LOCUS       NM_001008279            4035 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus FLII, actin remodeling protein (Flii), mRNA.
ACCESSION   NM_001008279 XM_213330
VERSION     NM_001008279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Revenu C, Ubelmann F, Hurbain I, El-Marjou F, Dingli F, Loew D,
            Delacour D, Gilet J, Brot-Laroche E, Rivero F, Louvard D and Robine
            S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Lin CH, Waters JM, Powell BC, Arkell RM and Cowin AJ.
  TITLE     Decreased expression of Flightless I, a gelsolin family member and
            developmental regulator, in early-gestation fetal wounds improves
            healing
  JOURNAL   Mamm Genome 22 (5-6), 341-352 (2011)
   PUBMED   21400204
  REMARK    GeneRIF: Decreased expression of Flightless I in early-gestation
            fetal wounds improves healing.
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Waters JM, Lindo JE, Arkell RM and Cowin AJ.
  TITLE     Regeneration of hair follicles is modulated by flightless I (Flii)
            in a rodent vibrissa model
  JOURNAL   J Invest Dermatol 131 (4), 838-847 (2011)
   PUBMED   21191408
  REMARK    GeneRIF: Flii appears to have a positive role in the regeneration
            of hair follicles, contrary to its negative influence on wound
            healing in skin
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Campbell HD, Fountain S, McLennan IS, Berven LA, Crouch MF, Davy
            DA, Hooper JA, Waterford K, Chen KS, Lupski JR, Ledermann B, Young
            IG and Matthaei KI.
  TITLE     Fliih, a gelsolin-related cytoskeletal regulator essential for
            early mammalian embryonic development
  JOURNAL   Mol Cell Biol 22 (10), 3518-3526 (2002)
   PUBMED   11971982
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Liu YT and Yin HL.
  TITLE     Identification of the binding partners for flightless I, A novel
            protein bridging the leucine-rich repeat and the gelsolin
            superfamilies
  JOURNAL   J Biol Chem 273 (14), 7920-7927 (1998)
   PUBMED   9525888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085829.1.
            
            On Dec 16, 2004 this sequence version replaced XM_213330.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085829.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4035
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /note="FLII, actin remodeling protein"
                     /db_xref="GeneID:287375"
                     /db_xref="RGD:1307590"
     exon            1..85
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3835
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /note="flightless I actin binding protein"
                     /codon_start=1
                     /product="protein flightless-1 homolog"
                     /protein_id="NP_001008280.1"
                     /db_xref="GeneID:287375"
                     /db_xref="RGD:1307590"
                     /translation="MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTG
                     LCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFK
                     LDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDSIPNQLFINLTDLLYLDLSE
                     NRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSNLPTS
                     LEGLSNLSDVDLSCNDLTRVPECLYTLPNLHRLNLSSNQIAELSLCIDQWVHLETLNL
                     SRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLELIPE
                     SLCRCPKLRKLVLNKNRLVTLPEAIHFLTEIEVLDVRENPSLVMPPKPADHTAEWYNI
                     DFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMS
                     DVAQEKNKNQEESTDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIEN
                     FVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAV
                     NLRNYLGAECRTAREEMGDESEGFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRV
                     YGKKNIKLEPVPLKGTSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKARLFAEKMNKN
                     ERKGKAEITLLVQGQEPPEFWDVLGGEPSEIKKHVPDDFWPPQPKLYKVGLGLGYLEL
                     PQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRA
                     AALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQG
                     PGISGKVKRDTEKKDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGFVLEG
                     RKFTRLAEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKPEDKEGKASAEGREEEEAAAE
                     TEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENP
                     KFLSHFKRKFIIHRGKRKVTQTLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFI
                     LKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDPSYSKQVINEGEEPENFFW
                     VGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQE
                     VYMWVGTQTSQVEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAW
                     STFRQAPA"
     exon            86..196
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            197..268
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            269..349
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            350..435
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            436..597
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            598..701
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            702..877
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1035
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1120
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1268
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1405
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1618
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1798
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1881
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1956
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2040
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2212
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2317
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2509
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2698
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2838
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3079
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3231
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3292
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3421
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3528
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3634
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3700
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..4004
                     /gene="Flii"
                     /gene_synonym="Fliih"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccataggag agctacgcca ccatggaggc caccggggtg ctgccgttcg tgcgcggcgt
       61 ggacctcagc ggcaacgact tcaagggcgg ctacttccct gagaatgtca aggctatgac
      121 cagcctgcga tggctaaagc tgaaccgcac aggtctctgc tacctgcctg aagaactagc
      181 agctctgcag aagctggagc acctgtctgt gagccacaac aatctgacca cgcttcatgg
      241 ggaactgtcc agcctgcctt cacttcgggc cattgtagct cgagccaaca gcctgaagaa
      301 ttctggagtc cccgatgata tcttcaagct ggatgatctc tccgttctgg acttgagcca
      361 taaccagttg acagaatgcc cacgagagct ggagaacgcc aagaacatgc tggtgctcaa
      421 cctcagccat aacagcattg actccatccc caaccagctg ttcatcaacc ttacggactt
      481 gctgtacctg gacctcagtg agaaccgcct agagagcctt ccccctcaaa tgcgccgcct
      541 cgtgcacctt cagacactgg tgctgaatgg aaacccgctg ctgcatgcac agctccggca
      601 gctcccggcc atgatggccc tacaaaccct gcatctgagg aacactcaac gcacccagag
      661 caacctcccc actagcctgg agggcctgag caacctttca gacgtggacc tgtcgtgcaa
      721 tgacttgaca agggtgccag agtgcctgta caccctcccc aacctgcacc gcctcaacct
      781 cagtagcaac cagatcgcag agctatctct gtgcatcgac cagtgggtgc acctggagac
      841 cttgaatctg tcccgcaacc agctcacctc cctgccttca gccatttgca agctcacgaa
      901 gctgaagaaa ttgtacctga actccaacaa gctggacttt gatgggctac cttctggcat
      961 cggcaagctc accagcctgg aggaattcat ggctgctaac aacaacctag aactgattcc
     1021 agaaagtctc tgcaggtgcc caaagctgag gaaactcgtc ctgaacaaga accgcctggt
     1081 gacccttcct gaggccatcc actttctgac agagatcgag gtcctggatg ttcgagaaaa
     1141 ccccagcttg gtcatgccgc ccaagcctgc tgaccacacc gccgagtggt acaacattga
     1201 cttctcacta cagaaccagc tgaggctggc gggtgcctcc ccggccacag tggccgccgc
     1261 tgcagctgta gggagcgggt ccaaggaccc cttggctcgc aagatgcggc tacggaggcg
     1321 caaggactcg gcacaggatg ttcaggccaa gcaagtgcta aagggcatgt cagacgttgc
     1381 ccaggagaaa aacaaaaacc aagaggaaag cacagatgcc cgagcacctg ggggaaaggt
     1441 acggcgctgg gaccagggcc tggagaagcc acgccttgac tactcggagt tctttacgga
     1501 ggatgtgggc cagctgcctg ggttgaccat ctggcaaatt gagaactttg tgcctgtgct
     1561 ggtggaggaa gccttccatg gcaagttcta cgaggccgac tgctacattg tgctcaagac
     1621 cttcctggat gacagcggct ccctgaactg ggagatctac tactggattg gcggggaggc
     1681 cacacttgac aagaaagcct gttctgccat tcatgctgtc aacctgcgca actatctggg
     1741 cgctgagtgc cgtactgcgc gggaggagat gggcgatgag agtgagggct tcctgcaggt
     1801 gtttgacaat gacatctcct acattgaagg cggaacagcc agtggcttct atactgtgga
     1861 agacacacac tatgttacca ggatgtaccg tgtgtatggg aaaaagaaca tcaaattgga
     1921 gcctgtgccc ctcaagggga cctcactgga tccgaggttt gtgtttctcc tggaccaagg
     1981 actggacatt tatgtatgga gaggggccca ggccacactg agcaacacca caaaggccag
     2041 actctttgca gagaaaatga acaagaatga gcggaaaggg aaggcggaaa tcacgctcct
     2101 ggtgcagggt caggagccac cggagttctg ggatgtgctg ggcggggaac cctctgagat
     2161 aaaaaagcat gtgcctgatg acttctggcc gccccagccc aagctataca aggtgggcct
     2221 ggggctgggc tacttggagc ttccgcagat caactacaag ctctcagtgg aacacaaaaa
     2281 acggcccaag gtggagctga tgccaggaat gaggctgttg cagagcctgc tggacacacg
     2341 atgtgtgtac atcctggact gctggtctga tgtattcatc tggcttggcc gcaagtcccc
     2401 acgcctagtg cgtgccgctg cactcaaact gggccaggag ctgtgtggga tgctacaccg
     2461 gccacgacat acagtggtca gccgcagcct ggagggcacc gaggcacagg tgttcaaggc
     2521 caagttcaaa aactgggatg atgtgttgac agtggactac acacgaaatg cagaggctgt
     2581 gctgcagggc ccggggatct ctgggaaggt gaagcgagac acggagaaga aagaccagat
     2641 gaaggctgac ctcactgcac tcttcctacc tcggcagcca ccaatgccac tggctgaggc
     2701 cgagcagctg atggaggagt ggaacgaaga cctggatggc atggagggct tcgtgctgga
     2761 gggccggaag ttcactcgac tggcagagga ggagtttggc cacttctaca cacaggactg
     2821 ctatgtcttc ctctgcaggt actgggtgcc tgtggagtac gaggaggaag agaagccaga
     2881 agacaaggaa gggaaggcct cggcagaggg cagagaagag gaggaagcag cagctgagac
     2941 agaggagaag cagccagagg aggattttca gtgcatcgtt tacttctggc agggccggga
     3001 ggcctccaac atgggctggc ttaccttcac attcagtctg cagaagaagt tcgagagcct
     3061 tttccctggc aagctagagg tagtacgcat gacacaacaa caggagaacc ctaagtttct
     3121 atcccacttc aaaagaaagt tcatcatcca ccggggcaag aggaaggtga cccagactct
     3181 ccagccgacc ctctatcaga tccggactaa tggcagtgcc ctctgcaccc ggtgcattca
     3241 gatcaacact gactccagtc ttctcaactc tgagttctgc ttcatcctca aggtcccctt
     3301 tgaaagcgag gacaaccaag gcatcgtgta tgcctgggta ggccgggcat cagaccctga
     3361 cgaagccaag ctggcagagg acatcctgaa caccatgttt gacccctcct acagcaaaca
     3421 ggtcatcaac gagggtgagg agccagagaa cttcttctgg gtaggcatcg gtgcacagaa
     3481 accctatgac gatgacgcag agtacatgaa gcacacgagg ctcttcaggt gctccaatga
     3541 gaagggctac ttcgcagtga ctgagaaatg ctctgacttt tgccaagatg acctggcaga
     3601 cgatgacatc atgctgctag acaatggcca agaagtgtac atgtgggttg ggactcagac
     3661 aagccaagtg gagatcaaac tgagtctgaa ggcttgccag gtatacatcc agcacacacg
     3721 ctctaaagaa catgagcggc cacgccgcct gcgcctggtc cgcaaaggta acgaacaacg
     3781 tgccttcacc cgctgcttcc atgcctggag cacgttccgt caagccccag cctaggcagt
     3841 acctgtgacc ccagatccag tgaggaggaa gaggcctcct agtacctgct tcatctactc
     3901 acatcctgca agcagcacac agcccaaagc cctaccagtg tgtccacgta tgtgcagaag
     3961 tagtttaaaa gatattaaat gcttttattt tcaatattaa aaaaaaaaaa aaaaaaaaaa
     4021 aaaaaaaaaa aaaaa
//
