin A
  JOURNAL   Cell Rep 14 (11), 2653-2667 (2016)
   PUBMED   26972007
REFERENCE   4  (bases 1 to 8412)
  AUTHORS   Tirupula,K.C., Ithychanda,S.S., Mohan,M.L., Naga Prasad,S.V.,
            Qin,J. and Karnik,S.S.
  TITLE     G protein-coupled receptors directly bind filamin A with high
            affinity and promote filamin phosphorylation
  JOURNAL   Biochemistry 54 (44), 6673-6683 (2015)
   PUBMED   26460884
REFERENCE   5  (bases 1 to 8412)
  AUTHORS   Cho,Y., Park,D. and Cavalli,V.
  TITLE     Filamin A is required in injured axons for HDAC5 activity and axon
            regeneration
  JOURNAL   J Biol Chem 290 (37), 22759-22770 (2015)
   PUBMED   26157139
REFERENCE   6  (bases 1 to 8412)
  AUTHORS   Liu,G., Thomas,L., Warren,R.A., Enns,C.A., Cunningham,C.C.,
            Hartwig,J.H. and Thomas,G.
  TITLE     Cytoskeletal protein ABP-280 directs the intracellular trafficking
            of furin and modulates proprotein processing in the endocytic
            pathway
  JOURNAL   J Cell Biol 139 (7), 1719-1733 (1997)
   PUBMED   9412467
REFERENCE   7  (bases 1 to 8412)
  AUTHORS   Ohta,Y., Stossel,T.P. and Hartwig,J.H.
  TITLE     Ligand-sensitive binding of actin-binding protein to immunoglobulin
            G Fc receptor I (Fc gamma RI)
  JOURNAL   Cell 67 (2), 275-282 (1991)
   PUBMED   1833070
REFERENCE   8  (bases 1 to 8412)
  AUTHORS   Gorlin,J.B., Yamin,R., Egan,S., Stewart,M., Stossel,T.P.,
            Kwiatkowski,D.J. and Hartwig,J.H.
  TITLE     Human endothelial actin-binding protein (ABP-280, nonmuscle
            filamin): a molecular leaf spring
  JOURNAL   J Cell Biol 111 (3), 1089-1105 (1990)
   PUBMED   2391361
REFERENCE   9  (bases 1 to 8412)
  AUTHORS   Ezzell,R.M., Kenney,D.M., Egan,S., Stossel,T.P. and Hartwig,J.H.
  TITLE     Localization of the domain of actin-binding protein that binds to
            membrane glycoprotein Ib and actin in human platelets
  JOURNAL   J Biol Chem 263 (26), 13303-13309 (1988)
   PUBMED   3138234
REFERENCE   10 (bases 1 to 8412)
  AUTHORS   Fox,J.E.
  TITLE     Identification of actin-binding protein as the protein linking the
            membrane skeleton to glycoproteins on platelet plasma membranes
  JOURNAL   J Biol Chem 260 (22), 11970-11977 (1985)
   PUBMED   4044584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474099.1.
            
            On or before Jan 5, 2009 this sequence version replaced
            XM_001056685.1, XM_238167.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ416060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093049, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..8412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..8412
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /note="filamin A"
                     /db_xref="GeneID:293860"
                     /db_xref="RGD:1560614"
     exon            1..542
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..8089
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /note="isoform 2 is encoded by transcript variant 4; actin
                     binding protein 280; filamin, alpha; Endothelial
                     actin-binding protein 280); filamin A, alpha"
                     /codon_start=1
                     /product="filamin-A isoform 2"
                     /protein_id="NP_001128071.1"
                     /db_xref="GeneID:293860"
                     /db_xref="RGD:1560614"
                     /translation="MSSSHSRSGQSAAGASPAGGIDTRDAEMPATEKDLAEDAPWKKI
                     QQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQM
                     QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEED
                     EEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDA
                     SKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLR
                     PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTA
                     NNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLE
                     PSGNIANKTTYFEIFTAGAGIGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTM
                     EGVHTVHVTFAGVPIPRSPYTVTVGQACNPTACRAVGRGLQPKGVRVKETADFKVYTK
                     GAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPF
                     EVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECD
                     DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGL
                     EKTGVAINKPAEFTVDAKHAGKAPLRVQVQDNEGHSVETTVKDNGNGTYSCSYVPRKP
                     VKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE
                     AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQA
                     TPTSPIRVKVEPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGL
                     AKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVSVTYGGDHIPKSPFSVGVSPSLDLS
                     KIKVSGLVDKVDVGKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNSV
                     VRFVPREEGPYEVEVTYDGVPVPGSPFPVEAVAPTKPSKVKAFGPGLQGGNAGSPARF
                     TIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIP
                     GSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLP
                     AEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYG
                     PGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVE
                     YTPYEEGVHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTV
                     ETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGS
                     PFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLV
                     EPVDVVDNADGTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASG
                     PGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVP
                     DVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDT
                     KAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNS
                     PFQVTALAGDQPTVQTPLRPQQLPSQYTYPQGSQQTWIPERPMVGVNGLDVTSLRPFD
                     LVIPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEMDIRYDNMH
                     IPGSPLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKA
                     EISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSMRMSHLKVG
                     SAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVK
                     KNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSL
                     SIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRV
                     KESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTY
                     CIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP
                     AEFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE
                     HIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPS
                     GALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPG
                     LVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYT
                     PMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQ
                     HATSGPGPADVSKVVAKGLGLSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEI
                     LVKHMGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRIMVP"
     exon            543..791
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            792..889
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1037
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1156
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1234
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1397
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1598
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1736
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1860
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1997
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2191
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2305
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2449
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2573
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2734
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2825
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2995
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3113
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3376
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3974
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4148
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4311
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4472
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4643
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4767
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4768..4924
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5114
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5115..5362
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5363..5458
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5459..5561
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5702
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5703..5831
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            5832..6005
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6006..6167
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6168..6371
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6372..6524
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6525..6647
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6648..6914
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            6915..7052
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7168
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7169..7301
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7302..7478
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7479..7697
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7698..7901
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
     exon            7902..8412
                     /gene="Flna"
                     /gene_synonym="RGD1560614"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcctcta gccccgccct tcgcccccat ttaaagggct cgctctttcc gcagtgcaac
       61 ctctgttctg tgcctcgtct ttcctgcgcg gaggtgccta ctactttaat taaagggccg
      121 tcccatcggc gaggctgcag caccgcccct aggttcctcg cgcctcaaaa tgagtagctc
      181 tcactcccgc tccggccaga gtgcggcagg cgcgtctccg gcaggcggta ttgatacacg
      241 ggacgctgag atgccggcta ccgaaaaaga cctagcagaa gatgcaccat ggaagaagat
      301 ccagcagaac acatttaccc gctggtgcaa tgagcacctt aagtgcgtga gcaagcgcat
      361 cgccaatctg cagacggacc tgagcgatgg attgcggctc atcgcgctgc ttgaggtact
      421 cagccagaag aagatgcacc gcaagcacaa ccaacgaccc actttccgcc agatgcagct
      481 ggaaaatgtg tctgtggcgc ttgaattcct ggaccgtgag agcatcaagc tcgtgtccat
      541 agacagcaag gccattgtgg atgggaatct gaaactgatc ttaggactca tctggaccct
      601 gatcctgcac tactccatct cgatgcccat gtgggatgag gaagaggatg aggaggccaa
      661 gaagcaaaca cccaaacaga ggcttctagg ctggattcag aacaagctgc cacagctgcc
      721 cattaccaac ttcagtcgag actggcagag tggccgggcc ctgggtgctc ttgttgatag
      781 ctgtgcccca ggcctatgtc ctgactggga ctcctgggat gctagtaagc ctgtgaacaa
      841 tgcacgggaa gccatgcagc aggctgacga ctggctgggc attcctcagg tgattacccc
      901 agaagaaatt gtggacccca acgtagatga gcattctgtt atgacttacc tgtctcagtt
      961 tcccaaggcc aaactgaagc caggggctcc tcttcggccc aaactgaacc caaagaaagc
     1021 ccgagcctat gggccaggca tcgagcccac aggcaatatg gtgaagaaga gagcagaatt
     1081 cactgtggag acccgaagtg caggacaggg agaggtgctg gtatatgtgg aggacccagc
     1141 tggacaccag gaagaggcaa aagtgactgc caataacgac aagaaccgta ctttctctgt
     1201 ctggtatgtc cctgaagtaa caggaactca taaggtgact gtgctctttg ctggccaaca
     1261 tattgccaag agcccctttg aggtgtatgt ggacaagtca cagggtgatg ccagcaaagt
     1321 gactgcccag ggccctggtc tggagcccag cggcaatatc gccaacaaga ctacctactt
     1381 tgagatcttc actgcaggag ctggcatagg cgaggtggaa gttgtcatcc aggaccctac
     1441 aggacagaaa ggcacagtgg aacctcagct ggaggccagg ggtgacagca cctatcgctg
     1501 tagctatcag cctaccatgg agggtgtcca tacagtacat gtcaccttcg ctggtgttcc
     1561 catccctcgc agcccctaca ctgtcactgt tggtcaagct tgtaacccaa ctgcctgccg
     1621 ggctgttggt agaggcctcc agcctaaggg tgtgcgagtg aaggaaacag ctgacttcaa
     1681 ggtgtacaca aaaggcgctg gcagtgggga gctaaaggtc actgtaaagg gtcccaaggg
     1741 tgaagagcgt gtaaagcaga aggacttagg ggatggtgtg tatggctttg aatattaccc
     1801 cacaatccct ggcacataca ctgtcaccat cacatggggt ggccagaaca ttggccgcag
     1861 tccgttcgag gtgaaggtag gcactgagtg tggcaatcag aaggttcggg catggggtcc
     1921 tggtctggaa ggtggcattg ttggcaagtc agcagacttc gtagtagagg ccattggtga
     1981 tgatgtgggc accttgggtt tctctgtgga aggtccatca caggcaaaga ttgaatgtga
     2041 cgacaagggt gatggctctt gtgatgtgcg ctattggccc caggaggctg gcgagtatgc
     2101 tgttcatgtg ctatgtaaca gtgaggatat ccggctcagt cccttcatgg ctgacatccg
     2161 tgaggcacct caggattttc acccagaccg ggtgaaggca cgtgggcctg gattggagaa
     2221 gactggtgta gctatcaaca agccagcaga gttcacagtt gatgccaagc atgctgggaa
     2281 ggcccctctt cgagttcaag ttcaggacaa tgaaggacac tctgtggaga caacagtcaa
     2341 ggacaatggc aatggtactt acagctgttc ttatgtgccc agaaagccag tgaagcacac
     2401 agccatggtt tcttggggag gtgtcagcat ccccaatagt cctttccggg tgaatgtggg
     2461 agctggcagc cacccaaaca aagtcaaggt gtatggtcca ggagtggcca agactgggct
     2521 caaggcccat gaacctacct actttactgt ggattgtact gaggcgggcc agggagatgt
     2581 cagcattggt atcaagtgtg cccctggagt agtgggcccc actgaggctg atattgactt
     2641 tgatatcatc cgtaatgaca atgacacctt cactgtgaaa tacacaccct gtggggctgg
     2701 cagctatacc atcatggttc tttttgctga ccaggccaca cccaccagcc ccatcagagt
     2761 caaagtggag ccttctcatg atgccagtaa agtgaaggct gagggtcctg gcctaaatcg
     2821 cactggtgtt gagcttggca aacccaccca tttcacagtc aatgctaaaa ctgctgggaa
     2881 aggcaagctg gatgttcagt tctcaggact ggctaaggga gatgcagtgc gagatgtgga
     2941 catcattgac caccatgata atacctacac cgtaaagtat actcctgtgc agcagggccc
     3001 agtaggtgtc agtgtcactt atggaggaga tcacataccc aagagtccat tttcagtggg
     3061 agtatctcca agcctggatc tcagcaagat taaggtgtct ggccttgttg acaaagtgga
     3121 tgttggcaaa gatcaagagt tcacagtaaa gtcaaagggt gcaggtggtc aaggcaaagt
     3181 agcatccaag attgtgagtc cctcaggtgc agcagtgccc tgcaaggtag agccaggcct
     3241 gggagctgac aacagtgtgg tccgttttgt gccccgtgaa gaggggcctt atgaggtgga
     3301 agtgacctat gatggtgtgc ctgtacctgg cagtcccttt ccagtagaag ctgtggctcc
     3361 taccaaaccc agcaaggtga aggcatttgg accagggctg caggggggca atgcaggctc
     3421 ccctgcccgc ttcaccattg atacaaaggg agctggcact ggtggcctgg gcctgacagt
     3481 ggaaggcccc tgtgaagcac agcttgagtg cctggacaat ggggacggta catgctctgt
     3541 gtcttatgtg cccactgagc ctggggacta caacatcaac atcctttttg ctgacaccca
     3601 cattcctgga tccccattca aggcccatgt ggttccttgt tttgatgcat ccaaggtgaa
     3661 gtgctcaggc cctgggctgg agcgggctac tgctggtgag gtagggcagt tccaagtaga
     3721 ctgctcaagt gctggcagtg ccgagttgac gattgagatc tgctctgagg caggactgcc
     3781 agctgaagta tacattcagg accatggtga tggcacacac accattacct atattcctct
     3841 ttgtcctggg gcttacactg ttaccatcaa gtatggtggc cagcctgtgc ccaacttccc
     3901 cagcaagcta caggtggagc ctgctgtaga tacctcaggc gtacagtgct atgggcctgg
     3961 gattgaaggt caaggtgtct tccgagaggc aaccactgag ttcagtgtag atgcccgggc
     4021 tcttacacag actggagggc cacatgtcaa ggcccgtgtg gccaacccct caggcaatct
     4081 gacagatacc tatgtgcaag actgtggtga tggcacatac aaagtggaat atactccata
     4141 tgaggaagga gtacactccg tggatgtgac ttatgatggc agccctgtac ccagcagccc
     4201 cttccaggtg cctgtaacag agggctgtga cccctcccgg gtgcgtgtcc atgggccagg
     4261 catccaaagt ggtaccacca acaaacccaa caagttcaca gtagagacta ggggagctgg
     4321 cacaggtggc ctgggcttgg ctgttgaggg tccctcagag gccaagatgt cttgtatgga
     4381 taataaagat ggcagctgct cggtagaata catcccctat gaagctggaa cctatagcct
     4441 taacgtcact tatggtggtc accaagtgcc aggtagcccc ttcaaggttc ctgtacatga
     4501 tgtgacagat gcatctaaag tcaagtgttc tggacctggc ttaagcccag gcatggtccg
     4561 tgccaacctc cctcagtcct ttcaggtaga cacaagcaaa gccggagttg ccccactgca
     4621 ggtcaaagta caggggccca aaggcctggt ggagccagtg gatgtagtgg acaatgctga
     4681 tggtactcag actgtcaact atgtgcccag ccgagaaggg tcctatagca tttctgtgct
     4741 gtatggtgaa gaagaagtgc cacggagccc cttcaaggtc aaggtgctgc ccacgcatga
     4801 tgccagtaag gtgaaggcca gtggacctgg actcaacacc actggtgtgc ctgccagcct
     4861 gcctgtggag ttcaccattg atgccaagga tgctggggag ggtctgttgg ctgtccagat
     4921 tacggaccct gaaggcaagc ccaagaagac acacatccaa gataatcatg atggcacata
     4981 cacagtggcc tatgtgccag atgtgacagg ccggtacaca atcctcatca agtatggtgg
     5041 tgatgagatc cccttttccc cataccgtgt ccgggctgtg cccactgggg atgccagcaa
     5101 gtgcacagtc acaggtgctg gcattggccc caccatccag attggagagg agacagtgat
     5161 tactgtggac acaaaagcag caggcaaagg caaagtgact tgcacagtgt gcacacctga
     5221 tggctcagag gtagatgtgg acgtggtgga gaatgaggat ggcacctttg acatcttcta
     5281 cacagccccg caaccgggca aatatgtcat ctgtgtgcgc ttcggtggcg agcatgtgcc
     5341 caacagcccc ttccaagtta cagctttagc tggggaccaa ccaacagtgc agaccccatt
     5401 aaggcctcag cagctgcctt cacagtatac ctatcctcag ggtagccagc aaacatggat
     5461 tccagagagg cccatggtgg gcgttaatgg gctggatgtg accagcctga ggccctttga
     5521 tcttgtcatc cccttcacta tcaagaaggg tgagatcact ggggaagttc gaatgccctc
     5581 tggcaaggtg gcccagcctt ccatcactga caacaaagat ggcactgtta ctgtgcgtta
     5641 ctcacccagt gaagctggcc tgcatgaaat ggacattcgc tatgacaata tgcatatccc
     5701 aggaagccct ctgcagttct atgttgatta tgtcaactgt ggtcacatca ctgcctatgg
     5761 tcctggcctt acccatggag tggtcaacaa acctgccacc ttcactgtca acaccaagga
     5821 tgcaggagaa gggggcttgt ctctggccat tgagggtcca tctaaagcag aaatcagctg
     5881 cactgacaac caggatggga catgcagtgt ctcttacctg cctgtgctgc ctggtgacta
     5941 cagcatccta gtcaagtaca atgaccagca catcccaggc agccccttca ctgccagagt
     6001 aacaggtgat gattccatgc gtatgtccca cctaaaggtg ggttctgctg ctgatatccc
     6061 catcaacatc tcagaaacag acctcagcct actcacagcc actgtggtgc caccttcagg
     6121 tcgagaggaa ccctgtctgc tgaaacggtt gcgtaatggc cacgtgggga tttccttcgt
     6181 gcccaaggag acaggggagc acctggtaca cgtgaagaag aatggccagc atgtggcaag
     6241 cagtcccatc ccagtagtga tcagccagtc ggagataggt gatgccagcc gtgtaagggt
     6301 ctctggtcaa ggcctccatg aaggccatac ctttgagcct gcagagttta ttattgacac
     6361 cagagatgca ggctatggtg ggctcagtct gtccattgag ggccctagca aagtagacat
     6421 caacacagag gacctggagg acggcacatg cagggtcacc tactgtccca cagagcctgg
     6481 aaactacatt ataaacatca aatttgctga ccaacatgtg cctggcagtc ctttttctgt
     6541 gaaggtgaca ggtgagggcc gggtaaaaga gagtatcaca cgcaggcgac gtgccccttc
     6601 tgtggccaat gttggcagtc attgtgacct cagcttgaag attcctgaaa ttagcatcca
     6661 agatatgaca gcccaggtga ccagcccatc aggcaagacc catgaggcag agattgtaga
     6721 aggagagaac catacttact gtatccgatt tgtgcctgct gagatgggga tgcatacagt
     6781 cagtgtcaag tacaagggcc agcatgtacc tgggagcccc ttccagttca ctgtgggacc
     6841 tctgggggaa gggggtgctc acaaggtccg tgctggaggc cctggcctag agagggctga
     6901 agctggagta ccagcggagt tcggcatttg gactagggaa gctggcgctg gaggcctggc
     6961 cattgctgtt gaaggcccta gcaaggctga gatctctttt gaggaccgaa aggatggctc
     7021 ttgtggtgtg gcctacgtag ttcaggagcc aggtgactat gaggtctcag tcaagttcaa
     7081 cgaggaacac atacctgata gccccttcgt ggtgcctgtg gcttctccgt ctggtgacgc
     7141 ccgccgcctt actgtttcta gtcttcagga gtcagggtta aaggtcaacc agccagcatc
     7201 ttttgcagtc agcctgaatg gagccaaagg ggcaattgat gccaaggtgc atagcccctc
     7261 aggagctctg gaggagtgct atgtcacaga gattgaccaa gataagtatg ctgtgcgttt
     7321 catcccacga gagaatggcg tctacttgat cgatgtcaag ttcaatggta ctcacatccc
     7381 tggaagtccc ttcaagattc gagttgggga gcctggtcat ggaggggacc caggcttagt
     7441 atccgcctat ggagcaggcc tggaaggtgg tgtcacaggg agcccagctg agtttattgt
     7501 gaacacaagc aatgcaggag ctggtgccct ttcggttacc attgatggcc cctccaaggt
     7561 gaagatggat tgccaggagt gccctgaggg ctaccgtgtc acctataccc ccatggcacc
     7621 tggcagctac ctcatctcca tcaagtatgg tggcccctat cacattgggg gaagcccctt
     7681 caaagccaag gtcacaggtc cccgtcttgt tagcaaccac agcctccatg agacatcatc
     7741 tgtgtttgtg gactctctga ctaaagttgc tactgttccc cagcatgcaa cctcaggccc
     7801 aggtcctgct gatgtcagca aggtagtagc caaaggcctg gggctaagca aagcttatgt
     7861 aggccagaag agcaacttca cagtagattg cagcaaagca ggtaacaaca tgttgctggt
     7921 gggcgtgcat ggcccaagga caccctgtga agagatcctg gtgaaacaca tgggcagtcg
     7981 cctctatagt gtctcctacc tgctcaaaga caaaggggaa tacacattgg tggtcaagtg
     8041 gggtgatgag catatcccag gcagcccata ccgcattatg gtgccctgag cttgccactt
     8101 tgccagccag aagctcccat ggcaatgagc atccccatac ctgtcttatc ccccaagaag
     8161 ccccattttc cttcctgtgc cctggaccct cccttccctg agtcactcta gccactattc
     8221 actgcagtcg cccttgccct gcgctgtgtt cacctgcctt tgggctttca cttgggcaga
     8281 gggagttatt tggtggcaga gcatgtcttc tttggttctg ggagggtgga agtcctatgt
     8341 acaaccacct cctagttctc tttcccaccc aagagaaata aaaattttgc ttccattgtc
     8401 ctgtgaatgt ag
//
